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New Ukrainian and world realities set new tasks for the higher educational establishments, which are related to the search for new, modern methods that allow to increase the effectiveness of training. Currently, topical are the issues of not only professional but also the personal development of the student forming the priority in the implementation of educational activities in universities, preparation for future professional activities, as well as for successful interaction in society. The concept of «individual social competence» is an important factor in creating a system of educational process which takes into account aspects of professional development, and at the same time the peculiarities of the formation of the student personality. The author analyses the concept of «competence», considers the key competences for lifelong learning, identified by the European Parliament and the Council of the European Union, including social competence, studies the scientific achievements of Ukrainian and foreign scientists, including G. Gedviliene, H. S. Han, K. M. Kemple, U.P. Kanning, M. Horenburg, G.W. Ladd, H. K. Ma, K. Monahan, M. Monnier, O.V. Varetska, N.I. Hlebova, D.V. Hubareva, O.I. Hura, M.O. Doktorovych, I.B. Zarubinska, O.O. Subina, V.M. Shakhrai. They explored different aspects of social competence of different age categories. The author concludes that, despite different interpretations, all scientists agree that social competence is an acquired skill, it can be formed and developed throughout life. It was also determined that the developed social competence determines the status of the individual in society, it affects the success in professional activities. The high level of social competence allows a person not only to be realized in professional activities, but also to influence the processes in society, which in turn determines its stability. The author’s definition of the concept of «individual social competence» is given in the paper; the author concludes that social competence is an integrated ability that contains other competencies: spiritual, civic, communicative, linguistic; the concept of social competence is closely related to professional competence, without the successful interaction of the individual with society it is impossible to acquire the skills and abilities inherent in a qualified specialist. Thus, an important task for modern higher education is the formation and development of social competence of students, which is the key to successful implementation of the future specialist in professional activities. The educational process should be aimed at forming a system of knowledge about interaction in society, understanding the system of social values, ability to cooperate in society, the ability to communicate constructively, because only a socially competent person can.

Lipoedema is a chronic progressive disorder of adipose tissue leading to an enlargement of lower extremities. It is considered to be rare; however, the prevalence of the disease is underestimated because it is commonly misdiagnosed as obesity or lymphedema and the general awareness is poor. The etiology of the disorder is considered to be multifarious, including genetic inheritance, hormonal imbalance and microcirculation alterations. Diagnosis is mainly based on medical history and physical examination. Management of lipoedema is focused on reducing the symptoms, improving the quality of life and preventing further progression of the disease. The aim of this paper is to raise the awareness of the disease and provide appropriate clinical guidance for the assessment of lipoedema. We searched through the PubMed/MEDLINE database and took into consideration all of the results available as of 6September, 2020 and outlined the current evidence regarding lipoedema epidemiology, etiology, clinical presentation, differential diagnosis, and management. Better understanding of lipoedema is crucial for establishing an early diagnosis and a proper treatment, which in turn will reduce the psychological and physical implications associated with the disease.

Admission Dysfunctions of the lumbosacral spine are among the most common problems related to the movement of contemporary society throughout the world, and its incidence increases with age. In recent years, increased interest in the issues fascia, which until recently was neglected in the etiology of low back pain. One of the therapeutic options that can be applied in the case of chronic pain syndrome lumbar-sacral spine techniques are easing myofascial (ang. Myofascial release, MFR), which is one of the latest methods in the field of manual medicine. Objective of the work The aim of the work was overview AD recently published study on the effectiveness of techniques easing myofascial pain in chronic lumbar-sacral spine. Material and methods To find the current investigate research (publications of the last 5 years) dedicated to MFR in the treatment of chronic pain, lumbar-sacral spine searched the following databases: PubMed, PEDro (Physiotherapy Evidence Database), ScienceDirect and Academic Search Premier. The following keywords: myofascial release, myofascial release therapy, myofascial pain, chronic low back pain. Results 9 qualified to review the studies investigating the effect of loosening myofascial pain and range of motion, functional limitations, muscles, as well as the quality of life in people with chronic pain lumbosacral spine. Conclusions The results of this review show that there is little research on the MFR employs treat ailments low back pain lumbar - sacral. Based on the studies included in this review can be concluded that the MFR can be an effective treatment for back pain lumbar - sacral, but there is a need for further research with a well-developed research procedure that will allow the standardization of this therapeutic method.

Admission Dysfunctions of the lumbosacral spine are among the most common problems related to the movement of contemporary society throughout the world, and its incidence increases with age. In recent years, increased interest in the issues fascia, which until recently was neglected in the etiology of low back pain. One of the therapeutic options that can be applied in the case of chronic pain syndrome lumbar-sacral spine techniques are easing myofascial (ang. Myofascial release, MFR), which is one of the latest methods in the field of manual medicine. Objective of the work The aim of the work was overview AD recently published study on the effectiveness of techniques easing myofascial pain in chronic lumbar-sacral spine. Material and methods To find the current investigate research (publications of the last 5 years) dedicated to MFR in the treatment of chronic pain, lumbar-sacral spine searched the following databases: PubMed, PEDro (Physiotherapy Evidence Database), ScienceDirect and Academic Search Premier. The following keywords: myofascial release, myofascial release therapy, myofascial pain, chronic low back pain. Results 9 qualified to review the studies investigating the effect of loosening myofascial pain and range of motion, functional limitations, muscles, as well as the quality of life in people with chronic pain lumbosacral spine. Conclusions The results of this review show that there is little research on the MFR employs treat ailments low back pain lumbar - sacral. Based on the studies included in this review can be concluded that the MFR can be an effective treatment for back pain lumbar - sacral, but there is a need for further research with a well-developed research procedure that will allow the standardization of this therapeutic method.

The article traces the changes in the aesthetic conventions of Modern art in accordance with the dynamics of literary development in Great Britain. The study focuses on three key areas: the impact of “the ancients and moderns” quarrel on European philosophical and literary thought; the nuances of critical and literary discourse in Enlightenment-era Great Britain; and the reception of the Enlightenment aesthetic values and novelties in Victorian criticism, linking them to the emergence of twentieth-century modernism. The subject involves the evolution of Enlightenment aesthetics and poetics in Great Britain, particularly the departure from classical art and literature models, and the emergence of concepts like imagination, novelty, and the reader’s subjective experience of art. Seminal literary-critical essays of the eighteenth century, including works by Joseph Addison, Henry Home, Richard Hurd, and Leslie Stephen’s monograph ‘History of English Thought in the Eighteenth Century”, are analyzed. The paper also examines philosophical texts by Michel de Montaigne, Francis Bacon, René Descartes, and Marquis de Condorcet to understand the oscillatory nature of philosophical thought before and during the Age of Enlightenment. The study contextualizes “the ancients and moderns” debate on models for literary excellence and accentuates its role in shaping the discourse of aesthetics and artistic creativity. Contributions by Enlightenment figures such as Addison, Home, and Hurd are explored, emphasizing how they reshaped the discourse of aesthetics by redefining the nature of beauty, the sublime, and the principles of artistic criticism, thereby influencing the literary and artistic productions of their time and beyond. Particular attention is paid to the critical views of Stephen who wrote about the “fluctuating mode” of the literature of the second half of the eighteenth century, illustrating his peculiar subjectivism as an exponent of the Victorian worldview (Stephen saw Sterne’s novels as a serious moral threat), and simultaneously reflecting the normative aesthetic views of the second half of the nineteenth century. The paper also demonstrates how the antinomianism in aesthetic thinking, which challenged traditional norms and values as seen in “the ancients and moderns” quarrel, was further evolved in the works of Friedrich Schiller and Friedrich Schlegel, the latter articulating the antinomy of “classic versus romantic”. This tradition of antinomian thinking, coupled with the rejection of the idea of linear progression in cultural evolution, a call for a reassessment of values amidst a paradigm shift in culture and the breakdown of traditional ethic and aesthetic systems, finds a notable and unique expression in Friedrich Nietzsche’s works, that significantly influenced the transition from Modernity to Postmodernity. In summary, it is argued that the Modern Age was the time of the emergence of a new aesthetic sensibility, and its aesthetic pluralism and anti-classical literary ideas were pivotal in redefining concepts of progress, novelty, and human consciousness in art and literature. This laid the groundwork for modernist art and literature, characterized by a departure from tradition and a quest for new artistic expressions of human experience.

The paper aims to clarify the biblical image-symbols in Frank Peretti’s mystical thrillers. The problem of the detailed analysis of the lingual representation of the biblical image-symbols and their pragmatic value is solved in the article by applying a complex of methods of linguistic poetics, cognitive linguistics, stylistics and methodological tools of discourse analysis. The paper considers the biblical images-symbols, used in American mystical thrillers written by the protestant author Frank Peretti, as biblical intertexts depicting not only biblical knowledge but also author’s intentions and beliefs in conveying the most profound ideas and principles of the literary texts. Executed in the written works by lexical means, biblical image-symbols become the heart of biblically-marked contexts, which are differentiated according to their addressee orientation into author`s and character`s biblically-marked contexts and their scope – into propositional, composite, and complex biblically-marked contexts. The lingual representation of the biblical image-symbols is differentiated according to their structure into one-component (anthroponyms, toponyms, artifact, animalistic, anthropomorphic) and multicomponent, (two-component, three-component and four-component). The type of semantic transposition in the meaning of the lingual representation and pragmatic value of the biblical image-symbols determined the distinguishing of metaphoric and metonymic linguistic classification of the biblical image-symbols. Metaphoric are classified according to their structure (onecomponent and multi-component), their stylistic characteristics (language and speech metaphoric linguistic representants of the biblical image-symbols), and their denotative meaning (anthropomorphic, naturalmorphic, zoomorphic, and phytomorphic). Metonymic are differentiated according to the kinds of the metonymic transference of meaning into four groups: metonymy of belonging, metonymy of place, metonymy of signs, and metonymy of phenomenon.

