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Introduction and purpose The term "probiotic" rooted in Latin, signifies 'for life,' reflecting the historical use of fermented products for therapeutic purposes. While browsing many websites devoted to healthy eating or popular science topics, we often came across the topic of probiotic food without any confirmation by scientific research. The aim of this paper is to confirm or exclude the presence of probiotics in popular foods. State of knowledge The paper reviews literature on the health benefits of various food that is traditionally considered probiotic, focusing on how they impact on varied health conditions. Defined by the WHO as living microorganisms conferring health benefits when consumed adequately, probiotics, mainly bacteria from Lactobacillus and Bifidobacterium genera, play a vital role in maintaining gut microbiota balance, regulating digestion, supporting the immune system and influencing mental and cardiovascular health. In addition, the paper also searches for scientific basis for their action. Material and methods A review of the literature available in the “PubMed” and Google Schoolar was conducted. We focused on checking whether the microorganisms contained in pickled food meet the WHO criteria for probiotics. Summary Our review managed to prove the probiotic effect of almost all presented food, except for miso. By reviewing many articles, we shed a lot of uncertainty on the repeated myth about the lack of probiotic effect of cucumbers preserved in vinegar and what is more, we found scientific assumptions about the probiotic effect of vinegar itself. Fermented food contains numerous strains of bacteria that are resistant to acid, bile and temperature in the human digestive tract and can be effectively used as a source of probiotics. Additionally, compared to probiotics from the pharmacy, fermented products provide not only probiotics, but also nutritional value, valuable fiber and vitamins, benefiting to our health.

Introduction and purpose: The purpose of this scientific paper is to review the current knowledge of the effects of red wine on human health, particularly with regard to cardiovascular disease. State of Knowledge: Since the 1990s, red wine has gained its status as a health-promoting alcohol through the French Paradox - when drunk in moderate amounts, it protects against cardiovascular disease. The authors have collected scientific papers on the health effects of alcohol, red wine and resveratrol-a polyphenol that is the main component with health-promoting effects of wine. On their basis, they analyzed the assumptions of the positive effects of wine reaching inconclusive conclusions. Summary: Despite the fact that both ethanol and resveratrol have a positive effect in in vitro studies, in population studies their effect is much less significant, either because the negative behavioral-health effects in the case of ethanol are omitted or the actual effective doses of resveratrol are omitted.

Context: Angular gyrus is an anatomical structure of the brain located in the parietal lobe, taking part in writing and reading, language-use, memory and attention and spatial recognition. It is supplied by the angular gyrus artery, which is one of the caudal branches of the middle cerebral artery. One of the clinical pathologies of the angular gyrus artery is the ischemic stroke of the angular gyrus in the dominant hemisphere, responsible for the presence of Gerstmann Syndrome: left-right disorientation, agraphia, alexia, acalculia and finger agnosia. This systematic review aims to present the variety of anomalies of the main cerebral artery and the angular gyrus artery. Objective: Preparing a systematic review of papers describing the course anomalies of the angular gyrus artery. Materials and methods: PubMed and Google Scholar electronic databases was searched for phrases: ‘Angular gyrus artery’, ‘Artery of angular gyrus’, ‘Middle cerebral artery branches’, ‘Branches of middle cerebral artery’, ‘Gerstmann Syndrome’ published between years 2015 and 2023. Also 3 papers published before 2000 were used. From the selected 30 papers, 6 were used to prepare this analysis. Results: The middle cerebral artery, from which arises the angular gyrus artery, is marked by a significant variety of its division, mainly the number of the dividing trunks of the artery. Depending on the type of the division, the angular gyrus artery can arise from the upper, middle or lower trunk and vary in sizes. It can also appear as a singular or two separate branches. Instances of the anomaly of both the angular gyrus artery and posterior parietal artery are rare, but reported. Conclusions: The angular gyrus artery is characterised by a number of anomalies in its course, separation from the middle cerebral artery, diameter and branching.

Introduction and purpose: Currently, the role of the gut microbiota in the pathogenesis of different diseases is being widely researched, the understanding of whether the dysbiosis of the gut flora demonstrates the significant role in Alzheimer disease (AD) is accentuated. The aim of this paper is to summarize the existing paper about the role of the gut microbiota - its diversity, stability and composition in this condition. The search was conducted using PubMed and Google Scholarship databases. Brief description of the state of knowledge: It is still uncertain if alteration in gut microbiome is a consequence of AD or its risk factor, but some findings suggest that the intestinal flora is able to influence the activity of the brain and lead to its dysfunctions. There is also the association between composition of the gut microbiome and AD. Results indicate that affected patients had less heterogeneity in their microbiome and the progression of AD led to alterations in the bacterial flora. Introducing modifications of the gut microbiota is considered as a therapeutic option for AD. Following personalized diet, probiotics, prebiotics and synbiotics administration or fecal microbiota transplantation (FMT) may be beneficial for affected patients. Conclusions: The subject of the role of the gut microbiota merits further research as foregoing results of conducted studies are pointing to its possibly meaningful role. Presently, still more data is needed as most of the research was collected on animal models and the analysis conducted on humans remains insufficient. We conclude that further studies are warranted in order to fully understand the pathophysiology of the disease and the possible usefulness of microbiome therapy.

Introduction and purpose: Apples are a widely consumed fruit globally and are known to be a great source of nutrition. Studies have shown that apples contain high levels of antioxidants, dietary fiber, and vitamins that contribute to numerous health benefits. This paper aims to provide a comprehensive review of the impact of apples on human health. State of knowledge: The paper reviews the current literature on the health benefits of apples, focusing on their impact on various health conditions such as cancer, cardiovascular diseases, diabetes, and obesity. Additionally, it examines the role of apples in improving intestinal, immune, and cognitive function. The paper also discusses the potential mechanisms by which apples exert their health benefits, such as high levels of flavonoids, polyphenols, and dietary fiber. Summary: In conclusion, the vast body of evidence reviewed in this paper supports the notion that consuming apples regularly can contribute to better health outcomes. They may help reduce the risk of chronic diseases, such as cancer, cardiovascular diseases, and diabetes, as well as promote healthy gut microbiota and immune function. Despite the controversy surrounding the use of pesticides in apple cultivation, the benefits of consuming apples outweigh the risks. Therefore, it is highly recommended to include apples as part of a balanced and nutritious diet to promote optimal health and wellbeing. As the saying goes, "An apple a day keeps the doctor away".

