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Lipoedema is a chronic progressive disorder of adipose tissue leading to an enlargement of lower extremities. It is considered to be rare; however, the prevalence of the disease is underestimated because it is commonly misdiagnosed as obesity or lymphedema and the general awareness is poor. The etiology of the disorder is considered to be multifarious, including genetic inheritance, hormonal imbalance and microcirculation alterations. Diagnosis is mainly based on medical history and physical examination. Management of lipoedema is focused on reducing the symptoms, improving the quality of life and preventing further progression of the disease. The aim of this paper is to raise the awareness of the disease and provide appropriate clinical guidance for the assessment of lipoedema. We searched through the PubMed/MEDLINE database and took into consideration all of the results available as of 6September, 2020 and outlined the current evidence regarding lipoedema epidemiology, etiology, clinical presentation, differential diagnosis, and management. Better understanding of lipoedema is crucial for establishing an early diagnosis and a proper treatment, which in turn will reduce the psychological and physical implications associated with the disease.

Admission Dysfunctions of the lumbosacral spine are among the most common problems related to the movement of contemporary society throughout the world, and its incidence increases with age. In recent years, increased interest in the issues fascia, which until recently was neglected in the etiology of low back pain. One of the therapeutic options that can be applied in the case of chronic pain syndrome lumbar-sacral spine techniques are easing myofascial (ang. Myofascial release, MFR), which is one of the latest methods in the field of manual medicine. Objective of the work The aim of the work was overview AD recently published study on the effectiveness of techniques easing myofascial pain in chronic lumbar-sacral spine. Material and methods To find the current investigate research (publications of the last 5 years) dedicated to MFR in the treatment of chronic pain, lumbar-sacral spine searched the following databases: PubMed, PEDro (Physiotherapy Evidence Database), ScienceDirect and Academic Search Premier. The following keywords: myofascial release, myofascial release therapy, myofascial pain, chronic low back pain. Results 9 qualified to review the studies investigating the effect of loosening myofascial pain and range of motion, functional limitations, muscles, as well as the quality of life in people with chronic pain lumbosacral spine. Conclusions The results of this review show that there is little research on the MFR employs treat ailments low back pain lumbar - sacral. Based on the studies included in this review can be concluded that the MFR can be an effective treatment for back pain lumbar - sacral, but there is a need for further research with a well-developed research procedure that will allow the standardization of this therapeutic method.

Admission Dysfunctions of the lumbosacral spine are among the most common problems related to the movement of contemporary society throughout the world, and its incidence increases with age. In recent years, increased interest in the issues fascia, which until recently was neglected in the etiology of low back pain. One of the therapeutic options that can be applied in the case of chronic pain syndrome lumbar-sacral spine techniques are easing myofascial (ang. Myofascial release, MFR), which is one of the latest methods in the field of manual medicine. Objective of the work The aim of the work was overview AD recently published study on the effectiveness of techniques easing myofascial pain in chronic lumbar-sacral spine. Material and methods To find the current investigate research (publications of the last 5 years) dedicated to MFR in the treatment of chronic pain, lumbar-sacral spine searched the following databases: PubMed, PEDro (Physiotherapy Evidence Database), ScienceDirect and Academic Search Premier. The following keywords: myofascial release, myofascial release therapy, myofascial pain, chronic low back pain. Results 9 qualified to review the studies investigating the effect of loosening myofascial pain and range of motion, functional limitations, muscles, as well as the quality of life in people with chronic pain lumbosacral spine. Conclusions The results of this review show that there is little research on the MFR employs treat ailments low back pain lumbar - sacral. Based on the studies included in this review can be concluded that the MFR can be an effective treatment for back pain lumbar - sacral, but there is a need for further research with a well-developed research procedure that will allow the standardization of this therapeutic method.

Information has been omnipresent and all-powerful for almost two centuries, and now possesses sophisticated and invasive means of imposing itself and creating opinion. It was crucial in the Enlightenment and in the preparation of the French Revolution by the intellectual and bourgeois elites. Its characteristic is to be the opposite of intangible truths, to be moving, malleable and adaptable. It is the new replacing the old. It is bracketed by history, because it ignores tradition and no longer needs the past. The creation of opinion in the 18th century introduced a concept of freedom that in fact conceals totalitarianism. People are told what to think. Information is a weapon against all forms of personal reflection and inner life. It imposes itself and imposes, making it impossible to distance oneself. It even kills the democracy it boasts about.

This study systematically investigates the primary issues and obstacles impeding the establishment of a functional and credible judiciary in Kosovo, adopting an international perspective. The research methodology includes a combination of qualitative and empirical analytical approaches to concrete actions based on a review of relevant literature, reports, and legal documents. This paper concludes that Kosovo should be ready to reach compromises, strengthen the independence, pro­fessionalism, transparency and accountability of judges and prosecutors, and increase public confidence in justice, to achieve a successful reform in the judicial system. The paper offers several recommendations for improving the quality and efficiency of justice in Kosovo, such as promoting cooperation and coordination with international factors in this field.

Introduction The rising prevalence of electronic cigarette (e-cigarette) use has prompted concerns regarding its potential health implications. While much attention has focused on respiratory and cardiovascular effects, injuries, oral trauma, and bone fractures linked to e-cigarette use have received less scrutiny. This paper aims to comprehensively review the landscape of injuries, oral trauma, and bone fractures induced by e-cigarettes, shedding light on this underexplored facet of e-cigarette-related harm. Material and Methods This literature review has analyzed 16 papers. Inclusion criteria: researches and case reports published after 2015. PubMed and Google Scholar has been searched to identify the papers. Analysis of the Literature Existing literature suggests a growing incidence of injuries, oral trauma, and bone fractures associated with e-cigarette use, albeit with limited systematic investigation. Mechanisms underlying these injuries range from device malfunctions to inadvertent impacts during use. Case reports highlight a spectrum of injuries, including oral burns, dental trauma, and skeletal fractures, often involving the face and mouth regions. Conclusions Despite the lack of comprehensive epidemiological data emerging evidence underscores the need for heightened awareness and preventive measures to mitigate e-cigarette-related injuries. Enhanced education, regulation of e-cigarette devices, and promotion of safer usage practices are crucial steps towards reducing the burden of e-cigarette-related harm on oral and skeletal health.

The dynamic secularisation of Polish young people and the fact that many of them are opt­ing out of religious classes prompts a critical analysis of the current model of Religious Education and the development of proposals that respond to contemporary socio-cultural challenges. In others words this article will seek to outline potential directions for modifying the current Religious Education model intended for secondary school students in Poland. This paper attempts to provide a synthetic answer to the following questions: Why is Religious Education in secondary schools today not leading to the expected results? What elements of it are inadequate for contemporary conditions? What should the model of Religious Education for young people look like in the context of a decline in religiousness? Where and how should catechesis be provided? This paper contributes to the discussion on the shape of Religious Education for young people in a changing society.

