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Graft failure (GF) is an extremely rare complication of autologous hematopoietic stem cell transplantation (auto-HSCT) with a frequency not exceeding 3–5 % of all cases of this technology. Primary graft failure is distinguished when restoration of hematopoiesis has not occurred by day +28 after hematopoietic stem cell transfusion, and secondary GF, implying the occurrence of neutropenia

Currently, lenalidomide is the only immunomodulatory drug (IMiD) approved for maintenance therapy in patients with newly diagnosed multiple myeloma who have received high-dose chemotherapy and autologous stem cell transplantation (ASCT). The maintenance with lenalidomide showed an advantage over placebo or observation for both progression-free and overall survival in a series of phase 3 randomized trials. Salvage ASCT can be performed after disease relapse in case of a long-term response after the first transplantation or if this option has not been performed before. Pomalidomide is a third-generation IMiD approved for the treatment of relapsed and refractory multiple myeloma, which is efficient in patients with resistance to lenalidomide and proteasome inhibitors. Structurally, lenalidomide and pomalidomide are similar, and therefore the latter can also be considered as a drug for maintenance, however, there are no relevant phase 3 randomized trials. In this article, we present a clinical case of a 60-year-old patient with newly diagnosed multiple myeloma who progressed after 2 lines of induction therapy, which included lenalidomide and two proteasome inhibitors (bortezomib, ixazomib). The use of Pd combination (pomalidomide, dexamethasone) made it possible to achieve a repeated response and implement of salvage ASCT. The second ASCT was carried out only 12 months later after the first due to the COVID-19 pandemic. Subsequent long-term maintenance therapy with pomalidomide resulted in a complete response and minimal residual disease negativity. The resulting response has persisted at the time of this writing for over 2 years. To discuss the presented clinical case, the data of the French phase 2 IFM 2013-01 study were used, in which patients with failed first-line transplantation in case of relapse received PCd (pomalidomide, cyclophosphamide, dexamethasone) induction, salvage ASCT, and maintenance by Pd until disease progression. Pomalidomide may be an acceptable substitute for lenalidomide in patients with prior intolerance or refractory to this IMiD.

Finding effective and safe medicines to fight SARS-CoV-2 infection is an urgent task. RPH-137 is an original trap fusion protein against SARS-CoV-2 virus. It comprises the angiotensin-converting enzyme type 2 extracellular domain and the human IgG1 Fc fragment.The aim of the study was to carry out a preclinical evaluation of the efficacy of RPH-137 and molnupiravir against SARS-CoV-2 infection.Materials and methods: the authors analysed RPH-137 expressed in a stable CHO cell line and molnupiravir used as an active pharmaceutical ingredient. Drug-mediated inhibition of virus-induced cytotoxicity was assessed in Vero cell culture. In vivo efficacy assessments were performed in Syrian hamsters. The animals were infected intranasally with SARS-CoV-2 (PIK35 clinical isolate) in the dose of 5 log TCID50. The authors evaluated body weight measurements, lung–body weight ratios, and lung histopathology findings and determined viral RNA levels in oropharyngeal swabs by RT-PCR using the amplification cycle threshold (Ct). The statistical analyses involved one- and two-way ANOVA, Student's t-test, and Mann–Whitney test.Results: RPH-137 and molnupiravir inhibited the cytopathic effect of SARS-CoV-2 in Vero cells; the EC50 values of RPH-137 amounted to 4.69 μg/mL (21.3 nM) and 16.24 μg/mL (73.8 nM) for 50 TCID50 and 200 TCID50, respectively, whereas the EC50 values of molnupiravir were 0.63 μg/mL (1900 nM) for both doses. Intramuscular RPH-137 (30 and 80 mg/kg) had no effect on the infection process in Syrian hamsters. The comparison with the challenge control group showed that intraperitoneal RPH-137 (100 mg/kg) had statistically significant effects on a number of parameters, including a 27% reduction in inflammation and a 30% reduction in the total lesion area of the lungs by Day 7. Intragastric molnupiravir (300 mg/kg twice daily) significantly inhibited SARS-CoV-2 infection.Conclusions: both RPH-137 and molnupiravir inhibited the cytopathic effect of SARS-CoV-2 in Vero cells. In Syrian hamsters, molnupiravir demonstrated a more pronounced inhibition of SARS-CoV-2 infection than RPH-137. However, RPH-137 had statistically significant effects on a range of parameters. This offers additional perspectives for further research.

