Search

Objective: This study compared the long-term effects of a mindful compassion program on improving depression in lung cancer patients, both in patient-caregiver dyads and in patient-only groups, and examined the moderating roles of anxiety and quality of life (QOL). Method: Participants consisted of 56 dyads, who were randomly assigned to either the dyadic or patient-only groups. Data collection included various assessments at different time points: baseline (T0), end of intervention (T1), and follow-up at the 5th month (T2), 8th month (T3), and 14th month (T4). Results: Patients in the dyadic group experienced a significant reduction in depressive symptoms. The dyadic intervention was particularly beneficial for younger patients and those with higher baseline QOL symptom distress. Improvements in patients’ mindfulness and self-compassion contributed to reduced depression by enhancing general health and lowering anxiety. Additionally, caregivers’ self-compassion played a role in reducing patients’ depression by improving patients’ QOL functioning and decreasing anxiety. Conclusions: Mindfulness and compassion interventions, whether provided dyadically or individually, can be tailored to each patient’s specific condition.

Phyllanthus emblica L. (P. emblica L.) is a widely consumed healthy fruit known for its taste and benefits. This study used association rule mining to demonstrate its anticancer properties, analyzing its 65 chemical components, 1767 related targets, and 4282 efficacy items. Myricetin was identified as a key component targeting CA2, which is involved in cancer pathways. The research suggested P. emblica L.’s potential against non-small cell lung cancer and esophageal cancer, which was supported by experiments showing significant growth inhibition in related cancer cells. This approach offers a more targeted and convincing understanding of P. emblica L.’s effects, improving upon traditional food research methods.

Epicatechin (EC) is a water-soluble natural organic compound belonging to the flavanol class of compounds. It exhibits various physiological activities such as anti-inflammatory, antioxidant, treatment of mitochondrial diseases, and prevention of cardiovascular diseases.To examineEC’s impact and mechanism on adult myoblasts’ insulin resistance. The effects of various EC concentrations on the viability of C2C12 adult myoblasts were measured, as were glucose consumption and glycogen content; in vitro antioxidant activity of EC was measured; cellular oxidative marker content and apoptosis were measured; and protein expression was detected by Western blot. A model of insulin resistance in C2C12 myogenic cells was established using palmitic acid. EC significantly increased the glucose consumption and glycogen content; EC increased the levels of CAT, SOD and GSH and decreased the levels of NO, MDA and ROS; EC decreased the apoptosis rate of cells; EC treatment upregulated the levels of GLUT4, p-AMPK, p-ACC, NRF2, and HO-1 proteins. These results suggest that EC can regulate the NRF2/HO-1 signaling pathway, enhance GLUT4 transport, activate AMPK/ACC pathway, enhance cellular uptake of glucose, thus effectively improving insulin resistance in C2C12 cells.

Previous studies have focused on the design of video lectures to improve students’ social presence by enhancing instructor presence for learners in lecture-based online courses; however, there has been limited emphasis on the peer presence in which learning from video lectures takes place. This study’s first objective is to develop a social presence (SP)-based teaching strategy to design online learning activities aimed at improving students’ social presence by providing social clues about peer presence and encouraging peer communication. The second objective is to compare students’ social presence, social interaction, and academic performance from lecture-based online learning supported by either a conventional teaching strategy or an SP-based teaching strategy. Using a quasi-experiment, we selected 81 Chinese university students to participate in a ten-week online course. The participants were randomly assigned to either an experimental group (EG) (N = 43) or a control group (CG) (N = 38). This study revealed that the SP-based strategy enhanced EG members’ social presence in online learning and that EG members achieved better academic performance than CG members. A significant correlation was found between the EG members’ academic performance and their social presence. The researchers also identified more concentrated social network sociograms with more cohesive subgroups in the EG members’ online interactions. The results indicate the necessity of applying an SP-based teaching strategy in lecture-based online courses to promote students’ social presence, social interaction, and academic performance.

This study investigated the impact of Oleanolic Acid (OA) on cholesterol metabolism and. MTT assays demonstrated that OA had no cytotoxic effects on HepG2 cells at concentrations below 20 μM. Subsequent experiments focused on 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), a key enzyme in cholesterol biosynthesis. OA significantly reduced HMGCR protein expression without affecting other enzymes. Further investigations revealed that OA reduced the protein and mRNA expression of HMGCR and its upstream regulator Sterol regulatory element binding protein-2 (SREBP-2) in HepG2 cells. OA activated Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK), enhancing HMGCR phosphorylation and inhibiting its activity. Molecular docking experiments suggested that OA could suppress HMGCR enzymatic activity through hydrophobic interactions, reducing catalytic efficiency. Overall, OA downregulated HMGCR expression and activity, leading to decreased cholesterol synthesis. These findings highlight OA’s regulatory role in cholesterol metabolism and its potential for improving atherosclerosis (AS), supporting its application in functional food development.

To effectively inhibit the formation of heterocyclic amines (HAs) is crucial for human health. Plant extracts with strong antioxidant activity could be applied to meat processing to prevent the formation of HAs. The results indicated that red pepper (Capsicum annuum L.) stalk extracts (RPSEs) exhibited antioxidant activity during the thermal processing of meat by decreasing protein and lipid oxidation and neutralizing free radicals. And effectively inhibited the formation of HAs in beef patties with an inhibition rate ranging from 29.5% to 89.3%. These benefits were achieved without adversely affecting the physical or chemical properties of grilled beef patties, except for a slight increase in hardness. Betaine-based deep eutectic solvent extracts resulted in a significant reduction of 65.4–89.3% and 67.5–84.7% for free and protein-bound HAs. Our research introduces a novel approach to diminish the levels of HAs in meat, enabling food producers to create more safety meat options.