Introduction and aim Diabetic foot ulcer (DFU) is a chronic condition that affects an increasing number of people each year[1]. Healing the ulceration requires cooperation between patients, specialists and scientists in order to achieve satisfactory results. Treating this type of wound is not only a therapeutic challenge[1,2,3,4,5,6], but also an economic one, which is why so much scientific research has already been made on this phenomenon[2,3]. Still scientists continue their quest for new cost-effective alternatives to current therapeutic options that would be consistent with contemporary knowledge and available engineering capabilities in pursuance of creating techniques and new dressings that will accelerate the healing of DFUs[2,3,7,8]. Factors such as stress, obesity, certain medications, and chronic diseases appear to negatively affect the process of repair [1,9,10,4,6,11]. Studies prove that aloe vera gel due to its healing properties, can be considered as a potential dressing that will expedite the mending process of diabetic foot ulceration[12,13,14]. In this paper, we performed a literature review of the applicability of aloe vera in the healing process of DFUs. Materials and methods Searching the available literature, including randomized clinical trials and systematic reviews, we drew on databases focusing on the effects of treatment for diabetic foot ulceration using Aloe vera. Conclusion: The current scientific research on the use of Aloe vera gel in diabetic foot ulcer treatment indicates that this method is safe, effective and inexpensive[2,3]. However the difficulty of treatment and the increasing prevalence of this type of wound pose a challenge to finding new solutions and exploring mechanisms in which aloe vera can have a possible role in the wound healing process. Nevertheless, this paper presents a promising impact of Aloe vera gel applicability in the healing process of diabetic foot ulcer.

Introduction and purpose: Currently, as the frequency of obesity is alarming, the role of many factors that could contribute in preventing and treating this condition are being researched, among them the certain food with beneficial health profiles - one of them is soybeans, specifically the isoflavones it contains. Populations that consume soy are known for lower risk of various disorders - among them obesity. The aim of this paper is to summarize the existing paper about the role of these bioactive components in the treatment of this condition. The search was conducted using PubMed and Google Scholarship databases. Brief description of the state of knowledge: Obesity is one of the leading challenges in today’s healthcare as it leads to various chronic diseases that are fraught in consequences. Current knowledge is pointing into the association between composition of the soy isoflavones and the lower risk of obesity. Results of the studies indicate that patients affected with obesity could benefit from introducing soy isoflavones into their diet along with other necessary modifications. Conclusions: Soy isoflavones are potential agents in the holistic obesity treatment. Consumption of isoflavones merits further recognition as foregoing results of conducted studies are pointing to its possibly meaningful role. It is worth mentioning that consumption of soy isoflavones is not only an anti-obese factor, but also presents various other health benefits and when consumed rationally poses no risk to human’s well being. We conclude that further studies would enable us to fully reveal the potential of those polyphenols.

The paper presents the analysis of two publications written by two pioneers of heart transplantation in the USSR, A.A. Vishnevsky with co-authors and G.M. Solovyov, which covered the state of the organ transplantation issue in 1971–1973 and gave predictions for its future development. It is shown that the authors of those publications saw and formulated the main trends in the development of the problem in one and the same way. Meanwhile, G.M. Solovyov, being the Director of the specialized Institute of Organ and Tissue Transplantation of the USSR Academy of Medical Sciences saw the issues of organ transplantation more in depth than A.A. Vishnevsky who headed the A.V. Vishnevsky Institute of Surgery of the USSR Academy of Medical Sciences. In particular, this concerned immunological studies. Shortly after its establishment in 1969, the Institute of Organ and Tissue Transplantation arranged a powerful laboratory of immunogenetics on its base. The staff of that laboratory (L.V. Smirnova, Yu.M. Zaretskaya, L.P. Alekseev, V.I. Shkurko, A.M. Sochneva, I.V. Petrova, etc.) conducted world-class immunological studies, which results inspired certain optimism among surgeons. A more complicated situation was with the clinical issues of organ transplantation, with the solution of organizational, moral and ethical issues, where, in addition to doctors, the active participation of legislators, economists, and healthcare organizers was required. This paper presents comparative data on the state of political, economic, and organizational issues of organ transplantation in the Russian Federation between the 2010s and early 2020s. It is shown that the planned in the 2020s tendency of their positive solution and further development inspires certain optimism.

The purpose of this work is to investigate dependence of the seasonal dynamics of HS (hemorrhagic strokes) and IS (ischemic strokes) risk on sex and age using meta-analysis. In total, 22 publications were selected for this meta-analysis, studying the seasonal dynamics of HS, of which 8 publications presented statistics separately for men and women, and three papers presented statistics for different age groups. Also, 28 publications studying the seasonal dynamics of IS were selected for meta-analysis, of which 11 publications presented statistics separately for men and women, and three papers presented statistics for different age groups. The meta-analysis of the seasonal dynamics of HS showed that HS risk is less likely in a warmer season compared with a colder one. In men, HS risk was the highest in winter and spring, and in women in winter. Dependence between HS risk and a decrease in air temperature was the same in men and women. According to the results of the meta-analysis (without regard to sex and age), the minimum probability of IS occurs in autumn. In women, IS risk was significantly higher in winter compared to other seasons. In men, the seasonal dynamics of IS was not expressed. In older people, the overall risk of stroke increased, especially IS. In people over 65 years of age, there was a significant dependence of an increase in HS risk on a decrease in air temperature. In people younger than 65 years, HS risk was not associated with cold. A decrease in temperature equally increased IS risk in both age groups. These results suggest that sex and age may influence the seasonal stroke risk.