This paper aims to present the specific functioning of the emotion of hatred from the point of view of the Aristotelian-Thomistic concept of emotions. This perspective is particularly relevant to the issue at hand because of its holistic and integral view of understanding human beings, including their emotional functions. In this paper, I consider the issue of the emotion of hatred in relation to other emotions against the backdrop of the structure of human action. When analyzing how hatred functions, I consider the notion of good and evil, which are linked to emotions and acts of will that play a vital role in the sphere of emotions. By correctly channeling one’s will towards the good, one is able to notice hatred arising within, and thus reflect upon it. Understanding how the emotion of hatred functions is essential for further research into how it is expressed.

Introduction and purpose Non-specific and specific lower back pain syndrome is one of the leading causes of musculoskeletal disability and affects more than half of the population worldwide. The aim of this paper is to confront the problem of lumbar pain, possible diagnostic options, conservative and surgical opportunities with long term satisfactory rate. State of knowledge The paper reviews literature on lower back pain syndrome, sciatica, radiculopathy and lumbar disc herniation in regards to detection of the problem, classifying it and possible methods of resolvement. The WHO defines lower back pain as one of the leading causes of musculoskeletal dysfunction and it focuses on reducing the occurrence by programs like WHO Rehabilitation 2030 Initiative, UN Decade of Healthy Ageing and others. The paper also focuses on non surgical options of treatment. Material and method A review of the literature available in the “PubMed” and Google Schoolar was conducted. We focused on differential diagnosis depending on clinical presentation and possible treatment methods depending on symptoms, pathogenesis of the disorder and available procedures. Summary Our review managed to present the current state of development, possible differential diagnosis, prevalence of neural compressions, sciatica and radiculopathy in different diagnostic options. By receiving multiple studies we confront varied opinions of specialists regarding the approach to lower back pain syndrome and favorable forms of care. Additionally we came to the conclusion that the difference of patients' long term satisfactory rate in regards to nonoperative and operative treatment is not significant, and flattens over the years.

Gilbert’s syndrome is the most common inherited jaundice worldwide. It affects 5-10% of the population. It is caused by a mutation of the UGT1A1 gene, which results in impaired bilirubin metabolism. It is a benign disease and does not affect the life expectancy of patients. Patients with Gilbert’s syndrome should be alert to factors that exacerbate the course of the disease, interactions with medications taken and possible comorbidities such as hemolytic anemia, cholelithiasis or schizophrenia. However, it is the responsibility of physicians with such patients under their care to properly educate patients. Gilbert’s syndrome carries not only the consequences associated with the mutation, but also has many benefits that patients may not be fully aware of. Mildly elevated bilirubin levels have an antioxidant and anti-inflammatory effect, which prevents the development of lifestyle diseases and cancer. Ongoing clinical trials suggest that this could be a great step toward new treatments for diseases affecting the entire human population. PURPOSE OF THE WORK: This review paper aims to show Gilbert’s syndrome as a multifaceted disease and to sensitize doctors' attention to patients with the described mutation. MATERIALS AND METHODS: An analysis of papers available in PubMed and Google Scholar was performed using the following key words: Gilbert’s syndrome, bilirubin, UDP-glucuronosyltransferase, Gilbert’s syndrome harmful and protective aspects, iatrogenic Gilbert’s syndrome RESULTS: The result of the work is to present Gilbert’s syndrome as a disease that carries medical problems directly related to the mutation, but also, in some cases, has a protective effect on affected individuals. The work highlights the complexity of the problem.

Introduction and purpose: Diabetes has emerged as a global lifestyle disease, with an alarming rise in cases, particularly of type 2 diabetes. In Poland, over 3 million people are diagnosed, and an estimated 4 million cases are expected by 2030. Effective treatment involves a multifaceted approach, including dietary intervention, physical activity, and pharmacological options. Incretins, such as glucagon-like peptide-1 (GLP-1), play a pivotal role in carbohydrate metabolism regulation, and GLP-1 analogs have become essential in managing type 2 diabetes. This paper explores the development and mechanisms of GLP-1 analogs, detailing their impact on insulin secretion, gastric emptying, and weight reduction. Description of the state knowledge: Various GLP-1 receptor agonists, including exenatide, liraglutide, dulaglutide, semaglutide, and the novel tirzepatide, are discussed. These drugs exhibit diverse pharmacokinetics, modes of administration, and effects on glucose metabolism and weight. Despite their efficacy, there is a concerning trend of off-label use, particularly for obesity treatment, leading to shortages for patients with valid prescriptions. This misuse is fueled by para-advertising on social media platforms, contributing to a surge in prescriptions and reimbursement costs. To address this, guidelines for GLP-1 analog use in obesity treatment are proposed, emphasizing the need for a stable drug supply and normalizing drug availability. Summary: In 2023, concerns intensified with reports of counterfeit GLP-1 analogs, prompting regulatory interventions. The paper concludes by underscoring the critical role GLP-1 analogs play in diabetes and obesity treatment, while emphasizing the importance of responsible prescription practices, guidelines adherence, and regulatory vigilance to ensure patient safety and mitigate the risks associated with misuse and counterfeit drugs.

Effective body posture entails the correct alignment of body parts in relation to each other and is crucial for preserving balance, stability, and the efficient operation of muscles and joints. The major types of posture abnormalities such as lordosis, kyphosis and scoliosis can lead to alterations in various areas of the body, such as stomatognatic system. The potential correlation between malocclusion and body posture remains a subject of controversy. The aim of this review is to investigate and evaluate the association between posture defects and malocclusion on the basis of literature. This literature review has analyzed 18 studies. Inclusion criteria: clinical researches published after 2010, regarding children and adults. PubMed and Google Scholar has been searched to identify the papers. In 18 analyzed studies, 2133 patients were enrolled (including 979 children aged 4-18). A positive correlation between scoliosis and different types of malocclusion has been proven by six papers. There are also other noteworthy dependencies, such as overjet and pelvic torsion, kyphosis and sagittal position of mandible, skeletal Class III and torticollis, cross bite and scapula plane. Adolescent Idiopathic Scoliosis significantly affects the stomatognathic system, leading to issues like crossbite, crowding, increased overjet, overbite, partial open bite, and midline deviation. Orthopedists should collaborate with orthodontists for comprehensive treatment, particularly during developmental stages.

This scientific paper focuses on the treatment of breast cancer, one of the most common cancers among women. Despite increased awareness and the popularity of screening tests, statistics indicate a significant rise in incidence. The paper presents breast-conserving treatment methods, including brachytherapy, as a modern technique with promising outcomes. It describes the physical properties of ionizing radiation used in brachytherapy, discussing the photoelectric effect, Compton effect, and the phenomenon of pair production. The paper then delves into the biological effects of ionizing radiation, emphasizing the dependence on the cell cycle phase. It highlights lethal, sublethal, and potentially lethal cellular damage, categorizing the effects of radiation interaction into early and late responses. The discussion transitions to the application of brachytherapy in breast cancer treatment, focusing on various techniques such as LDR, PDR, and HDR. The paper provides a detailed description of brachytherapy's use in breast-conserving treatment, considering contraindications, treatment planning, and Accelerated Partial Breast Irradiation (APBI) techniques. The radioisotopes used in brachytherapy are also presented, with special attention to Iridium-192. The physical and practical aspects related to this isotope are discussed, along with other commonly used radioisotopes such as Cesium-137, Cobalt-60, and Strontium-90. The paper concludes with a summary, emphasizing the significance of brachytherapy in breast cancer treatment and outlining its prospects for development. The authors highlight precision and shortened therapy duration.