In the paper, on the basis of a multimodal critical discourse analysis of political posters and social media posts, the authors outline the complex interplay of multimodal means serving to convey a political leader’s charisma. The paper aims to advance a set of historically conventionalized features typical of the charismatic personality (such as intelligence, self-confidence, persistence, ability to inspire, sociability, dominance, narcissism, and vision), present the updated definition of this notion, and substantiate theoretical and methodological grounds for the study of the interplay of multimodal means portraying a charismatic political leader that assist in conveying a political speaker’s charisma creation through its graphical image, namely political posters and social media posts. The results of the study reveal that charisma is a complex communicative and cognitive phenomenon reflecting person’s beliefs about certain innate, obtained or promoted by media, internal or external subliminal traits of a leader. These beliefs are shaped in the recipients’ consciousness during interactive communication on the basis of the leader’s strategy, techniques, and methods used in oral or written communication, as well as a set of linguistic and extralinguistic means associated with the speaker’s ability to satisfy certain needs of the community. As a study material the authors opted for the images of Boris Johnson, a politician already acknowledged as a charismatic one by international audiences, who has been a prominent political figure for almost a decade and has recently come to the forefront of political and diplomatic support of Ukraine in the ongoing Russian-Ukrainian war. The carried out analysis proves the highly informative as well as subliminal potential of multimodal visual pictographic means aimed at creating a charismatic image of a public person. The authors outline a set of verbal (elliptical sentences, catchy slogans in imperative mood, assonance, alliteration, the use of first person plural pronoun “We”, the lexical unit together, etc.) and visual-graphical means (font of the message, symbolic colour scheme, clothes style, body posture, gestures, oculesic features, etc.), whose interaction is aimed at triggering cognitive processes in the recipient’s mind in perceiving a charismatic image of the politician. Boris Johnson’s charisma is confirmed by the survey conducted among British and Ukrainian respondents as well as by his subscribers’ reactions, comments and likes following his posts on social media. The carried out analysis allows summarising the markers of a politician’s charisma portrayed on social media as follows: the number of comments and likes for their posts; informality while addressing the Prime Minister by his first name “Boris” and presence of a “popular name” “BoJo”; high degree of the followers’ messages expressiveness actualised through verbal means (significant amount of exclamatory sentences, interjections, evaluative epithets and idiomatic expressions), as well as graphical-visual means, in particular through the usage of graphic emoticons (emojis), serving to intensify the overall expressiveness of a message. The conclusion is that social media graphical images are aimed at conveying charismatic political leaders’ vision, offering their followers support and promise of a better future, portraying them as approachable, down-to-earth, considerate but at the same time serious leaders, ready to work to endure a better future. The results of the performed study can provide grounds for interdisciplinary research of both oral and written charismatic communication within the cognitive approach framework considering verbal, nonverbal and paralingual means’ (physiological, psychological, social, etc.) interplay that allows the audience to perceive a speaker as a charismatic one.

The article represents an attempt to build and apply a linguosemiotic model of existential conflict research in modern English fictional discourse. The modern tendency of philological and socio-humanistic studies to involve the tools of semiotics, discourse theory, and multimodality in the process of complex analysis of a literary work as an artistic model of reality is highlighted. The research is based on practical blocks of illustrative material, selected discursive fragments from a literary work, which contain an existential conflict. Basically, the key point here is the analysis of intra- and interpersonal conflict based on the theoretical achievements of semiotics and linguosemiotics (Ch. Pierce, Yu. Lotman, U. Eco, G. Pocheptsov) and the theory of discourse and multimodality (G. Kress, K. O’Halloran, C . Forceville, M. Halliday). It makes it possible to provide a detailed research of existential conflict in fictional discourse with the identification of latent, ambivalent meanings and the relevant reconstruction and interpretation of the conflict by the reader. The paper aims at projecting the modern tendency towards the synergy of various aspects of conflict studies across the humanities. Therefore, the goal of the paper is to outline the advantages of an integral approach to the study of conflict in modern linguistic conflictology and to build a linguosemiotic model for the analysis and interpretation of existential conflict in fictional discourse. Thus, the paper`s core objectives involve: 1) to study the achievements of the semiotic and multimodal approach in its application to synthetic level communicative systems containing conflict; 2) to reveal the place, role and potential of the existential conflict in fictional discourse using the above-mentioned methods; 3) to present a linguosemiotic model for the study of existential conflict in modern English fictional discourse. The theoretical and methodological base of the research involves general-scientific methods of analysis, synthesis, deduction as well as the method of linguosemiotic and multimodal analysis to determine the components of semiosis of existential intrapersonal conflict in fictional discourse. The results of the research consist in the creation of an integral semiotic model of the analysis of existential conflict in modern English-language fictional discourse, which assumes the presence of a static and dynamic component in its structure, revealed, in particular, in the process of semiotic reading of the work in three successive stages of mimesis, semiosis, and synthesis. The process of conflict interpretation presupposes a comprehensive approach to semiotic reading activity developed in consecutive steps. The linguosemiotic means of representing the existential conflict at different levels of the literary work, which have a multimodal nature, have been revealed. The temporal, psychological, and sign-symbolic characteristics of the existential conflict, which make up the semiotic space or semiosphere of the literary work, are analyzed and classified. As a result of the identification and unification of the factors that determine the way of development of existential conflict in fictional discourse, the linguosemiotic model of the analysis of this type of intrapersonal conflict was reconstructed. The model covers the study of the semiotic components of the sign-symbolic, psychological and temporal space and the surface and deep levels of the semiotic reading of the literary work, at which the cognitive, behavioral and emotional aspects of the conflict are decoded and reconstructed.

Introduction The rising prevalence of electronic cigarette (e-cigarette) use has prompted concerns regarding its potential health implications. While much attention has focused on respiratory and cardiovascular effects, injuries, oral trauma, and bone fractures linked to e-cigarette use have received less scrutiny. This paper aims to comprehensively review the landscape of injuries, oral trauma, and bone fractures induced by e-cigarettes, shedding light on this underexplored facet of e-cigarette-related harm. Material and Methods This literature review has analyzed 16 papers. Inclusion criteria: researches and case reports published after 2015. PubMed and Google Scholar has been searched to identify the papers. Analysis of the Literature Existing literature suggests a growing incidence of injuries, oral trauma, and bone fractures associated with e-cigarette use, albeit with limited systematic investigation. Mechanisms underlying these injuries range from device malfunctions to inadvertent impacts during use. Case reports highlight a spectrum of injuries, including oral burns, dental trauma, and skeletal fractures, often involving the face and mouth regions. Conclusions Despite the lack of comprehensive epidemiological data emerging evidence underscores the need for heightened awareness and preventive measures to mitigate e-cigarette-related injuries. Enhanced education, regulation of e-cigarette devices, and promotion of safer usage practices are crucial steps towards reducing the burden of e-cigarette-related harm on oral and skeletal health.

Introduction and purpose Non-specific and specific lower back pain syndrome is one of the leading causes of musculoskeletal disability and affects more than half of the population worldwide. The aim of this paper is to confront the problem of lumbar pain, possible diagnostic options, conservative and surgical opportunities with long term satisfactory rate. State of knowledge The paper reviews literature on lower back pain syndrome, sciatica, radiculopathy and lumbar disc herniation in regards to detection of the problem, classifying it and possible methods of resolvement. The WHO defines lower back pain as one of the leading causes of musculoskeletal dysfunction and it focuses on reducing the occurrence by programs like WHO Rehabilitation 2030 Initiative, UN Decade of Healthy Ageing and others. The paper also focuses on non surgical options of treatment. Material and method A review of the literature available in the “PubMed” and Google Schoolar was conducted. We focused on differential diagnosis depending on clinical presentation and possible treatment methods depending on symptoms, pathogenesis of the disorder and available procedures. Summary Our review managed to present the current state of development, possible differential diagnosis, prevalence of neural compressions, sciatica and radiculopathy in different diagnostic options. By receiving multiple studies we confront varied opinions of specialists regarding the approach to lower back pain syndrome and favorable forms of care. Additionally we came to the conclusion that the difference of patients' long term satisfactory rate in regards to nonoperative and operative treatment is not significant, and flattens over the years.

Gilbert’s syndrome is the most common inherited jaundice worldwide. It affects 5-10% of the population. It is caused by a mutation of the UGT1A1 gene, which results in impaired bilirubin metabolism. It is a benign disease and does not affect the life expectancy of patients. Patients with Gilbert’s syndrome should be alert to factors that exacerbate the course of the disease, interactions with medications taken and possible comorbidities such as hemolytic anemia, cholelithiasis or schizophrenia. However, it is the responsibility of physicians with such patients under their care to properly educate patients. Gilbert’s syndrome carries not only the consequences associated with the mutation, but also has many benefits that patients may not be fully aware of. Mildly elevated bilirubin levels have an antioxidant and anti-inflammatory effect, which prevents the development of lifestyle diseases and cancer. Ongoing clinical trials suggest that this could be a great step toward new treatments for diseases affecting the entire human population. PURPOSE OF THE WORK: This review paper aims to show Gilbert’s syndrome as a multifaceted disease and to sensitize doctors' attention to patients with the described mutation. MATERIALS AND METHODS: An analysis of papers available in PubMed and Google Scholar was performed using the following key words: Gilbert’s syndrome, bilirubin, UDP-glucuronosyltransferase, Gilbert’s syndrome harmful and protective aspects, iatrogenic Gilbert’s syndrome RESULTS: The result of the work is to present Gilbert’s syndrome as a disease that carries medical problems directly related to the mutation, but also, in some cases, has a protective effect on affected individuals. The work highlights the complexity of the problem.

Introduction and purpose: Diabetes has emerged as a global lifestyle disease, with an alarming rise in cases, particularly of type 2 diabetes. In Poland, over 3 million people are diagnosed, and an estimated 4 million cases are expected by 2030. Effective treatment involves a multifaceted approach, including dietary intervention, physical activity, and pharmacological options. Incretins, such as glucagon-like peptide-1 (GLP-1), play a pivotal role in carbohydrate metabolism regulation, and GLP-1 analogs have become essential in managing type 2 diabetes. This paper explores the development and mechanisms of GLP-1 analogs, detailing their impact on insulin secretion, gastric emptying, and weight reduction. Description of the state knowledge: Various GLP-1 receptor agonists, including exenatide, liraglutide, dulaglutide, semaglutide, and the novel tirzepatide, are discussed. These drugs exhibit diverse pharmacokinetics, modes of administration, and effects on glucose metabolism and weight. Despite their efficacy, there is a concerning trend of off-label use, particularly for obesity treatment, leading to shortages for patients with valid prescriptions. This misuse is fueled by para-advertising on social media platforms, contributing to a surge in prescriptions and reimbursement costs. To address this, guidelines for GLP-1 analog use in obesity treatment are proposed, emphasizing the need for a stable drug supply and normalizing drug availability. Summary: In 2023, concerns intensified with reports of counterfeit GLP-1 analogs, prompting regulatory interventions. The paper concludes by underscoring the critical role GLP-1 analogs play in diabetes and obesity treatment, while emphasizing the importance of responsible prescription practices, guidelines adherence, and regulatory vigilance to ensure patient safety and mitigate the risks associated with misuse and counterfeit drugs.