Wuyi rock tea residues, generated after brewing or aroma extraction, are rich in nutrients. This study aimed to prepare ACE inhibitory peptides from the protein hydrolysate of Wuyi rock tea residues and investigate their stability. The optimal proteolysis conditions for neutral protease were optimized as: a substrate concentration of 2% (w/v), pH 7.0, hydrolysis temperature of 45°C, enzymatic digestion time of 3 h, and enzyme dosage of 6800 U/g. Under these conditions, the ACE inhibition rate of protein hydrolysate of Wuyi rock tea residues reached 70.47 ± 0.29% at a concentration of 0.5 mg/mL. Additionally, the prepared ACE inhibitory peptides demonstrated excellent stability against acid, base, heat, and certain metal ions. These findings suggest that the proteins extracted from Wuyi rock tea residues can serve as a promising source to produce highly active ACE inhibitory peptides. These peptides could be utilized in the development of nutraceuticals, functional foods, and pharmaceuticals.

Dihydrotanshinone I (DHT), a lipophilic compound extracted from Salvia miltiorrhiza, has cardiovascular protective effects, but the underlying molecular mechanisms of action have rarely been reported. Based on this, whether DHT affects cholesterol metabolism by regulating LDLR is investigated in this work. The results revealed that DHT can increase LDLR expression and promote LDL uptake by HepG2 cells. Meanwhile, DHT stabilizes LDLR mRNA expression by activating the epidermal growth factor receptor/extracellular signal-regulated kinase 1/2 (EGFR/erk1/2) signaling pathway. In addition, DHT inhibits the expression of the proprotein convertase subtilisin/kexin type 9 (PCSK9) by down-regulating the liver nuclear transcription factor 1 A (HNF1A) and up-regulating the forkhead box O3 (FOXO3). All of these indicate that DHT increases LDLR expression at the post-transcriptional and post-translational levels thereby promoting LDL-C metabolism. The potential mechanism of DHT to improve lipid metabolism has been revealed as a promising drug against AS.

Introdução A Avaliação de Tecnologias em Saúde (ATS) ocorre rotineiramente pelo Ministério da Saúde (MS). A análises realizadas pela CONITEC tem como objetivo recrutar as melhores evidências de modo a estabelecer uma relação de custo-efetividade sobre esta tecnologia. As recomendações favoráveis a incorporação ocorre paralelamente a criação dos Protocolos Clínicos e Diretrizes Terapêuticas (PCDT) para que haja uma otimização nas condutas e, consequente, acesso ao usuário. O processo de incorporação é algo complexo e interdisciplinar, não isentando as diferentes esferas governamentais de sofrer com a judicilização. As judicializações de medicamentos padronizados ocorrem indiferentemente a incorporação, impactando a gestão de recursos financeiros na saúde. O objetivo deste trabalho é discutir o perfil de judicialização de medicamentos padronizados no Componente Especializado da Assistência Farmacêutica da Secretaria de Saúde do Distrito Federal (SESDF). Métodos Trata-se de um estudo retrospectivo, transversal, que visa demonstrar o impacto orçamentário e evidenciar a judicialização de medicamentos pertencentes ao elenco do CEAF durante o ano de 2022 na SESDF. Os dados utilizados foram retirados do Sistema de Gestão de Estoque (Sis-materiais) e do Sistema de Informação da Farmácia Judicial (SISFAJ) e tratados pelo programa Microsoft Excel. Resultados O Núcleo de Farmácia Ambulatorial Judicial possui 1333 pacientes cadastrados para o favorecimento via judicial de 265 itens. Dos itens cadastrados no NUFAJ, aproximadamente 11% são referentes a medicamentos padronizados na SESDF, sendo responsável pelo gasto de 4.396.199,43 reais em 2022 em judicialização. Dos medicamentos pertencentes ao elenco do CEAF, os que tiveram maior representatividade orçamentária foram: Nusinersen, Rituximabe, Omalizumabe, Iloprosta, Eltrombopague, Mepolizumabe, Somatropina, Micofenolato de mofetila, produto a base de canabidiol, Sirolimo, Infliximabe, Ambrisentana e Adalimumabe, respectivamente. Equivalente a 88% do valor gasto com medicamentos judicializados e padronizados no DF. Desses medicamentos, seis deles (Nusinersen, Omalizumabe, Iloprosta, Mepolizumabe, produto à base de canabidiol, Ambrisentana) são medicamentos recém padronizados pelo MS, mas que ainda não haviam processo de aquisição finalizado. Discussão e conclusões Notável que a incorporação dos medicamentos pelo MS não caracteriza o fornecimento imediato ao usuário. Sabe-se que os processos de aquisição é algo extenso e complexo que envolve um conjunto de exigências legais, o que causa demora no fornecimento do medicamento. Entretanto, a lentidão dos processos de aquisições, sobrecarrega os gastos das secretarias estaduais com as judicializações. Como exemplo temos o mepolizumabe que foi incorporado pelo MS em 2021, mas o fornecimento pela SESDF ocorreu somente em março de 2023, o que dificultou o acesso pelos usuários. A demora da aquisição pelo MS, sobrecarrega aquisição via estadual por demandas judiciais, uma vez que o processo ocorrerá via dispensa de licitação, gestão de recursos, sendo a dispensa de licitação algo que deve ocorrer de maneira excepcional. O não fornecimento imediato da decisão judicial, resulta no sequestro de verba por determinação judicial, causando danos indiretos ao erário público, por alterar o planejamento de recursos financeiros. É imprescindível que haja uma celeridade nos processos de aquisição dos medicamentos recém padronizados, de modo a garantir o acesso e a promoção à saúde e melhorar a gestão de recursos financeiros na saúde.