Introduction and purpose: In our work, we focused on presenting the role of collagen supplementation and its impact on skin and joint health. We considered studies discussing the differences in the effects of collagen from various plant and animal sources. We also examined the influence of the degree of hydrolysis on the absorbability of the supplement. The aim of the paper is to comprehensively summarize knowledge on collagen supplementation, differentiating between its sources and forms. Material and methods: In our paper, we endeavored to address the subject of oral collagen supplementation comprehensively. We explored studies about various forms and sources of collagen. We also delved into the collagen supplementation impact on skin and joints health and impact of additives in enhancing the positive effect of collagen . State of knowledge: Oral collagen supplementation can be beneficial for skin and joints health. It promote collagen synthesis in human body increasing strength of skin and joints. The higher the degree of collagen hydrolysis, the more easily it is absorbed by the body. Additives in the form of vitamin C and A can enhance collagen synthesis. Results and conclusions: This review article indicates a growing interest in oral collagen supplementation and its impact on health. Although there are encouraging findings regarding positive effects, further research is necessary to better understand and determine the optimal conditions for achieving maximum supplementation benefits. This information may be crucial for clinical decisions made by physicians regarding joint reinforcement and anti-aging effects on the skin.

Introduction and purpose The term "probiotic" rooted in Latin, signifies 'for life,' reflecting the historical use of fermented products for therapeutic purposes. While browsing many websites devoted to healthy eating or popular science topics, we often came across the topic of probiotic food without any confirmation by scientific research. The aim of this paper is to confirm or exclude the presence of probiotics in popular foods. State of knowledge The paper reviews literature on the health benefits of various food that is traditionally considered probiotic, focusing on how they impact on varied health conditions. Defined by the WHO as living microorganisms conferring health benefits when consumed adequately, probiotics, mainly bacteria from Lactobacillus and Bifidobacterium genera, play a vital role in maintaining gut microbiota balance, regulating digestion, supporting the immune system and influencing mental and cardiovascular health. In addition, the paper also searches for scientific basis for their action. Material and methods A review of the literature available in the “PubMed” and Google Schoolar was conducted. We focused on checking whether the microorganisms contained in pickled food meet the WHO criteria for probiotics. Summary Our review managed to prove the probiotic effect of almost all presented food, except for miso. By reviewing many articles, we shed a lot of uncertainty on the repeated myth about the lack of probiotic effect of cucumbers preserved in vinegar and what is more, we found scientific assumptions about the probiotic effect of vinegar itself. Fermented food contains numerous strains of bacteria that are resistant to acid, bile and temperature in the human digestive tract and can be effectively used as a source of probiotics. Additionally, compared to probiotics from the pharmacy, fermented products provide not only probiotics, but also nutritional value, valuable fiber and vitamins, benefiting to our health.

Introduction and purpose: The purpose of this scientific paper is to review the current knowledge of the effects of red wine on human health, particularly with regard to cardiovascular disease. State of Knowledge: Since the 1990s, red wine has gained its status as a health-promoting alcohol through the French Paradox - when drunk in moderate amounts, it protects against cardiovascular disease. The authors have collected scientific papers on the health effects of alcohol, red wine and resveratrol-a polyphenol that is the main component with health-promoting effects of wine. On their basis, they analyzed the assumptions of the positive effects of wine reaching inconclusive conclusions. Summary: Despite the fact that both ethanol and resveratrol have a positive effect in in vitro studies, in population studies their effect is much less significant, either because the negative behavioral-health effects in the case of ethanol are omitted or the actual effective doses of resveratrol are omitted.

Context: Angular gyrus is an anatomical structure of the brain located in the parietal lobe, taking part in writing and reading, language-use, memory and attention and spatial recognition. It is supplied by the angular gyrus artery, which is one of the caudal branches of the middle cerebral artery. One of the clinical pathologies of the angular gyrus artery is the ischemic stroke of the angular gyrus in the dominant hemisphere, responsible for the presence of Gerstmann Syndrome: left-right disorientation, agraphia, alexia, acalculia and finger agnosia. This systematic review aims to present the variety of anomalies of the main cerebral artery and the angular gyrus artery. Objective: Preparing a systematic review of papers describing the course anomalies of the angular gyrus artery. Materials and methods: PubMed and Google Scholar electronic databases was searched for phrases: ‘Angular gyrus artery’, ‘Artery of angular gyrus’, ‘Middle cerebral artery branches’, ‘Branches of middle cerebral artery’, ‘Gerstmann Syndrome’ published between years 2015 and 2023. Also 3 papers published before 2000 were used. From the selected 30 papers, 6 were used to prepare this analysis. Results: The middle cerebral artery, from which arises the angular gyrus artery, is marked by a significant variety of its division, mainly the number of the dividing trunks of the artery. Depending on the type of the division, the angular gyrus artery can arise from the upper, middle or lower trunk and vary in sizes. It can also appear as a singular or two separate branches. Instances of the anomaly of both the angular gyrus artery and posterior parietal artery are rare, but reported. Conclusions: The angular gyrus artery is characterised by a number of anomalies in its course, separation from the middle cerebral artery, diameter and branching.

Introduction and purpose: Apples are a widely consumed fruit globally and are known to be a great source of nutrition. Studies have shown that apples contain high levels of antioxidants, dietary fiber, and vitamins that contribute to numerous health benefits. This paper aims to provide a comprehensive review of the impact of apples on human health. State of knowledge: The paper reviews the current literature on the health benefits of apples, focusing on their impact on various health conditions such as cancer, cardiovascular diseases, diabetes, and obesity. Additionally, it examines the role of apples in improving intestinal, immune, and cognitive function. The paper also discusses the potential mechanisms by which apples exert their health benefits, such as high levels of flavonoids, polyphenols, and dietary fiber. Summary: In conclusion, the vast body of evidence reviewed in this paper supports the notion that consuming apples regularly can contribute to better health outcomes. They may help reduce the risk of chronic diseases, such as cancer, cardiovascular diseases, and diabetes, as well as promote healthy gut microbiota and immune function. Despite the controversy surrounding the use of pesticides in apple cultivation, the benefits of consuming apples outweigh the risks. Therefore, it is highly recommended to include apples as part of a balanced and nutritious diet to promote optimal health and wellbeing. As the saying goes, "An apple a day keeps the doctor away".

