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Experiments on 36 dogs revealed a relationship of inhibition and stimulation of lipid peroxidation (LPO) and reactivity of myocardial infarction (MI) concerning outcomes of healing. It is shown that in complicated IM it is necessary to optimize LPO turning its dynamics to uncomplicated disease forms. In hyperreactive MI it is judicious to use antioxidants while in hyporeactive LPO stimulation is indicated using ultraviolet radiation of the blood.

In comparing the neurotropic action of probon and amidopyrine it became evident that both analgesics inhibit the behavioral reactions of rats in "open field" tests, fail to produce any protective action with respect to the reflex reaction of the heart in response to pain stimulation and attenuate such an effect of seduxen. By lengthening the hexobarbital-induced sleep probon and amidopyrine change the EEG nature typical of the effect produced by barbiturates. The difference between the study analgesics is rather a quantitative one, viz. in many rests probon is more potent and its action manifestes itself in a wider range of dosages.

A hypothesis on blocking factor formation in carcinogenesis is discussed. Destabilisation of cell membranes and increased levels of proteolytic enzymes in tumor tissue are considered to be the trigger mechanism. Protease level in large bowel tumor was found to be higher than in normal tissue. Plasminogen level in cancer patients was significantly higher than in healthy subjects. Application of different experimental schemes of treatment with membrane-stabilizing drugs and an inhibitor of protease was followed by antitumor and antiblocking effects. Sorption of rheumatoid factor and immune complexes from plasma led to a decrease in the blocking activity of plasma in vitro. In cases of rectal cancer, plasmapheresis was followed by tumor regression and a fall in immune complex concentration.

The intraperitoneal injection of analgin (1000 mg/kg), antipurine (400 mg/kg), amidopyrine (100 mg/kg) 3 hours before the irradiation of mice in a dose of 800 R led to survival of 30 to 45% of the animals (against 12.5% in control) and to increase in the average duration of life of the animals that perished. 80-95% of mice survived the period of "intestinal deaths" (the 7th day after the irradiation) after combined prophylactic use of purasolone derivatives and cystamine before the irradiation of these animals in a dose of 1050 R. The radioprotective effect of pyrasolone derivatives given in therapeutic doses was less pronounced.

Antirheumatic preparations chiefly inhibited (in vitro) the specific microbial stimulation of the reaction of blast transformation of lymphocytes (RBL) in the patients with torpid rheumocarditis caused by addition of streptococcus nucleoproteid into the medium. Specifically stimulated RBL became intensified in healthy donors on addition to the culture medium of amidopyrin and mephenaminic acid; as to delagil, it depressed the specifically stimulated RBL both in healthy donors and in patients.