Introdução O Sistema Único de Saúde deve garantir o acesso universal, integral e igualitário a todos os brasileiros, sendo a Política Nacional de Assistência Farmacêutica uma das ações a garantir o acesso ao medicamento. A Relação de Medicamentos Essenciais é uma das estratégias de otimização de acesso ao medicamento e, consequente, racionalização dos recursos financeiros. Os medicamentos disponíveis na SUS nem sempre são capazes de contemplar todas as necessidades de saúde da população, o que potencializa a judicialização da saúde. A judicialização tem impacto negativo orçamentário, uma vez que, devido a cerelidade do cumprimento de decisão judicial, acarreta compras com dispensa de licitação, com a aquisição de medicamentos mais onerosos. O objetivo deste trabalho é identificar o perfil farmacoeconômico dos medicamentos judicilizações na Secretaria de Saúde do Distrito Federal (SESDF). Métodos Trata-se de um estudo retrospectivo que visa analisar o perfil e o impacto orçamentário no ano de 2022 referentes à judicialização de medicamentos na SESDF. Os dados utilizados foram retirados do Sistema de Gestão de Estoque (Sis-materiais), incluídos somente medicamentos disponibilizados para o Núcleo de Farmácia Ambulatorial Judicial, e foram tratados pelo programa Microsoft Excel. Resultados A SESDF apresenta cerca de 1333 pacientes na Farmácia Ambulatorial Judicial, sendo 265 itens de materiais a medicamentos judicializados. Cerca de 25% referem-se a medicamentos padronizados e 75% a medicamentos não padronizados. No ano de 2022 foram gastos 38.562.023,27 reais, sendo 11% dos gastos referentes a medicamentos padronizados. Discussão e conclusões A grande maioria do elenco padronizado judicializado refere-se a pacientes não contemplados pelo Protocolo Clínico e Diretrizes Terapêuticas (PCDT) ou medicamentos que ainda não foram adquiridos pelo Ministério da Saúde, como o caso do Nusinersen. Dos medicamentos não padronizados que consomem grande parte do orçamento gasto com judicilização, estão a Pirfenidona, Nintedanibe, ocrelizumabe e ruxolitinib, sendo os três primeiros medicamentos referentes aos tratamentos de doenças crônicas, como a Fibrose Cística Pulmonar e Esclerose Múltipla. Os quatro juntos consumiram cerca de 29,4% do orçamento para atender somente 13% dos pacientes judicilizados no ano de 2022. Os quatro medicamentos já tiveram suas análises pela CONITEC no qual não recomendaram a incorporação. Verifica-se que a judicilização não é um fator determinante para a incorporação dessas tecnologias no âmbito do SUS. Em destaque, verifica-se que a relação da incorporação de um medicamento com um CID de doença específica, também fortalece a judicialização, uma vez que se refere a pacientes que não contemplam os critérios de inclusão dos PCDT’s. Logo, a incorporação do medicamento amarrado ao CID, favorece a judicilização de saúde, visto que o sistema judicial não compreende os critérios utilizados na ATS. Futuramente, uma reanálise dessas tecnologias seria relevante, uma vez que poderá haver novos estudos clínicos que possam corroborar com o benefício do uso desses fármacos e melhorar a perspectiva de saúde de pacientes com doenças raras e incuráveis. O entendimento do perfil farmacoeconômico dos medicamentos judicializados podem subsidiar o desenvolvimento de estratégias estaduais a fim de diminuir a judicialização de medicamentos no SUS e otimizar os recursos da saúde na esfera estadual.

Investigar el papel del IMC, las moléculas del perfil lipídico en suero y los cocientes lipoproteicos en los pólipos colorrectales.

ABSTRACT Fatigue vibration is a primary cause of fruit damage during transportation. Drawing on the Palmgren–Miner fatigue accumulation damage theory and the correlation between fruit vibration damage characteristics and external vibration excitation, this paper proposes a fruit vibration fatigue accumulation damage model and its method for parameter determination. Using pears as the research objects, we conducted fatigue damage vibration and critical fatigue damage vibration tests under various conditions to determine the vibration fatigue constant of the pears. By utilizing the critical value of the damage area specified in the pear grading standard for premium grade, we derived the threshold acceleration value for pear damage. These findings serve as a technical foundation for advancing our understanding of fruit vibration fatigue damage mechanisms and guiding the development of cushioning packaging to protect fruit from vibrations.

ABSTRACT Banana stalk production for fiber is an important crop activity in southern China. The fiber extraction technology used has a great impact on the effectiveness and quality of the fiber from banana stalks. A mechanical model of the process for banana stalk fiber extraction was developed through theoretical analysis. The existing problems of machines for banana stalk fiber extraction include high rates of fiber impurity and damaged fibers. A 3-factor 3-horizon orthogonal rotation combination test was established. The rates of fiber impurity and damaged fibers were the evaluation indices. The significant order of the factors determining the rate of fiber impurity, from largest to smallest, was the gap between the scraper and the holding plate, the number of scrapers, and the rotational speed of the scraping knives roller. The significant order of factors for the rate of damaged fiber was the gap between the scraper, the rotational speed of the scraping knives roller, and the number of scrapers. The optimized banana straw fiber extraction machine was tested in the field. The results show that the development of this model can provide valuable experience and references for understanding and improving other similar agricultural machinery and equipment.

Driven by its healthy and nutritious attributes, the US avocado market has experienced tremendous growth over the past two decades. This publication provides a comprehensive overview of US avocado production and trade. The US avocado market, marked by the decline of already limited US domestic production, is increasingly reliant on imports, especially those from Mexico. This overview aims to inform industry stakeholders and policymakers of the current state of the industry and offer insights into its sustainability.

This study constructs a deep learning-based model to predict internet addiction among college students and analyzes significant influencing factors. A random survey of 4,895 students from a university in Shandong Province was conducted using questionnaires on general information, internet addiction (CIAS-R), personality (CBF-PI-B), psychological traits (SDS, SAS), parenting styles (EMBU), behavioral issues (SAS-C), and social support (ASSRS) to establish a database. A predictive model was developed using a 1D Convolutional Neural Network (1D-CNN), extracting key influencing factors of internet addiction. The model showed 92.77% accuracy, with high precision and recall rates for predicting normal users and addicts. The gradient calculation indicates that in second-year students, negative and withdrawal behaviors, depression, over-interfering families, and anxiety significantly contribute to Internet addiction, with factors exceeding 0.5. The 1D-CNN model offers robust performance and accuracy in predicting internet addiction, identifying significant factors for early prevention and potential integration with apps for real-time monitoring.