The analytical review presents the clinical, neurobiological, and neuropsychological aspects of post-stroke aphasia as well as the role of the right hemisphere in speech recovery. The paper shows the influence of size, topography, lesion depth, cerebral hemodynamic plasticity, initial morphometric characteristics of the brain, and handedness on the functional recovery of aphasia. The review considers the typology and mechanisms of the appearance of "stealing symptoms" of homologous and non-homologous regions of the intact hemisphere. The "low-level" and "high-level" models of language competence of the right hemisphere are analyzed. The study describes the topography of the brain activation regions in the intact hemisphere during various speech task-solving. The paper shows the heterochrony between impressive and expressive speech recovery in aphasics and its bilateral inter-lateral distribution. The authors conclude that to clarify the mechanisms of aphasia recovery, it is necessary for a comprehensive account of clinical, neurobiological and neuropsychological patterns of speech disorder reparation in different post-stoke epochs. The paper notices that a deeper understanding of the impact of structural and functional repairment of speech processes on the aphasia outcome, it needs to assess the relationship between the degree of speech disorders reduction and the lateral vector of speech architectonics in the post-stroke period.

The research was aimed at analyzing current approaches to the organization and design methodology of visualization database built on the basis of computer vision. Such approaches are necessary for effective development of diagnostic systems using artificial intelligence (AI). A training data set of high quality is a mandatory prerequisite for that. Material and methods. The paper presents the technology for designing an annotated database (SBT Dataset) that contains about 1000 clinical cases based on the archived data acquired by the Federal Neurosurgical Center, Novosibirsk, Russia including data on patients with astrocytoma, glioblastoma, meningioma, neurinoma, and patients with metastases of somatic tumors. Each case is represented by a preoperative MRI. The Results and discussion. The dataset was built (SBT Dataset) containing segmented 3D MRI images of 5 types of brain tumors with 991 verified observations. Each case is represented by four MRI sequences T1-WI, T1C (with Gd-contrast), T2-WI and T2-FLAIR with histological and histochemical postoperative confirmation. Tumors segmentation with verification of the tumor core elements boundaries and perifocal edema was approved by two certified experienced neuroradiologists. Conclusion. The database built during the research is comparable in its volume and quality (verification level) with the state-of-the-art databases. The methodological approaches proposed in this paper were focused on designing the high-quality medical computer vision systems. The database was used to create artificial intelligence systems with the “physician assistant” functions for preoperative MRI diagnostics in neurosurgery.

The timely diagnosis and treatment of maxillofacial pathologies where the tongue plays an important role requires an accurate description of the organs structure and development. The paper presents a review of the current research data on the features of embryonic development, macro- and microanatomy, morphometry and ultrasound anatomy of the human tongue during the prenatal development. The selected papers, published in the Russian and English languages, cover the period of the last decade. We generalized the obtained data using the empirical and theoretical approaches. The macroscopic study of the external structure of the tongue was underrepresented in the current studies, usually performed in combination with morphometry. The studies of histotopograms in combination with histochemical methods were numerous, contributing to the more detailed classification of the tongue development stages. The selected papers focused on the period of human embryonic development and the correlating histological characteristics of the tongue. The morphometric characteristics and the blood supply of the tongue in the prenatal period require further research.

The present work focuses on developing a model of the duodenum considering motility, biochemical reactions occurring under effects produced by secreted digestive juices, and absorption of reaction products in normal conditions and in case of functional disorders. Analysis of literature sources allowed identifying basic bile components and pancreatic and intestinal juice enzymes influencing fats, proteins and carbohydrates that enter the duodenum. The paper provides a simplified scheme showing how food components are transformed allowing for the neural-humoral mechanism of digestion regulation. Chyme that enters the duodenum is considered a homogenous mixture, which changes its composition during chemical reactions. Mathematical tasking includes mass and momentum conservation equations for a multi-component viscous fluid. The secretion of digestive juices and absorption of components resulting from chemical reactions are described with mass effluents in a pipe in the wall layer. The peristaltic law of the duodenum wall movement was applied to describe the tract motility; the movement characteristics do not depend on the composition of the mixture. Numeric experiments produced necessary results to describe the hydrolysis of the 5 % starch solution under exposure to pancreatic amylase. Obviously, not all the amount of starch enters a chemical reaction and this is well in line with experimental data. The paper provides data on concentration fields for the components of glucose, amylase, and starch at different moments in time and the fluid velocity field. The next stage in the model development is expected to consider absorption of food components, functional disorders of secretion / absorption and intestinal motility as well as influence exerted by neural and humoral mechanisms. In future, the developed model can be applied to predict areas with elevated risks of developing functional disorders, ulcer formation, and other defects of the intestinal mucosa. This will help a physician to prescribe personified therapy and diet.

Introduction and purpose of the work. Aesthetic medicine currently has many methods to keep our skin in the best possible condition, and one of these methods is the use of tissue stimulators. The purpose of the following paper is to analyze, present and apply tissue stimulators in anti-aging prevention. Review methods. The paper is based on a review of literature about tissue stimulators, aesthetic medicine and anti-aging therapy. Most of the publications used were from Pubmed and Google Scholar electronic databases. State of the art description. Aesthetic medicine is a department that over the past few years has been closely associated with the slowing down of skin aging processes. In humans, over the years, proliferative processes slow down, the rate of collagen and elastin degradation increases, and the intercellular matrix is reduced. Substances known as tissue stimulators used in anti-aging therapies mean that the above processes can be delayed. Conclusion. The expectations of patients visiting aesthetic medicine clinics regarding activities that improve their appearance are increasing. They are unable to accept their own aesthetic defects, which is why they often strive for unnatural effects. Tissue simulator treatments can be a valuable way for patients to maintain healthy and rejuvenated skin.

