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У більшості випадків очищення вихідного продукту процесу виробництва оцтової кислоти здійснюється шляхом ректифікації. Оскільки процес ректифікації полягає в розділенні сумішей на фази по температурі кипіння, то стає зрозуміло, що досить важливим технологічним параметром є температура та концентрація суміші, що обробляється. Зазвичай, дані технологічні параметри задаються кип’ятильником при ректифікаційній колоні, який ще зветься кубом колони. Саме тому існує потреба у якісному та ефективному керуванні кип’ятильником, як одним із важливих технологічних об’єктів. У роботі розроблена та проаналізована система керування кип’ятильником на базі MPC-регулятора. Робота MPC-регулятора базується на визначенні поведінки об’єкта та прогнозування майбутньої поведінки, після чого за рахунок оптимізації керування на певному проміжку часу здійснюється виведення його на бажану траєкторію. Проміжок часу на якому здійснюється розрахунок оптимальної траєкторії ще називається горизонтом. Визначення горизонту впливає на характер здійснюваного керування, тому його вибір повинен бути обраний виходячи з характеру динамічних властивостей об’єкту керування. Саме тому при розробці даних регуляторів потрібно досліджувати характер впливу даних параметрів на перебіг процесу. В результаті дослідження було отримано стратегії керування для різних значень горизонтів прогнозування та керування. Проаналізувавши результати роботи регулятора при різних налаштуваннях горизонтів прогнозування та керування можна дійти висновку, що при збільшенні горизонту прогнозування збільшується час перехідної характеристика, але також зменшується перерегулювання. Тому при виборі оптимального значення потрібно керуватися впливом перерегулювань на процес.

The study presents the results of the correlation between students’ predictive competence and their personal characteristics. The relevance and novelty of the research results are attributed to the specification of the problematic issue connected with predictive competence. The latter is determined through the students’ subjective characteristics which are associated with self-assessment of academic achievements in the examination situation. The developed predictive competence is one of the acmeological invariants of professionalism and a resource that increases stress resistance. The aim of the research is to study the correlation between personality traits of students of the youth age period and the adequacy of their self-assessment of the academic achievements in a stressful examination situation. The study hypothesizes that personal characteristics of students determine the adequacy level of their self-assessment of the academic results and reduce the level of examination stress. The sample of the study comprises 287 first- and second-year students of the youth age period, majoring in natural sciences and socio-economic educational areas and specialties of Udmurt State Agrarian University (Izhevsk) (their average age is 18.5; 45% are girls, 55% are boys). The methods (tools) of the research are as follows: in order to fix the components of self-assessment of academic achievements and the level of mental tension of young people in the examination situation, the authors used the Dembo – Rubinstein technique (in the original modification); to determine the features of predictive skills, the “Anticipatory Consistency Test” developed by V. D. Mendelevich (ACT) was used; to measure the manifestations of anxiety as a personal quality that affects the stress level during examinations, the “The Taylor Manifest Anxiety Scale” was applied (adapted by T. A. Nemchin, V. G. Noskaridze), to measure the level of the control locus the “Rotter’s Locus of Control Scale” (adapted by E. F. Bazhin, E. A. Golynkina, A. M. Etkind) was used. The study results. Positive correlation between the locus of control and personal anxiety and negative cor- relation between the predictive competence and situational tension are characteristic of students with an adequate self-assessment of academic achievements. Developed predictive competence reduces the exam stress. The conclusion. Adequate self-assessment of academic achievements in a stressful situation contributes to the management of one’s own activities and to a better manifestation of competencies while performing intellectual tests. The obtained results are used to improve the personality-oriented program for the development of adequate self-assessment of academic achievements which serves as a stress resistance resource of students of the youth age period.

The aim of the research was to study the response of various flax genotypes to the treatment of plants with a sulfonylurea herbicide – Magnum (active ingredient is metsulfuron-methyl) and to identify resistant forms for use in breeding programs for herbicide resistance. In 2018-2020 an assessment of 24 varieties and promising lines of fiber flax of domestic and foreign selection for resistance to this herbicide was carried out, the treatment of crops with the preparation was carried out at the recommended consumption rate of 0.01 kg/ha in the “herringbone” phase. It has been proved that the use of this herbicide leads to uneven plant growth during the “herringbone – flowering” period, which negatively affects the yield and quality of flax fiber. The decrease in the main indicators of the productivity and quality of the fiber in the variant with the use of the herbicide in comparison with the control, depending on the genotype was: in plant height – up to 44.4 %, in the weight of the technical part – 71.1 %, in the fiber mass – 74.8 %, in «myklost» (the ratio of the technical length of stem to its diameter)– 46.3 %, in the length of the elementary fiber – 27.7 %. A high level of resistance (over 80 %) to the herbicide Magnum for all analyzed traits was shown by the varieties Atlant (Russia) and Mogilevsky (Belarus). It was shown that when treating fiber flax plants with the herbicide, as a rule, an increase in inflorescence occurs due to a decrease in the technical length of the stem. It results in rise of the main indicators of seed productivity in most of genotypes under the influence of the Magnum preparation – the number of bolls and seeds per plant (up to 3.2 times). The exception was the variety Vega 2 (Lithuania), which had a decrease in the number of bolls per plant in the variant with herbicide treatment compared with the control by 1.8 times, and in the number of seeds by 5.3 times. This varietywasalso the most sensitive to the effect of Magnum in all parameters of productivity and fiber quality. The results are consistent with the data obtained whentreating various collection samples of fiber flax with a tank mixture Magnum + Herbitox L + Miura at the recommended consumption rates (0.007 + 0.6 + 1.0 kg(l)/ha).