Introduction and aim Diabetic foot ulcer (DFU) is a chronic condition that affects an increasing number of people each year[1]. Healing the ulceration requires cooperation between patients, specialists and scientists in order to achieve satisfactory results. Treating this type of wound is not only a therapeutic challenge[1,2,3,4,5,6], but also an economic one, which is why so much scientific research has already been made on this phenomenon[2,3]. Still scientists continue their quest for new cost-effective alternatives to current therapeutic options that would be consistent with contemporary knowledge and available engineering capabilities in pursuance of creating techniques and new dressings that will accelerate the healing of DFUs[2,3,7,8]. Factors such as stress, obesity, certain medications, and chronic diseases appear to negatively affect the process of repair [1,9,10,4,6,11]. Studies prove that aloe vera gel due to its healing properties, can be considered as a potential dressing that will expedite the mending process of diabetic foot ulceration[12,13,14]. In this paper, we performed a literature review of the applicability of aloe vera in the healing process of DFUs. Materials and methods Searching the available literature, including randomized clinical trials and systematic reviews, we drew on databases focusing on the effects of treatment for diabetic foot ulceration using Aloe vera. Conclusion: The current scientific research on the use of Aloe vera gel in diabetic foot ulcer treatment indicates that this method is safe, effective and inexpensive[2,3]. However the difficulty of treatment and the increasing prevalence of this type of wound pose a challenge to finding new solutions and exploring mechanisms in which aloe vera can have a possible role in the wound healing process. Nevertheless, this paper presents a promising impact of Aloe vera gel applicability in the healing process of diabetic foot ulcer.

Introduction and purpose: Currently, as the frequency of obesity is alarming, the role of many factors that could contribute in preventing and treating this condition are being researched, among them the certain food with beneficial health profiles - one of them is soybeans, specifically the isoflavones it contains. Populations that consume soy are known for lower risk of various disorders - among them obesity. The aim of this paper is to summarize the existing paper about the role of these bioactive components in the treatment of this condition. The search was conducted using PubMed and Google Scholarship databases. Brief description of the state of knowledge: Obesity is one of the leading challenges in today’s healthcare as it leads to various chronic diseases that are fraught in consequences. Current knowledge is pointing into the association between composition of the soy isoflavones and the lower risk of obesity. Results of the studies indicate that patients affected with obesity could benefit from introducing soy isoflavones into their diet along with other necessary modifications. Conclusions: Soy isoflavones are potential agents in the holistic obesity treatment. Consumption of isoflavones merits further recognition as foregoing results of conducted studies are pointing to its possibly meaningful role. It is worth mentioning that consumption of soy isoflavones is not only an anti-obese factor, but also presents various other health benefits and when consumed rationally poses no risk to human’s well being. We conclude that further studies would enable us to fully reveal the potential of those polyphenols.

RESEARCH OBJECTIVE: The research investigates how young boys progress in life after the loss of their fathers. It explores the adjustments they make, the coping mechanisms they develop to navigate life, and the male roles they assume in the family. Additionally, it examines how family can aid and support their coping and adjustment process. THE RESEARCH PROBLEM AND METHODS: This study utilises a case study methodology focused on gaining an understanding of the lives of two adolescent boys who experienced the death of their fathers in the early formative years of their lives. THE PROCESS OF ARGUMENTATION: The paper focuses on five themes- family dynamics, life transitions with and without their fathers, post-loss reassignment of family roles, present circumstances, and future goals. RESEARCH RESULTS: A qualitative analysis of the data revealed that participants’ belief systems, family support, and striving toward future goals helped them to be resilient in this event. CONCLUSIONS RECOMMENDATIONS AND APPLICABLE VALUE OF RESEARCH: While most research typically emphasises the negative impacts of death on people, this study demonstrates how individuals’ can be resilient, dependent on both person-related factors and environmental factors. To help adolescents who are grieving become resilient, the paper offers intervention and coping strategies through counselling, the availability of support networks, and combined efforts by the state and educational institutions.

RESEARCH OBJECTIVE: Governments across the world were forced to impose social distancing and lockdown measures to prevent the spread of COVID-19, caused by coronavirus SARS-CoV-2 that emerged in December 2019. Following the declaration of COVID-19 as a pandemic, the disruptions, including restrictive measures such as school closures had severe impacts on the physical, emotional and mental health of all people, especially children with special needs. There was also scant data, particularly in low-to-middle-income countries. Existing literature stems mostly from western countries, thus the need to perform a comprehensive review on this topic. THE RESEARCH PROBLEM AND METHODS: The primary objective of the systematic review is to understand the impact of COVID-19 and restrictive measures such as school closures on the educational outcomes and physical and mental health of school-going children with special needs. THE PROCESS OF ARGUMENTATION: This systematic review used the PRISMA 2020 checklist where four databases and grey literature were searched for full text articles, peer reviewed publications in the English language that were published during January 2019–December 2021. RESEARCH RESULTS: The literature search identified 1294 publications, of which 25 key papers were selected. These studies investigate the impact on children with special needs across the globe, with a majority of papers from Europe. We found that COVID-19 and the digitalization of schooling had severe impacts on the physical and mental health of children with special needs and their parents/caregivers. CONCLUSIONS, RECOMMENDATIONS AND APPLICABLE VALUE OF RESEARCH: These studies highlight the need for an inclusive school environment to ensure that the learning outcomes for children everywhere are achieved. Further, a hybrid model that includes classroom learning with novel inventive methods would be beneficial for children with special needs.

Ad hoc corpora are considered effective to deliver native-like technical (and legal) translation. This paper explores how the translation of a system-specific document such as an Italian procura alle liti (power of attorney to appear in court) can be addressed. Translating this legal document may be problematic due to the fact that it is not recurrent in the common law system, which contemplates other types of special powers of attorney (PoAs). This paper explores whether and to what extent a corpus-based translation is possible when L2 parallel texts are difficult to find in native contexts. To this aim, a translation project with technical translators and lawyers is carried out. The participants compose an ad hoc corpus which they consult as a language reference tool. The paper findings report that the translators' corpus-based translation is mostly a word-by-word rendering of the source text, which may sound unnatural to an expert of the field. The lawyers' translation partly deviates from source words, but addresses the communicative function of the source text. The paper highlights the need for a balance between the two strategies, for example by focusing on textual functionality and/or paraphrasing, although at the cost of a reduced formulaicity.

Forensic Linguistics as a discipline has gone through more than 30 years of development in China, which can be divided into the brewing period, the establishment and development period, and the comprehensive improvement period. Scholars have presented the origin and development of forensic linguistics in the form of papers, monographs, translations, textbooks, seminars, conferences and other forms, which promotes the future development of forensic linguistics. In the past decade, the study of forensic linguistics has mainly focused on the theoretical research of forensic linguistics, the application of legislative and judicial language, the translation and teaching of legal language. This paper will adopt the method of literature research to summarize the origin and development of Chinese forensic linguistics in the past 30 years, and to anticipate the future development direction of forensic linguistics in the light of the current research characteristics and the hotspot of the times, so as to provide references for the theoretical development and application practice of current forensic linguistics, and to better guide future discipline development in China.

This paper presents sociocultural profiles of the Ostroh Bible (1581) and the King James Version of the Bible (1611) in terms of their agency, authoritative status and regulative functions. Despite scholarly and popular attention given to both texts, no attempts have been made so far to compare them. This paper intends to break the mold and focuses on the causes and results of the collective agency of the two versions at the textual, paratextual and extratextual levels as well as on the gatekeeping role of these translations and the ways they affected the development of their respective cultures. It is also demonstrated that the OB and the KJV performed the function of “the second originals.” Also subject to analysis are the prefaces to the two editions, which disclose information about important translation figures and deal with issues of universal and sacred history.