The aim of the given study is investigation of influence onosteodestruction markers and quality of life parameters of therapy with generic preparation of pamidronic acid (pomegara) in patients with multiple myeloma (MM) and lytic bone lesions. For this purpose prior to the beginning of the study and every 4 week after pomegara injection throughout 16 weeks blood СТХ (terminal crosslinking telopeptide of type I collagene) concentration and urine DPD (deoxypyridinoline) were detected. In addition monitoring of tumor symptoms intensity using MDASI (M.D. Anderson Symptom Inventory) and FACT (Functional Assessment of Cancer Therapy) questionnaires was conducted and pain intensity was also investigated using analogue scale. Study is finished in eighteen patients. Bone resorbtion markers (serum СТХ and urine DPD) have essential decreased after fourth pomegara injection to 33 % of median initial value for CTX (р < 0.05) and to 73 % – for DPD (р=ns). Statistically significant increasing of integrated quality of life parameter in comparison with initial value is registered by 12th week of treatment (р < 0.05). The majority of pomegara side effects were mild and moderate severity and preparation cancelling has not necessary. The frequency and spectrum of complications (fever, skeletal and muscular pain, etc.) corresponded to the similar parameters revealed in large controlled studies of bisphosphonate treatment in MM. Careful monitoring of renal function during pomegara treatment has not shown significant negative effect, including patients with initial renal involvement. According to data received in this restricted volume study we can conclude that pomegara treatment in patients with MM and lytic bone lesions result in decrease of bone destruction, quality of life improvement and decrease severity of pain. Drug acceptability did not principally differ from original pamidronate shown in controlled studies.

The article describes a method of detecting the predicted theoretically transfer local perturbation effect on one of the interface flat liquid zone to another when it thermomigration in the crystal. The results of experimental studies of the features of the induced perturbation and its impact on the stability of the flat zone as a whole. It was found that the effect of induced instability could be the basis for a method of forming semiconductor wafers in volume of regular structures in the form of bands of deep electron-hole transitions and through the conducting channels. A method of using induced instability effect for silicon device structures.

The simulation of the photoluminescence and dark current-voltage characteristics of heterostructures with a single layer of quantum dots. The presence of the peak quantum transitions in the main points at 1,2 eV (modeling) and 1,12 eV (experimental). The experimental peak has a greater width (0,13 eV) at half maximum fundamental radiation transitions in quantum dots, compared to the modeled (0,06 eV). There is a shift of the experimental peak to longer wavelengths by about 65 meV, indicating that the presence in the dispersion structure the size of quantum dots. The dark current-voltage simulated characteristic at a temperature of 90 K and zero bias shows the value of the dark current density of 10-7 A/cm2, which is much smaller than the measurement results (10-6 A/cm2). There is a difference in the nature of the distribution depending on when the negative and positive displacement between experiment and simulation results associated with the presence of quantum dots larger.

The article presents research results of the crystal structure of the silicon regions, locally recrystallized in the process of thermomigration liquid silicon-aluminum areas of a silicon substrate. Selective etching of silicon is found that recrystallized in the channel, there are areas that have increased defects. Determined that these areas are located at the surfaces of the substrate, the depth of these areas does not exceed the thickness of the liquid zone. Out defective areas, the channel has low densities of dislocations and a high degree of monocrystalline silicon. Using the methods of x-ray diffractometry and transmission electron microscopy high resolution revealed that on the border of the channel and the substrate are dislocation half-stitch, which lie in the surface layers of the front and back sides of the substrate. In recrystallized areas are detected the {311} - defects.