The issue of psychological feasibility of distance learning is understudied and remains relevant both in theoretical and practical terms. The purpose of the study viewed in the article is to identify the connection between students’ preferences to study using the Internet and electronic textbooks with their personal psychological traits. Presumably, confident, self-organized students have a positive attitude towards their use, while anxious, emotionally unstable students have a negative attitude. The study involves 1st–4th year students (N = 270, aged from 17to 21years; 61.3% women) students, who specialize in Economics and Agricultural Industry in Izhevsk State Agricultural Academy. We used the following techniques: questionnaire developed by O. N. Malakhova, O. A. Zhuchenko, aimed at studying students’ preferences and Cattell’s Personality Factor Questionnaire (16-PF), form C, which has the goal to study personality traits that are significant for the research. It was found that there was a direct interconnection between students’ preference to use digital educational resources with their personal psychological traits. The study revealed that students with self-discipline and analytical mindset have a negative attitude to the use of electronic textbooks and distance learning. It was found that among the main personal psychological characteristics of students, which influence their preferences, are sensitivity and radicalism, anxiety and lack of self-discipline. We did not confirm the hypothesis put forward in the study. The applied aspect of the problem under study can be implemented in educational practice to increase the efficiency of educational process and in the development of digital training courses. The research perspectives are related to the study of teacher preferences.

The author considers the decisions of the state authorities at the all-Union and republican levels on the settlement of the “Aukhov problem” in Dagestan during the period of perestroika 1985— 1991. The authors identified the conflicts in Chapaevo in 1985 and in Novokuli in 1989 as the key points of the problem. The focus of the study includes all parties to the conflict: representatives of government bodies, public structures (organizations, fronts, movements), the media and ethnic minorities (Chechens-Akkins, Laks, Avars, Kumyks). A retrospective method of historical research is used: the sequence of actions of all parties to the conflict, the cause-and-effect relationships of existing contradictions are studied. The authors concluded that, despite the containment of the conflict within certain limits, it still turned into aggressive physical and political forms of confrontation. It is pointed out that the actions of the authorities were often thoughtful and consistent, but were protracted and slow. Separately, the prolongation of preventive measures and the lack of mechanisms to resist the already erupted conflict are noted. In conclusion, it is emphasized that the problem remains unresolved to the present, therefore it is important to study and analyze the experience and mistakes of the past.

The correction of free radical oxidation processes is one of the most promising strategies of neuroprotection in acute cerebrovascular disorders.The aim of the study is an experimental study of the neuroprotective effects of 3-hydroxypyridine and erythropoietin derivatives, as well as their combined use.Materials and methods. The study was performed on 109 male Wistar rats. The neuroprotective effect of the substances was studied on a hemorrhagic stroke model. The study drugs were administered to the animals intraperitoneally. Carbamylated darbepoetin was administered three times in advance at the dose of 100 µg/kg within intervals of 3 days, the last injection took place 1 hour before the operation (the total dose was 300 mg/kg). Etoxidol was administered once 1 hour before the surgery at the dose of 50 mg/kg. The survival rate, behavioral features and the state of the animals on the 1st, 3rd, 7th and 14th days were recorded, and the morphological assessment of the brain was carried out.Results. The investigated substances had a positive effect on both the survival rate of the animals during the first day and on the 14th day. The best survival rates on the 14th day were recorded in the group of a combined use of ethoxydol and carbamylated darbepoetin (75%). Thus, in this group of rats, a faster recovery of neurological disorders was already distinguished from the first day on. By the 7th day, more than 50% of the rats receiving the combination of the studied drugs, had had a slight neurological deficit (up to 3 points on the McGrow scale); by the 14th day there had been only minor changes in the neurological status in the rats of this group. A pronounced neuroprotective effect of the combination of 3-hydroxypyridine and erythropoietin derivatives has been confirmed by a histological examination of brain slices – a more rapid decrease in the size of perifocal edema and microcirculation disorders, less damage to neurons and glial elements, and faster processes of resorption and organization of hemorrhage. A macroscopic examination of the brain sections stained with triphenyltetrazolium chloride of the dying rats, showed that perifocal necrosis had been the main cause of high mortality in the control group after the 3rd day.Conclusion. As a result of the experiment, the nephroprotective effect of the studied derivatives of 3-hydroxypyridine and erythropoietin has been proved. Moreover, the combination of these drugs has shown a greater neuroprotective activity than their isolated use. The additive effect of these drugs was due to their action mechanism resulting from the synergism of various structures and components of the cells.

