1. [IMPACT OF LONG-TERM ADAPTATION TO COLD ON THE STATE OF CARDIOVASCULAR SYSTEM].
- Author
-
Maslov LN and Naryzhnaia NV
- Subjects
- Acclimatization, Aldosterone metabolism, Angiotensin II metabolism, Animals, Arctic Regions, Catecholamines metabolism, Cold Temperature, Coronary Disease epidemiology, Coronary Disease metabolism, Humans, Hypertension epidemiology, Hypertension metabolism, Myocytes, Cardiac metabolism, Myocytes, Cardiac pathology, Rats, Receptors, Adrenergic, alpha metabolism, Adaptation, Physiological, Cardiovascular Physiological Phenomena, Cardiovascular System physiopathology, Coronary Disease physiopathology, Hypertension physiopathology
- Abstract
The inhabitancy in Far North increases a probability of development of coronary heart disease, acute myocardial infarction and arterial hypertension. Catecholamines and NO deficiency play a substantial role in the development of cold hypertension but are not involved in acclimatization cardiac hypertrophy. Data of in vivo experiments indicate in favor of an involvement of α-adrenergic receptors (ARs) in the mechanism of an appearance of cold hypertension. Cold acclimatization promotes an elevation of β3-AR density and decrease in β1-AR and β2-AR quantity on sarcolemma of cardiomyocytes. Experimental data indicate about the important role of aldosterone and angiotensin-II in the development of acclimatization hypertension. Catecholamines, aldosterone and angiotensin-II are not involved in cold hypertrophy of heart. Experimental data say on the important role of endothelin ETA-receptor in the formation of cold hypertrophy of heart and cardiofibrosis. Thyroid hormones play substantial role in the development of cold hypertension and cardiac hypertrophy.
- Published
- 2015