A model for the study of generation-recombination processes in the direct intermediate band photovoltaic nanostructures was proposed. The model allows to calculate the functional characteristics and the efficiency of solar radiation conversion. The nanostructures with embedded quantum dots InAs / GaAs were experimentally grown. It is shown that the model enough correctly describes the experimental effect of increasing the shortcircuit current due an additional absorption of infrared photons.

The article considers the features and possibilities of flow cytometric diagnostics of plasma cell neoplasms, taking into account the classification of lymphoid and hematopoietic tissue tumors of the World Health Organization, revision of 2017 and the NCCN clinical recommendations, 2021. Standardized flow cytometric protocols (the Euro-Flow conception) and algorithms for both the diagnosis of plasma cell tumors and the detection of minimal residual disease in plasma cell myeloma are described.

We present the results of the study of the structure and surface morphology of InxGa1–xAs thin films on a GaAs substrate. Thin films were obtained by magnetron sputtering from a specially formed In0.45Ga0.55As target in an argon atmosphere. The obtained samples of thin films were studied by Raman scattering, atomic force microscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. It was shown that the grains of the films obtained at a substrate temperature below 600 °C were not faceted and were formed through the coalescence of grains with a size of 30–65 nm. At a substrate temperature of 600 °C, films consisted of submicron grains with a visible faceting. It was determined that the average grain size increased and the root-mean-square roughness of thin films decreased due to an increase in the substrate temperature. Thin films obtained at a substrate temperature of 600 °C possessed the best structural properties

The article provides the analysis of regulatory documents and scientific publications concerning the design speed of rolling stock. The material is provided from the perspective of a methodological approach to establishing the design speed at the level of the maximum value achieved during dynamic and strength tests and track impact tests of the object that meets requirements of technical documentation. Values of strength and dynamic properties of cars obtained during tests performed in track sections with characteristics established in test methods should comply with requirements of regulatory documents. At the same time, during the operation of car running gear, rail geometry and track superstructure, basically have a state that is different from that in which tests were performed. Proceeding from this, in order to ensure traffic safety in operation, permissible speeds are set for tracks of various states and structures. Thus, for freight cars with three-piece bogies, the maximum speed, especially when empty, is limited due to the deterioration of its dynamic properties associated with change in the operation of design parameters and characteristics of bogie elements as well as its rigidity couplings. Due to the deterioration of dynamic properties , the design speed cannot be implemented, including on the track that meets requirements of test methods, on which it was initially confirmed. The maximum permissible speeds of freight cars that are acceptable from the safety point of view are traditionally established based on the results of tests performed since the middle of the last century. When applying innovative freight cars with bogies of a new design, to assess traffic safety, it will be necessary to carry out a large number of tests and to gain operating experience, during which it is necessary to estimate the influence of various factors on traffic safety. In fact, it is necessary to repeat tests to set running speeds, but in a short time, which is very cost-intensive. Based on the foregoing, in order to eliminate the risks associated with safety violation, to confirm the design speed and in order to reduce costs when applying new rolling stock, a full-scale virtual method has been proposed that provides the use of a computer simulation, in which the design speed specified in the technical documentation is set at the stage of rolling stock development, taking into account the operational variability of car running gear and the track state.

Primary lymphoma of the central nervous system (PLCNS) is a rare form of extranodal lymphoma characterized by an aggressive course. In recent decades, the treatment of this disease has undergone significant changes. Modern treatment of PLCNS consists of two steps – induction and consolidation of remission. Improved overall survival of PLCNS patients was achieved through the use of combined immunochemotherapy regimens with high doses of methotrexate and/or cytarabine, which are currently the standard of induction therapy. High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation at the consolidation stage provides the most complete elimination of the residual tumor clone. The most effective modes of conditioning are those with the inclusion of tiotepa. In elderly and comorbid patients who are not candidates for autologous hematopoietic stem cell transplantation, promising results were obtained while using maintenance therapy with procarbazine or temozolomide, and further researches will allow us to study the effectiveness of monocolonal anti-CD20 antibodies – rituximab and obinutuzumab.Treatment options for patients with relapses and / or refractory forms of PLCNS are limited. Certain successes were obtained with the use of new drugs – ibrutinib, nivolumab, lenalidomide, obinutuzumab.