Introduction. The drugs affecting a mitochondrial dysfunction, oxidative stresses, apoptosis and inflammation of the vascular wall, have a high potential for the prevention and treatment of atherosclerotic lesions. In this regard, the use of EPOR/CD131 heteroreceptor agonists which have a similar spectrum of pharmacological effects, is one of the promising strategies in the treatment of cardiovascular diseases.Materials and Methods. The study was carried out on 68 C57Bl/6J male mice. Atherosclerosis was simulated in transgenic animals with an endotheliospecific knockdown of the Polg gene by simulating a balloon injury and keeping on a Western diet. Then, the studied drugs were injected once every 3 days at the dose of 20 μg/kg for 27 days. On the 28-th day, the animals were euthanized and the area of atherosclerotic plaques was assessed. The gene expression associated with the processes of inflammation, antioxidant protection, apoptosis, and angiogenesis was also determined in the aortic tissues. In addition, the endothelium protective effect of peptides on primary cultures of endothelial cells of wild and transgenic Polg-D257A mice was studied.Results. No statistically significant effect of drugs on the area of lipid infiltration have been found. However, the studied peptides have significantly reduced the expression of proinflammatory genes (iNos, Icam1, Vcam1, Sele, Il6, Tnfa), the genes associated with angiogenesis (Vegfa, Kdr, and Hif1a), the expression of proapoptic factors; they decreased the Bax/Bcl-2 ratio by more than 1.5 times. In addition, when supplemented with H2 O2 in vitro, peptides dose-dependently increased endothelial cell survival.Conclusion. The erythropoietin-based peptides can be used to improve the functional state of the vascular wall against the background of atherosclerotic lesions and have a depressing effect on pathobiological processes associated with a mitochondrial dysfunction. In addition, the studied peptides have a significant endothelial protective effect in the induction of oxidative stress in vitro.

The efficacy of intraabdominal chemotherapy in management of local recurrences of colon cancer was studied. Intraabdominal intraoperative and early postoperative chemotherapy made it possible to prolong of the recurrenceless term and to improve the life quality of the patients with local recurrences of colon cancer. There was observed a tendency to increase the five-year survival.

The efficacy of intraabdomlnal chemotherapy in patients with prevailing forms of colon cancer, such as peritoneal carcinomatosis, local disseminated and local recurrent colon cancer was estimated. The comparative analysis showed that the intraabdominal chemotherapy allowed to amend the remote results of the treatment in the cases with carcinomatosis, local disseminated colon cancer and local recurrence.

The chemical composition (ions, elements, polycyclic aromatic hydrocarbons) of aerosol and gaseous impurities (SO2, HNO3, HCl, NH3) in the surface layer of the atmosphere in Barentsburg, located on the Western Svalbard island (Svalbard archipelago), is analyzed. Atmospheric aerosol and gaseous impurities brought to the Arctic from middle latitudes and deposited on snow and ice not only interact with various natural objects, but also spread to long distances with melting dirty snow and ice. Air sampling was carried out following to methodology adopted by the international networks of the atmospheric monitoring programs in South-East Asia (EANET) and Europe (EMEP). In 2011-2015, the observations of the chemical composition of the atmospheric ground layer were performed daily during the light season (April–September), and monthly from April 2016 to 2018. The largest total ion concentrations were observed in 2011–2012. Seasonal variability of ion concentrations in the aerosol was characterized by high values in the cold period (October–February) and low values in the warm one (May–June). High values of the coefficient of correlation between ions Na+ and Cl− (r = 0,93) as well as between Mg2+ and Cl− (r = 0,81) throughout the year show that the main source of the aerosol is the sea surface. The significant correlation between ions K+, NO3-, NH4+, SO42−, K+, SO42− in the polar night point to the influence of local sources: coal mining at the mine and its3 combustion at thermal power plants. Emission of polycyclic aromatic hydrocarbons and the gaseous impurities (SO2, HNO3) into the atmosphere, especially during the polar night, is also influenced by local sources. Among the elements the maximum enrichment of the aerosol was revealed for As, Cr, Zn, Mo, Cd, Sn, Sb, W, and Pb with a low content of Cd, Sn, Sb, W, and Pb in the coal, sludge and on the underlying surface. On the basis of the elemental composition of the aerosol and the back-trajectory analysis, it was shown that the air masses enriched in heavy metals come to the area of the Barentsburg settlement from middle latitudes.

In conditions of vegetative trial carried out against selective backgrounds in 2017-2019 the response of 27 flax samples to a decrease in soil acidity to neutral pHKCl was studied. The scheme of the experiment was as follows: variant I (control) − pHKCl 5.3-5.5, P2O5 − 320-340 mg/kg, K2O − 81-92 mg/kg; variant II − pHKCl 6.2, P2O5 − 312-345 mg/kg, K2O − 84-98 mg/kg. It has been shown that during the «herringbone» phase in the majority of studied flax genotypes against the background of pH 6.2, the symptoms of “physiological oppression” of flax were observed: small spots developed on the upper leaves, the plants stopped growing, the stems thickened, and the tops of severely affected plants died off. As a result, at the beginning of the growing season at plant height of 7-10 cm, most of the samples were severely affected (from 69 to 100 %). The exceptions were varieties of fibre-flax Hermes (France), Vega 2 (Lithuania), Atlant (Russia) and linseed genotypes No. 3896 (Russia) and Norlin (Canada), which had a weak and medium degree of affection (8.3-45.5 %). Moreover, these genotypes showed a high level of both biological (75-90 %) and agronomic (77.3-85.6 %) resistance in the phase of "early yellow ripeness". The identified flax collection samples can be used as sources of resistance to flax «physiological oppression» caused by stressful edaphic factors in a neutral environment. On the basis of the analysis of the main elements of fiber productivity in studied flax genotypes, it has been established that against the background of pH 6.2 the reduce in plant height was from 11.4 to 52.1 % relative to the control, weight of the technical part of the stem − from 7.2 to 83.4 % , fiber mass − from 9.6 to 85.1 %. For the first time, on the basis of hybridological analysis, an assumption was done as to the pres-ence of a strong dominant gene, controlling the resistance to high soil pH values in the Hermes (France) flax variety and the linseed line No. 3896 (Russia).