Introduction: Xenotransplantology, the field of transplantation involving organs or tissues between different species, holds great promise for addressing the global organ shortage crisis. However, the development of new technologies without proper legislative preparation raises significant moral and ethical considerations. This paper provides an overview of the current state of xenotransplantology, highlighting its revolutionary potential alongside the moral dilemmas it entails. Aim of the study: The aim of this study is to assess current social, ethical, religious, and legal trends regarding the issue of xenotransplantation. Materials and methods: To obtain up-to-date information concerning trends in xenotransplantation, a review of the PubMed and Google Scholar databases, along with the latest legislative reports in both Europe and Poland, was performed. Conclusions: Firstly, the authors briefly report on the current situation concerning transplantology and the widely spread organ donor crisis. Next, the issue of species boundaries and the moral status of non-human animals is addressed. The assessment of ethical implications of utilizing animals as organ donors is examined, along with the legal acts regulating this issue. Moreover, the authors attempt to evaluate the cultural and religious differences related to this concern. Furthermore, this study discusses the allocation and distribution of xenotransplants, considering issues of justice, fairness, and access to this innovative medical technology. Lastly, the paper delves into the risks and uncertainties associated with xenotransplantation, including the possibility of cross-species disease transmission and intensified course of organ rejection disease.

Introduction and Purpose: Coeliac disease is an increasingly prevalent disorder worldwide. It is estimated to affect about 1% of the population and its symptoms heavily impact people's lives. The aim of this paper is to delve into the topic of coeliac disease and present basic information about its origins, current diagnostic methods, and the challenges associated with its treatment. This article includes all the necessary information from up-to-date sources. State of Knowledge: Coeliac disease was discovered a long time ago, but it is still not completely understood. Every year, new research is published regarding different populations in various countries. While we know more about the disease, its symptoms, and causes, we are still far from fully understanding all the inflammatory processes occurring in the human body. There is solid evidence that this enteropathy is caused by gluten, and the only way to reduce the clinical manifestation of coeliac disease is to adhere to a gluten-free diet. However, some patients do not benefit from this type of diet and still suffer from coeliac disease. New drugs currently being developed offer hope for these individuals, as they attempt to target the immunological reaction and mitigate the immune response in the small intestine. Conclusion: As approximately 1% of the population suffers from this disease, it is crucial to diagnose patients in the early stages of its development. Early diagnosis can prevent the development of other disorders that coexist with coeliac disease, which can be particularly dangerous, especially for children. This paper provides up-to-date information about the clinical manifestations of the disease, as well as methods of diagnosis.

This article focuses on the promotional aspects related to the tourist attractiveness of the neighboring countries-Poland and Slovakia. The purpose of the article is to analyze the issue in question and point out the importance of the search for ways to increase the effectiveness of management of the area of tourism promotion in both countries. The authors used an empirical research method with quantitative-statistical and qualitative studies on specific promotional campaigns. The Olympic Games have the greatest marketing potential among sporting events, as the most important sporting event in the world. The possibility of organizing such an event in Poland and Slovakia would certainly serve to improve the recognition rates of both countries. The authors will try to demonstrate this potential as part of the considerations in this article. Acknowledgement: This paper was supported by the project NP-KSV-ET-01-2023-12/ST - International cooperation in the field of development, management and law in tourism and sports between the Republic of Poland and Slovak Republic. The views expressed in this paper are those of the authors and should not be taken as reflecting the position of any authority, entity or institution. This article presents the legal status as of 25 March 2023.

Aim: to provide a literature review of the current data on various pathomechanisms of left ventricular (LV) remodeling in heart failure (HF) patients and their role in the development and progression of myocardial dysfunction. This paper is a first part of the review, devoted to the current state of pathophysiology of LV remodeling in HF. Material and methods. The thematic scientific papers, published during the last decade, constituted the study material. The research methodology involved bibliosemantic method and structural and logical analysis. Results and discussion. LV remodeling is the result of complex changes at the molecular, cellular and tissue levels, affecting the myocardial mass, geometry and performance, and ultimately leading to HF development and progression. LV systolic dysfunction occurs through the numerous mechanisms, including the defects in sarcomere function, abnormal excitation-contraction coupling and calcium homeostasis, ion channel dysfunction, mitochondrial and metabolic abnormalities, depressed cardiomyocytes survival signaling, redox pathobiology, inflammation and inadequate vasculogenesis. The term «LV diastolic dysfunction» covers the alterations in diastolic distensibility, filling or relaxation of the LV, regardless of whether LV (global) systolic function is normal or abnormal, and regardless of whether the patient has clinical manifestations of HF. The up-to-date pathophysiological paradigm of the development and progression of HF with LV diastolic dysfunction and preserved LV (global) systolic function considers systemic inflammation as a key pathomechanism of structural and functional changes of the myocardium, promoted by various cardiovascular and extracardiac conditions. In its turn, the systemic inflammation promotes endothelial dysfunction, contributing to multiple end-organ damage. Conclusion. The deepening one`s knowledge of various pathomechanisms of LV remodeling and related myocardial dysfunction in HF patients is an important prerequisite for identifying new perspectives on further fundamental research аnd more rational designing of future clinical trials.

Oral mucosa is an inner lining of oral cavity, which maintains different functions including protection of epithelial integrity. Pathology of oral mucosa can develop in response to the action of pathogenic microorganisms, viruses, and various traumatic factors; it can be a result of systemic pathology of a patient as well. Pain and discomfort usually accompanies such conditions leading to decrease of patient wellbeing. The basis of the pharmacological regulation of the regeneration process is the stimulation of wound healing. The aim is to summarize and discuss the spectrum of remedy options that are used to stimulate epithelization of oral mucosa. The overall goal of the paper is to provide full and comprehensive information for dentists and their patients about medicament variety, ways of theirs application and dosage. Methods. Relevant literature from MEDLINE (PubMed), Google Scholar, and in open access journals which are published by Elsevier was selected using the following key words «oral mucosa», «epithelization», and «remedy» were used in various combinations by the year of 2023. In total there were found 48 papers. To the selected scientific papers we applied the inclusion and exclusion criteria to choose the relevant ones. Conclusions. A significant number of drugs for the treatment of inflammatory processes in the oral cavity are available nowadays on dental market. Numerous studies substantiates the effectiveness of their use in dentistry. Therefore, when choosing pharmacological drugs, preference is given to drugs with a complex effect, which locally affect various links of the pathogenetic mechanism of the occurrence of diseases and do not disturb human wellbeing.