The objective of the study a detailed, systematic review of the world literature data, which includes all aspects of recommendations for vaccination against SARS-COV‑2 in cancer patients.Materials and methods. Information search was carried out in PubMed, MedLine, Scopus, Web of Science, RSCI.The work included data from literature and information sources that were published before February 2021.Results. The data of retrospective and prospective clinical studies are analyzed. This paper reflects considerations and recommendations for the vaccination of cancer patients by Russian and foreign specialists in the context of COVID‑19 pandemic. The review presents current recommendations for vaccination against SARS-COV‑2 in patients with solid tumors, hematological malignancies, recipients of hematopoietic stem cells and cell therapy.Conclusion. To date, groups at increased risk of infection with the new coronavirus have been identified. These groups include patients with cancer. The presence of tumor does not allow a delay in start of therapy, and requires careful monitoring and observation. In this regard, despite the pandemic, the treatment of cancer patients must be continued regardless of the circumstances. Cancer patients should not be deprived of the opportunity to be vaccinated against SARS-COV‑2. Every patient should be decided individually. At the moment, there are no officially approved recommendations for vaccination against SARS-COV‑2 for cancer patients. Before the creation and approval of final recommendations for cancer patients, it is necessary to focus on compliance with sanitary and anti-epidemic measures and the prevention of COVID‑19 infection. The global cancer community continues to actively develop recommendations for the optimal vaccination against SARS-COV‑2 in cancer patients.The most relevant ones are outlined in this article.

The article considers the pedagogical conditions for teachers to acquire physical training in the system of professional development of the necessary important qualities in the process of professional training in order to further apply the knowledge they have gained in their professional activities.

The minimum residual disease (MRD) for hematopoietic and lymphoid systems tumors is an important component of patient examination during therapy. The MRD detection is performed to evaluate the effect of therapy and risk stratification during chemotherapy (acute leukemia) or at the end of it (peripheral B-cell lymphomas). The main laboratory methods for MRD assessing are molecular (polymerase chain reaction) and immunological (multi-parameter flow cytometry (FC)) methods. Immunological evaluation of MRD is the standard of clinical protocols for the treatment of childhood acute lymphoblastic leukemia during induction therapy. In the case of acute leukemia in adults, MRD assessment is usually performed at the end of the consolidation course. Clinically significant and practically standardized is the immunological assessment of MRD in B-cell chronic lymphocytic leukemia.In multiple myeloma (in World Health Organization (2016) classification – plasma cell myeloma (PCM)), work is also underway to standardize protocols and unify approaches to MRD detection. With the introduction of new drugs and treatment regimens, as well as transplantation clinical outcome of patients significantly improved and MRD value is considered as a prognostic factor. To date, the use of the MRD value as a biomarker of treatment response in PCM has been approved by the US Food and Drug Administration.With the accumulation of our knowledge regarding the MRD and to establish the clinical significance of the FC in PCM, International Multiple Myeloma Study Group (IMWG) in 2011 was added the following definition to the traditional criteria of PCM complete remission: “Immunophenotypic complete remission” – the immunophenotypically absence of aberrant clonal plasma cells in the bone marrow when analyzing at least 1 million myelocaryocytes using a multiparameter FC (4 or more parameters).This article discusses the evolution of immunological approaches using a multi-parameter FC to detect MRD in patients with PCM in accordance with various existing protocols, features of the preanalytical stage and general rules for FC detection of MRD in PCM.

