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[Antinicrobial, antiexudative and immunotropic properties of chlorhexidine bigluconate in combination with zinc oxide, succinic and ascorbic acids].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2011; Vol. 74 (2), pp. 44-6. - Publication Year :
- 2011
-
Abstract
- Optimal combination of chlorhexidine bigluconate with ascorbic acid, succinic acid, and zinc oxide was found as a result of comparative trials. The composition shows antioxidative effects and is capable of initiating antibody producing and phagocytosis. This combination can be used as an active substance of orodispersible tablets for the treatment respiratory tract infections.
- Subjects :
- Administration, Oral
Animals
Anti-Bacterial Agents therapeutic use
Antibody Formation
Antioxidants therapeutic use
Ascorbic Acid chemistry
Ascorbic Acid therapeutic use
Chlorhexidine chemistry
Chlorhexidine pharmacology
Chlorhexidine therapeutic use
Drug Combinations
Escherichia coli drug effects
Immunologic Factors therapeutic use
Male
Mice
Mice, Inbred BALB C
Phagocytosis drug effects
Rats
Staphylococcus aureus drug effects
Succinic Acid chemistry
Succinic Acid therapeutic use
Tablets
Zinc Oxide chemistry
Zinc Oxide therapeutic use
Anti-Bacterial Agents pharmacology
Antioxidants pharmacology
Ascorbic Acid pharmacology
Chlorhexidine analogs & derivatives
Exudates and Transudates drug effects
Immunologic Factors pharmacology
Succinic Acid pharmacology
Zinc Oxide pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 21476286