Effective body posture entails the correct alignment of body parts in relation to each other and is crucial for preserving balance, stability, and the efficient operation of muscles and joints. The major types of posture abnormalities such as lordosis, kyphosis and scoliosis can lead to alterations in various areas of the body, such as stomatognatic system. The potential correlation between malocclusion and body posture remains a subject of controversy. The aim of this review is to investigate and evaluate the association between posture defects and malocclusion on the basis of literature. This literature review has analyzed 18 studies. Inclusion criteria: clinical researches published after 2010, regarding children and adults. PubMed and Google Scholar has been searched to identify the papers. In 18 analyzed studies, 2133 patients were enrolled (including 979 children aged 4-18). A positive correlation between scoliosis and different types of malocclusion has been proven by six papers. There are also other noteworthy dependencies, such as overjet and pelvic torsion, kyphosis and sagittal position of mandible, skeletal Class III and torticollis, cross bite and scapula plane. Adolescent Idiopathic Scoliosis significantly affects the stomatognathic system, leading to issues like crossbite, crowding, increased overjet, overbite, partial open bite, and midline deviation. Orthopedists should collaborate with orthodontists for comprehensive treatment, particularly during developmental stages.

This scientific paper focuses on the treatment of breast cancer, one of the most common cancers among women. Despite increased awareness and the popularity of screening tests, statistics indicate a significant rise in incidence. The paper presents breast-conserving treatment methods, including brachytherapy, as a modern technique with promising outcomes. It describes the physical properties of ionizing radiation used in brachytherapy, discussing the photoelectric effect, Compton effect, and the phenomenon of pair production. The paper then delves into the biological effects of ionizing radiation, emphasizing the dependence on the cell cycle phase. It highlights lethal, sublethal, and potentially lethal cellular damage, categorizing the effects of radiation interaction into early and late responses. The discussion transitions to the application of brachytherapy in breast cancer treatment, focusing on various techniques such as LDR, PDR, and HDR. The paper provides a detailed description of brachytherapy's use in breast-conserving treatment, considering contraindications, treatment planning, and Accelerated Partial Breast Irradiation (APBI) techniques. The radioisotopes used in brachytherapy are also presented, with special attention to Iridium-192. The physical and practical aspects related to this isotope are discussed, along with other commonly used radioisotopes such as Cesium-137, Cobalt-60, and Strontium-90. The paper concludes with a summary, emphasizing the significance of brachytherapy in breast cancer treatment and outlining its prospects for development. The authors highlight precision and shortened therapy duration.

Introduction and purpose: In our work, we focused on presenting the role of collagen supplementation and its impact on skin and joint health. We considered studies discussing the differences in the effects of collagen from various plant and animal sources. We also examined the influence of the degree of hydrolysis on the absorbability of the supplement. The aim of the paper is to comprehensively summarize knowledge on collagen supplementation, differentiating between its sources and forms. Material and methods: In our paper, we endeavored to address the subject of oral collagen supplementation comprehensively. We explored studies about various forms and sources of collagen. We also delved into the collagen supplementation impact on skin and joints health and impact of additives in enhancing the positive effect of collagen . State of knowledge: Oral collagen supplementation can be beneficial for skin and joints health. It promote collagen synthesis in human body increasing strength of skin and joints. The higher the degree of collagen hydrolysis, the more easily it is absorbed by the body. Additives in the form of vitamin C and A can enhance collagen synthesis. Results and conclusions: This review article indicates a growing interest in oral collagen supplementation and its impact on health. Although there are encouraging findings regarding positive effects, further research is necessary to better understand and determine the optimal conditions for achieving maximum supplementation benefits. This information may be crucial for clinical decisions made by physicians regarding joint reinforcement and anti-aging effects on the skin.

Introduction and purpose The term "probiotic" rooted in Latin, signifies 'for life,' reflecting the historical use of fermented products for therapeutic purposes. While browsing many websites devoted to healthy eating or popular science topics, we often came across the topic of probiotic food without any confirmation by scientific research. The aim of this paper is to confirm or exclude the presence of probiotics in popular foods. State of knowledge The paper reviews literature on the health benefits of various food that is traditionally considered probiotic, focusing on how they impact on varied health conditions. Defined by the WHO as living microorganisms conferring health benefits when consumed adequately, probiotics, mainly bacteria from Lactobacillus and Bifidobacterium genera, play a vital role in maintaining gut microbiota balance, regulating digestion, supporting the immune system and influencing mental and cardiovascular health. In addition, the paper also searches for scientific basis for their action. Material and methods A review of the literature available in the “PubMed” and Google Schoolar was conducted. We focused on checking whether the microorganisms contained in pickled food meet the WHO criteria for probiotics. Summary Our review managed to prove the probiotic effect of almost all presented food, except for miso. By reviewing many articles, we shed a lot of uncertainty on the repeated myth about the lack of probiotic effect of cucumbers preserved in vinegar and what is more, we found scientific assumptions about the probiotic effect of vinegar itself. Fermented food contains numerous strains of bacteria that are resistant to acid, bile and temperature in the human digestive tract and can be effectively used as a source of probiotics. Additionally, compared to probiotics from the pharmacy, fermented products provide not only probiotics, but also nutritional value, valuable fiber and vitamins, benefiting to our health.

Introduction and purpose: The purpose of this scientific paper is to review the current knowledge of the effects of red wine on human health, particularly with regard to cardiovascular disease. State of Knowledge: Since the 1990s, red wine has gained its status as a health-promoting alcohol through the French Paradox - when drunk in moderate amounts, it protects against cardiovascular disease. The authors have collected scientific papers on the health effects of alcohol, red wine and resveratrol-a polyphenol that is the main component with health-promoting effects of wine. On their basis, they analyzed the assumptions of the positive effects of wine reaching inconclusive conclusions. Summary: Despite the fact that both ethanol and resveratrol have a positive effect in in vitro studies, in population studies their effect is much less significant, either because the negative behavioral-health effects in the case of ethanol are omitted or the actual effective doses of resveratrol are omitted.

Context: Angular gyrus is an anatomical structure of the brain located in the parietal lobe, taking part in writing and reading, language-use, memory and attention and spatial recognition. It is supplied by the angular gyrus artery, which is one of the caudal branches of the middle cerebral artery. One of the clinical pathologies of the angular gyrus artery is the ischemic stroke of the angular gyrus in the dominant hemisphere, responsible for the presence of Gerstmann Syndrome: left-right disorientation, agraphia, alexia, acalculia and finger agnosia. This systematic review aims to present the variety of anomalies of the main cerebral artery and the angular gyrus artery. Objective: Preparing a systematic review of papers describing the course anomalies of the angular gyrus artery. Materials and methods: PubMed and Google Scholar electronic databases was searched for phrases: ‘Angular gyrus artery’, ‘Artery of angular gyrus’, ‘Middle cerebral artery branches’, ‘Branches of middle cerebral artery’, ‘Gerstmann Syndrome’ published between years 2015 and 2023. Also 3 papers published before 2000 were used. From the selected 30 papers, 6 were used to prepare this analysis. Results: The middle cerebral artery, from which arises the angular gyrus artery, is marked by a significant variety of its division, mainly the number of the dividing trunks of the artery. Depending on the type of the division, the angular gyrus artery can arise from the upper, middle or lower trunk and vary in sizes. It can also appear as a singular or two separate branches. Instances of the anomaly of both the angular gyrus artery and posterior parietal artery are rare, but reported. Conclusions: The angular gyrus artery is characterised by a number of anomalies in its course, separation from the middle cerebral artery, diameter and branching.

Introduction and purpose: Apples are a widely consumed fruit globally and are known to be a great source of nutrition. Studies have shown that apples contain high levels of antioxidants, dietary fiber, and vitamins that contribute to numerous health benefits. This paper aims to provide a comprehensive review of the impact of apples on human health. State of knowledge: The paper reviews the current literature on the health benefits of apples, focusing on their impact on various health conditions such as cancer, cardiovascular diseases, diabetes, and obesity. Additionally, it examines the role of apples in improving intestinal, immune, and cognitive function. The paper also discusses the potential mechanisms by which apples exert their health benefits, such as high levels of flavonoids, polyphenols, and dietary fiber. Summary: In conclusion, the vast body of evidence reviewed in this paper supports the notion that consuming apples regularly can contribute to better health outcomes. They may help reduce the risk of chronic diseases, such as cancer, cardiovascular diseases, and diabetes, as well as promote healthy gut microbiota and immune function. Despite the controversy surrounding the use of pesticides in apple cultivation, the benefits of consuming apples outweigh the risks. Therefore, it is highly recommended to include apples as part of a balanced and nutritious diet to promote optimal health and wellbeing. As the saying goes, "An apple a day keeps the doctor away".

Introduction and aim Diabetic foot ulcer (DFU) is a chronic condition that affects an increasing number of people each year[1]. Healing the ulceration requires cooperation between patients, specialists and scientists in order to achieve satisfactory results. Treating this type of wound is not only a therapeutic challenge[1,2,3,4,5,6], but also an economic one, which is why so much scientific research has already been made on this phenomenon[2,3]. Still scientists continue their quest for new cost-effective alternatives to current therapeutic options that would be consistent with contemporary knowledge and available engineering capabilities in pursuance of creating techniques and new dressings that will accelerate the healing of DFUs[2,3,7,8]. Factors such as stress, obesity, certain medications, and chronic diseases appear to negatively affect the process of repair [1,9,10,4,6,11]. Studies prove that aloe vera gel due to its healing properties, can be considered as a potential dressing that will expedite the mending process of diabetic foot ulceration[12,13,14]. In this paper, we performed a literature review of the applicability of aloe vera in the healing process of DFUs. Materials and methods Searching the available literature, including randomized clinical trials and systematic reviews, we drew on databases focusing on the effects of treatment for diabetic foot ulceration using Aloe vera. Conclusion: The current scientific research on the use of Aloe vera gel in diabetic foot ulcer treatment indicates that this method is safe, effective and inexpensive[2,3]. However the difficulty of treatment and the increasing prevalence of this type of wound pose a challenge to finding new solutions and exploring mechanisms in which aloe vera can have a possible role in the wound healing process. Nevertheless, this paper presents a promising impact of Aloe vera gel applicability in the healing process of diabetic foot ulcer.

Introduction and purpose: Currently, as the frequency of obesity is alarming, the role of many factors that could contribute in preventing and treating this condition are being researched, among them the certain food with beneficial health profiles - one of them is soybeans, specifically the isoflavones it contains. Populations that consume soy are known for lower risk of various disorders - among them obesity. The aim of this paper is to summarize the existing paper about the role of these bioactive components in the treatment of this condition. The search was conducted using PubMed and Google Scholarship databases. Brief description of the state of knowledge: Obesity is one of the leading challenges in today’s healthcare as it leads to various chronic diseases that are fraught in consequences. Current knowledge is pointing into the association between composition of the soy isoflavones and the lower risk of obesity. Results of the studies indicate that patients affected with obesity could benefit from introducing soy isoflavones into their diet along with other necessary modifications. Conclusions: Soy isoflavones are potential agents in the holistic obesity treatment. Consumption of isoflavones merits further recognition as foregoing results of conducted studies are pointing to its possibly meaningful role. It is worth mentioning that consumption of soy isoflavones is not only an anti-obese factor, but also presents various other health benefits and when consumed rationally poses no risk to human’s well being. We conclude that further studies would enable us to fully reveal the potential of those polyphenols.