Relevance of the research. Information on composition, ice content and geochemical characteristics of frozen rocks is necessary for exploration of oil and gas condensate fields of Yamal, Gydan and Taimyr. Among the factors determining the tundra landscapes ecology of the cryolithozone, underground ice and their melting have great importance. The hydrochemical composition and rare-earth elements content in syngenetic ice wedge retain the information on the moisture sources and conditions of their formation. The main ions correlation and rare-earth elements distribution in the ice composition can be used to estimate the influence of such natural factors as precipitation, sea and volcanic aerosols and anthropogenic pollution. The main aim of the research is to identify chemical elements sources and to assess the impact of the ice type on hydrochemical composition and rare-earth elements distribution in different genetic types of ice – wedge, seasonal and firn ice. Objects: ice wedge, sediments rocks, seasonal ice, surface water, taken in expeditions Earth Cryosphere Institute, Tyumen scientific centre SB RAS in 2009–2014. Methods of chemical research: inductively coupled plasma mass spectrometry, atomic absorption spectrometry, emission photometry, chromatography. Results. It is established that marine and continental aerosols influenced the chemical composition of ice wedge studied in the coastal zone of the key areas of Belyj island, Sibiryakova island, Western Yamal and Western Taimyr. Fresh and ultrafresh syngenetic ice wedge is formed by freezing melt water, which contains snow-sorbed sea aerosols – suspended in the atmosphere solid and liquid particles. Ice wedge in the lake Sokhonto area long-distanced from the sea has no signs of marine influence according to the main ions content. Ice wedge with mineral inclusions was formed not only due to snow melt water with aerosols of continental origin, but also due to the suprapermafrost water. It was found out that lanthanide content in water-soluble form has increased in comparison with both сlark values and the content in the modern surface ice. In the most of examined syngenetic ice wedge the participation of marine aerosols is confirmed taking into account the cerium anomaly. Moreover according to the distribution of rare-earth elements the correlation between light and heavy rare-earth elements typical for ice wedge, equal to 0,9, and correlation between lanthanum and the other lanthanides, equal to 0,2, are observed. Sea ice inherits the mineralization and composition of sea water. Lake ice varies in depth and reflects seasonal changes in hydrochemical composition of ice and increases in concentration of marine aerosols in the snow covering the lake ice. Firn ice of the polar Urals has a very low mineralization, there are no impurities of sea aerosol. The natural mechanism of rare earth elements accumulation in water-soluble form in combination with iron, thorium and yttrium is implemented in ice wedge of the Holocene and Neopleistocene. Melting out ice wedge may lead to the flow of rare-earth elements in the surface water.

The aim of the study was to test whether P-αB can be positioned as a preventing and treating agent for cardiovascular diseases.Materials and methods. The study was performed on sexually mature male Wistar rats. Endothelial dysfunction was modulated by a 7-days intraperitoneal administration of L-NAME at the dose of 2.5 mg/100 g. P-αB, or erythropoietin (EPO), was used for therapy at the dose of 2.5 µg/100 g × 3 times for 7 days, the total dose was 7.5 µg/100 g. The function of endothelium was estimated by an endothelium-dependent and endothelium-independent vasodilation. In addition, a histological assessment of the abdominal aortic wall state and the analysis of eNos, Tnf and Il-1β genes expression were performed. To estimate prothrombotic properties, P-αB and EPO were administered, at the doses of 2.5 and 5 µg/100 g (3 times a day for 7 days, the total doses were 7.5 µg/100 g and 15 µg/100 g, respectively) and on the 8th day, the time of ferric (III) chloride-induced carotid artery thrombosis was estimated.Results. Theresults of the functional tests for endothelium-dependent and endothelium-independent vasodilatation, as well as the histological picture of the aorta have evidenced that P-αB and EPO do not affect L-NAME-induced hypertension but improve the endothelium function. At the same time, P-αB shows a significantly higher endothelial-protective activity, reducing the coefficient of endothelial dysfunction from 5.1±0.15 to 2.72±0.12. In addition, P-αB has significantly increased the expression of eNos and reduced the expression level of Tnf and Il-1β mRNA genes. Carrying out Ferric (III) chloride-induced carotid artery thrombosis has revealed that P-αB (5 µg/100 g × 3 times a day for 7 days, total dose was 15 µg/100 g) has a lower but statistically significant prothrombotic activity than EPO.Conclusion. P-αB can be positioned as an atheroprotector because of its ability to prevent the death of endothelial cells, as well as to reduce remodeling and proinflammatory activation of the vascular wall. However, the prothrombotic properties of P-αB limit its use as a preventing and treating agent for atherosclerosis-associated diseases.

The article presents an overview of the urban development situation in the city of Tyumen over a century of Soviet and post-Soviet construction. The city with a fairly impressive number of objects to be proud of, and with a historical layout that is of special interest, has developed a number of problems, particularly in its transport infrastructure, which must be addressed as soon as possible. The authors offer several options for solving the acute urban planning issues by changing the transport situation both on a city-wide scale and on the example of two iconic urban areas.