The subject of research in the article are algorithms for fast calculation of autoregression coefficients in digital spectral analysis and estimation of the number of arithmetic operations required for their implementation. The aim of the article – comparative analysis of the speed of different algorithms for calculating the coefficients of autoregression as part of the algorithms of spectral analysis, including analysis of the complexity of their microcontroller implementation. Tasks to be solved: selection of spectral analysis methods suitable for diagnostics of technological equipment, analysis of methods for calculating autoregression coefficients and derivation of relations for estimating software complexity of algorithms and calculation of numerical estimates of addition and multiplication for some algorithms, adaptation of developed methods and estimates to microcontrollers. spectrum Applied methods: algorithm theory, Fourier transform, natural series, microcontroller programming. The results obtained: it is shown that spectral estimation methods based on Yul-Walker equations, which require the calculation of autoaggression coefficients, combine sufficient resolution and resistance to interference with acceptable implementation complexity. Estimates of the number of additions and multiplications for the Levinson, Durbin, and Trench algorithms are obtained, and their comparative analysis is performed. The calculation times for microcontroller arithmetic with fixed and floating points were count upon. Conclusions: When constructing spectrum analyzers for the diagnosis of technological equipment, it is advisable to use the Yul-Walker method. A comparison of Levinson, Durbin, and Trench algorithms for calculating autoregression coefficients showed that the Trench method requires a minimum number of additions, and the Durbin method requires a minimum number of multiplications. At microcontroller realization of spectrum analyzers, it is necessary to consider features of the arithmetic used by the controller. The Trench method is the fastest in the case of floating-point arithmetic and small-scale modeling. In other cases, Durbin's method is more effective.

The objective of study is to estimate the efficiency of extracorporeal free light chains of immunoglobulin elimination in patients with monoclonal gammopathies (n = 12) during hemodialysis using selective filters.Materials and methods. A blood and dialysate free light chains concentrations change was criterion of efficiency.Results and conclusion. The selective free light chains filtration give the possibility of an adequate anti-tumor therapy, could prevent the development of irreversible renal failure and hypoalbuminemia.

Interaction of rolling stock and track is a fundamental physical process while running cars, locomotives and trains on the railway. The Research, Design and Technological Institute of the rolling stock (JSC "VNIKTI") for more than twenty years conducting research to reduce cost of energy for traction.The Institute has developed rail lubrication technology performed by locomotive leading the train, but with the improvement: the lubrication of the internal rolling surface of the rail in curve performed by leading locomotive and on sections where lubrication made on side surface of the head of the outer rail - by lubricating cars. This technology can reduce the side impact of the rolling stock on the railway track in curved sections, to reduce resistance to motion while maintaining the length of the braking distance. The effect of reducing the side impact to the track is achieved by reducing the coefficient of friction on the rolling surface of the inner rail and the side surface of the outer rail, which leads to a proportional reduction of transverse forces of creep. Such reduction of transverse forces in creep decreases the normal reaction at the flange of the oncoming wheel and, consequently, reduces motion resistance (reduction in energy consumption for traction), reduce wear, both wheel flanges of rolling stock and rails in curves.Lubrication of rail by traction unit in the train has a broad perspective of application on the railway network of JSC "Russian Railways". The minimum cost of additional equipping locomotives with devices automatically applying friction modifiers and manufacture of friction modifiers will payback considerable profit by savings of traction resources and by savings associated with a reduction in regrinding of wheelsets and replacement of rails in curves.

The article presents results of pilot and theoretical studies of JSC VNIKTI in the field of interaction of railway track and a rolling stock and perspective of their application. Questions of longitudinal dynamics in the conditions of different types of braking of trains of increased weight and lengths and their influence on infrastructure are considered. Analysis of dynamic qualities and indicators of impact of model of coupled trainset on track is carried out by means of computer modeling, and impact evaluation of action of longitudinal force on carriage indicators, both dynamic and by impact on track, is given at different conditions of railway track. As a result of testing in 2015 of doubled trains weighing up to 14,200 tonnes at various types of braking the following conclusions were obtained: 1. The considerable array of experimental data on interaction of a rolling stock and way at emergency braking is received allowing a quantitative assessment to this process. 2. When performing asynchronous emergency brakings the “practical top” of the compressive forces in the train (1600 kN) has been for the first time reached and the moment of loss of stability of a rolling stock in a rail gauge has been recorded. 3. When performing synchronous braking sufficient stability of the conducted locomotive and nearby the standing car is confirmed at influence of longitudinal forces. 4. The received results of pilot and theoretical studies can be used for modification of normative documentation for development of local instructions for safe driving of the coupled trains, and furthermore at the organization of pilot trips of the coupled trains of higher weight.