To investigate the role of body mass index (BMI), serum lipid profile molecules and their derivative indexes in colorectal polyps.

Commented article: ZHANG, Ziyu; XU, Xinyue. The enlightenment of Chinese philosophy to the construction of contemporary ecological civilization. Trans/Form/Ação: Unesp journal of philosophy, Marília, v. 47, n. 4, “Eastern thought”, e0240070, 2024. Available at: https://revistas.marilia.unesp.br/index.php/transformacao/article/view/14658.

ABSTRACTLow-density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) play a pivotal role by regulating plasma low-density lipoprotein cholesterol (LDL-c) levels. Dihydromyricetin (DMY), the most abundant natural flavonoid in rattan tea, has proven anti-atherogenic effects, but the underlying molecular mechanisms remain poorly understood. Therefore, we studied the effects of DMY on LDLR and PCSK9. The results showed DMY promoted LDLR protein and mRNA expression and increased LDL uptake in HepG2 cells. DMY inhibited intracellular PCSK9 protein and mRNA expression. And it also significantly reduced PCSK9 levels in the cell culture medium. Furthermore, DMY inhibited the expression of PCSK9 through the liver nuclear transcription factor 1 A (HNF1A) and increased the protein expression of LDLR. Taken together, our results support the idea that DMY regulates LDL-c metabolism through PCSK9/LDLR signaling. This study reveals the potential mechanism of DMY’s anti-atherogenic effect and provides a theoretical basis for dietary DMY supplementation.

ABSTRACTThe bacterial communities of Zaopocu (ZPC), a tropical specialty fermented food in Hainan Island, were characterized in this study using high-throughput sequencing. Firmicutes and Proteobacteria were the two dominant phyla. The primary genus in ZPC_A was Weissella, while ZPC_B and ZPC_C had Lactobacillus as the dominant genus. The biomarker lactic acid bacteria (LAB) in ZPC_A were Lactobacillus brevis, Weissella confusa, and Leuconostoc citreum, whereas Lactobacillus amylolyticus and Lactobacillus helveticus were significantly higher in ZPC_B. In contrast, Lactobacillus pontis and Lactobacillus fermentum were the core LAB in ZPC_C. ZPC_A has the highest value of titratable acid (TA), amino acid, and lactic acid. TA had the most powerful influence on the structure of the bacterial communities, whereas salinity had a negligible effect. It is worth noting that ZPC may also faces food safety issue because opportunistic pathogenic bacteria like Stenotrophomonas and genes closely associated with Staphylococcus aureus infection were highly detected.

ABSTRACTUltrasonic-assisted enzymatic extraction (UAEE) technology was employed to extract the polysaccharides from Dendrobium offcinale Kimura et Migo (D. offcinale). The extraction conditions were optimized by central composite design (CCD) found in the response surface methodology (RSM). The polysaccharide yield (34.05 ± 1.03%) was well matched with the predicted value, as obtained under the optimum parameters: enzyme activity of 2040 U/g, a liquid-solid ratio of 71 mL/g, and a time of 84 min. Compared to other extraction methods, UAEE was able to yield D. offcinale polysaccharide (DOP) highly efficiently in a shorter extraction time period and at a lower extraction temperature. The extracted polysaccharide (DOPUAEE) showcased a better nitrite scavenging ability, a high antioxidant activity, and more potency in inhibiting α-glucosidase, expanding its versatility in food applications.

ABSTRACTGlycoprotein VI (GPVI) is the major collagen receptor on the platelet surface and is important in mediating granule secretion and atherothrombosis. Sulforaphane (SFN), a dietary isothiocyanate enriched in cruciferous vegetables, exerts multiple biological activities. This study aimed to investigate the efficacy of SFN on GPVI-mediated signaling and platelet granule secretion in vitro. We herein demonstrated that SFN greatly attenuated granule secretion in human gel-filtered platelets in response to collagen, including inhibiting CD62P and CD63 expression and PF4, CCL5, and ATP release. Mechanistically, these inhibitory effects of SFN were mainly mediated by its attenuation of cytosolic phospholipase A2 (cPLA2) phosphorylation and thromboxane A2 (TxA2) generation. Moreover, SFN did not further decrease the inhibitory effects of p38 MAPK inhibitor SB203580 on cPLA2 phosphorylation, TxA2 generation and granule secretion. Thus, SFN attenuates platelet granule secretion via down-regulating GPVI-mediated p38 MAPK/cPLA2/TxA2 signaling, which may play important preventive roles in cardiovascular diseases.

ABSTRACTThis study aimed to analyze metabolite abundances and proteome differences between buffalo milk from Binglangjiang (BBM) and Dehong (DBM). Untargeted UPLC-MS/MS, label-free proteomics approach, and bioinformatics analyses including GO, KEGG, and PPI were performed. The results revealed that catechol, L-proline, γ-aminobutyric acid, hippuric acid, creatinine, and betaine were detected in BBM and DBM as the major metabolites. One hundred thirteen proteins, mainly within the molecular weight range of 20–80 kDa, were identified, and the differential protein numbers of BBM were higher than those of DBM. These proteins were primarily involved in cholesterol metabolism, Staphylococcus aureus and Salmonella infections, the peroxisome proliferator-activated receptor signaling pathway, and coagulation cascades. Relative abundances of α-s1-casein, α-s2-casein, and β-casein were plentiful in BBM, while κ-casein, albumin, and α-lactalbumin were in DBM. PPI network analysis indicated that the identified proteins were highly interconnected. These findings promote a better understanding of quality biomarkers in dairy product improvements.

