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1. Threefold exposure to moderate hypobaric hypoxia decreases the expression of Cu,Zn-superoxide dismutase in some regions of rat hippocampus.

Author

Stroev SA, Tyul'kova EI, Pelto-Huikko MT, and Samoilov MO

Subjects
Animals, CA1 Region, Hippocampal enzymology, CA3 Region, Hippocampal enzymology, Dentate Gyrus enzymology, Male, Oxidative Stress, Rats, Rats, Wistar, Hippocampus enzymology, Hypoxia enzymology, Neurons enzymology, Superoxide Dismutase metabolism
Abstract

The effect of moderate hypobaric hypoxia on the expression of a peptide antioxidant Cu,Zn-superoxide dismutase in rat hippocampal neurons was evaluated in an immunocytochemical study. The expression of Cu,Zn-superoxide dismutase decreased significantly in the dorsal hippocampus (CA1 and CA2) and tended to decrease in ventral regions (CA3 and dentate gyrus) by the 24th hour after 3-fold exposure to hypoxia.

Published
2011
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