In the humanities and social sciences, the concept of the Anthropocene has become the starting point for theoretical analyses of the immediate relationship between the environmental preconditions for the existence of civilization and the human actions whose consequences threaten these preconditions. From the philosophical-anthropological point of view, reflections on the concepts of the Anthropocene focus not only on a critical analysis of the claims about human that originate in the natural sciences but also on an understanding of the overall role of humanity in the new geological-climatic regime of the Earth. The primary purpose of this paper is to highlight two-pronged problem areas, which include both the problem of anthropological constants as specific ways of making statements about humans and the problem of using them to reflect on the conceptual system of the Anthropocene. In particular, this paper emphasizes hypotheses and claims from the Anthropocene concept of Earth System Science that point to humans becoming a geobiophysical force in the Anthropocene. Three areas in which anthropological constants could be subsequently subjected to a deeper analysis are proposed.

This paper is based on the concept of environmental political philosophy and from its perspective, it highlights the weaknesses and contradictions of contemporary, existing democracies. It aims to formulate an outline of the concept of environmental democracy, following the accounts of M. Bookchin, R. Morrison and H. Skolimowski, as well as international environmental law enshrined in United Nations documents and resolutions. It is based on the hypothesis that the preservation of a democratic political system in a situation of a collapsing planetary system (the Anthropocene) requires improving the foundations of democratic theory with the insights of the Earth system sciences, particularly of political ecology and critical environmentalism. Through philosophical analysis, explanation and interpretation, this paper explores an environmental democracy that would, on the one hand, preserve the basic constitutional principles of current democratic constitutional regimes, and, on the other hand, reconcile them with the current state of understanding in the Earth sciences concerning the vulnerability of the planetary system. In a sense, J. Habermas’s understanding of human rights characterizes the concept of environmental democracy as a realistic utopia. The author concludes by drawing up the imperative of sustainability, which he sees as a guiding organizing principle of institutions and public policies for the climatic, demographic and economic regime of the Anthropocene.

In my paper, I reconstruct Jerzy Wróblewski’s theory of interpretation. My goal is to show that this theory has the characteristics of a paradigmatic theory because of the importance of the presumption of common language, which is a fundamental element of this theory. This presumption is decisive in shaping the picture of interpretation and, consequently, gives the theory in question the status of a model theory defining a postulated model of legal interpretation. In the paper, I discuss various aspects of this presumption, highlighting its importance in preserving the principle of universal access to practical (legal) discourse. At the same time, I question the views that challenge this presumption by claiming that the language of law is a code accessible only to a cognitively privileged group of professional lawyers.

This paper presents the question of the dynamics of the sacrament of marriage arising from the wedding vows according to the rite celebrated in the Catholic liturgy. The aim of the paper is to explain what it means to celebrate the sacrament of marriage every day, not only on the wedding day. The theme is developed based on the concept of ritual as a phenomenon involving the activities of introducing a person to a new state of life in society. According to researchers, ritual perpetuates certain values in culture and human consciousness. In the light of theological sources, in Christian rituals, marriage is a theological reality. This means that the sacrament of marriage involves the rite of a man and a woman making four promises concerning their future life together and including their relationship with God. These pledges are a promise of fidelity, love, honesty and accompanying the other person for the rest of their lives, which means ‘dialogue of life’. Sacramentality, on the other hand, signifies a guarantee of access to God’s grace, which is necessary to build a family community according to the Gospel. The sacrament of marriage appears here as a Christian ritual celebrated that commemorates every moment of life together, with references to the grace given by God. Looking at the sacrament of marriage as a ritual makes it possible to see two dimensions of the dynamics of the marital relationship: a horizontal relationship, involving the dialogue between the spouses, and a vertical relationship, involving the dialogue of the spouses with God. Viewed in this way, Christian marriage is a reality unfolding in the individual lives of persons, as well as socially and ecclesiastically.

This paper considers three recent studies on the negative theology of the Neoplatonists and Dionysius the Areopagite. The first is that of Lloyd Gerson, who argues that the One in Plotinus does not lack transcend existence but only definite existence; the second is the contrary thesis of Eric D. Perl that not only the One of Plotinus but the God of Dionysius transcend all being in such a way that they cannot be credited with existence. After some criticism of both the paper turns to the argument of Timothy D. Knepper that even the ineffability of the divine cannot be stated on our present plane of knowledge; it concludes with some reflections on the appeal to present or future experience as alternatives to epistemology as this is commonly understood in the analytical tradition of philosophy.

Apophatic theology is an approach in theology that emphasizes the limitation of human language and concepts in describing the nature of the Divine. Rooted in ancient religious traditions, apophatic theology has gained attention in contemporary discourse for its potential convergence with the scientific method. This paper expands on a novel application of this approach in which the formal methods of science such as logic and mathematics are engaged to inquire into how God thinks and to what degree the modes of human reasoning can be projected on the nature of the Divine mind. This application has been proposed by Michał Heller and is referred to as the logical apophatism. In the course of the analysis carried out in this paper more in-depth understanding of the logical apophatism has been obtained by contrasting it with classical approaches to negative theology such as the Triplex Via and supplementing with recent advances within the cognitive sciences. It is concluded that Heller’s use of the apophatic approach is manifestly non-standard and its novelty consists in the shift of emphasis from the negative character of the language of theology to the logic of the Divine mind and the logic that underpins the workings of the Universe.

RESEARCH OBJECTIVE: The aim of the paper was to discuss a function of passion in professional personal lives of eminent Cracow musicians. THE RESEARCH PROBLEM AND METHODS: The paper raises the problem of the role of passion in the process of shaping musical eminence, answers the question of the scope of experiencing it as well as it manifesting in activities of outstanding individuals. In conducted research and interpretations, the qualitative perspective and biographical method were applied. The leading technique was problem-concentrated qualitative interview, partially structured, carried out with ten eminent instrumentalists. THE PROCESS OF ARGUMENTATION: The theoretical basis for this reading of the experience of educational biographies was provided by the Model of Authentic Vocation of J. Weller and the Dualistic Model of Passion of A. Bonneville-Roussy, G. Lavigne and R. Vallerand. The interpretations of the research material described the topography of experiencing passion. RESEARCH RESULTS: The article describes autonomous passion associated with musical mastery, instrumental motivation to practice, as well as distinguishes important factors that determine the experience of passion, persistence or burnout (tenacity, ambition, community transfer, conflict of motives, work overload), and concretizes the qualities of musical passion of outstanding musicians: professionalization, love of music, integrity, creativity, strength and determination in pursuit of goals, as well as humility in the face of challenges. CONCLUSIONS, INNOVATIONS AND RECOMMENDATIONS: Deciphering the senses and meanings that prominent Cracow musicians attributed to passion suggests that it was autonomous, harmonious and instrumental, motivated by the pursuit of mastery, and that the trajectories of the musicians’ professional biographies were a manifestation of a “professionalization of passion,” which formed the core of their educational experience and constituted and defined their life creed.