ABSTRACTThe effects of microbial contamination on the rancidity of Huangjiu (Chinese rice wine) during pottery jar storage were studied. With the increase in the rancidity of Huangjiu, the alcohol content decreased, while the conductivity increased significantly. The sour taste and umami taste of Huangjiu increased, leading to flavor deterioration. Meanwhile, the increase in biogenic amine content makes Huangjiu unfit for drinking. The changes in components showed that the degree of rancidity was related to the metabolism of organic acids and amino acids caused by contaminated microorganisms. According to the analysis of microbial community structure, more microorganisms were found in the severe rancid Huangjiu. This indicated that with the aggravation of the degree of rancidity, the community structure of the contaminated microorganisms becomes complex, and potentially pathogenic microorganisms such as Arcobacter species were detected. Therefore, the change of components of Huangjiu will also affect the community structure of contaminated microorganisms.

La irrupción de la Web 2.0 y de las tecnologías de la información y comunicación (TIC) ha provocado un cambio sustancial en el ámbito educativo, con una incidencia más que evidente en el campo específico de la adquisición de segundas lenguas. Dado que la integración de la tecnología digital en la enseñanza debería orientarse adecuadamente para estimular de manera efectiva la motivación de aprendizaje de los estudiantes y lograr los objetivos de enseñanza, este proyecto utiliza el podcast como un medio digital complementario en la enseñanza del vocabulario. Su objetivo es guiar a los estudiantes en el uso de la tecnología para potenciar su motivación en el aprendizaje del vocabulario español, fomentar el desarrollo del autoaprendizaje y mejorar la eficacia del aprendizaje. En este artículo se aborda la experiencia de diseño y aplicación del podcast en la enseñanza de vocabulario español para estudiantes universitarios sinohablantes, basada en el modelo ADDIE como un proceso de desarrollo instruccional. A continuación, se realiza un análisis sobre los resultados de una experiencia práctica en la asignatura de comprensión lectora y expresión escrita española para conocer las consideraciones, valoraciones y opiniones del alumnado. También se analiza el rendimiento de aprendizaje de los alumnos para determinar si existe una relación significativa a través de la implementación del podcast en la enseñanza de vocabulario. Finalmente, se proponen propuestas y sugerencias para la aplicación del podcast en la enseñanza/aprendizaje de ELE.

Abstract In the past ten years, new progress has been made in the study of Chinese overseas, which provides important scientific basis for the work of Chinese overseas and the formulation of relevant policies. Through data mining and analysis of overseas Chinese literature from 2008 to 2021, this work studied the co-occurrence relationships among keywords, authors, research institutions, publication sources of target articles, references and citations. The results suggest a few things. In terms of keyword analysis, there is a high probability that keywords coexist among overseas Chinese, Chinese society and Chinese history. In addition, the degree of cooperation between authors and research institutions in overseas research in China is not high. In terms of target journals, references and citations, resources such as Journal of Overseas Chinese Historical Studies, Overseas Chinese Publishing Company and People’s Publishing House are the main publications published by most overseas Chinese research institutions. In addition, academic articles cite fewer of the journal’s journals. Based on the above problems, this study puts forward relevant recommendations for decision-making, in order to further promote the exchange, sharing and development of China’s overseas research results.

Commented Article: YANG, Baohong. Criticism of Feuerbach thought by Marx and Engels through the Reflection on the Text of the German Ideology. Trans/Form/Ação: Unesp Journal of Philosophy, v. 47, n. 1, e0240002, 2024. Available in: https://revistas.marilia.unesp.br/index.php/transformacao/article/view/14519.

In this work, the effects of electric pulse treatment on the discharge and electrochemical properties of rolled and extruded AZ61 as anode of Mg-air battery were studied. The microstructure, electrochemical behavior and surface morphology after discharge were discussed to relate the discharge performance. The experimental results show that compared with the original magnesium anode (rolled and extruded), the magnesium anode treated by electric pulse has more negative corrosion potential, lower impedance value, higher discharge voltage and better specific energy. This is because electric pulse treatment can cause the coarse second phase in magnesium anode to dissolve and the grains to become more uniform. In particular, in the discharge process, the surface of magnesium anode after electric pulse treatment will form micro cracks, which is beneficial to promote the self-stripping of discharge products. It is worth noting that the effect of electric pulse treatment on rolled anode is better than that of extruded anode. It may be due to the different dislocation density in the two anodes. During the electric pulse treatment, the dislocation density in the alloy is highly correlated with the dissolution rate of β-Mg17Al12, which ultimately affects the volume fraction of the second phase in the alloy.

This work presented a new PEG modified calix[4]arene stationary phase (C4A-PEG-2PTSC) for gas chromatographic (GC) separations. The statically coated C4A-PEG-2PTSC column exhibited moderate polarity and column efficiency of 2224 plates m-1 determined by 1-octanol at 120 oC. The results showed that the C4A-PEG-2PTSC column exhibited the good separation performance for various types of analytes containing halogenated benzenes, benzaldehydes, phenols, alcohols, anilines isomers and showed the different retention behavior with the comparative columns. Importantly, it showed the better separation capacity of toluidine and xylidine isomers than commercial HP-35 column. Moreover, it was applied in practical sample analysis to detect the content of isomer impurities. This work exhibited the good application potential of C4A-PEG-2PTSC stationary phase in GC analyses.

In the fiercely competitive landscape of the peer-to-peer accommodation platform Airbnb, understanding customers’ online recommendation behavior is essential for optimizing competitiveness and harnessing the potential of electronic word-of-mouth. This study aims to provide comprehensive insights into the factors driving customers’ issuance of positive or negative recommendations based on their experiences. Leveraging 10,101 online reviews from Airbnb users, we employ the Structural Topic Model to determine latent topics relating to customers’ recommendation intentions. This study reveals that positive recommendations are primarily influenced by hedonic values tied to the overall experience, including crucial aspects such as convenience for exploring points of interest, local authenticity, social interaction, and emotional fulfillment. These findings highlight the significance of providing memorable and enriching experiences to elicit positive reviews from customers. On the other hand, negative recommendations are closely linked to utilitarian values focused on practical concerns such as check-in procedures, cleanliness, comfortableness, and amenities. Understanding these utilitarian factors is vital for hosts and platform administrators to improve service quality and address potential issues that may lead to negative reviews. Furthermore, this study emphasizes the significant role of hosts in shaping both positive and negative recommendations. This research contributes valuable insights to the field of peer-to-peer accommodation, highlighting the significance of various factors influencing customers’ recommendation behavior.

