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[Enzymological bases of the physiological action of regulatory peptides].
- Source :
-
Nauchnye doklady vysshei shkoly. Biologicheskie nauki [Nauchnye Doki Vyss Shkoly Biol Nauki] 1986 (2), pp. 13-23. - Publication Year :
- 1986
-
Abstract
- The examination of enzymes involved in the neuropeptides metabolism shows that the same substance can be hydrolysed by different peptidases. At the same time each of these enzymes can take part in destruction of different in their structure and functional significance peptides. The analysis of the conditions ensuring selective, regulating action of the definite neuropeptidases in the process of peptides formation and destruction is necessary for the understanding of the regulatory peptides physiological role. Substrate specificity of the enzyme, its localisation in some tissues and organs in brain and periphery, the organisation of enzyme or enzymatic complexes in a cell, the specific inhibitors influence are considered as such conditions. These conditions are examined for a number of peptidases involved in enkephalin metabolism, angiotensin I and II, bradykinin, substance P and others. The significance of such enzymologic approach in the investigation of regulatory peptides function is illustrated by concrete examples.
- Subjects :
- Angiotensin II metabolism
Animals
Bradykinin metabolism
Brain enzymology
Catalysis
Enkephalins metabolism
Hydrolysis
Multienzyme Complexes metabolism
Organ Specificity
Protease Inhibitors pharmacology
Rats
Subcellular Fractions enzymology
Substrate Specificity
Endopeptidases metabolism
Nerve Tissue Proteins metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0470-4606
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nauchnye doklady vysshei shkoly. Biologicheskie nauki
- Publication Type :
- Academic Journal
- Accession number :
- 3516230