Introduction and purpose of the work. Aesthetic medicine currently has many methods to keep our skin in the best possible condition, and one of these methods is the use of tissue stimulators. The purpose of the following paper is to analyze, present and apply tissue stimulators in anti-aging prevention. Review methods. The paper is based on a review of literature about tissue stimulators, aesthetic medicine and anti-aging therapy. Most of the publications used were from Pubmed and Google Scholar electronic databases. State of the art description. Aesthetic medicine is a department that over the past few years has been closely associated with the slowing down of skin aging processes. In humans, over the years, proliferative processes slow down, the rate of collagen and elastin degradation increases, and the intercellular matrix is reduced. Substances known as tissue stimulators used in anti-aging therapies mean that the above processes can be delayed. Conclusion. The expectations of patients visiting aesthetic medicine clinics regarding activities that improve their appearance are increasing. They are unable to accept their own aesthetic defects, which is why they often strive for unnatural effects. Tissue simulator treatments can be a valuable way for patients to maintain healthy and rejuvenated skin.

Introduction: Xenotransplantology, the field of transplantation involving organs or tissues between different species, holds great promise for addressing the global organ shortage crisis. However, the development of new technologies without proper legislative preparation raises significant moral and ethical considerations. This paper provides an overview of the current state of xenotransplantology, highlighting its revolutionary potential alongside the moral dilemmas it entails. Aim of the study: The aim of this study is to assess current social, ethical, religious, and legal trends regarding the issue of xenotransplantation. Materials and methods: To obtain up-to-date information concerning trends in xenotransplantation, a review of the PubMed and Google Scholar databases, along with the latest legislative reports in both Europe and Poland, was performed. Conclusions: Firstly, the authors briefly report on the current situation concerning transplantology and the widely spread organ donor crisis. Next, the issue of species boundaries and the moral status of non-human animals is addressed. The assessment of ethical implications of utilizing animals as organ donors is examined, along with the legal acts regulating this issue. Moreover, the authors attempt to evaluate the cultural and religious differences related to this concern. Furthermore, this study discusses the allocation and distribution of xenotransplants, considering issues of justice, fairness, and access to this innovative medical technology. Lastly, the paper delves into the risks and uncertainties associated with xenotransplantation, including the possibility of cross-species disease transmission and intensified course of organ rejection disease.

Introduction and Purpose: Coeliac disease is an increasingly prevalent disorder worldwide. It is estimated to affect about 1% of the population and its symptoms heavily impact people's lives. The aim of this paper is to delve into the topic of coeliac disease and present basic information about its origins, current diagnostic methods, and the challenges associated with its treatment. This article includes all the necessary information from up-to-date sources. State of Knowledge: Coeliac disease was discovered a long time ago, but it is still not completely understood. Every year, new research is published regarding different populations in various countries. While we know more about the disease, its symptoms, and causes, we are still far from fully understanding all the inflammatory processes occurring in the human body. There is solid evidence that this enteropathy is caused by gluten, and the only way to reduce the clinical manifestation of coeliac disease is to adhere to a gluten-free diet. However, some patients do not benefit from this type of diet and still suffer from coeliac disease. New drugs currently being developed offer hope for these individuals, as they attempt to target the immunological reaction and mitigate the immune response in the small intestine. Conclusion: As approximately 1% of the population suffers from this disease, it is crucial to diagnose patients in the early stages of its development. Early diagnosis can prevent the development of other disorders that coexist with coeliac disease, which can be particularly dangerous, especially for children. This paper provides up-to-date information about the clinical manifestations of the disease, as well as methods of diagnosis.

This article focuses on the promotional aspects related to the tourist attractiveness of the neighboring countries-Poland and Slovakia. The purpose of the article is to analyze the issue in question and point out the importance of the search for ways to increase the effectiveness of management of the area of tourism promotion in both countries. The authors used an empirical research method with quantitative-statistical and qualitative studies on specific promotional campaigns. The Olympic Games have the greatest marketing potential among sporting events, as the most important sporting event in the world. The possibility of organizing such an event in Poland and Slovakia would certainly serve to improve the recognition rates of both countries. The authors will try to demonstrate this potential as part of the considerations in this article. Acknowledgement: This paper was supported by the project NP-KSV-ET-01-2023-12/ST - International cooperation in the field of development, management and law in tourism and sports between the Republic of Poland and Slovak Republic. The views expressed in this paper are those of the authors and should not be taken as reflecting the position of any authority, entity or institution. This article presents the legal status as of 25 March 2023.

The ‘migration’ of concepts from one language to another, which takes place in cultural exchange, frequently gives rise to changes in the target language, primarily involving the lexical field. The reception of the Romanist legal tradition in China has led to the formation of a specialized lexicon which, along with the translation and production of Roman law-related works, has been subject to constant growth. This kind of terminological transposition has often resulted in the emergence in Chinese of more than one translatant for the same Latin word. As a concrete example of this phenomenon, this paper aims at providing a synoptical overview of the rendering in Chinese of the concepts of dolus and culpa, two legal institutions also largely connected to the field of commercial law. The sources analyzed from a diachronic and contrastive perspective range from the earliest manuals of Roman law published in China at the beginning of the twentieth century to recent documents, translated or directly composed in Chinese. More specifically, this paper will try to answer the following questions: what is the historical evolution of the main terms used in Chinese to express the concepts of dolus and culpa? What are the criteria adopted by Chinese translators/authors in choosing these terms? What are the main features and issues related to the linguistic rendering of the two legal institutions? As for the results of this study, attention will be paid to one of the peculiarities of the linguistic rendering of the concept of culpa, that is the use of two different translatants: guoshi 过失 and guocuo 过错. At the same time, another aspect on which this paper will shed light is the existence of a plethora of translatants related to the concept of dolus (qizha 欺诈, guyi 故意, zhaqi 诈欺, etc.). In this sense, on the one hand, it will be shown how the presence of multiple translatants is acceptable and useful when they are used to express the different shades of meaning conveyed by dolus and culpa that cannot be rendered by means of one single translatant for each of these two notions; on the other hand, this paper will highlight the necessity of a higher homogeneity and standardization of the Chinese Romanist lexicon.

The aim of this paper is to propose a reinterpretation of the meaning of the lost colossus of Constantine the Great from the Forum of his name in Constantinople, in the light of the iconography of the emperor on the cameo from the cathedral in the Pomeranian town of Cammin. Although the gem was lost during the last war, it is known to us thanks to archival photographs and the plaster cast housed at Göttingen University. On this basis, Gerda Bruns associated the jewel with the statue of Constantine on the porphyry column in the New Rome, and her identification has since been widely accepted by the scholarly milieu. In recent years one has been able to observe growing popularity of this interpretation among researchers, who however refrain in their studies from pointing to the consequences of such a reconstruction of the statue’s form. The author of this paper points out that Constantine purposefully chose the iconographical type of Alexander-ktistes as a model for his own representation in order to allude to his great predecessor and the founder of a number of cities which bore his name. The iconography of the statue became then a part of the programme of the celebrations arranged on the occasion of the dedication of Constantinople, in which numerous references to Alexander played the key role. This new understanding of the colossus, placing its significance within the frames of political propaganda, better matches the actual historical circumstances and the ruler’s attitude towards Christendom than traditional interpretations which recognised the statue as Helios or Apollo, and thus introduced an incoherence — difficult to explain — in Constantine’s attitude towards the new religion. This cumbersome question, which baffled the inquisitive minds already in the Constantinople of the Byzantine era, will be considered unsubstantial if we correctly interpret the monument on the Forum solely in the political and propagandistic context.