We study experimentally the effect of the axial tension load on the residual stresses relaxation in the surface-hardened hollow cylindrical specimens of D16T aluminium alloy at a temperature of 125 ℃. The surface is hardened by the air shot-peening. We describe the testing machine and the routine of experiment. The experimental curves of hardened specimens creep under the axial loads 353, 385, 406.2, 420 MPa and test duration of 100-160 hours are obtained. The axial and circumferential residual stresses after the hardening and the creep at the given temperature and load conditions are constructed by the method of circles and strips. The significant qualitative and quantitative changes of residual stresses take place under the tension load $\bar \sigma$ in comparison with the thermal exposure (heat exposal with no load). The relaxation of residual stresses is essentially independent of the thermal exposure. In contrast, the loading leads to the significant residual stresses relaxation and to the changes in the distribution type. The axial and circumferential residual stresses evolve from the compressive to the tension with the increase of the axial tension load. Also the depth of residual stresses location changes with the increase of the axial tension load from the 600 microns in the original state after the air shot-peening to the 250-300 microns after the creep under the given loading. It is very important for the engineering applications to take into account the described behaviours of the residual stresses in the hardened specimens of D16T alloy when predicting the characteristics of endurance of the surface-hardened details operate under the elevated temperatures.

В статье рассматривается влияние И.С.Кона на многие аспекты современных исследований в области гендера и сексуальности. Авторы делают вывод о том, что именно И.С.Кон выделил несколько ключевых тенденций, описывающих современное состояние гендерного порядка в аспекте сексуальности, а именно индивидуализацию и плюрализацию культур и стилей жизни, которая заставляет говорить уже не о единой или даже нескольких «нормативных моделях», а о «сексуальностях» во множественном числе. В предлагаемой работе на примере теории сексуальных конфигураций, предложенной канадской исследовательницей С. ван Андерс, показывается многообразие сочетаний различных гендерных идентичностей с множеством сексуальных предпочтений. В статье подчеркивается, что, как и предупреждал И.Кон, именно гендерные отношения и сексуальность в настоящее время оказались в центре повестки дня, поскольку на них экстраполируются многие более масштабные и серьезные проблемы. Культурное и, в частности, гендерное разнообразие воспринимается многими людьми как угроза потери самых базовых ориентиров в непредсказуемом и изменчивом мире. В статье приводятся примеры разных типов государственной политики по отношению к бинарным и не-бинарным гендерным категориям в разных странах Европы, Азии и Северной Америки.

Aim. To estimate the incidence of acute myeloid leukemias (AML) in Moscow adults and to evaluate the efficiency of their treatment. Subjects and methods. Data on Moscow residents who were first diagnosed with AML in 2010 were retrospectively collected. The efficiency of their treatment was evaluated from the rates of complete remissions (CR), recurrences, deaths, and 4-year overall (OS) and relapse-free survival (RFS). The data as of September 1, 2013, were analyzed. Results. According to the 2010 pooled materials of the city’s municipal hematology departments, AML (non-M3 types) was diagnosed in 286 patients whose median age at diagnosis was 64.9 years (range, 18.2-92.0 years). The notified incidence rate was 2.9 (3.3 for men and 2.6 for women) cases per 100,000 population. 118 (41%) patients received intensive chemotherapy (ICT); 119 (42%) had chemotherapy with low-dose cytarabine (LDC); 7 (2%) had that with hypomethylating agents (HA); and 42 (15%) had palliative therapy (PT). During first-line therapy, none of the patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the entire group, the early (within the first 60 days) mortality rates were 42% (119 deaths); that of patients with primary refractory disease was 32% (90 deaths). CR was achieved in 77 (27%) patients: 57 (48%) on ICT, 17 (14%) on LDC, and 3 (43%) on HA. Recurrences occurred in 37 (48%) of the 77 patients who had achieved CR at a median follow-up of 43.9 months. Four-year OS in all the patients receiving PT was 9.8±1.9% (18.2±3.9% in the patients on ICT versus 4.5±2% in those of LDC; p=0.028); 4-year RFS was 36.1±5.7% (39.6±6.7% in the patients on ICT versus 31.3±11.6% in those on LDC; p=0.8). Conclusion. High mortality rates in the induction, which are caused by the limited resources of accompanying therapy, poor sanitary conditions, and no own opportunities to perform allo-HSCT, remain a key problem of AML therapy in adults.