Endometriosis is a chronic gynaecological disease characterized by the presence of the uterine mucosa that functions in accordance with the menstrual cycle outside of its usual location. This disease significantly reduces the quality of life of women facing numerous ailments, most often pain, and may lead to reduced fertility. The prevalence of endometriosis is difficult to determine due to the complexity and lengthy diagnosis. It is estimated that this disease occurs in 3-8% of women of reproductive age, and symptoms may also appear after menopause. It is worth noting that the relationship between the disease's severity and endometriosis symptoms is often not proportional. The aim of the paper is to present a case report of a 23-year-old female patient with endometriosis, to differentiate the disease from irritable bowel syndrome and to draw attention to the problematic and lengthy diagnostic process due to the multitude of symptoms from various organs. Material and method: Study of an individual case of a patient and a review of scientific articles available in Google Scholar and a review of publicly available textbooks in the field of medicine. The paper emphasizes the need to broaden the knowledge about endometriosis by specialists in many fields of medicine and points to the lack of quick, minimally invasive tests enabling efficient diagnosis of the disease. Increasing the awareness of doctors including other specializations than gynaecology, organizing campaigns to increase awareness of the disease among women, which may contribute to earlier diagnosis of patients, earlier application of an effective treatment, and improvement of patients' quality of life.

Introduction:Lipid disorders are one of the most common modifiable risk factors for cardiovascular disease. Until now, the mainstay of dyslipidemia treatment was the use of widely available statins. These drugs, despite significantly lowering cholesterol and bringing its concentration to desired values were associated with a number of side effects. In addition, the need for daily use of statins is inconvenient for patients and leads to their irregular use and, consequently, failure to achieve the desired effect. The new drug, inclisiran, which is a PCSK9 inhibitor, represents the future in the treatment of lipid disorders. Studies conducted to date have explored the drug's mechanism of action, frequency of administration to achieve the desired effect, and side effects. The results of these studies have confirmed the significant efficacy of inclisiran,which may become a major form of treatment for dyslipidemia in the future. Purpose of the work: This article reviews the state of knowledge based on available studies on inclisiran. The aim of the review is to present the most important information about this drug related to the mechanism of action, effects on the body or assessment of efficacy. Materials and methods: The authors, based on databases such as PubMed, Scopus and Google Scholar, created a paper summarizing a review of currently available publications, concerning a new drug in the treatment of dyslipidemia- inclisiran. The authors searched for available information , using terms under the heading "key words" contained in other scientific papers. Summary Inclisiran is a novel drug that represents the future in the treatment of dyslipidemia. Due to the lack of systemic effect, it has insignificant side effects, and the need for such rare administration will allow to obtain the desired lipid concentrations even in patients who do not cooperate.

The primary purpose of this paper is to determine and prove the impact of loads with different intensities on the treadmill on the heart frequency, as well as to prove the relationship and impact of some anthropometric and motor parameters on the physiological one in the manifest space. In harmony with the purpose of the research, three basic hypotheses have been presented that cover the anthropological research fields. In this paper, 19-year-old students of the Faculty of Sports Sciences are included. To achieve the purpose of the paper, a sample of 80 students who were regular students during the year 2022/2023 was included. Four anthropometric variables, three motor tests (running tests) and four physiological tests (pulse at rest and during loads) are included in this paper. For the three groups of the system of variables, the basic statistical and distribution parameters for each variable, as well as the measures of asymmetry and normal distribution, were calculated. Then the correlations between the variables in the manifest space, as well as the correlations between the system of variables. In order to determine the relationship between predictor variables (anthropometric and motor characteristics) and criterion variables (results of functional skills), regression analysis was applied in the manifest space. The processing of the results shows that the obtained values do not deviate from the normal distribution, which completes their metric characteristics. The impact of morphological and motor factors on heart rate results has not been proven.

This paper summarizes the data from updated international protocols and guidelines for diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM). The invasive and non-invasive diagnosis techniques and their combinations are briefly reviewed; the evidentiary foundations for each diagnostic option and tool are analyzed. The paper describes a customized algorithm for sequential diagnosis and differential diagnosis of patients with suspected ATTR-CM with allowance for the combination of clinical signs and diagnostic findings. Along with the awareness of primary care providers about the red flags of the disease and visualization criteria, as well as providing information to the patients about the possibility of performing therapy of ATTR amyloidosis and the risks of delayed diagnosis, the proposed algorithm enables timely patient routing and prescribing specific treatment.

There are a lot of diseases known today, which are caused by genetic abnormalities. Advances in genetics and biotechnology brought about gene editing technologies that can produce almost any gene, which ultimately led to the emergence of a new class of medicines - gene therapy products (GTPs). The aim of the study was to analyse international experience in development and authorisation of GTPs. The review highlights the challenges in GTP development, related to the search for an optimal approach to therapeutic gene delivery to the target cells. Viral vectors were shown to be a promising gene delivery system, with adenovirus (AV) and adeno-associated virus (AAV) based products demonstrating the highest efficacy and safety. The paper reviews current approaches to gene editing that allow modification of AVs and AAVs to improve GTP efficacy and safety. These modifications are carried out with the aim of, e.g., including a large therapeutic gene into a viral vector, decreasing viral protein expression levels, and decreasing viral vector immunogenicity. The review summarises GTP authorisation procedures in the USA and the European Union, including data on FDA and EMA subcommittees and departments entrusted with advisory functions. The paper mentions that there is one Russian-produced GTP authorised in the Russian Federation, and some other GTPs are in the pipeline. Therefore, the Russian regulatory framework and the Eurasian regulations and recommendations should be updated in order to accommodate for GTP development and authorisation.