Paul de Lacvivier This paper aims to highlight how the trial of Louis XVI expresses a complete inversion of the legal principles of Old Christian France, where the authority of the absolute King submits to superior customary and divine laws, against the Revolution, which makes the ‘general will’ a God allowing for unrestrained legal positivism. After recalling how the assassination of the King allowed the vicious circle of terror, the trial of Marie-Antoinette and the revolutionary trials, we propose an explanation of the legal principles that can lead to this kind of totalitarianism. To do so, we present some cases from 19th century Japan, which, when compared with the revolutionary trials and the pre-revolutionary Christian world, provide a key to understanding: the hierarchy of positive, natural and divine laws greatly explains how such and such a legal system can allow or not the justification of mass crimes or totalitarianism. Jason Morgan In his 2022 volume Common Good Constitutionalism, and in a series of essays and other works prior to the book’s release, Harvard Law School professor Adrian Vermeule advances a new vision for the American republic. Against the two dominant strains of constitutional interpretation in the United States, namely originalism and progressivism (“living constitutionalism”), Vermeule argues for common good constitutionalism, a return to the ius commune pursuit of that which is good for all in accordance with the natural law. While Vermeule’s work is ambitious and his intervention into originalist-progressivist debates welcome, a question remains: will common good constitutionalism be able to overcome America’s Enlightenment civil religion? In this paper, I consider the challenges which America’s Enlightenment civil religion poses to common good constitutionalism (and any other attempt to think past the Constitution from within a constitutional framework), concluding that common good constitutionalism, insofar as it is predicated on the pre-existing Constitution and deployed within the American politico-theological domain, cannot overcome America’s Enlightenment civil religion to effect the common good.

The term „Lublin Philosophical School” refers to the mode of philosophizing devised in the 1950’s at the Catholic University of Lublin. After a brief history, the paper first discusses some methodological features of this mode and the social role of philosophy as a self-awareness of culture. Employing the School’s philosophy, the paper then considers the issue of post-truth and that of the value-ladenness of science. The post-truth approach replaces evidence with emotions, and in consequence, argumentation is replaced with power. This in turn threatens the human person, her rationality and freedom. Admitting that science is value-laden and values are subjective leads to denying the cognitive status of science. Lublin philosophy offers such a concept of value and scientific knowledge which allows one to solve the problem created by the value-ladenness of science. Thus, the paper shows that the Lublin School’s philosophy can provide answers to contemporary problems and evaluate intellectual developments of culture.

The aim of this paper is to present the changes in the perception of the Archbishop of Can-terbury and Catholic saint Thomas Becket in England during the reign of the Tudor dynasty. The author’s starting point is the intellectual currents that emerged in England in the fifteenth and early sixteenth centuries that sought to challenge Catholic traditions. The author argues that in the long run they laid the foundations for a systemic struggle in the 1630s and 1640s against the cult of Thomas Becket as a symbol of Catholic England. The paper uses printed sources by such authors as Erasmus of Rotterdam, Mathew Parker, John Foxe, Francis Go-dwin, royal documents from the Reformation era in England as well as articles and studies by foreign authors. The paper concludes that despite the measures taken, the reformers never succeeded in removing Thomas Becket from the religious landscape of England.

There is some debate among interpreters of Aquinas as to whether he attributed a doctrine of creation to Plato and Aristotle. Mark Johnson has noted many texts where Aquinas does appear to attribute to Plato and Aristotle an understanding of creation. Yet, an initial glance at Summa Theologiae I.44.2 would suggest he did not. This paper first examines what various interpreters of Aquinas have had to say on the matter. Secondly, it argues that Summa Theologiae I.44.2, taken in context with the proceeding article and De Potentia III.5, need not be read as denying such a doctrine to Plato and Aristotle. Thirdly, this paper concludes that because Plato and Aristotle do not actually possess doctrines of creation, they cannot be the chief sources for Aquinas’ own thought on this matter. Instead, to attribute creation to Plato and Aristotle, Aquinas interprets them through Avicenna. Thus, Avicenna is the chief source for Aquinas’ understanding of creation.

Oral mucosa is an inner lining of oral cavity, which maintains different functions including protection of epithelial integrity. Pathology of oral mucosa can develop in response to the action of pathogenic microorganisms, viruses, and various traumatic factors; it can be a result of systemic pathology of a patient as well. Pain and discomfort usually accompanies such conditions leading to decrease of patient wellbeing. The basis of the pharmacological regulation of the regeneration process is the stimulation of wound healing. The aim is to summarize and discuss the spectrum of remedy options that are used to stimulate epithelization of oral mucosa. The overall goal of the paper is to provide full and comprehensive information for dentists and their patients about medicament variety, ways of theirs application and dosage. Methods. Relevant literature from MEDLINE (PubMed), Google Scholar, and in open access journals which are published by Elsevier was selected using the following key words «oral mucosa», «epithelization», and «remedy» were used in various combinations by the year of 2023. In total there were found 48 papers. To the selected scientific papers we applied the inclusion and exclusion criteria to choose the relevant ones. Conclusions. A significant number of drugs for the treatment of inflammatory processes in the oral cavity are available nowadays on dental market. Numerous studies substantiates the effectiveness of their use in dentistry. Therefore, when choosing pharmacological drugs, preference is given to drugs with a complex effect, which locally affect various links of the pathogenetic mechanism of the occurrence of diseases and do not disturb human wellbeing.

Endometriosis is a chronic gynaecological disease characterized by the presence of the uterine mucosa that functions in accordance with the menstrual cycle outside of its usual location. This disease significantly reduces the quality of life of women facing numerous ailments, most often pain, and may lead to reduced fertility. The prevalence of endometriosis is difficult to determine due to the complexity and lengthy diagnosis. It is estimated that this disease occurs in 3-8% of women of reproductive age, and symptoms may also appear after menopause. It is worth noting that the relationship between the disease's severity and endometriosis symptoms is often not proportional. The aim of the paper is to present a case report of a 23-year-old female patient with endometriosis, to differentiate the disease from irritable bowel syndrome and to draw attention to the problematic and lengthy diagnostic process due to the multitude of symptoms from various organs. Material and method: Study of an individual case of a patient and a review of scientific articles available in Google Scholar and a review of publicly available textbooks in the field of medicine. The paper emphasizes the need to broaden the knowledge about endometriosis by specialists in many fields of medicine and points to the lack of quick, minimally invasive tests enabling efficient diagnosis of the disease. Increasing the awareness of doctors including other specializations than gynaecology, organizing campaigns to increase awareness of the disease among women, which may contribute to earlier diagnosis of patients, earlier application of an effective treatment, and improvement of patients' quality of life.