Central nervous system (CNS) involvement in advanced non-Hodgkin’s lymphoma (NHL) occurs in 5–29 % of cases. Primary CNS lymphoma (PLCNS) significantly less revealed: 1–2 % of lymphoma cases and 5 % of all malignant CNS diseases. Historically, PLCNS treated with radiotherapy, but the majority of patients had no long-term remission. Combined treatment (chemotherapy + radiation therap y) has been developed to improve radiotherapy efficacy. The research results, according to several authors, allowed to develop the bas is of modern medical approaches, which includes a combination of high-doses methotrexate and cytarabine with radiation therapy for remission consolidation. New drugs — temozolomide, topotecan and rituximab — in combination with conventional preparates have been studied. Treatment results of 11 patients with primary (8) or secondary (3) CNS lymphomas treated in Botkin Municipal Clinical Hospital was analyzed. In 9 from 11 (all with primary lesion) diffuse B-large cell lymphoma w as diagnosed (by immunohistochemistry). All primary patients received 3.5–5 g/m2 methotrexate and 2–4 doses 2 g/m2 cytarabine (except 2 patients); 3 patients in addition received ifosfamide, vincristine and etoposide under a pediatric protocol BFM-90. Subsequently , all patients received 46 Gy cranial irradiation. 75 % of pa tients achieved complete or partial remission. One patient died from infectious complication after 2nd chemotherapy course. 2 patients have early progression. Five patients are alive with follow-up from 6 months to 3.5 years and 4 of them remains in remission. Therapy with methotrexate + cytarabine was accompanied by III–IV grade neutropenia in the majority of patients, but its duration w as not great. The data obtained are consistent with results of modern treatment protocols PLCNS.

In this work the kinetics of liquid-phase oxidation of n-alkanes C10–C13 on the titanium silicalite-shaped heterogeneous catalyst DP-1 with aqueous hydrogen peroxide in methanol at a temperature of 40–60°C was studied in a continuous reactor. It is shown that the rate of n-alkanes oxidation to alcohols and ketones increases with increasing reaction temperature and the initial concentration of the n-alkanes and hydrogen peroxide. For the kinetics of oxidation of n-alkanes C10–C13 on the heterogeneous catalyst DP-1 with aqueous hydrogen peroxide in methanol the exponential equation was used. The parameters of the kinetic equations of the main and side reactions were determined. These data can be used when calculating the integrated plants producing the higher fatty alcohols C10–C13 fraction

The possibility of roughness reducing of the Ge/Si (100) film using low-temperature layer of Ge (LT-Ge) has been investigated. It was shown that the substrate temperature change character during the growth process influences on the surface morphology of the grown Ge/LT-Ge/Si films. Samples were obtained by the method of molecular-beam epitaxy.

The kinetics of residual stresses and physical and mechanical properties of the hardened air shot-blasting layer of smooth specimens and specimens with semicircular cuts of aluminum D16T and B95 alloys as a result of time-temperature expositions and multicycle fatigue tests is investigated. This research was done for symmetric loading cycle in terms of bending and tension-compression tests and the base of 107 cycles. The growth of increment of the endurance limit of hardened parts with stress concentrators in comparison with non-reinforced specimens is established experimentally and by calculation. It is shown that the time-temperature exposition causes the relaxation of residual stresses and the reduction of increment of the endurance limit. In fact, surface plastic hardening significantly affects the growth of microhardness in comparison with samples unhardened. Microhardness decreases to values corresponding to unhardened sample after time-temperature expositions. The surface hardening increases the roughness layer and further time-temperature exposition and fatigue tests have no effect on these parameters. There is agreement between the calculated and experimental data.