The article presents various types of acute rhinosinusitis progression in pediatric practice depending on the duration of the disease, based on the available modern consensus papers and clinical guidelines. The main clinical terminology of the nosological forms of rhinosinusitis was determined, and aspects of their differential diagnosis and stages of the treatment were studied. The authors provided insight into disease pathogenesis, taking into account literature review data on the spectrum of the most common bacterial agents of the nose and paranasal sinuses pathologies. The available data on the treatment of rhinosinusitis are summarized from the perspective of consensus papers and modern clinical guidelines of the Ministry of Health of the Russian Federation, the use of which for the prescription of treatment is the most important quality criterion for medical care provided. A clinical case of the treatment of acute bacterial uncomplicated rhinosinusitis in a 12-year-old child is described. In this case, an aerosolized form of topical antibiotic therapy combined with a mucolytic component was used as a drug of choice alongside with the standard irrigation-elimination therapy and nasal decongestants, which gives an advantage in achieving the maximum effective concentration of the active substance at the site of inflammation. A drug with a mucoactive effect helps to decrease mucus viscosity and discharge, and at the same time facilitates the entry of an active substance into the tissues and inhibits bacterial adhesion to the epithelium of the respiratory tract. Antibacterial component – thiamphenicol, a derivative of chloramphenicol with a mechanism of action associated with inhibition of bacterial protein synthesis has a broad spectrum of action and a maximum degree of accumulation and action in the site of inflammation due to the method of delivery to the epithelium of the respiratory tract.

Due to improvements in the medical techniques used, virtual reality technologies are increasingly used to treat various diseases. Simultaneously, various ethical issues emerged. Knowing exactly what problems the treating physician and the patient may be facing is important to increase the effectiveness of therapy. This will help minimize or at least prevent negative consequences. A qualitative secondary study was conducted on the ethical issues arising from the application of virtual reality technologies in treatment. Papers suitable for analysis were searched using the keywords virtual reality, ethical issues, and medicine. The works of the last 10 years were selected, most of the sources being at most 5 years old. After analyzing papers and studies which describe the experience of applying virtual reality technologies in medicine, the range of ethical problems that are currently relevant was determined most accurately. Firstly, the vulnerability of patients is evident, which arises from the realism of the avatars and the deep immersion in the virtual world. Without the physicians supervision, the patient may experience a high degree of psychological pressure, which has a negative effect. Secondly, strong emotional involvement is possible, which may develop attachment to the artificial intelligence and cause derealization, depersonalization, and other mental disorders. Thirdly, active interaction with the virtual world may be accompanied by long-lasting effects, such as gaming disorder. Finally, patients may have difficulties in distinguishing between reality and simulation, which affects autonomous choice and compromises informed consent. Virtual reality technologies may potentially change the lives of trauma patients and improve their quality of life. However, these changes are accompanied by ethical issues that must be addressed with respect to the vulnerability and nature of trauma.

Background. Acute pancreatitis is recognized as a common disease, occasionally accompanied by the development of local complications that require surgical debridement. Rare complications of pancreatitis may occur in clinical practice, which is one of the reasons for their untimely diagnosis and treatment. Pancreaticopleural fistula and high small bowel obstruction develop in less than 1% of acute pancreatitis cases. Therefore, possible options for management of these complications are considered valuable. Description of clinical cases. The clinical examples, provided in the present paper, describe pancreaticopleural fistula and high small bowel obstruction that develop against the peripancreatic mass in the abdominal cavity. Patient K., 44, was hospitalized to the Regional Clinical Hospital of Emergency Medical Care, Krasnodar Krai, and preliminary diagnosed with bilateral hydrothorax and type II respiratory failure; pleural puncture was performed. Following the extended examination, a clinical diagnosis was made as follows: “Acute necrotic pancreatitis spreading to a pancreatic tail cyst. Reactive double pleurisy”. The postoperative period was indicated with repeated recurrence of right hydrothorax, and pancreaticopleural fistula (diagnosed by measuring amylase activity in the brown fluid effused from the right pleural cavity, which appeared to be 41216 IU/l (not normally determined)). The right pleural cavity and pseudocyst of the pancreatic tail were drained, resulting in obliteration of the pancreatbcopleural fistula. Patient V., 50, was hospitalized and transferred to the surgical department of the Regional Clinical Hospital No. 2, Krasnodar Krai, and diagnosed with “pancreonecrosis, extensive purulent-necrotic peripancreatitis.” The patient underwent puncture-drainage treatment. The postoperative period was complicated by acute small bowel obstruction. Surgical treatment involved Braun enteroesterostomy. The patient recovered. Conclusion. Pancreaticopleural fistula refers to a rare complication of acute pancreatitis, manifested by hydrothorax. Its diagnosis is based on the determination of amylase activity in the effusion. Drainage of the pleural cavity and pancreatic pseudocyst contributes to obliteration of the fistula. The intestinal obstruction, another complication of pancreatitis, requires open surgical treatment when a conservative therapy appears ineffective.

Background. All types of alopecia fall into two main categories: scarring and non-scarring alopecias. Among these, certain types frequently pose challenges in differential diagnosis due to their similar clinical manifestations, thus necessitating specific examinations to be made for confirmation of the diagnosis. For instance, trichotillomania may be easily confused with alopecia areata. Description of clinical cases. The paper presents three clinical observations of patients with both scarring and non-scarring alopecia and highlights the challenges in establishing a definitive diagnosis due to the similarities in clinical presentations. The study emphasized the importance of thorough examination and close attention to patients with long-standing areas of hair thinning, along with the necessity for meticulous differential diagnostic efforts. In addition, the significance of pathological examination is considered as an indispensable tool for the evaluation of most similar cases of scarring and non-scarring alopecias. Conclusion. Early verification of the diagnosis and timely initiation of therapy for hair disorders appear crucial, both for the potential restoration of hair growth and for the prevention of further hair loss.

