1. Will 68 Ga PSMA-radioligands be the only choice for nuclear medicine in prostate cancer in the near future? A clinical update.
- Author
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Cuccurullo V, di Stasio GD, Evangelista L, Ciarmiello A, and Mansi L
- Subjects
- Adenocarcinoma blood, Adenocarcinoma secondary, Bone Neoplasms diagnostic imaging, Bone Neoplasms secondary, Carbon Radioisotopes pharmacokinetics, Choline analogs & derivatives, Choline pharmacokinetics, Edetic Acid pharmacokinetics, Fluorine Radioisotopes pharmacokinetics, Fluorodeoxyglucose F18 pharmacokinetics, Gallium Isotopes, Humans, Male, Mass Screening, Neoplasm Staging methods, Positron Emission Tomography Computed Tomography, Prostate-Specific Antigen blood, Prostatic Neoplasms blood, Prostatic Neoplasms pathology, Radionuclide Imaging methods, Radionuclide Imaging trends, Sensitivity and Specificity, Adenocarcinoma diagnostic imaging, Algorithms, Edetic Acid analogs & derivatives, Gallium Radioisotopes pharmacokinetics, Nuclear Medicine trends, Oligopeptides pharmacokinetics, Prostatic Neoplasms diagnostic imaging, Radiopharmaceuticals pharmacokinetics
- Abstract
Prostate Cancer (PCa) represents the most common malignant tumor in men but according to the European Association of Urology (EAU) guidelines, a mass screening for PCa diagnosis should not be performed due to over-diagnosis and over-treatment related problems. An early clinical diagnosis is possible, mainly based on digital rectal examination and Prostatic Specific Agent (PSA) testing. However, the only mandatory test to define the presence of PCa is ultrasound guided-biopsy, obtained on multiple samples, which has also a high prognostic value. In this context, diagnostic imaging plays an important role as confirmed by EAU that in a 2016 update of their guidelines on PCa stated the importance of Positron Emission Tomography (PET) with
11 C- or18 F-choline combined with computed tomography (CT) to identify local relapse, lymph node involvement and metastatic spread at all stages. Consequently, in 2017, the European Association of Nuclear Medicine (EANM) together with the Society of Nuclear Medicine and Molecular Imaging (SNMMI) published new guidelines for68 Ga-Prostate Specific Membrane Antigen (PSMA) PET/CT to help physicians in the recommendation, execution and interpretation of PET/CT scans in patients with PCa. Thus, the aim of this 'evidence paper' is to define the current diagnostic algorithm in PCa in order to increase the general level of confidence in approaching such a crucial topic., (Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.)- Published
- 2018
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