This study considers TED talks as an effective authentic resource for mastering English. The purpose of the article is to outline a methodology for using TED talks in teaching English for specific purposes (ESP) at the university level. To achieve this goal, we set the following objectives: to introduce and describe the steps of utilizing TED talks, as well as provide examples to each step. We applied a number of methods which helped to fulfil the task of the paper. They include establishing the cognitive and educational value of ESP and its place in the system of university education; defining the tasks and its content of the discipline; developing methodical means and organizational forms of training according to these tasks and content. TED talks are informative presentations delivered by experts in their fields. They provide a great opportunity for language teachers to incorporate authentic listening and speaking tasks in their teaching methods. A welldesigned lesson plan that utilizes TED talks as a teaching tool can benefit ESP students in various ways. The methodology of incorporating TED talks in the teaching process should involve a series of steps that aim to maximize effective learning outcomes. These steps include selecting the theme of the talk, searching the TED talk, delivering the speech, designing pre-listening and post-listening activities. The article presents examples of exercises that can be done at each step with reference to specific TED talks from the site https:// ed.ted.com. The first step ensures that the chosen TED talks are suitable and engaging. Teachers can provide students with choices and allow them to vote. The aim of the second step is to support students’ understanding of the TED talk. The third step develops listening comprehension skills. The fourth step engages and promotes students’ active listening skills. The fifth step helps to develop skills of discourse analysis. The video content that the teacher chooses for the lesson should correspond to the professional interests of students. In such a way this video will be able to increase the motivation to study not only a foreign language but also specialized disciplines. The work with TED talks, however, differs from ordinary academic lectures and presentations. Thus, it requires special training of both the teacher and students. Firstly, students` level of English is an important factor defining the choice of a lecture. The teacher considers the level of listening skills, knowledge of the topic, and terminology. Secondly, it is important to take into account the duration of the presentation. If students are not familiar with the topic, they can have some difficulties with comprehension. Therefore, they will need to listen to the lecture twice. So, the preferable length of the video should be about 5-6 minutes. Incorporating TED talks as a teaching tool in English for Specific Purposes can be a highly effective way of promoting active learning in the classroom. TED talks are a source of authentic and relevant topics for students to engage in while providing a more enjoyable and efficient way of learning. The methodology of using videos from the resource has clear benefits. They include improving comprehension skills, vocabulary acquisition, note-taking, and speaking skills. By following the steps mentioned in this paper, lecturers can deliver enriching, pedagogical sessions that will provide students with a foundation to become successful professionals in their respective fields.

The issue of the relationships between anxiety and aggressiveness among Ukrainian women in war conditions has been dealt with in this article. The relevance of the chosen topic is beyond doubt, since social problems based on psychological factors are especially relevant during the war. It is substantiated that a change in the usual living conditions leads to a significant increase in anxiety and aggressiveness among women. In this paper, the attention is paid specifically to the study of anxiety and manifestation of aggressiveness by women who are in war conditions. It is worth noting that currently in the psychological and social literature, the number of publications about the problem of anxiety is increasing, since anxiety occupies a special place, as it often leads to a decrease in work capacity, productivity, difficulties in communication, etc. It has been found out that the level of anxiety can be manifested in the aggressive women’s behaviour in the war conditions. It is noted that the state of anxiety and aggressiveness is the most common phenomenon among women in war conditions. The results of the analysis and generalization of scientific sources are presented in this paper. It has been identified that the problem of anxiety and aggressiveness is one of the topical issues of modern psychology. The need for timely identification and work with the anxiety, anxious behaviour and aggressiveness of women in war conditions and after military aggression has been emphasized. The analysis of the questionnaire conducted among Ukrainian women in war conditions has been carried out, and the degree of their influence on women’s daily lives and life activities in war time has been determined. The purpose of this work is theoretical substantiation and empirical study of the specific of the relationships between anxiety and the manifestation of aggressive behaviour of Ukrainian women in war conditions. The object of this study is the anxiety of Ukrainian women in war conditions, whereas the subject of this study is the character of the relationship between anxiety and the manifestation of aggressiveness of Ukrainian women in war conditions. The conceptual hypothesis of this research lies in the assumption of the presence of significant relationship between anxiety and the manifestation of aggressiveness of Ukrainian women in war conditions, and it has been fully confirmed. Considering the influence of war conditions on the anxiety and aggressiveness of Ukrainian women, the relationship between the mentioned psychological categories has been claimed. It has been revealed that the state of anxiety can be manifested in the aggressive behaviour of women in war conditions. It is noted that the state of anxiety and aggressiveness is the most common phenomenon among women in war conditions. According to the results of this study, there have been identified those significant relationships between indicators of anxiety and certain forms of aggressiveness among Ukrainian women in war conditions. It is substantiated that the high level of manifestation of anxiety is caused by certain psychological features. It has been found out that the increase in the level of anxiety, indicators of family anxiety and anxious behaviour is associated with an increase in the level of aggressiveness of Ukrainian women. The practical significance lies in the fact that the obtained results can be used by employees of psychological services, practical psychologists during counselling at various stages of psychotherapeutic work with women in war conditions.

In this paper we have analysed a graphic novel “Maus. A survivor tale” by Art Spiegelman as well as some variants of its translations in the framework of theory of multimodal discourse analysis (ADM) (O`Halloran). The article focuses on analysing the corpus of investigation on its language and nonlanguage level. The aim of the research is to explain in terms of the multimodal discourse analysis theory of main principles of graphic novel translation while observing the way of source language graphic novel transmutation and reconstructing its architecture in the target novel. The methods having been applied in the present paper are those of linguistic observation and description, empiric comparison of translation variants and translation results analysis using ADM tools. Applying methods of ADM in the process of analysing graphic novel results from the necessity to respond to the main challenges of ADM theory for the studies in theory and practice of translation, as well as semiotics and general linguistics. The objectives of the article are to outline the iconic-textual structure of the graphic novel under the analysis, to characterise the visual level of the investigated graphic novel, to generalise arising problems to the translator. The concept of multimodality derived from semiotics is being studied in the article explaining the reason for applying the multimodal approach in the study of the graphic novel. Modalities represented in the graphic novel on non-language level are systematised through different types of multimodal phenomena and their relevance for target text meanings transcreation is described. Both visual and language modalities, which are important for the construction of the meaning, are focused attention to and the multimodal phenomena are piled and systematised in the article. The relationship between the visual and written modalities are discussed and the role and importance for the translation process are explained. Until now there are different investigations of the Maus, but there is no investigation from the multimodal perspective. The investigators focuse on the discursive and pragmatic part, as well as on the expressive value of the work, compare the characteristics of the translation; draw attention to the problems of the literary style of the work Maus; study the role of images in the creation of the work. However, there is still no study of graphic novels from the perspective of multimodal discourse analysis. By means of a series of operations of translation techniques the original text is reconstructed in the translation variant. It involves compressing or widening of the original text, removing inconsistencies between different modalities, reinterpreting “language shell” so that a semiotic content could be preserved and the author’s message transmitted without corruption, for that redrawing some characters or chapters, removing, or replacing some visual symbols with different ones. Illustrative material shows a certain logic scheme to follow the process of translation taking into consideration different multimodal phenomena, as well as the absence of some of its constituents. On the one hand, extralinguistic objects engraved in pictures of the graphic novel may present the reason for the translation technique of addition, and on the other hand the absence of some details in the pictures may justify the translation technique of omission. Evaluating functional types of multimodal phenomena also may lead one to adequate selection of synonyms or a phrase to choose in a process of translation having as a “guide” visual image supporting language level of a graphic novel. The term “graphic novel” is specified as well as the difference between terms “comic” and “graphic novel” is outlined. Graphic novel format is proved to assimilate to the literary novel with the content of memoirs, autobiography, history, documentary reports etc. Maus is the first graphic novel dealing with Holocaust theme aimed at the adult audience. According to the definition of the graphic novel, Maus is seen to share discursive mechanisms with visual narrative instruments, embedded in multimodal phenomena. The types of multimodal phenomena are selected in the present investigation and grouped with illustrative examples taken from the corpus. In the framework of ADM theory, the selection of translation techniques and operations are justified, and the reasons for certain translation variants are explained. As it is shown in the paper, graphic novel translation differs from literal one. The most important characteristics of graphic novel translation distinguishing this genre of literature have been outlined: 1) the graphic novel translation unit obligatory consists of both verbal and visual parts; 2) the intonation of the characters of the graphic novel is a part of a style and is taken into consideration in the course of translation; 3) visual part of the graphic novel is presented by multimodal phenomena that influence the strategies of translation. General recommendations for the translation of the historic graphic novel have been given, mainly: 1) for the purpose of collecting information from the visual part. It is recommended to read and discover the entire content of the novel before starting the translation, paying attention to the multimodal phenomena and their types mentioned in this article. Attention is paid to past events, other extralinguistic meaningful objects. An individual language style is translated with the same style and is maintained throughout the text; 2) on the language level, it is recommended to choose at least the sentence as the minimum translation unit of the graphic novel using substitution techniques within the unit as long as the final sentence reflects the same message. However, the largest translation unit can be chosen. Appropriate options are a speech bubble (speech bubbles) or the entire page. Bubbles (speech balloons) often contain colloquial speech, which differs much more between languages than literal text of a book. The ease of colloquial speech is nearly impossible to achieve without the freedom to change the order, composition, and number of sentences. Often, it is not the character-specific phrases that need to be translated, but rather the emotion of outrage or joy, recreating it using the character’s language (such as the speech of the immigrant, the main character, Vladek, or his wife); 3) the use of bold. It is understood that it is not necessary to use bold type in the same units that appear in the original. The most important thing is to convey the same meaning and intonation in the translation avoiding the “word for word” translation; 4) the language style of the author and the characters. The author and the characters of the graphic novel have their own language style, which is part of the meaning. Characters may have their own characteristic expressions and circumstances that explain the choice of phrase translations. After reading the text and visualising the novel, it becomes clearer what type of the target text of the protagonist should be created to remain truthful and sound natural; 5) “Litmus paper”. It is recommended to read the translation after a couple of days without looking at the original text thinking about whether or not the author would choose the same words, style, intonation; 6) Culture references create a certain atmosphere and are translated (6.1) literally as in the example of gefiltefish translation or (6.2) simplification is used the culture in case of translation of the same unit into Russian рыбафиш; 7) translation of anthroponyms and proper names. It is not recommended to translate the proper names of the historical graphic novel taking into account the documentary part of the novel. The same variants of anthroponyms are maintained throughout the text; 8) accuracy is the second priority after avoiding meaning corruption. One should try to preserve accuracy if it is possible, respecting the condition of preserving the meaning without corrupting it. To achieve the effect of equal perception of the novel by the reader both in the original language and in the translation language, two things are needed: understanding what is said in the original text and reconstructing it in the target text. The ADM theory, in this respect, is the tool to achieve the most adequacy and the most accuracy at the same time.