Currently, the issue of increased dentin sensitivity after operations for hard dental tissue preparation during the therapeutic treatment of the carious process, as well as during orthopedic treatment of various types with non-removable dentures, has retained its relevance. Pain management is the prevention of postoperative complication development and ensures high-quality treatment results. Aim. The purpose of the literature review in this paper was to draw specialists’ attention to the use of low-solvent adhesive systems of various types to manage postoperative sensitivity of hard dental tissues. Materials and methods. More than 30 literature sources focused on studying action mechanisms of known generations of dental adhesive systems and their effects on changes in postoperative sensitivity of dental hard tissues as a result of a high-quality protective film formation on the dentin surface have been analyzed. Results. The use of various adhesive systems to reduce postoperative sensitivity of soft tissues with the formation of a high-quality protective film on the dentin surface that seals the dentinal tubules is of great importance for obtaining qualitative treatment results and increasing its effectiveness. However, various reactive substances (solvents, acetone), which are components of most adhesives, have a strong impact on their quality and significantly reduce the indications for their use. Conclusions. Thus, studying the action mechanisms of adhesives on dental tissues, searching for the formulation of new adhesive systems with a lower solvent content would expand the indications for their use as therapeutic and prophylactic drugs to reduce pain sensitivity of hard dental tissues after preparation.

Introduction In the new globalized world, noise pollution has started to become a public health problem. We searched for publications about noise pollution in our study. In our study, we examined the noise pollution articles in the Web of Science (WoS) database. Material and Methods A total of 2722 papers were identified which were published between 2001 and 2020, finally, 1815 articles were analyzed. VOSviewer (version 1.6.11) tool used for bibliometric web visualizations. Results When trend analysis was applied to the number of articles by years, a statistically significant increase was detected. The United States contributed the most publications. The countries with the most articles per million population were determined to be Scotland, Singapore, and Ireland, respectively. Most articles on noise pollution were published in the journal Applied Acoustics. The three most used keywords are “noise pollution”, “noise” and “traffic noise”. Conclusions This study showed that there has been a trend of an increasing number of articles on noise pollution in recent years. Also it can be considered that this bibliometric study will help identify gaps in the current research data.

Background. Unexpected transmission of an infectious disease agent with a kidney graft to a recipient is a rare event but it is associated with significant morbidity and mortality, especially when exposed to multidrug-resistant bacteria that have not been eliminated by standard antibiotic prophylaxis.Objective. To demonstrate the need for immediate removal of a primary infected kidney graft in the event of local purulent complications due to the rapid development of sepsis in immunocompromised patients.Results. The paper describes a clinical course of the infectious process in two kidney recipients each of whom underwent transplantation of a primary infected graft from a single donor, taking into consideration the transplantectomy timing and the treatment outcomes.Conclusion. The Case Report shows the need for immediate transplantectomy in a kidney graft recipient when local purulent complications are detected with confirmed primary infection of the graft due to a high risk of the rapid development of sepsis and threat to life.

Background: C-reactive protein (CRP) is a commonly determined biomarker of inflammation and may reflect the progression of a vascular disease. CRP values within 12 to 24 hours of stroke symptom onset are an independent predictor of adverse functional outcome in terms of the level of motor recovery in the first year of follow-up. Objective: This study aims to provide a complementary analysis of the scientific literature and critically review studies on the use of CRP as a potential biomarker associated with stroke and affecting the achievement of neurorehabilitation progress in post-stroke patients. Methods: This critical review of the literature was prepared based on the following inclusion criteria: (1) original research, (2) studies indexed in PubMed, Scopus and PEDro databases, (3) full-text articles in English, (4) papers published in 2012 – 2022, and (5) papers addressing the use of PCR assay as a biomarker of rehabilitation effectiveness. Results: Based on a review of PubMed, Scopus and PEDro databases, 47, 56 and 9 papers, respectively, were selected based on precisely selected keywords and included in full for further full text review. In this review, the most important scientific rationale was included in response to the aim of this paper. Summary: Recognition of the role of inflammatory and immunological factors in the development of atherosclerosis and the occurrence of ischaemic stroke provides scope for the search for new methods of stroke risk assessment and the development of new methods to prevent stroke. Further empirical validation and unequivocal demonstration of the levels of CRP as a potential marker that affects the health status of a post-stroke patient are needed to ensure the greatest possible level of motor recovery and ability to function independently in terms of all activities of daily living.

INTRODUCTION: Retinoids are a broad group of natural and synthetic compounds derived from vitamin A. Many studies have shown strong anti-aging effects, and they have also been shown to have therapeutic effects on acne vulgaris or psoriasis. Vitamin A and its derivatives make the skin more elastic and smooth, cause a decrease in fine wrinkles and cause an increase in fibroblast activity and collagen fiber production. Retinoid compounds regulate biological processes of the skin such as immune processes, angiogenesis, proliferation and differentiation. THE AIM OF STUDY: The purpose of this paper is to discuss the effects of retinoids and the use of the substances in skin diseases. MATERIALS AND METHOD: Literature review of PubMed, Google Scholar and Science Direct and evaluation of available randomized controlled trials using retinoids in terms of treatment effectiveness in terms of skin quality, anti-aging benefits use in dermatology. CONCLUSIONS: Vitamin A and its derivatives plays an important role in anty-aging prevention and treatment of skin diseases, such as acne vulgaris, psoriasis and photo-aging. There are still many ongoing studies and not known opportunities of its use to treat other skin diseases that we should be aware of and keep track of new papers that indicate such.