The method of numerical modeling of wave scattering by periodic impedance grating is considered. In the case of a harmonic dependence of the field on time and the uniformity of the structure along a certain axis, the three-dimensional problem reduces to considering of two 2D problems for the components of the E-polarized and H-polarized waves. The signle nonzero component of the electric field created by the incident E-polarized wave is the solution of the boundary value problem for the Helmholtz equation with Robin boundary conditions. It follows from the physical formulation of the problem that its solutions satisfy the Floquet quasiperiodicity condition, the condition of finiteness of energy in any bounded region of the plane. Also, the difference between the total and incident fields satisfies the Sommerfeld radiation condition. Following the ideas of the works of Yu.V. Gandel, using the method of parametric representations of integral operators, the boundary-value problem reduces to two systems of integral equations. The first one is the system of singular equations of the first kind with additional integral conditions. The second system consists of the Fredholm boundary integral equations of the second kind with a logarithmic singularity in the integrand. A discrete model for various values of the discretization parameter is equivalent to systems of singular integral equations. By solving these equations, approximate values of the main field characteristics are determined. The method of parametric representations of integral operators makes it possible to obtain systems of integral equations of other types. In particular, the initial boundary-value problem reduces to a system consisting of hypersingular integral equations of the second kind and the Fredholm integral equation of the second kind. A numerical experiment was conducted for cases of different location of tapes. Calculations were performed for the proposed model and the model based on hypersingular equations. They showed the closeness of the obtained results in a wide range of parameters studied.

The article is aimed at researching the tools and parameters of assessing the effectiveness of innovation activity, increasing the competence of tourism enterprises, improving the competitiveness of innovative enterprises, international tour-operator-ranking. The system of tourism multipliers is substantiated, which special constituents are: an innovation multiplier, which represents an increase in income in the tourism economy, possible as a result of the implementation of a new product, changes in service technology, in the marketing, process, service, organizational or other innovations; also the company’s sustainability growth multiplier as an indicator of the estimated business reputation of the tourism company as part of the overall corporate strategy, market share and participation in the distribution/redistribution of tourist flows.

Flax (Linum usitatissimum L.) is used for the production of textile, oils, pharmaceuticals, and composite materials. Fusarium wilt, caused by the fungus Fusarium oxysporum f. sp. lini, is a very harmful disease that reduces flax production. Flax cultivars that are resistant to Fusarium wilt have been developed, and the genes that are involved in the host response to F. oxysporum have been identified. However, the mechanisms underlying resistance to this pathogen remain unclear. In the present study, we used transcriptome sequencing data obtained from susceptible and resistant flax genotypes grown under control conditions or F. oxysporum infection. Approximately 250 million reads, generated with an Illumina NextSeq instrument, were analyzed. After filtering to exclude the F. oxysporum transcriptome, the remaining reads were mapped to the L. usitatissimum genome and quantified. Then, the expression levels of cinnamyl alcohol dehydrogenase (CAD) family genes, which are known to be involved in the response to F. oxysporum, were evaluated in resistant and susceptible flax genotypes. Expression alterations in response to the pathogen were detected for all 13 examined CAD genes. The most significant differences in expression between control and infected plants were observed for CAD1B, CAD4A, CAD5A, and CAD5B, with strong upregulation of CAD1B, CAD5A, and CAD5B and strong downregulation of CAD4A. When plants were grown under the same conditions, the expression levels were similar in all studied flax genotypes for most CAD genes, and statistically significant differences in expression between resistant and susceptible genotypes were only observed for CAD1A. Our study indicates the strong involvement of CAD genes in flax response to F. oxysporum but brings no evidence of their role as resistance gene candidates. These findings contribute to the understanding of the mechanisms underlying the response of flax to F. oxysporum infection and the role of CAD genes in stress resistance.

Two licensed vaccines Gardasil and Cervarix, containing main capsid protein L1 virus-like particles antigen, are used for prevention of diseases associated with human papilloma virus. L1 cannot provide protection against all pathogenic strains of HPV, shows low efficacy in middle and old age vaccinated patients, and are not therapeutically effective. The next generation of vaccines that contain minor protein L2 conserved epitopes as well as oncoproteins E6 and E7 promise to provide broad protection against all HPV, and prevent the emergence and spread of skin lesions.

Method of determination of potassium cyanate in carbamylated darbepoietin alpha drug substance was developed. The method is based on derivatization of cyanate by methyl ester of anthranilic acid followed by formation bicyclic derivative (1-H,3-H-quinazolinedione), which is able to fluorescence. Application of this method to determine potassium cyanate in protein drugs was investigated. Interference of excipients on this method was evaluated. The validation was performed: specificity, linearity, accuracy, precision, limit of quantitication.

The article presents an algorithm for modeling diffraction on slits made on a flat screen made of actual materials. As a result, the boundary conditions of Schukin-Leontovich lead to the mixed boundary value problem. According to the method of Y.V. Gandel and V.D. Dushkin the solution of the problem can be reduced to a system of paired integral equations with singular and logarithmic singularities. The author has created and debugged a PC program that performs the numerical solution of the arising problems, and a series of computational experiments has been performed. This work has been carried at School of Mathematics and Computer Sciences of V. N. Karazin Kharkiv National University within the state budget themes: "Modeling of the dynamics of folding systems with the method of identifying problem situations."

