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In experiments on rats there was researched bioavailability of zinc oxide (ZnO) nanoparticles. There were determined the content of Zn in blood serum and tibia, intestinal uptake of macromolecules of egg albumin, some hematological, biochemical and immune indices, liver cells apoptosis. The results obtained show that the uptake of nanoparticles of ZnO enables restoration of this microelement status damaged by zinc deficit diet.

Optimal combination of chlorhexidine bigluconate with ascorbic acid, succinic acid, and zinc oxide was found as a result of comparative trials. The composition shows antioxidative effects and is capable of initiating antibody producing and phagocytosis. This combination can be used as an active substance of orodispersible tablets for the treatment respiratory tract infections.

Dental plaque is one of the reasons for odontogenic infection. Although multiple bacteria are involved in these processes, A.actinomycetemcomitans and S.mutans are considered directly responsible for localized aggressive periodontitis and caries respectively. On the other hand, it seems clear that the oral flora utilizes especially not well polished surfaces or without bacteriastatic capacity in order to obtain better adhesion. Based on those facts we expect to prove the inhibitory capacity "in vitro" of some materials used for teeth restoration and for the cementation of accessories against one common bacterium in the human flora and two pathogenic bacteria of the oral cavity. We prepared, following the manufacturer's instructions, 18 discs for each one of the materials used in the study (2 composites and 2 ionomeros of glass). 6 discs of each material are incubated with A. actinomycetemcomitans, S. mutans and E. coli. 3 of them are incubated directly on the discs and the other 3 are incubated previously in an artificial saliva for 24 days. From the results, should be highlighted that only one of the materials demonstrated inhibitory capacity against A. actinomycetemcomitans and E. coli. None of them demonstrated inhibitory capacity against S. mutans.

Morphologic investigation of the condition of the pulp of teeth in 15 dogs in the use of different kinds of temporary fixing cements after preparation for meta-ceramic crowns. It was determined microscopically that the use of the temporary fixing cement Provicol considerably diminishes inflammatory changes in the pulp of the prepared teeth and it assists the much quicker restoration of its normal histophysiology (normalization of oxidation-reduction processes, cellular elements of the pulp and especially the layer of the odontoblasts, their participation in formation of the replacing dentin).