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[Stereotaxic destruction of the ventrolateral thalamic nucleus in combination with the transplantation of fetal and xenogeneic tissue in Parkinson's disease].
- Source :
-
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 1995 Jul-Sep (3), pp. 3-5. - Publication Year :
- 1995
-
Abstract
- Four patients with Stage III-IV Parkinson's disease were operated on. Stereotactic cryodestruction of the ventrolateral nucleus was made, followed 10 minutes later by implantation of mixed fetal and xenogenic nerve tissue cells. The nerve cells-the fetal part-are obtained from human fetuses in the age range of 14-18 weeks of development. Tissues from the ventral portion of the midbrain and basal ganglia of the forebrain were used. Neurogenic layings of Notch Drosophila melanogaster mutants serve as a xenograft. The mixture of nerve cells were prepared in ratios of 1000:20 and 1000:12. The follow-up of the patients lasted a year. Relapses were absent. The effect occurred on the operating table (in the combination of nuclear destruction and nerve cell transplantation) and only 6 months later only during transplantation of nerve cells (without destruction). An attempt of transplanting the above fetal xenogenic mixture of nerve cells to patients previously undergone 2 ineffective stereotactic operations provided no significant clinical effect. The concurrent destruction of ventrolateral nuclei in combination with fetal xenogenic tissue grafting is considered to be promising.
- Subjects :
- Animals
Basal Ganglia embryology
Basal Ganglia transplantation
Cryosurgery
Drosophila melanogaster
Female
Follow-Up Studies
Humans
Male
Mesencephalon embryology
Mesencephalon transplantation
Middle Aged
Nerve Tissue transplantation
Transplantation, Heterologous
Transplantation, Homologous
Brain Tissue Transplantation methods
Fetal Tissue Transplantation methods
Stereotaxic Techniques
Thalamic Nuclei surgery
Subjects
Details
- Language :
- Russian
- ISSN :
- 0042-8817
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
- Publication Type :
- Academic Journal
- Accession number :
- 7483955