The article focuses on the issue of architectural education in Russia. In this essay, the author presents objective historical factors and reviews encyclopedic data with the aim of understanding the essence of the notion “architectural environment design” and its positioning as an architectural profession. Consideration is given to the practice of the professional qualification “architect/designer”.

The results of detailed study of the Urosozero greenstone structure (northwestern part of the Vodlozero domain) of the Fennoscandian Shield are presented. The composition and the U-Pb zircon age of the volcanic rocks were studied. The Urosozero structure is composed mainly of mafic-felsic volcanic rocks rather than the sediments. Mafic and ultramafic volcanics were obtained under high degree source melting followed by crustal contamination. Intermediate and acid volcanics vary from andesites to rhyolites and are similar in composition to the volcanics of the Shiloss and Lake Kamennoe greenstone structures. The methamorphism of dacites occurred at T = 400–610 °С and P > 4 kbar. SIMS SHRIMP-II U-Pb dating of the dacite specimen was carried out on separate zircon grains at the Centre of Isotopic Research (VSEGEI, St. Petersburg). The ages received include 2875 ± 9 Ma as the time of volcanism and 2709 ± 8 Ma as the time of metamorphism. So, the volcanism of the Uros greenstone structure is synchronous with the volcanism of the northern Vodlozero domain.

The article describes a case of pregnancy in a patient with osteogenesis imperfecta. It is of note that both local and foreign medicine this disorder is a contraindication to pregnancy due to a high risk of maternal and fetal complications. The authors review literature on pre-pregnancy planning and preparation, pregnancy management, types of deliveries and approaches to anesthesia in female patients with osteogenesis imperfecta. Special attention is paid to anesthesiological complications during delivery, ways of their management and correction. Due to a high inheritance rate of this disorder, genetic consulting and extracorporeal fertilization methods are of great importance.

Late Pleistocene and Holocene polygonal-wedge ice is studied in the lower course of the Yenisei River. Ice distribution, features of the formation, chemical and microbiological composition were determined. It was established that ice wedges were formed on the slopes of the depression, in coastal-marine lagoons and in thermokarst during Holocene. The evidence of thermoabrasion and thermokarst in sediments as well as the marine signal in composition of polygonal-wedge ice allowed clarifying the southern limit of the Holocene transgression.

The rate of tuberculosis-concomitant urologic diseases in reproductive-aged women was 77.3% of cases. In women with tuberculosis, the risk factors of urologic diseases may include chronic female genital inflammatory diseases; sexually transmitted infections; menstrual dysfunctions; and female sex hormone imbalance.All reproductive-aged women with extrarenal tuberculosis, irrespective of the location and pattern of a specific process, form a group at risk for urinary tract tuberculosis. The possibilities for the early diagnosis of urinary tract diseases in reproductive-aged women with tuberculosis may be effectively enhanced by comprehensive urological examination. Management tactics for this category of patients should be elaborated jointly with phthisiatrists.

The normal function of reproductive organs should be regarded as one of the most important indicators of women’s health. During combination therapy, female patients with tuberculosis, regardless of the location of the process, have significant ovarian functional impairments contributing to different menstrual dysfunctions, as well as anatomic and functional changes in the reproductive organs. This all is certain to negatively impact the quality of life in women suffering from tuberculosis.In assessing the quality of life, it has become obvious that its low indicators are noted in virtually every three patients with tuberculosis.Hormone modulation therapy with due regard for hormonal changes, the presence of hormone-dependent diseases, the pattern and location of tuberculous lesion, and the specific features of performed specific therapy results in reproductive system rehabilitation and improves the responsiveness of the body as a whole, which is accompanied by a clear increase in the quality of life in this contingent of patients.

We developed a long (600-year) dataset for the concentrations of 26 elements in tree rings of larch from the Taymir Peninsula, the northernmost region in the world (ca. 72°N) where trees grow. Tree rings corresponding to the time period from 1300 to 1900 A.D. were studied. Eleven wood strips, each from a different larch tree, were cut into ca. 100 mg samples usually consisting of ten consecutive tree rings (but occasionally five). Between 19 and 40 consecutive samples resulted from each tree, yielding a total of 277 samples. The replication of each time interval ranged from three (for periods 1300-1400 A.D. and 1600-1700 A.D.) to six (for 1450-1600 A.D.). Wood samples were digested with concentrated HNO 3 for measurement of Li, B, Na, Mg, Al, Si, P, Cl, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Rb, Sr, Y, Zr, Nb, Mo, Ag, Cd, Sn, Sb, I, Ba, La, Ce, Nd, W, Au, Pb, Bi, Th, and U using solution Inductively Coupled Plasma Mass Spectrometry (ICPMS). Fourteen elements (V, Co, As, Y, Nb, Mo, Sb, La, Ce, Nd, W, Au, Th, and U) with extremely low concentrations were eliminated from consideration as unreliable. Here we report our sample preparation and measurement procedure, as well as the observed concentrations in tree rings, emphasizing considerations for developing representative and reliable denrodochemical datasets.