The paper is aimed at filling the gap in learning the formative image peculiarities of the English and American Imagistic poetry by analyzing the correspondence of the internal and the external and their correlation. This is where the answer lies, why T.S. Eliot called Imagism “an opening salvo” of English/ American Modernist poetry. It also explains the reason for a long-term effect of this short-term “school” in the English poetry of the twentieth century. Imagism hasn’t left any extended or profound theory as far as the criteria for producing “hard, dry images” (T.E.Hulme) are concerned. Since then the problem has been under-studied and calls for more in-depth analysis. The modern theoretical background of the paper includes the ideas of S. Averintsev and M. Gasparov, Paul Ricoeur and Gaston Bachelard; the criticism of the Imagism founders (T.E. Hulme and E. Pound) as well as its present-day English and American researchers. The major theoretical points highlight the important features of image transformation in Imagism: the dual (semantic and psychological) nature of an image (P. Ricoeur); loss of its axiological constituent thus forfeiting its wholeness (M. Girshman); its non-permanent essence (G. Bachelard). All these “new” sides underlie too general and vague definition of an image as “an intellectual and emotional complex in an instant of time” given by Ezra Pound, his definitive denial of using images as “ornaments” and the emphasis on the image affiliation with speech, not language. The fight doesn’t have to be limited only to opposing Romanticism (as in Hulme’s “Romanticism and Classicism”). Equally significant and far more sophisticated is the distinction between Symbolic and Imagistic essence of an image (Pound’s “Retrospect” and “Gaudier Brzeska”). For Pound, the main criterion is the receptive potential of an image, its semantic openness which offsets its meaning as finally fixed in some symbol. The paper examines the possibility to apply Roland Barthes’s idea (“L`imagination du signe”, 1962) of the crucial influence of the interior (symbolic) relationship and two exterior (paradigmatic and syntagmatic) relationships on the formation of both single image and the total imagery of a certain type of art conscience – consequently, of Symbolism, Romanticism and Imagism. In the early period of Imagism development (the poetry of F. Flint, E. Storer, to a lesser extent, of T.E. Hulme) the images still preserve the inner affinity with the signified objects (concepts) as seen in Romantic and Symbolic image “patterns”. And throughout Imagism development, this inner affinity is being weakened until a distant outer resemblance is left. It is clearly seen in Hulme’s “Autumn”, Pound’s “In a Station of the Metro”, H.D.’s “Oread”, “Hermes of the Ways” et al. The close reading of the W.C. Williams’s poem “The Red Wheelbarrow” is carried out in front of the “Tall Nettles” by Edward Thomas (1878–1917), his contemporary, who is now considered to be one of the “non-Modernist modern” poets. It is stated that the central image of the red wheelbarrow in its every detail constitutes a modern pastoral while Thomas’s nettles stand for psychological matrix of personal melancholy and despair. Syntagmatic relations also involve the further interaction of signs in the form of “superposition”, forming montage as one of the important Мodernist techniques not only in poetry, but also in Мodernist prose. And it becomes evident that it is not a mechanically borrowed cinema technique, as it is commonly viewed, but a deeper, “syntagmatic” similarity. The result of the research, based on the analysis undertaken, seems to prove its initial point: the poems of T.E. Hulme, Ezra Pound, W. Carlos Williams, Hilda Doolittle (H.D.) taken as models, manifest that the image in Imagism is every time constructed as a new actual syntagma of the common imagination of a poet and a reader to become the unique image for every single poem without its further “universal” use in any virtual paradigm.

Introduction and purpose of the work. Aesthetic medicine currently has many methods to keep our skin in the best possible condition, and one of these methods is the use of tissue stimulators. The purpose of the following paper is to analyze, present and apply tissue stimulators in anti-aging prevention. Review methods. The paper is based on a review of literature about tissue stimulators, aesthetic medicine and anti-aging therapy. Most of the publications used were from Pubmed and Google Scholar electronic databases. State of the art description. Aesthetic medicine is a department that over the past few years has been closely associated with the slowing down of skin aging processes. In humans, over the years, proliferative processes slow down, the rate of collagen and elastin degradation increases, and the intercellular matrix is reduced. Substances known as tissue stimulators used in anti-aging therapies mean that the above processes can be delayed. Conclusion. The expectations of patients visiting aesthetic medicine clinics regarding activities that improve their appearance are increasing. They are unable to accept their own aesthetic defects, which is why they often strive for unnatural effects. Tissue simulator treatments can be a valuable way for patients to maintain healthy and rejuvenated skin.

Introduction: Xenotransplantology, the field of transplantation involving organs or tissues between different species, holds great promise for addressing the global organ shortage crisis. However, the development of new technologies without proper legislative preparation raises significant moral and ethical considerations. This paper provides an overview of the current state of xenotransplantology, highlighting its revolutionary potential alongside the moral dilemmas it entails. Aim of the study: The aim of this study is to assess current social, ethical, religious, and legal trends regarding the issue of xenotransplantation. Materials and methods: To obtain up-to-date information concerning trends in xenotransplantation, a review of the PubMed and Google Scholar databases, along with the latest legislative reports in both Europe and Poland, was performed. Conclusions: Firstly, the authors briefly report on the current situation concerning transplantology and the widely spread organ donor crisis. Next, the issue of species boundaries and the moral status of non-human animals is addressed. The assessment of ethical implications of utilizing animals as organ donors is examined, along with the legal acts regulating this issue. Moreover, the authors attempt to evaluate the cultural and religious differences related to this concern. Furthermore, this study discusses the allocation and distribution of xenotransplants, considering issues of justice, fairness, and access to this innovative medical technology. Lastly, the paper delves into the risks and uncertainties associated with xenotransplantation, including the possibility of cross-species disease transmission and intensified course of organ rejection disease.

Introduction and Purpose: Coeliac disease is an increasingly prevalent disorder worldwide. It is estimated to affect about 1% of the population and its symptoms heavily impact people's lives. The aim of this paper is to delve into the topic of coeliac disease and present basic information about its origins, current diagnostic methods, and the challenges associated with its treatment. This article includes all the necessary information from up-to-date sources. State of Knowledge: Coeliac disease was discovered a long time ago, but it is still not completely understood. Every year, new research is published regarding different populations in various countries. While we know more about the disease, its symptoms, and causes, we are still far from fully understanding all the inflammatory processes occurring in the human body. There is solid evidence that this enteropathy is caused by gluten, and the only way to reduce the clinical manifestation of coeliac disease is to adhere to a gluten-free diet. However, some patients do not benefit from this type of diet and still suffer from coeliac disease. New drugs currently being developed offer hope for these individuals, as they attempt to target the immunological reaction and mitigate the immune response in the small intestine. Conclusion: As approximately 1% of the population suffers from this disease, it is crucial to diagnose patients in the early stages of its development. Early diagnosis can prevent the development of other disorders that coexist with coeliac disease, which can be particularly dangerous, especially for children. This paper provides up-to-date information about the clinical manifestations of the disease, as well as methods of diagnosis.

This article focuses on the promotional aspects related to the tourist attractiveness of the neighboring countries-Poland and Slovakia. The purpose of the article is to analyze the issue in question and point out the importance of the search for ways to increase the effectiveness of management of the area of tourism promotion in both countries. The authors used an empirical research method with quantitative-statistical and qualitative studies on specific promotional campaigns. The Olympic Games have the greatest marketing potential among sporting events, as the most important sporting event in the world. The possibility of organizing such an event in Poland and Slovakia would certainly serve to improve the recognition rates of both countries. The authors will try to demonstrate this potential as part of the considerations in this article. Acknowledgement: This paper was supported by the project NP-KSV-ET-01-2023-12/ST - International cooperation in the field of development, management and law in tourism and sports between the Republic of Poland and Slovak Republic. The views expressed in this paper are those of the authors and should not be taken as reflecting the position of any authority, entity or institution. This article presents the legal status as of 25 March 2023.

The professional activity of a specialist in modern society is primarily determined by their ability to make competent information interactions. Definitely, information is one of the main resources for the scientific, technical and socio-economic development of society. It plays an important role in the process of educational space modernization where the formation of the ability to find, analyse and process this information takes on special importance, requiring the development of innovative approaches to the research competence shaping future Ph.Ds. in their postgraduate studies. The article is aimed at substantiation of methodological approaches to solving the problem of building research competence of future Doctors of Philosophy during postgraduate studies. The objectives of the paper are to define the meaning of the basic component of the article – “approach”, to analyse the fundamental approaches that provide building research competence of future Doctors of Philosophy as well as to substantiate the expediency of their use. Complex methods for solving the problems of a scientific paper have been used, including theoretical analysis and synthesis of ideas, results, theoretical statements (explained in scientific literature), generalization and systematization of the results of available investigations of the highlighted issue. Study results. The modern educational system focuses on building future specialists’ competence as a result of their readiness and ability to solve educational problems and carry out research activities. The present paper is devoted to the problem of training future Doctors of Philosophy during postgraduate studies because the transmission to new educational standards significantly increased the relevance of the problem of building research competence that determines a lecturer’s ability to investigate, plan and organize his /her work effectively to achieve the predicted result. The analysis of scientific and pedagogical studies established the conceptual core of methodological approaches to building future specialist’s competence during postgraduate studies. In order to have the holistic view of research competence, its structure and meaning, as well as the laws of its development in relation to future Doctors of Philosophy, fundamental methodological approaches have been systematized, namely acmeological, systemic, cluster, personality-oriented, technological, axiological, competence-based, praxiological, facilitative, participatory, synergistic, meta-subject, and hermeneutic ones. Taking into account the development of new standards and the features of educational paradigms that provide the effectiveness of building research competence of future Doctors of Philosophy, the above mentioned complex approaches have been considered as basic and optimal ones. The analysis of best practices clearly shows that there is no common vision of the principles of combining methodological approaches in solving the issue of building research competence. The article presents the experience of combining methodological approaches in solving the issue of building research competence based on the principle of mean full dominants. The author has found out that the use of these approaches will provide the successful process of building research competence of future Doctors of Philosophy, their ability to create fundamental scientific developments focused on the shaping of educational space that will develop and improve the personality qualities of future Doctors of Philosophy for successful self-realization.

