1. [ADP-ribose and cADP-ribose--endogenous regulators of cellular ionic balance. Cardiotropic effects of ADP-ribose].
- Author
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Kuz'min VS, Sosulina LIu, Sukhova GS, and Ashmarin IP
- Subjects
- Adenosine Diphosphate Ribose metabolism, Adenosine Diphosphate Ribose pharmacology, Animals, Cyclic ADP-Ribose metabolism, Cyclic ADP-Ribose pharmacology, Cyclic ADP-Ribose physiology, Heart physiology, Humans, Myocardial Contraction drug effects, Potassium Channels metabolism, Receptors, Purinergic metabolism, Adenosine Diphosphate Ribose physiology, Calcium metabolism, Heart drug effects, Myocardium metabolism
- Abstract
Functions and possible mechanisms of action of adenosine diphosphate ribose (ADP-ribose) and its cyclic analogue--cycle-ADP-ribose (cADP-ribose)-- substances pretend to role of novel second messengers are reviewed. Possible mechanisms of ADP-ribose and cADP-ribose synthesis regulation and metabolism are analyzed. Prospective mechanisms of ADP-ribose and cADP-ribose transportation into the cell are described. ADP-ribose and cADP-ribose are considered as endogenous regulators of ionic balance (in particular regulators of calcium balance) in different tissues. Effects of ADP-ribose on isolated heart of frog and warm-blooded animal (rat), as well as on rat heart in vivo are discussed. The role of ionic channels and receptors, gated by ADP- and cADP-ribose in regulation of cardiomyocyte ionic balance in normal and pathological condition are analyzed. The possible role of purine receptors in ADP-ribose and cADP-ribose effects on heart are discussed.
- Published
- 2006