The paper formulated optimization problem formulation production of carbon products. The analysis of technical and economic parameters that can be used to optimize the production of carbonaceous products had been done by the author. To evaluate the efficiency of the energy-intensive production uses several technical and economic indicators. In particular, the specific cost, productivity, income and profitability of production. Based on a detailed analysis had been formulated optimality criterion that takes into account the technological components of profitability. The components in detail the criteria and the proposed method of calculating non-trivial, one of them - the production cost of each product. When solving the optimization problem of technological modes of production into account constraints on the variables are optimized. Thus, restrictions may be expressed on the number of each product produced. Have been formulated the method of calculating the cost per unit of product. Attention is paid to the quality indices of finished products as an additional constraint in the optimization problem. As a result have been formulated the general problem of optimizing the production of carbon products, which includes the optimality criterion and restrictions.

The problems of study and utilization of plant germplasm collections and arrangement of genetic resources based on botanical, functional, morphological, biochemical, and genetical principles are underlined in the article. The types of identified and systemized germplasm collections and genetic resources of flowering plants are described. The search path and methods of identification, differentiation, arrangement, and selection of genetic donors and germplasm collections of traits of ontogenetic and phylogenetic adaptation are shown in the article.

The aim of clinical case presentation. To draw attention of specialists to rare neoplastic bowel diseases.Original points. Article presents the case of small intestinal neurilemoma in 69 years-old woman with incidental abdominal pain. Abdominal ultrasound investigation (US) was diagnostic (it demonstrated the volume lesion located at the loops of ileum with thickened vascularized walls) and helical computer tomography – CT (tumor with irregular outlines ileum, with the lobular heterogeneous structure was revealed, contrast agent accumulation was uneven). Ileectomy with formation of end-to-end anastomosis was carried out. The resected speciemen revealed signs of neurilemoma at histological study.Conclusion. It was possible to detect ileal tumor at abdominal US and CT. The diagnosis was verified at histological investigation.

Ideas concerning an efficiency of breeding program, seed production and adequate strain testing are reviewed regarding to up-to-date requirements need for agriculture. The efforts are focused on ecological plant adaptation to stresses. That is why, there is extremely necessary to develop a range of cultivars and varieties with desirable characteristics which could provide germplasm protecting and prevention of yield losses under stress conditions. Moreover, there should be organized seed stocks, taking into account the all cultivated area in Russia. Ecological stable plant cultivation is a most suitable way of plant growing that also leads to precise strain identification for all cultivars handled in a considered region.

Purpose. Geological and geochronological study of main stages of granulitic metamorphism in the geological evolution of the Bug granulitic complex of the Ukrainian Shield (USh). Methodology. The study consisted of field works, laboratory analytical investigations of rock samples and scientific generalization of the obtained data. Rock sampling was fulfilled within in detail described exposures of quarry walls. Laboratory investigations included such methods: rock chemical analysis on main, rare and REE elements; chemical analysis of rock-forming minerals; rare and REE analysis of zircon; studying of an internal structure and measurement of U-Pb isotope relations in zircon (SHRIMP II, VSEGEI, St.-Petersburg). Findings. We have proved that the studied zircon belongs to granulitic type by its morphology, internal structure and chemical composition. Containing zircon two-pyroxene gneisses answer to P-T parameters of granulitic metamorphic facies on the base of rockforming minerals composition. Thus, the established radiological zircon age 3499± 33 Ma fixes time of the earliest stage of granulitic metamorphism of the Bug rock complex. Originality. The Paleoarchean granulitic metamorphic facies have been identified in the Bug rock complex for the first time. This data significantly supplements our tions about early geological history of USh as a fragment of early Precambrian crust. Practical value. Practical usage of received results in geological mapping of the Dniester-Bug province will promote more valid metallogenic assessment and increase of prospecting efficiency within this province and USh as a whole. [ABSTRACT FROM AUTHOR]

The analysis concerning the importance of maintaining a given temperature mode of an extruder while manufacturing polymer materials was carried out. An adaptive system of controlling the temperature mode of the extruder in a normal operating mode under conditions of disturbances of different nature was studied. The adaptive control system is based on the autoregressive-moving average model, uses the recursive least-squares method and its modifications for estimating the model parameters. The studies of the adaptive control system were carried out by introducing disturbances into the system operation. Changes of the power consumption of heat, for example, due to the dissipation of mechanical energy, were considered as the disturbances. The proposed control system of the polymer extrusion process has shown high efficiency under conditions of disturbances of different nature, confirmed by the given results of the conducted studies. [ABSTRACT FROM AUTHOR]

An adaptive system of controlling the temperature mode of an extruder under normal operation conditions is presented. The analysis concerning the importance of maintaining the given temperature of the extruder when manufacturing polymer materials was carried out. The necessity in applying the principle of adaptation while conducting the process was substantiated. As a controlling object, a single-screw three-zone extruder was used. As a model, the autoregressive-moving average model was proposed. The results of studying the adaptive control system with different methods of identifying the model parameters, basing on the recursive methods of least squares and their modifications, were given. The synthesis and studies of various structures of the adaptive controller were carried out. On the pretext of the conducted studies, the most effective structure of the adaptive control system, which supports the device at the specified temperature level, was proposed. [ABSTRACT FROM AUTHOR]