This academic article offers a model of the English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO (hereinafter referred to as the EUS) as a supplement to the Ukrainian National Corpus (hereinafter referred to as the UNC), where texts are presented as a hierarchical structure. In an effort to provide a more comprehensive view of NATO, UN, and WTO official and business documents, a mechanism of use of our model envisages determination of the exact position of a text in all UNC corporas, what essentially simplifies the practical process of search and automated translation of texts and special terminology in particular. In consequence, the author offers to increase the number of unique texts that will ensure the representativeness of the EUS in the Ukrainian National Corpus, and to divide the whole process of the EUS formation into elementary tasks that will increase the UNC efficiency. The practical value of the research lies in a possibility to use the EUS for texts parallel translation and terminological phrases separation on the basis of such texts. The methodological potential of our research is based on the works of well-known Ukrainian and foreign scholars (V. Bohorodytskyi, I. Baudouin de Courtenay, K. Brugman, W. Wundt, B. Delbruck, G. Paul, O. Potebnia, P. Fortunatov, W. Scherer, H. Steinthal, A. Schleicher et al.), who strengthened the scientific interest to the problem of translation and corpus of texts in particular. The object of the research is a model of the English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO. The purpose of the research is to prove that the model of the English-Ukrainian sub-corpus of official and business documents texts can become a full-fledged informational foundation for the formation of texts parallel corpus within the Ukrainian National Corpus. The methods of observation and experiment were applied to analyze empirical, review, conceptual analytical tools that specify the meaning of described objects and phenomena given their qualitative affiliation to the UNC. The study focuses on a number of tasks, in particular: - to determine a theoretical and linguistic basis of the concept “English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO”; - to determine the mechanism of updating of the English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, WTO within the UNC; - to find out the specifics of formation and filling-in of the EUS; - to substantiate the relevant methodology of examination of official and business texts of NATO, UN, and WTO in the English-Ukrainian sub-corpus of texts of official and business documents; - to single out and itemize the advantages of the English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO within the UNC. Analysis of the English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO as a construct of the parallel corpus of texts of the UNC was carried out in several stages. The first stage envisaged description and inventory. Theoretical works on the history of the Ukrainian National Corpus were reviewed and generalized, and the concept of “English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO” was determined. It was found out that the UNC is the object of research in such areas of linguistic studies as the applied and corpus linguistics that construe the corpus of texts as a translator’s tool. This encourages us to highlight the advantages and disadvantages of the UNC and justify the expediency of our proposal to develop the English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO. Definition of the UNC as a national corpus of texts that contains only Ukrainian texts and does not envisage a parallel translation evidenced the need to create a proposal of a parallel corpus of texts with an updated English-language database. The selection of lexical items with the official and business semantics is based on documents of international organizations, such as NATO, UN, and WTO. At the same stage, we determine the purpose of the research, in particular, the formation of the English-Ukrainian sub-corpus of texts of official and business documents, which envisages a parallel translation of NATO, UN, WTO texts. This sequence of procedures allowed us to carry out consideration and interpretation of existing theoretical provisions and inventory of factual research materials. Theoretical and corpus analysis methods were used in the research. The second stage envisaged analysis and differentiation. Special aspects of filling-up of the EUS with official and business texts of NATO, UN, and WTO were characterized. Theoretical analysis of the EUS was carried out in order to establish a clear hierarchy of the UNC structure. The main types of participants of the EUS formation (students, teaching staff) were differentiated and the behavioral model of every participant in the process was developed. The specifics of presentation of the English-Ukrainian sub-corpus of texts of official and business documents of NATO, UN, and WTO in the UNC was established. This final stage, where methods of observation and experiment were used, evidenced determination of an exact place of a text in the EUS (belonging to a certain category of homogeneous texts) that becomes a crucial factor in choosing a translation option. Numerous terminological phrases and expressions in the analyzed official and business documents of UN, NATO, WTO, which act as identifiers in the EUS, were systematized. An increase in the number of unique texts (official and business texts) was noted, which ensures the representativeness of not only the English-Ukrainian sub-corpus of official and business documents texts, but of the UNC in general. The final stage of the research confirmed the expediency of the division of the whole process of sub-corpus formation into elementary tasks. We generalized the statement that the EUS is a dynamic, context-dependent sub-corpus (only official and business texts of international organizations, such as NATO, UN, WTO) and an optimal algorithm designed to be easily downloaded and used. Conclusion. The analysis conducted in the present paper is meant to illustrate a new approach to forming a modern model of the sub-corpus of texts of official and business documents. The model of the English-Ukrainian sub-corpus of official and business documents texts of NATO, UN, and WTO provides for a clear division into categories of homogeneous texts and a quick search for special terminology of international organizations, such as NATO, UN, and WTO, in the EUS. In the context of the texts analyzed in the current paper numerous separated words and expressions-identifiers can help to carry out search and refer to a relevant text in the sub-corpus. Compilation of terminological nominations glossary, their functional and stylistic labeling and assimilation into the commonly used vocabulary of the EUS and later on in the UNC are currently at the stage of formation and approval. To this end, the current research manifests the concept of the EUS as a sub-corpus of the UNC that allows the prompt presentation of relevant texts of the official business style and coverage of the broadest range of interested readers.

The article aims to study the poetics evolution of a great Polish poet and prose writer, Nobel prize winner Czesław Miłosz towards a fundamentally new comprehensive literary form: from “Piesek Przydrożny” (“Roadside Dog” 1997) to “Abecadło” (“Milosz`s ABC`s” 1997) and “Inne Abecadło” (“A Further Alphabet” 1998). The purpose stimulates the usage of the analytical, hermeneutics and receptive methodology, as well as textual analysis. It is stressed that the years of this work publication indicate the writerєі success in his determined search for a form that would be capable, containing immense life material, countless events, lives and artistic-philosophical reflections, to create the picture of the 20th century. The paper highlights why “Piesek Przydrożny” does not meet any requirements for containing the unlimited number of life facts within a text. We’ve noted the organizing function of Piesek in the system of a fictional unity. Moving freely, Piesek made it possible for Miłosz to create a certain series of philosophical pieces (“Ubóstwo wyobraźni”, “Wzniosłość”, “Pieśń dziadowsku”, “Со upadek”, “Powieść”, “Gombrowicz”, “Polski literat”) and several tragic essays – “Ojcowskie kłopoty”, “Zmartwienia historyka” and others. It is proven that while the form of this book contains a variety of material, it still cannot give Miłosz the absolute freedom he was striving for. The writer was determined to find the form which would, according to him, “allow for much freedom”, “not pursue beauty but just register facts”. Considering Е. Brazgovskaya’s findings, the productivity of the alphabet (аbecadło) is proved. The paper expresses the idea that one can treat the alphabet (аbecadło) as a kind of a memoir genre. The innovative structure of “Abecadło”, consisting of essays-novels, is analyzed. The article traces the associative connections which cement 200 essays into a single entity, creating the image of the epoch.

Oral mucosa is an inner lining of oral cavity, which maintains different functions including protection of epithelial integrity. Pathology of oral mucosa can develop in response to the action of pathogenic microorganisms, viruses, and various traumatic factors; it can be a result of systemic pathology of a patient as well. Pain and discomfort usually accompanies such conditions leading to decrease of patient wellbeing. The basis of the pharmacological regulation of the regeneration process is the stimulation of wound healing. The aim is to summarize and discuss the spectrum of remedy options that are used to stimulate epithelization of oral mucosa. The overall goal of the paper is to provide full and comprehensive information for dentists and their patients about medicament variety, ways of theirs application and dosage. Methods. Relevant literature from MEDLINE (PubMed), Google Scholar, and in open access journals which are published by Elsevier was selected using the following key words «oral mucosa», «epithelization», and «remedy» were used in various combinations by the year of 2023. In total there were found 48 papers. To the selected scientific papers we applied the inclusion and exclusion criteria to choose the relevant ones. Conclusions. A significant number of drugs for the treatment of inflammatory processes in the oral cavity are available nowadays on dental market. Numerous studies substantiates the effectiveness of their use in dentistry. Therefore, when choosing pharmacological drugs, preference is given to drugs with a complex effect, which locally affect various links of the pathogenetic mechanism of the occurrence of diseases and do not disturb human wellbeing.

Endometriosis is a chronic gynaecological disease characterized by the presence of the uterine mucosa that functions in accordance with the menstrual cycle outside of its usual location. This disease significantly reduces the quality of life of women facing numerous ailments, most often pain, and may lead to reduced fertility. The prevalence of endometriosis is difficult to determine due to the complexity and lengthy diagnosis. It is estimated that this disease occurs in 3-8% of women of reproductive age, and symptoms may also appear after menopause. It is worth noting that the relationship between the disease's severity and endometriosis symptoms is often not proportional. The aim of the paper is to present a case report of a 23-year-old female patient with endometriosis, to differentiate the disease from irritable bowel syndrome and to draw attention to the problematic and lengthy diagnostic process due to the multitude of symptoms from various organs. Material and method: Study of an individual case of a patient and a review of scientific articles available in Google Scholar and a review of publicly available textbooks in the field of medicine. The paper emphasizes the need to broaden the knowledge about endometriosis by specialists in many fields of medicine and points to the lack of quick, minimally invasive tests enabling efficient diagnosis of the disease. Increasing the awareness of doctors including other specializations than gynaecology, organizing campaigns to increase awareness of the disease among women, which may contribute to earlier diagnosis of patients, earlier application of an effective treatment, and improvement of patients' quality of life.

Introduction:Lipid disorders are one of the most common modifiable risk factors for cardiovascular disease. Until now, the mainstay of dyslipidemia treatment was the use of widely available statins. These drugs, despite significantly lowering cholesterol and bringing its concentration to desired values were associated with a number of side effects. In addition, the need for daily use of statins is inconvenient for patients and leads to their irregular use and, consequently, failure to achieve the desired effect. The new drug, inclisiran, which is a PCSK9 inhibitor, represents the future in the treatment of lipid disorders. Studies conducted to date have explored the drug's mechanism of action, frequency of administration to achieve the desired effect, and side effects. The results of these studies have confirmed the significant efficacy of inclisiran,which may become a major form of treatment for dyslipidemia in the future. Purpose of the work: This article reviews the state of knowledge based on available studies on inclisiran. The aim of the review is to present the most important information about this drug related to the mechanism of action, effects on the body or assessment of efficacy. Materials and methods: The authors, based on databases such as PubMed, Scopus and Google Scholar, created a paper summarizing a review of currently available publications, concerning a new drug in the treatment of dyslipidemia- inclisiran. The authors searched for available information , using terms under the heading "key words" contained in other scientific papers. Summary Inclisiran is a novel drug that represents the future in the treatment of dyslipidemia. Due to the lack of systemic effect, it has insignificant side effects, and the need for such rare administration will allow to obtain the desired lipid concentrations even in patients who do not cooperate.