Introduction:Lipid disorders are one of the most common modifiable risk factors for cardiovascular disease. Until now, the mainstay of dyslipidemia treatment was the use of widely available statins. These drugs, despite significantly lowering cholesterol and bringing its concentration to desired values were associated with a number of side effects. In addition, the need for daily use of statins is inconvenient for patients and leads to their irregular use and, consequently, failure to achieve the desired effect. The new drug, inclisiran, which is a PCSK9 inhibitor, represents the future in the treatment of lipid disorders. Studies conducted to date have explored the drug's mechanism of action, frequency of administration to achieve the desired effect, and side effects. The results of these studies have confirmed the significant efficacy of inclisiran,which may become a major form of treatment for dyslipidemia in the future. Purpose of the work: This article reviews the state of knowledge based on available studies on inclisiran. The aim of the review is to present the most important information about this drug related to the mechanism of action, effects on the body or assessment of efficacy. Materials and methods: The authors, based on databases such as PubMed, Scopus and Google Scholar, created a paper summarizing a review of currently available publications, concerning a new drug in the treatment of dyslipidemia- inclisiran. The authors searched for available information , using terms under the heading "key words" contained in other scientific papers. Summary Inclisiran is a novel drug that represents the future in the treatment of dyslipidemia. Due to the lack of systemic effect, it has insignificant side effects, and the need for such rare administration will allow to obtain the desired lipid concentrations even in patients who do not cooperate.

The primary purpose of this paper is to determine and prove the impact of loads with different intensities on the treadmill on the heart frequency, as well as to prove the relationship and impact of some anthropometric and motor parameters on the physiological one in the manifest space. In harmony with the purpose of the research, three basic hypotheses have been presented that cover the anthropological research fields. In this paper, 19-year-old students of the Faculty of Sports Sciences are included. To achieve the purpose of the paper, a sample of 80 students who were regular students during the year 2022/2023 was included. Four anthropometric variables, three motor tests (running tests) and four physiological tests (pulse at rest and during loads) are included in this paper. For the three groups of the system of variables, the basic statistical and distribution parameters for each variable, as well as the measures of asymmetry and normal distribution, were calculated. Then the correlations between the variables in the manifest space, as well as the correlations between the system of variables. In order to determine the relationship between predictor variables (anthropometric and motor characteristics) and criterion variables (results of functional skills), regression analysis was applied in the manifest space. The processing of the results shows that the obtained values do not deviate from the normal distribution, which completes their metric characteristics. The impact of morphological and motor factors on heart rate results has not been proven.

This study examines the concepts of rhetoric used in ancient times, using a process of research based upon “Interpretivist Research Philosophy”. Common thinking among rhetoricians and philosophers in general argues that one concept of rhetoric was utilized. This paper argues that there were at least three concepts of rhetoric known in Antiquity. Each was unique in its own right and contributed to what was to be a new body of knowledge. Research conclusions stem from a study of the works of ancient authors, including Plato and Aristotle, and from schools of philosophies, including the writings of Stoics and Sophists. The reviewed literature supports the thesis presented in this paper that at least three concepts of rhetoric were known and used.

Background: C-reactive protein (CRP) is a commonly determined biomarker of inflammation and may reflect the progression of a vascular disease. CRP values within 12 to 24 hours of stroke symptom onset are an independent predictor of adverse functional outcome in terms of the level of motor recovery in the first year of follow-up. Objective: This study aims to provide a complementary analysis of the scientific literature and critically review studies on the use of CRP as a potential biomarker associated with stroke and affecting the achievement of neurorehabilitation progress in post-stroke patients. Methods: This critical review of the literature was prepared based on the following inclusion criteria: (1) original research, (2) studies indexed in PubMed, Scopus and PEDro databases, (3) full-text articles in English, (4) papers published in 2012 – 2022, and (5) papers addressing the use of PCR assay as a biomarker of rehabilitation effectiveness. Results: Based on a review of PubMed, Scopus and PEDro databases, 47, 56 and 9 papers, respectively, were selected based on precisely selected keywords and included in full for further full text review. In this review, the most important scientific rationale was included in response to the aim of this paper. Summary: Recognition of the role of inflammatory and immunological factors in the development of atherosclerosis and the occurrence of ischaemic stroke provides scope for the search for new methods of stroke risk assessment and the development of new methods to prevent stroke. Further empirical validation and unequivocal demonstration of the levels of CRP as a potential marker that affects the health status of a post-stroke patient are needed to ensure the greatest possible level of motor recovery and ability to function independently in terms of all activities of daily living.

INTRODUCTION: Retinoids are a broad group of natural and synthetic compounds derived from vitamin A. Many studies have shown strong anti-aging effects, and they have also been shown to have therapeutic effects on acne vulgaris or psoriasis. Vitamin A and its derivatives make the skin more elastic and smooth, cause a decrease in fine wrinkles and cause an increase in fibroblast activity and collagen fiber production. Retinoid compounds regulate biological processes of the skin such as immune processes, angiogenesis, proliferation and differentiation. THE AIM OF STUDY: The purpose of this paper is to discuss the effects of retinoids and the use of the substances in skin diseases. MATERIALS AND METHOD: Literature review of PubMed, Google Scholar and Science Direct and evaluation of available randomized controlled trials using retinoids in terms of treatment effectiveness in terms of skin quality, anti-aging benefits use in dermatology. CONCLUSIONS: Vitamin A and its derivatives plays an important role in anty-aging prevention and treatment of skin diseases, such as acne vulgaris, psoriasis and photo-aging. There are still many ongoing studies and not known opportunities of its use to treat other skin diseases that we should be aware of and keep track of new papers that indicate such.

Introduction and purpose: The aim of artificial sweeteners is to replace the sweetness of sugar without contributing to the higher energy consumption or unfavorable metabolic effects conventional sugar causes. Synthetic sweeteners - one of the most popular groups - are labeled as safe for use in foods and represented by acesulfame K, aspartame, neotame, saccharin, sucralose, cyclamate and advantame. Although they underwent safety procedures, their possible unbeneficial effects are still being evaluated. In this paper we focus on their impact on the gut microbiome. Brief description of the state of knowledge: For now, the advantage of search conducted on animals is observed. Those papers show the possibility of a relationship between artificial sweeteners and composition of the gut microbiota. Changes that were observed affected the gut microbiota in a negative way as they may be responsible for causing disbalance in the conglomerate of microorganisms. Studies on humans are limited. Long term consumption of acesulfame K and sucralose is linked with modulation of the composition of the microbiota. It has also been shown that synthetic sweeteners are able to increase the ability of bacteria to form a biofilm. Conclusions: Heretofore published paperworks about the impact of synthetic sweeteners on the gut microbiota are not sufficient to conduct valuable and unambiguous conclusions. Evidence collected until now is leading to a deduction that gut microbiota can be affected by the consumption of the sugar surrogates although more data is needed to clearly determine their possible role.