Despite the widespread acetylene production by the carbide method, today there are still problems of controlling an acetylene generator, related to perturbations that act on the object. For improving the regulation quality a fuzzy control system of acetylene generator temperature regime is proposed in the paper. The fuzzy system includes a controller, designed in the Fuzzy Logic Toolbox, and using the triangular membership functions and the Mamdani's fuzzy inference algorithm. A mathematical model of the object was analytically obtained and given by a transfer function in the form of the first-order lag block with delay. Using the Simulink environment, the simulation and comparative analysis of the fuzzy control system and with PI controller was carried out. The comparison of the integral performance index allows drawing the conclusion that the control system with a fuzzy controller has a smaller deviation from the predetermined value [ABSTRACT FROM AUTHOR]

The paper considers an extruder as an object of mathematical modeling. We address the issue of mathematical modeling of the thermal mode control of extrusion process of polymeric materials. Crucially, we develop a mathematical model, which takes into account basic factors, influencing the increase of work efficiency of the extruder. [ABSTRACT FROM AUTHOR]

This study considers using of pellicle reactors to be one of the main directions of sulfating technology. In this paper, we address the problem of determining the mass transfer coefficient dependences from temperature, irrigation density, and air-gas stream speed. In addition, we illustrate the research results of physical and chemical properties of sulfated products. [ABSTRACT FROM AUTHOR]

To study and induce meiotic recombination in plants, we generated and analyzed transgenic tomato hybrids F1-RecA and F1-NLS-recA-LicBM3 expressing, respectively, the recA gene of Escherichia coli and the NLS-recA-licBM3 gene. It was found that the recA and NLS-recA-licBM3 genes are inherited through the maternal and paternal lineages, they have no selective influence on the pollen and are contained in tomato F1-RecA and F1-NLS-RecA-LicBM3 hybrids outside the second chromosome in the hemizygous state. The comparative analysis of the meiotic recombination frequency (rf) in the progenies of the transgenic and nontransgenic hybrids showed that only the expression of the recA gene of E. coli in cells of the F1-RecA plants produced a 1.2-1.5-fold increase in the frequency of recombination between some linked marker genes of the second chromosome of tomato.

The efficacy of intraabdominal chemotherapy in patients with prevailing forms of colon cancer, such as peritoneal carcinomatosis, local disseminated and local recurrent colon cancer was estimated. The comparative analysis showed that the intraabdominal chemotherapy allowed to amend the remote results of the treatment in the cases with carcinomatosis, local disseminated colon cancer and local recurrence.

The efficacy of intraabdominal chemotherapy in management of local recurrences of colon cancer was studied. Intraabdominal intraoperative and early postoperative chemotherapy made it possible to prolong of the recurrenceless term and to improve the life quality of the patients with local recurrences of colon cancer. There was observed a tendency to increase the five-year survival.

Homologous DNA recombination in eukaryotes is necessary to maintain genome stability and integrity and for correct chromosome segregation and formation of new haplotypes in meiosis. At the same time, genetic determination and nonrandomness of meiotic recombination restrict the introgression of genes and generation of unique genotypes. As one of the approaches to study and induce meiotic recombination in plants, it is recommended to use the recA gene of Escherichia coli. It is shown that the recA and NLS-recA-licBM3 genes have maternal inheritance and are expressed in the progeny of transgenic tomato plants. Plants expressing recA or NLS-recA-licBM3 and containing one T-DNA insertion do not differ in pollen fertility from original nontransgenic forms and can therefore be used for comparative studies of the effect of bacterial recombinases on meiotic recombination between linked genes.

531 patients with non-complicated and non-metastatic colon cancer were operated on during 1995-2008 years. Surgery was radical in all cases. Various types of surgical treatment of the colon cancer, postoperative complications and lethality were analyzed. Open methods reported a 1,6% complications rate and lethality rate was 0,4%. Whereas, laparoscopically operated patients showed the complication rate of 3,6% and lethality was 1,2%. Overall 5-year survival was 91,7% for T1-3N0M0; 75,6% for T4N0M0 and 55,3% for T1-4N1-2M0 stages.

The purpose of the investigation was to study the extension of a physiologic hypoganglionic area in the distal rectum in adults and to define its implication in diagnosing Hirschprung's disease. Thirty-five cadaver distal rectal portions were examined. The extension of a physiologic hypoganglionic area in adults ranged from 7.5 to 50.0 mm (24.4+/-10.9 mm). The authors could determine any element of the intramural nervous system to a level of 40 mm where there was a compact ganglionic deposit with nerve commissures, which is typical of the normal structure of an intermuscular nerve plexus. The extension of a physiologic hypoganglionic area was as large as 40.0 mm in 4 of the 35 cases and 50.0 mm in 1 case. By taking into account these data, it is expedient to use the modified O. Swenson transanal biopsy.

Hybrid genes containing the reporter gene for thermostable lichenase and model genes recA, recA1, cry3a, cry3aM, and ssp1 were constructed. The expression of these genes was studied in prokaryotic and eukaryotic cells. The presence of lichenase in the hybrid proteins was shown to facilitate analysis of the hybrid protein expression in transgenic organisms. Owing to high relative activity and thermostability of lichenase, the activity of this enzyme can be measured by simple, rapid and sensitive qualitative and quantitative methods that do not require costly equipment and reagents. Using the zymograms method, molecular masses of the lichenase-containing hybrid proteins can be precisely estimated. This method is proposed instead of Western blotting using lichenase as a translational reporter. Our results showed that the use of thermostable lichenase as a translational reporter yields the data that are problematic to obtain using traditional methods of gene expression analysis, which is of importance for fundamental and applied research.