1. [Stereotaxic destruction of the ventrolateral thalamic nucleus in combination with the transplantation of fetal and xenogeneic tissue in Parkinson's disease].
- Author
-
Lebedev VV, Voĭtyna SV, Savel'ev SV, Korochkin LI, Molnár M, and Sukhikh GT
- Subjects
- Animals, Basal Ganglia embryology, Basal Ganglia transplantation, Cryosurgery, Drosophila melanogaster, Female, Follow-Up Studies, Humans, Male, Mesencephalon embryology, Mesencephalon transplantation, Middle Aged, Nerve Tissue transplantation, Transplantation, Heterologous, Transplantation, Homologous, Brain Tissue Transplantation methods, Fetal Tissue Transplantation methods, Stereotaxic Techniques, Thalamic Nuclei surgery
- Abstract
Four patients with Stage III-IV Parkinson's disease were operated on. Stereotactic cryodestruction of the ventrolateral nucleus was made, followed 10 minutes later by implantation of mixed fetal and xenogenic nerve tissue cells. The nerve cells-the fetal part-are obtained from human fetuses in the age range of 14-18 weeks of development. Tissues from the ventral portion of the midbrain and basal ganglia of the forebrain were used. Neurogenic layings of Notch Drosophila melanogaster mutants serve as a xenograft. The mixture of nerve cells were prepared in ratios of 1000:20 and 1000:12. The follow-up of the patients lasted a year. Relapses were absent. The effect occurred on the operating table (in the combination of nuclear destruction and nerve cell transplantation) and only 6 months later only during transplantation of nerve cells (without destruction). An attempt of transplanting the above fetal xenogenic mixture of nerve cells to patients previously undergone 2 ineffective stereotactic operations provided no significant clinical effect. The concurrent destruction of ventrolateral nuclei in combination with fetal xenogenic tissue grafting is considered to be promising.
- Published
- 1995