The kinetics of residual stresses and physical and mechanical properties of the hardened air shot-blasting layer of smooth specimens and specimens with semicircular cuts of aluminum D16T and B95 alloys as a result of time-temperature expositions and multicycle fatigue tests is investigated. This research was done for symmetric loading cycle in terms of bending and tension-compression tests and the base of 107 cycles. The growth of increment of the endurance limit of hardened parts with stress concentrators in comparison with non-reinforced specimens is established experimentally and by calculation. It is shown that the time-temperature exposition causes the relaxation of residual stresses and the reduction of increment of the endurance limit. In fact, surface plastic hardening significantly affects the growth of microhardness in comparison with samples unhardened. Microhardness decreases to values corresponding to unhardened sample after time-temperature expositions. The surface hardening increases the roughness layer and further time-temperature exposition and fatigue tests have no effect on these parameters. There is agreement between the calculated and experimental data.

The effect of air shot blasting and temperature exposure without load on residual stresses and limit endurance of smooth specimens and specimens with semicircular notches of aluminum alloy D16T and V95 was investigated experimentally. This research was done for the symmetric loading cycle in terms of bending and tension-compression tests and the base of 107 cycles. The check of the calculated mean integral residual criterion stress to estimate the increment of the endurance limit of hardened parts with stress concentrators was completed. It was established experimentally and theoretically, that there is increment of increase in endurance limit hardened parts with stress concentrators in comparison with non-reinforced specimens, and temperature exposure leads to residual stresses relaxation and reduce the increment of the endurance limit.

The effect of air shot blasting and temperature exposure without load on residual stresses and limit endurance of smooth specimens and specimens with semicircular notches of aluminum D16T and V95 alloys was investigated experimentally. This research was done for the symmetric loading cycle in terms of bending and tensioncompression tests and the base of 107 cycles. The check of the calculated mean integral residual criterion stress to estimate the increment of the endurance limit of hardened parts with stress concentrators was completed. It was established experimentally and theoretically, that there is increment of increase in endurance limit hardened parts with stress concentrators in comparison with non-reinforced specimens, and temperature exposure leads to residual stresses relaxation and reduce the increment of the endurance limit.

The influence of both, the composite material based on the protein-mineral components including the prolonged form of the recombinant human bone morphogenetic protein 2 (rhBMP-2) and the method of the titanium implant’s surface treatment, on the reparative osteogenesis and adhesion strength of the bone tissue – implant’s surface contact was evaluated. Covering of implants with the composite coating promotes significant acceleration of the bone tissue regeneration processes in the site of implants loading. The composition coating with prolonged form of the rhBMP-2 promoted increasing of the neogenic bone tissue’s adhesion with the implants, as compared with the coating without recombinant human bone morphogenetic protein. The implants treated with microarc oxidation demonstrated higher values of the breakout force during the separation of the implants from the bone than the implants treated with sandblasting method.

X-ray diffraction experiment allows determining of magnitudes of complex coefficients in the decomposition of the studied electron density distribution into Fourier series. The determination of the lost in the experiment phase values poses the central problem of the method, namely the phase problem. Some methods for solving of the phase problem result in a set of feasible solutions. Cluster analysis method may be used to investigate the composition of this set and to extract one or several typical solutions. An essential feature of the approach is the estimation of the closeness of two solutions by the map correlation between two aligned Fourier syntheses calculated with the use of phase sets under comparison. An interactive computer program ClanGR was designed to perform this analysis.

Synthesis of library functional anchor groups with xanthene fluorescent dye on solid-phase support. Prepared CPG can be used for synthesis fluorescent probes for RT-PCR

Recombinant chimeric constructions RTA-DHFR and RTВ-DHFR consisting of ricin Aand B-subunits genes (RTA and RTB) and dihydrofolate reductase (DHFR) gene were cloned and expressed in Escheriсhia coli. Antigenic properties of RTA and RTB retained in chimeric proteins RTA-DHFR and RTВ-DHFR.