Objetivo: Explorar la eficacia clínica de la ablación por radiofrecuencia guiada por mapeo de alta densidad en el tratamiento de la fibrilación auricular persistente. Método: Ciento noventa pacientes con fibrilación auricular persistente que recibieron ablación por radiofrecuencia se dividieron en dos grupos: convencional (n = 105) y mapeo de alta densidad (n = 85). Se recopilaron y compararon los indicadores de eficacia. Resultados: La diferencia en la tasa total de recurrencia posoperatoria entre los dos grupos fue estadísticamente significativa (11,58% vs. 23,81%; χ2 = 5055; p = 0.025). Los efectos de los diferentes métodos de tratamiento en el puntaje SF-36 variaron (FSF-36 tratamiento = 43.142, p < 0.05), y los puntajes SF-36 a los 3, 6 y 12 meses de ambos grupos siguieron el mismo orden: grupo de mapeo de alta densidad > grupo convencional. Por su parte, la cirugía guiada por mapeo de matriz de alta densidad (OR: 0.453; IC95%: 0.232-0.784; p < 0.001) es un factor protector contra la recurrencia. Conclusión: Para los pacientes con fibrilación auricular persistente, el uso de electrodos Pentaray para mapear con mayor precisión en la matriz auricular verificó aún más que la tasa de éxito de la estrategia de ablación individualizada es similar a la de la cirugía convencional, mejorando significativamente el estado de salud posterior del paciente y reduciendo la incidencia de reacciones adversas.

Objetivo: Investigar si los implantes de titanio impresos en 3D modificados con superficies de iones de magnesio y zinc pueden promover el cierre de tejidos blandos orales. Método: Se seleccionaron conejos grandes blancos de Nueva Zelanda como animales experimentales, y los dientes mandibulares izquierdo y derecho de cada animal se dividieron al azar en grupo experimental y grupo control, cada uno con 18 casos. Se extrajeron los primeros premolares bilaterales después de administrar anestesia general y se colocaron implantes en los grupos tratados con y sin modificación iónica de la superficie de magnesio/ zinc. Resultados: Bajo observación a simple vista, la combinación del material del implante y el tejido blando circundante en el grupo experimental fue significativamente mejor que en el grupo de control. La tinción de fluorescencia mostró que el valor de densidad de fluorescencia del grupo experimental fue significativamente mayor que el del grupo control (p < 0.05). Conclusiones: Los implantes de titanio impresos en 3D basados en la modificación iónica de la superficie de magnesio/zinc promueven el cierre de los tejidos blandos orales con resultados significativos.

Este estudo tem como objetivo fornecer uma visão geral da tradução e da disseminação da literatura chinesa em língua portuguesa desde 1979, ano em que se iniciou a Reforma e Abertura na China, até o presente, com ênfase nas características e tendências nesse período. Trata-se de uma introdução de estudos no âmbito de projeto sobre a interação entre tradução chinês-português e intercâmbio cultural entre China e Países de Língua Portuguesa. Para tal, foram coletados dados sobre obras literárias chinesas traduzidas para o português em plataformas online, como Goodreads, Amazon, Skoob, Wook, além do banco de dados do acervo bibliográfico Worldcat. A partir da perspectiva da Comunicação Tradutória (Yin, Yu & Deng, 2022), uma nova corrente teórica interdisciplinar de Estudos da Tradução, foram realizadas análises quantitativas e qualitativas com base nos dados coletados, a fim de apresentar as diferentes fases de desenvolvimento da tradução e da disseminação da literatura chinesa traduzida para o português, suas principais características e tendências nas futuras trocas interculturais. Os resultados mostram que diversos tipos de literatura chinesa foram traduzidos para o português, abrangendo desde obras clássicas, como o Tao Te Ching, até romances contemporâneos chineses e trabalhos literários escritos por renomados escritores chineses no exterior, entre outros. Por outro lado, embora o número de obras literárias chinesas de escritores da China continental e sua tradução direta do chinês para o português tenham aumentado na última década, a tradução da literatura chinesa para o português ainda enfrenta certa marginalização no mundo lusófono. Paralelamente, a tradução indireta ainda possui uma presença relativamente maior.

O presente estudo tem como base a minha tradução publicada《蓝鸦》(2019), do português para o chinês, da prosa ficcional Azul-Corvo (2010). Com bases nos conceitos de “tradução não platônica” e de “tradução da letra” defendidos por Antoine Berman (1985). O objetivo deste trabalho é propor uma tradução que consiga recriar a “letra” de Azul-Corvo em chinês e defender que o modelo hermenêutico de Berman é particularmente útil quando se verifica um tamanho choque linguístico entre a língua de partida e a de chegada tal como no caso do par português–chinês, pois a abordagem bermaniana destaca as características de diferença e estranheza interlinguísticas e interculturais, permitindo assim uma perspectiva mais ampla que toma em consideração uma pluralidade de estratégias de tradução.