The primary purpose of this paper is to determine and prove the impact of loads with different intensities on the treadmill on the heart frequency, as well as to prove the relationship and impact of some anthropometric and motor parameters on the physiological one in the manifest space. In harmony with the purpose of the research, three basic hypotheses have been presented that cover the anthropological research fields. In this paper, 19-year-old students of the Faculty of Sports Sciences are included. To achieve the purpose of the paper, a sample of 80 students who were regular students during the year 2022/2023 was included. Four anthropometric variables, three motor tests (running tests) and four physiological tests (pulse at rest and during loads) are included in this paper. For the three groups of the system of variables, the basic statistical and distribution parameters for each variable, as well as the measures of asymmetry and normal distribution, were calculated. Then the correlations between the variables in the manifest space, as well as the correlations between the system of variables. In order to determine the relationship between predictor variables (anthropometric and motor characteristics) and criterion variables (results of functional skills), regression analysis was applied in the manifest space. The processing of the results shows that the obtained values do not deviate from the normal distribution, which completes their metric characteristics. The impact of morphological and motor factors on heart rate results has not been proven.

The present paper is aimed at studying the artistic mind of the modern English writer John Fowles as the creator of the original worldview in its postmodern style. It has been specified that British artistic culture does not demonstrate neither the extremes, peculiar to the art of “transition” or “frontier” nor sharp denial of everything that seemed inviolable. Inclining towards realistic forms of the English classics, a lot of postmodern authors, including Fowles, prefer a synthesis of the old with the new. This applies both to postmodernism and all avant-garde and neo-avant-garde movements, aimed at fundamental changing of the general ideas about the beauty and ugliness. “The French Lieutenant’s Woman”, written by John Fowles, proposes such a postmodern synthesis in the context of the “playing with the past” thesis. In his novel, the author presents a special type of “new reality”, corresponding to the period of the profound changes inside the movement during the period starting from the end of the 19th century till the end of the 20th century. Instead of the typical for English literature “hero in search”, the novel under consideration demonstrates an existential type of a man. The above-mentioned hero, who is embodied in the images of Charles and Sarah, seeks his individual freedom and “corrects” his own destiny. It should be emphasized that gaining true freedom is possible only through overcoming various life and social obstacles associated with breaking class and social ties, as well as with great internal suffering. Fowles’s peculiar style of narration helps to reveal the main theme of the novel. The author uses postmodern irony, which is meta-irony, and pastiche. The method of “overlapping epochs” forms an original intertext whereby the semantic field of the novel increases. The literary significance of the outlined method is multifaceted: an elitist reader perceives text-subtext-intertext; a “mass” reader gets acquainted with the work at the level of an entertaining storyline. The author of the article also analyses a mythological component of the novel “The French Lieutenant’s Woman”. A mention should also be made that Fowles in the analysed work acts both as a creator and a destroyer of the socio-ethical and literary myth of the Victorian era. Of primary interest to the writer was the literary myth of the time of Queen Victoria, which in the minds of readers has long been romanticized and become a legend. Therefore, the article shows the connection of everything that happens according to the tradition of English romantic narration and the principles of reformation of characters and situations that no longer correspond to the romantic worldview. The ironic understanding of the gentleman’s code of honor and the object of his passion, the reduction of love conflicts and places of romantic meetings are illustrated by specific examples from the text of the novel. The present paper has also devoted considerable attention to the psychology of the protagonists as well as the problem of the plot and compositional unity of the novel “The French Lieutenant’s Woman”. It is proved that the development of the storyline of the novel is a polystructural and polysemantic phenomenon. If Sarah’s character combines the traditional features of both “woman with a secret” and “infernal woman”, then respect for Charles’s traditional aristocracy is being called into question: it is repeatedly mentioned that he did not receive a Cambridge diploma, that he is an amateur paleontologist, that he considers the possibility of getting married for money, and that there is a very strong element of carnal passion in his romantic relationship with Sarah. The article offers the author’s commentary on the compositional completion of the novel. It is argued that the trinity of the epilogue, first of all, explains the “world-chaos” antithesis. The formula of the dissipating world, according to the author of the article, was supposed to become the basis of the postmodernist text in the original version of the novel “The French Lieutenant’s Woman”.

The article outlines three lexical-semantic fields of word-formation rows with the suffix -ment. The aim of the paper is to investigate three lexical-semantic fields which consist of the lexical-semantic field denoting improvement, confinement and feelings. To achieve this aim, the following tasks should be completed such as investigating motivation relations in derived words with the suffix -ment and analyzing their structure with the help of the applicative generative model. The methods of componential and comparative analysis and the relator language of the applicative generative model were applied for fulfilling the above-mentioned tasks. To build word-formation rows, the words are segmented according to their motivation relations. Etymological aspect is not taken into account. Every field consists of lexical-semantic groups. The lexical-semantic field denoting the action of improvement consists of fifty-eight words, which are classified into seven lexical-semantic groups. This field is represented by thirteen R-structures. The lexical-semantic field of feelings includes two lexicalsemantic groups which contain six R-structures. The lexical-semantic field of confinement includes twenty-one words represented by six R-structures. Paradigmatic relations in lexical-semantic groups were analyzed in order to illustrate interfiled connections. Synonymic rows and antonymic pairs in lexical-semantic groups and hyperonyms distinguished in lexical-semantic fields prove paradigmatic relations. Lexical-semantic fields consist of nouns because the suffix -ment generates, mainly, nomina actionis. The term word-formation row is described in the paper as this notion which is a complex unit of word-formation hasn’t been studied thoroughly yet. The word-formation row in every lexicalsemantic field is highlighted in the article. The more lexical-semantic groups comprise the lexical-semantic field, the more R-structures the word-formation row has in a lexical-semantic field. Besides, this fact proves that English words with the suffix -ment are polysemous and variable. The polysemy of these words is illustrated via interfiled connections, e.g., the word fulfillment with the meaning “a feeling of satisfaction” belongs to the lexical-semantic field of feelings, and with the meaning “the act of doing smth. that you have promised or intended to do” this word can be involved in the lexical-semantic group of achievement which belongs to the lexical-semantic field of improvement. The relator language of the applicative generative model is used to investigate R-structure of English words with the suffix -ment. This analysis helps to create word-formation rows. R=rows of artificial language and L=rows of natural language are described. The research results lead to the conclusion that three lexical-semantic fields can be characterized by polysemous character of English words with the suffix -ment which are represented by interfiled connections. The variety of R-structures comprising wordformation rows shows the variativity of the investigated words and proves the idea that words may be derived not only from verbs but also nouns and adjectives. Interfield connections in three lexicalsemantic fields demonstrate that all words with the suffix -ment can be grouped into lexical-semantic fields. It can be useful and significant for linguists to create different English dictionaries. So, the aim of the further study is to arrange all existing words with the suffix -ment into lexical-semantic fields and make an attempt to create the dictionary of R-words and L=words with the suffix -ment.

The paper focuses on the urgent problems of linguadidactics caused by Covid-19 pandemic and the need to implement online learning at all Ukrainian institutions of higher learning. English for Specific Purposes online learning involves modern methods that are constantly being improved. They are aimed at effective interaction of all participants in the learning process. The Department of Foreign Languages in Lviv polytechnic national university analyzed the feedback from the teaching staff and students concerning methods applied in online classes which were held during the quarantine period in 2020–2021. Observations of teaching experience, as well as the positive feedback from students proved that online learning English for specific purposes can be as effective as the offline one. The study considers a number of important principles that should be followed in order to succeed in distance learning. English for Specific Purposes online tools involved both synchronous and asynchronous methods. The former methods included videoconferences held with the help of various applications, e.g. Zoom, Microsoft Teams, Google Meet etc. Asynchronous means consisted of using instant messengers, email, educational platforms, i.e. virtual learning environment of the university based on the Moodle platform. We conducted a survey among students of five groups of different technical specialties. The survey aimed at finding out their opinion concerning effectiveness of ESP online lessons. It helped to discover what kind of difficulties the students had faced. The survey also allowed us to understand which types of activities were better perceived during video conferences in comparison with lessons in the classroom (i.e. listening and watching video). The analysis of the results obtained brought us to a conclusion about the most efficient way of conducting online classes. Thus, a combination of asynchronous and synchronous methods appeared to be the most effective tool for online mastering of ESP. On the one hand, the asynchronous method can be effective to consolidate lexical and grammar material, as well as develop reading skills. On the other hand, synchronous method provides direct communication in the «student-teacher» format and is the most effective means of transmission and acquiring new knowledge in the discipline of English for Specific Purposes. It also develops speaking skills while involving students in work with breakout rooms. The paper also discusses the issue of students’ knowledge and skills assessment. The process of control has become automated and, thus, more convenient. Diagnostic and control works were performed in the form of current and final tests, hosted on the Moodle platform (virtual learning environment of Lviv Polytechnic National University). This greatly facilitates teacher’s work; as such tests contain a convenient option of automatic checking the correctness of students’ answers to the tests.

Background: C-reactive protein (CRP) is a commonly determined biomarker of inflammation and may reflect the progression of a vascular disease. CRP values within 12 to 24 hours of stroke symptom onset are an independent predictor of adverse functional outcome in terms of the level of motor recovery in the first year of follow-up. Objective: This study aims to provide a complementary analysis of the scientific literature and critically review studies on the use of CRP as a potential biomarker associated with stroke and affecting the achievement of neurorehabilitation progress in post-stroke patients. Methods: This critical review of the literature was prepared based on the following inclusion criteria: (1) original research, (2) studies indexed in PubMed, Scopus and PEDro databases, (3) full-text articles in English, (4) papers published in 2012 – 2022, and (5) papers addressing the use of PCR assay as a biomarker of rehabilitation effectiveness. Results: Based on a review of PubMed, Scopus and PEDro databases, 47, 56 and 9 papers, respectively, were selected based on precisely selected keywords and included in full for further full text review. In this review, the most important scientific rationale was included in response to the aim of this paper. Summary: Recognition of the role of inflammatory and immunological factors in the development of atherosclerosis and the occurrence of ischaemic stroke provides scope for the search for new methods of stroke risk assessment and the development of new methods to prevent stroke. Further empirical validation and unequivocal demonstration of the levels of CRP as a potential marker that affects the health status of a post-stroke patient are needed to ensure the greatest possible level of motor recovery and ability to function independently in terms of all activities of daily living.

INTRODUCTION: Retinoids are a broad group of natural and synthetic compounds derived from vitamin A. Many studies have shown strong anti-aging effects, and they have also been shown to have therapeutic effects on acne vulgaris or psoriasis. Vitamin A and its derivatives make the skin more elastic and smooth, cause a decrease in fine wrinkles and cause an increase in fibroblast activity and collagen fiber production. Retinoid compounds regulate biological processes of the skin such as immune processes, angiogenesis, proliferation and differentiation. THE AIM OF STUDY: The purpose of this paper is to discuss the effects of retinoids and the use of the substances in skin diseases. MATERIALS AND METHOD: Literature review of PubMed, Google Scholar and Science Direct and evaluation of available randomized controlled trials using retinoids in terms of treatment effectiveness in terms of skin quality, anti-aging benefits use in dermatology. CONCLUSIONS: Vitamin A and its derivatives plays an important role in anty-aging prevention and treatment of skin diseases, such as acne vulgaris, psoriasis and photo-aging. There are still many ongoing studies and not known opportunities of its use to treat other skin diseases that we should be aware of and keep track of new papers that indicate such.