ABSTRACT The objective of this study was to identify differentially expressed genes (DEG) between females and males in early bovine embryos. Superovulated cattle (n = 4) in the age span of 16–18 months were artificially inseminated with semen from the same bull that has been proven to be fertile. Blastocysts were collected by routine non-surgical uterine flushing on day 7 after insemination. This study determines the sex of embryos using a micro-injection pipette to collect a few blastomeres through the Zona pellucida. The remaining blastomeres were used for single-cell RNA sequencing (scRNA-seq) analysis on the Illumina platform, followed by differential expression analysis, Gene Ontology (GO) function analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The criteria for identifying DEG will be set at |log2(Fold change)| ≥ 1 and P

El ciclo hidrológico natural se ve muy afectado por el cambio climático. En particular, en algunas zonas montañosas, las precipitaciones pueden variar significativamente en el tiempo y el espacio, por lo que es muy importante identificar los procesos hidrológicos de las cuencas hidrográficas con alta resolución. Para analizar estos problemas, la prueba Mann-Kendall, la prueba T móvil, el estimador de pendiente Sen y la prueba de correlación de rango Spearman se combinan con la función de interpolación espacial ArcGIS. Se analiza y discute la evolución de las características de distribución espacial y temporal de las precipitaciones y la escorrentía en las cuencas montañosas típicas. Los resultados muestran que las precipitaciones disminuyen de sur a norte, de alta altitud a baja altitud. Esta diferencia se produce principalmente en el oeste de la cuenca. Las conclusiones son las siguientes: 1) la serie de precipitaciones y escorrentías cambió repentinamente en 1991; 2) el valor extremo de la tendencia de las precipitaciones se mueve del centro al oeste; 3) para la relación entre la escorrentía de la temporada de inundaciones y la escorrentía anual, la serie muestra una tendencia ascendente significativa (nivel de confianza del 95 %), lo que indica que la distribución desigual de la escorrentía ha aumentado de forma notable desde la década de 1960.

This study investigated the ability of Lactiplantibacillus plantarum SCS3 (L. plantarum SCS3) to alleviate oxidative stress in diabetic mice. Diabetic mouse model was established by administering 50 mg/kg (bodyweight) of streptozocin for 5 days. We then applied 0.5 mL of 1.0 × 1010 CFU/mL L. plantarum SCS3 cell suspension (TGa group), its intracellular contents (TGb group), or boiled intracellular contents (TGc group) to mice for ten weeks. Compared with the model group (MG), weight loss and hyperglycemia were most effectively ameliorated in the TGc group compared to the other treatment groups; based on the enzyme linked immunosorbent assay, levels of insulin and glycosylated hemoglobin were improved; the reactive oxygen species level decreased, while superoxide dismutase, catalase, and glutathione levels in the TGc mice increased significantly (P

From the Past to the Present, Taiwan, as part of the Chinese cultural circle, has experienced distinct changes in family reality. Politics, economy, migration, and globalization have been or are the crucial factors influencing families. Polygamy, extended family, nuclear family, transnational family, same-sex marriage and diversified family construct the contexts of families in Taiwan. These multi-family forms seem to ingratiate themselves with the popular concept of ‘diversity’, which has been articulated since the 21st century. Many people think that ‘diversity’ could eliminate conflicts, because not any part will be ignored; ‘diversity’ shows tolerance and social progress. In fact, there are at the same time, increasing conflicts and problems occurring because of diversity. What would be the potential causes of problems? And how could these problems and conflicts in the families be dealt with? The core solutions seem not easy to find. Since the 1960s, Chiara Lubich’s concepts: ‘unity’, ‘mutual love’, and ‘the model of the new family’ have spread into Taiwan. Her concepts have influenced many families to live in a new way. In this paper, several historical and current family models in Taiwan as well as the relationship between Chiara Lubich’s concept of ‘unity’ and families will be explored to see whether her concepts could be a possible path to reconcile the conflicts of families, and how it could be possibly put into practice.

Object: To explore the factors related to health-promoting lifestyles of the elderly based on social-ecosystem theory. Design: A cross-sectional survey study was carried out to include 627 elderly people in communities in three cities of Hebei Province (Shijiazhuang, Tangshan, and Zhangjiakou) from October 2021 to January 2022 for questionnaire survey (601 validly returned cases). Venue: Three cities of Hebei Province (Shijiazhuang, Tangshan, and Zhangjiakou). Participants: 627 elderly people. Interventions: A cross-sectional survey study. Main measurements: The questionnaire survey was conducted by using the general demographic data, health promotion life scale, frailty scale, general self-efficacy scale, health engagement scale, General Self-Efficacy Scale, The family Adaptability, Partnership, Growth, Affection, and Resolve scale, and Perceived Social Support Scale. Results: The total health promotion lifestyle score for the elderly was 100.20 ± 16.21, which was at the lower limit of the good level, with the highest mean score for nutrition (2.71 ± 0.51) and the lowest mean score for physical activity (2.25 ± 0.56). Stepwise linear regression showed that exercise frequency (95% confidence interval (CI) 1.304–3.885), smoking status (95% CI −4.190 to −1.556), self-efficacy (95% CI 0.071–0.185), health management (95% CI 0.306–0.590), frailty (95% CI −3.327 to −1.162) in the microsystem, marital status (95% CI 0.677–3.660), children's attention to the elderly health (95% CI 4.866–11.305), family care in the mesosystem (95% CI 1.365–4.968), and pre-retirement occupation (95% CI 2.065–3.894), living area (95% CI 0.813–3.912), whether receive community-based chronic disease prevention and management services (95% CI 2.035–8.149), social support (95% CI 1.667–6.493) in the macrosystem were the main factors affecting health promotion of life in the elderly (P

Se considera a los países de América Latina y el Caribe como una extensión natural de “la Ruta Marítima de la Seda” y participantes indispensables en la cooperación internacional de “la Franja y la Ruta”. En el siglo XXI, las relaciones económicas y comerciales entre China y la región han avanzado a pasos agigantados. Sin embargo, han salido a la luz unos problemas tales como el desequilibrio comercial y la estructura irracional de comercio y de inversión. “La Franja y la Ruta” apuesta por la conectividad global, lo que proporciona nuevas ideas y direcciones para resolver los problemas mencionados y nuevas oportunidades para el desarrollo de la cooperación económica y comercial entre China y América Latina y el Caribe. En el ámbito del comercio, es necesario optimizar la estructura comercial y promover la balanza comercial mediante la expansión de las importaciones de bienes no tradicionales de la región a China, la promoción del comercio de servicios y el desarrollo del comercio electrónico; en el ámbito de la inversión de China en la región, es necesario mejorar la estructura de la inversión directa mediante la inversión en la industria manufacturera y en la infraestructura, promover la diversificación de los objetos de la inversión mediante el apoyo financiero, y mejorar la capacidad y la voluntad de invertir de las empresas privadas y las PYME.

A pandemia de COVID-19 trouxe grandes desafios aos gestores do Sistema Único de Saúde (SUS), tais como a manutenção de abastecimento de medicamentos utilizados para intubação orotraqueal para pacientes graves, denominado como Kit Intubação (KI). A gestão da assistência farmacêutica (AF) precisou de estratégias inovadoras para a manutenção do abastecimento do KI. Este artigo tem como objetivo descrever a experiência da AF no estado mais populoso do Brasil nas ações relacionadas ao do abastecimento do KI durante a pandemia. Trata-se de um relato de experiência sobre a gestão realizada para abastecimento de 22 medicamentos nos estoques de hospitais públicos de administração direta e indireta, sob gestão estadual e municipal. Dentre as principais ações realizadas pela Coordenadoria de Assistência Farmacêutica da Secretaria de Estado da Saúde de São Paulo temos: gestão do abastecimento, elaboração de relatórios gerenciais; centralização da logística de distribuição de medicamentos; gestão de compras nacionais e internacionais, gestão documental, financeira e de estratégias de comunicação. Conclui-se que as ações gerenciais da AF foram fundamentais para o sucesso do monitoramento e a manutenção de estoques hospitalares no momento de escassez do KI assim como trabalho em equipe e articulação junto aos gestores da AF.

Abstract Contributions from traditional knowledge and history have proven useful in recent years to advance drug discovery. In response to the emergence of covid-19, scientists revisited traditional Chinese medicine. This source of inspiration for drugs to treat this new disease is described here at three different levels: traditional Chinese medicinal herbs, traditional Chinese medical formulas, and traditional Chinese medical texts. Drug discovery inspired by traditional Chinese medicine still faces serious resistance for various reasons, including its system of formulas and clinical trial design. A perspective that includes related issues would benefit the reasonable application of traditional knowledge in drug research and development.

1,3-Dioleoyl-2-palmitoylglycerol (OPO) was synthesized by enzymatic interesterification using palm stearin rich in tripalmitin (PPP) and ethyl oleate. Enzymatic interesterification parameters such as temperature, water content, enzyme load, and substrate molar ratio were optimized. High contents of C52 (primarily OPO and its isomeric compounds) production (46.7%) and sn-2 palmitic acid (PA) content of 75.3% were detected. In addition, OPO-human milk fat substitute (HMFS) was blended with coconut, soybean, algal and microbial oils at a weight ratio of 0.70:0.18:0.11:0.004:0.007 to simulate fatty acids in human milk fat (HMF) according to the mathematical model. The main and important fatty acids in the Final-HMFS were within the ranges of those present in HMF. The Final-HMFS could promote the absorption of fats and minerals and the development of retina tissues in infants. The mixture of L-ascorbyl palmitate (L-AP) and vitamin E (VE) resulted in a synergistic antioxidant effect both in OPO-HMFS and OPO-HMFS emulsions. This finding has great significance in improving the quality and extending shelf-life of HMFS.

Objetivo: describir diferentes diagnósticos diferenciales de la obstrucción de la vía lagrimal Materiales y Métodos: revisión bibliográfica y análisis de artículos encontrados mediante el buscador PubMed asociados al tema Resultados: se hizo un análisis total de 23 artículos sobre los temas epífora, disgenesia del drenaje lagrimal, dacrioestenosis, dacriocistocele congénito y malformaciones craneofaciales asociadas a obstrucción de la vía lagrimal. Se hizo revisión de la epidemiología, presentación clínica, diagnóstico, manejo y complicaciones de cada patología. Conclusiones: existen diversos diagnósticos diferenciales de la obstrucción de vía lagrimal que se deben conocer y diagnosticar de manera temprana para poder decidir el mejor tratamiento, ya sea el conservador o el sondaje lagrimal.

La amplificación por recombinasa y polimerasa combinada con la extracción rápida de ADN para la identificación sobre el terreno de Deinagkistrodon acutus, una especie en peligro de extinción En este estudio se aborda la utilización de la amplificación por recombinasa y polimerasa (RPA en su sigla en inglés) en combinación con la extracción rápida de ADN para identificar sobre el terreno a Deinagkistrodon acutus, una especie de serpiente que se encuentra en peligro de extinción debido a la sobreexplotación y la destrucción del hábitat. Con vistas a su conservación, es muy conveniente disponer de un método eficiente de identificación que permita combatir la captura y el comercio ilegales de la especie. Se capturaron 14 ejemplares de 12 especies de serpiente (incluida D. acutus) en las regiones montañosas del sureste de China. Se extrajo el ADN genómico con un método de lisis alcalina que llevó cinco minutos. Se diseñaron cebadores para la RPA, específicos de la especie, a partir de las secuencias de la región del código de barras de la subunidad I de la citocromo c oxidasa, y se estableció un sistema optimizado de análisis mediante RPA. Se comprobaron la especificidad y sensibilidad del ensayo, que se validó mediante la identificación de 10 muestras comerciales de la sustancia sin elaborar conocida como Qi She derivada de D. acutus. En condiciones de RPA optimizadas, se amplificó una banda única de 354 pb solo para D. acutus, pero no para las especies de serpiente relacionadas. El proceso se puede llevar a cabo en 30 minutos a temperatura ambiente. La identificación de la sustancia comercial sin tratar Qi She permitió validar la eficacia del sistema de análisis establecido. Al combinar el análisis mediante RPA con la extracción rápida de ADN, establecimos un método de identificación de D. acutus sobre el terreno con buena especificidad y sensibilidad. Podría convertirse en un instrumento eficiente para llevar a cabo la supervisión rigurosa de la captura y el comercio ilegales de D. acutus.