Introduction and purpose: The aim of artificial sweeteners is to replace the sweetness of sugar without contributing to the higher energy consumption or unfavorable metabolic effects conventional sugar causes. Synthetic sweeteners - one of the most popular groups - are labeled as safe for use in foods and represented by acesulfame K, aspartame, neotame, saccharin, sucralose, cyclamate and advantame. Although they underwent safety procedures, their possible unbeneficial effects are still being evaluated. In this paper we focus on their impact on the gut microbiome. Brief description of the state of knowledge: For now, the advantage of search conducted on animals is observed. Those papers show the possibility of a relationship between artificial sweeteners and composition of the gut microbiota. Changes that were observed affected the gut microbiota in a negative way as they may be responsible for causing disbalance in the conglomerate of microorganisms. Studies on humans are limited. Long term consumption of acesulfame K and sucralose is linked with modulation of the composition of the microbiota. It has also been shown that synthetic sweeteners are able to increase the ability of bacteria to form a biofilm. Conclusions: Heretofore published paperworks about the impact of synthetic sweeteners on the gut microbiota are not sufficient to conduct valuable and unambiguous conclusions. Evidence collected until now is leading to a deduction that gut microbiota can be affected by the consumption of the sugar surrogates although more data is needed to clearly determine their possible role.

During the autumn season, it is common for mushroom pickers to eat poisonous mushrooms. This is due to many reasons, including the ignorance of pickers. The most common is the misidentification of inedible species as edible mushrooms. The result is poisoning, which in many cases requires hospitalization. This paper presents a case report of toadstool poisoning by a 62-year-old female patient. In addition, other relevant publications on intoxication, diagnostic methods and treatment are reviewed. The purpose of this paper is to present the management and treatment of a case of toadstool poisoning. The effects of mushroom poisoning can range from mild disorders, mainly gastrointestinal to organ failure and even death. Significant elevations of liver enzymes and prothrombin time are important in laboratory tests in cases of intoxication. Treatment most often involves specific antidotes, such as Sylimarin, Acetylcysteine. The diagnosis in most cases is made on the basis of the clinical picture and a thorough interview with the patient, and the diagnosis is established by detecting toxins in a urine test. The prognosis is better if patients with toadstool poisoning are admitted to the hospital early. It is worth noting that gastrointestinal syndromes can also result from eating raw or inadequately cooked mushrooms, and by eating them excessively or too often. Proper diagnosis and treatment of mushroom poisoning can save lives. It is very important to raise public awareness of mushroom poisoning, as well as early detection of potential signs of intoxication. Cooperation with the poison center and mycologists is very important, especially in high-risk cases.

The current paper presents an overview of phonostylistic devices (alliteration, assonance, rhyme, onomatopoeia) most commonly used in slogans and taglines of the modern car industry. The advertising slogan, being limited by space and time, is viewed as an important part of any marketing campaign. In a similar manner to previous studies, this paper confirms that a slogan is an effective type of storytelling for brands. However, it differs from the tagline, which is supposed to be long lasting. In an endeavour to convey some characteristics or information about the product and make it memorable for the consumer, brand designers resort to various linguistic devices that make the advertising language effective. The analysis of commercial advertising slogans and taglines demonstrated that such phonological devices as assonance and rhyme are infrequent, while alliteration is the most productive sound technique. As for onomatopoeia, it appeared to be the rarest device in the analysed bulk of slogans and taglines. The obtained results show the capacity of these sound techniques to enhance brand image. Numerous examples provided in the paper are tailored to support this statement. Moreover, the paper addresses the issue of sound symbolism, since the interest in its manifestation in marketing is on the rise. Thus, from a phonosemantic vantage point, the most productive phonemes are sibilants, plosives and sonorants. Their recurrent character contributes to the creation of a brand image. The overall results may have significant implications for marketing teams that seek to create ear-catching and memorable slogans and taglines as well as shed light on the consumer’s psychology.

This paper studies the effect of Mandarin proficiency on poverty reduction and its mechanism. The China General Social Survey (CGSS) is taken as the data source. From the perspective of social integration, the poverty reduction effect of Putonghua and its mechanism are empirically studied from the perspective of social interaction, social fairness, and social trust. The findings showed that improving the ability to listen and speak Mandarin positively affects social interaction, social trust, and social fairness. It showed that Putonghua proficiency positively correlates with the suppression of economic poverty. After the occurrence of poverty, whether a sample of absolute poverty or relative poverty, the ability to listen and speak in Mandarin has a specific inhibitory effect on social interaction, social trust, and social fairness. After the occurrence of poverty, the frequency of social interaction, social trust, and social public since have been reduced to a certain extent. Specifically, the ability to express Mandarin has shown remarkable results in improving social interaction, and the ability to listen among ordinary people has shown remarkable results in enhancing social fairness. The results of this paper provide empirical evidence of poverty alleviation in China via Improving Mandarin Proficiency. This research is also of great significance for optimizing poverty alleviation paths through language in the post-poverty alleviation era.

Prophylaxis against edema involves the removal of excess lymph fluid from a specific area of the body. The presence of lymph accumulation, is a sign of abnormalities in the functioning of the lymphatic system, which has lost the ability to properly transport lymph. Swelling otherwise known as lymphedema is among the chronic diseases that adversely affect the functioning of human systems. Lymphedema is one of the most common disorders of the lymphatic system. Its correct function is to drain lymph into the lymphatic vessels, and from there it travels to the lymph nodes. Its malfunction is the failure to drain the lymph into the lymphatic vessels or the lymph nodes. As a result of the abnormal lymph circulation, swelling usually occurs in the lower and upper extremities. The swelling at first appears to be painless, but over time it becomes hard thus reducing the functional capacity of the limbs. Over time, the skin and subcutaneous tissue can become infected, which can affect the formation of a cancer such as lymphosarcoma. Increasingly, so-called dynamic Plastering is being used to assist and alleviate lymphedema. Kinesiology Taping (KT) otherwise known as dynamic patching enables the reduction of swelling by elevating the skin, thus increasing the surface area between the skin and fascia. This results in body fluids having more room to flow freely to the lymph nodes, and this reduces our swelling and lymph accumulation in the extremities.[2] The purpose of this paper is to show the use of Kinesiology Taping to reduce lymphedema. The paper is based on a review of articles in reputable journals from past years.

Chronic diseases of the osteoarticular and muscular system belong to a group of health problems that lead to a limitation of the organism's efficiency, making it difficult or impossible for individuals to function normally. Of the forms of treatment used for chronic diseases of the osteoarticular system, rehabilitation is by far the most common. These activities are mainly financed by the National Health Fund, as well as by social insurance. A complementary role is played by local governments that finance medical rehabilitation for their residents in the form of health policy programmes, implemented as public health tasks. An important argument in favour of rehabilitation at the self-governmental level is the long waiting time for medical rehabilitation services financed by the National Health Fund. The aim of the paper was to show the role of local government in increasing access to therapeutic rehabilitation services for patients with musculoskeletal diseases. The paper discusses such issues as the importance of musculoskeletal diseases for the efficiency of individuals, organization and financing of guaranteed services in curative rehabilitation, as well as increasing access to these services at the local government level.

Formalization of natural language metaphors is a notorious problem in artificial intelligence and in other overlapping domains. It is semantic vagueness that makes metaphors resistant to formulaic or algorithmic descriptions. Great effort has been invested into modeling metaphors computationally but the issue remains methodologically uncertain and needs further research. This paper works on a practical solution to the problem how metaphorical meaning can be represented in a way suitable for computation. The research agenda of this paper is interdisciplinary; it brings together an algebraic heuristic-driven theory for metaphors developed in artificial intelligence and an applied theory of meaning that comes from cognitive linguistics. This agenda postpones theoretical speculation and argument and is solely solution-focused, which contributes to the value of this paper’s attempt to bridge the cognitive science disciplines whose compatibility, though declared, is seldom demonstrated in a piece of practical research. This paper works with metaphors of human emotions that are linguistically manifested in modern English discourse. Emotions by virtue of their ineffability as qualia are rich in metaphorical conceptualizations and serve the research agenda well. This paper in a meaningful way exposes and ranks designated properties of the FEAR, SADNESS, HAPPINESS, and RELAXATION/SERENITY concepts and arranges these properties into general-purpose ontologies that explicitly specify metaphorically preferred emotion conceptualizations and are good candidates for computation. In prospect, this paper will account for some theoretical aspects of the research and probe the algorithmic and repetitive nature of schemas that license metaphorical expressions in natural language.

The main goal of the current overview is to assess major trends in studying of fine motor skills neurobiology.Materials and techniques. PubMed (MedLine), Embase databases have been used for Information search. Search depth is 5 years (2016 – 2021). 12 papers that are more relevant to the topic have been chosen from the primary paper array (n=49). MAXQDA (Verbi Software GmbH, Germany) has been used for content analysis.Results and discussion. The current state is characterized by interdisciplinary integration using both complex experimental laboratory models and modern bionic and information technologies.Conclusion. Contemporary trends in the problem studying is the widespread utilization of information technologies and the development of approaches to neurorehabilitation with motor deficiency consideration. Fine motor skills recovery in patients with CNS lesions requires further interdisciplinary integration.

The aim of this paper was to prove the relationship between motor skills and anthropometric characteristics as a predictive system with effectiveness and results in running the discipline at 400 meters as situational-motor variables of the criteria system. The research was done by testing 60 samples of men 18 years old, ± 6 months, of the Faculty of Physical Education and Sports in Prishtina. Regarding the anthropometric variable, bigger correlation has been shown by the variable dermal tipple of the arm (AMTP) which correlate positively with running in 400 meter, from which we can conclude that the fullest in the upper limbs are students, the more slowly realize running in the 400 meters and conversely. The measurements were executed during September in the hall of the Faculty, in 400 meter runs in the stadium "FadilVokrri" Prishtina. The only condition that was used during the determination of the sample was: that the students are involved in regular physical education classes (and on the day of the measurement be healthy, without the flu, cold or other symptoms). The variables which are applied in this research have been 8 anthropometric variables and 1 motor-specific variables. The results obtained after their processing indicate that the impact of anthropometric variables is higher in running 400 meters. Short distance running and long distance running reduces the impact of anthropometric parameters whereas the influence of metabolic factors of energy production is increased. These results were also confirmed using regression analysis, so that groups of predictors of anthropometric characteristics, specific motor skills that statistically significantly influenced each variable of individual criteria. The results obtained from regression analysis indicate that in the variable 400 m running from low start (MV400MU) does not affect any anthropometric variables applied.We can emphasize that the test (F-test) is more valuable if the multiple correlation is greater, in the concrete case of this paper is significant (Sig = 0.645), because the value of the F-test is = 0.753.