Introduction and purpose: The aim of artificial sweeteners is to replace the sweetness of sugar without contributing to the higher energy consumption or unfavorable metabolic effects conventional sugar causes. Synthetic sweeteners - one of the most popular groups - are labeled as safe for use in foods and represented by acesulfame K, aspartame, neotame, saccharin, sucralose, cyclamate and advantame. Although they underwent safety procedures, their possible unbeneficial effects are still being evaluated. In this paper we focus on their impact on the gut microbiome. Brief description of the state of knowledge: For now, the advantage of search conducted on animals is observed. Those papers show the possibility of a relationship between artificial sweeteners and composition of the gut microbiota. Changes that were observed affected the gut microbiota in a negative way as they may be responsible for causing disbalance in the conglomerate of microorganisms. Studies on humans are limited. Long term consumption of acesulfame K and sucralose is linked with modulation of the composition of the microbiota. It has also been shown that synthetic sweeteners are able to increase the ability of bacteria to form a biofilm. Conclusions: Heretofore published paperworks about the impact of synthetic sweeteners on the gut microbiota are not sufficient to conduct valuable and unambiguous conclusions. Evidence collected until now is leading to a deduction that gut microbiota can be affected by the consumption of the sugar surrogates although more data is needed to clearly determine their possible role.

During the autumn season, it is common for mushroom pickers to eat poisonous mushrooms. This is due to many reasons, including the ignorance of pickers. The most common is the misidentification of inedible species as edible mushrooms. The result is poisoning, which in many cases requires hospitalization. This paper presents a case report of toadstool poisoning by a 62-year-old female patient. In addition, other relevant publications on intoxication, diagnostic methods and treatment are reviewed. The purpose of this paper is to present the management and treatment of a case of toadstool poisoning. The effects of mushroom poisoning can range from mild disorders, mainly gastrointestinal to organ failure and even death. Significant elevations of liver enzymes and prothrombin time are important in laboratory tests in cases of intoxication. Treatment most often involves specific antidotes, such as Sylimarin, Acetylcysteine. The diagnosis in most cases is made on the basis of the clinical picture and a thorough interview with the patient, and the diagnosis is established by detecting toxins in a urine test. The prognosis is better if patients with toadstool poisoning are admitted to the hospital early. It is worth noting that gastrointestinal syndromes can also result from eating raw or inadequately cooked mushrooms, and by eating them excessively or too often. Proper diagnosis and treatment of mushroom poisoning can save lives. It is very important to raise public awareness of mushroom poisoning, as well as early detection of potential signs of intoxication. Cooperation with the poison center and mycologists is very important, especially in high-risk cases.

The paper is devoted to the issue of assessing the range of inclusive teacher competencies by the pedagogical community and their comparative significance for achieving the required learning results by students with disabilities. The paper presents the results of an empirical study aimed at identifying the general and specific in assessing the importance of inclusive competencies of a teacher by various subjects of staffing the inclusive educational process at school. The study involved 983 pedagogical workers employed in mass and correctional schools, as well as in pedagogical universities. They were asked to assess the significance of a set of indicators of the competence of an inclusive teacher, obtained on the basis of an analysis of the texts of 59 approximate basic educational programs for the training of future specialists in the field of inclusion. The results of the study demonstrated that a holistic assessment paradigm has not been formed in the pedagogical community in relation to the inclusive competencies of a teacher, which is expressed in the divergence of the corresponding assessment positions of university teachers who train teachers, teachers of mass and special schools. This confirms the need for further development of the model of inclusive competence of a teacher, its empirical verification and subsequent implementation in educational programs of continuous teacher education in accordance with the rapidly changing conditions of professional activity of teachers in an inclusive school.

This paper studies the effect of Mandarin proficiency on poverty reduction and its mechanism. The China General Social Survey (CGSS) is taken as the data source. From the perspective of social integration, the poverty reduction effect of Putonghua and its mechanism are empirically studied from the perspective of social interaction, social fairness, and social trust. The findings showed that improving the ability to listen and speak Mandarin positively affects social interaction, social trust, and social fairness. It showed that Putonghua proficiency positively correlates with the suppression of economic poverty. After the occurrence of poverty, whether a sample of absolute poverty or relative poverty, the ability to listen and speak in Mandarin has a specific inhibitory effect on social interaction, social trust, and social fairness. After the occurrence of poverty, the frequency of social interaction, social trust, and social public since have been reduced to a certain extent. Specifically, the ability to express Mandarin has shown remarkable results in improving social interaction, and the ability to listen among ordinary people has shown remarkable results in enhancing social fairness. The results of this paper provide empirical evidence of poverty alleviation in China via Improving Mandarin Proficiency. This research is also of great significance for optimizing poverty alleviation paths through language in the post-poverty alleviation era.

The present paper explores the methods for effective mastering the past tense relying on an activity-based approach following the Common European Framework of Reference for Languages. The aim of the research is to facilitate the teaching and revising the grammar material on the past simple (indefinite) tense, the past continuous (progressive) tense, and the past perfect tense in the process of training undergraduates, Ph.D. students, academic and clinical teachers at a medical university. The results of the research have been integrated into the 1st edition of “Medical English for Academic Purposes” (2018) and “Medical English for Public Health Purposes” (2021). The authors developed the methodological mechanisms to support courses in professional English at higher medical educational institutions through an activity-based approach, which ensures the effective acquisition of a foreign language, promotes the formation of a linguistic personality capable not only of communicating in all areas, but also of successful integration into the international community. The paper provides a wide range of scaffolding activities and methods: using visuals (graphic organizers, charts, etc.), selecting historically meaningful texts, peer-to-peer talk, strategic pairings, “real-life tasks” and modelling situations, the “fishbowl” model and others. The suggested methodological algorithm is feasible for both oral and written communication, reading and listening comprehension activities, group work, individual and self-directed work in class, as well as for in-class or self-paced learning, depending on the features of the curriculum and students’ English proficiency. The receptive aspect of teaching is represented by read-and-translate exercises, targeted texts describing significant events in the history of medicine, as well as true-false exercises to check students’ comprehension. Meanwhile, the reproductive aspect of teaching covers exercises involving opening the brackets, filling the blanks, as well as creating negative and interrogative forms of verbs. Eventually, the productive aspect of teaching is ensured by a wide range of creative speaking and writing activities and “real-life tasks”, aimed at developing students’ communicative competence in English for Professional Purposes (in-class speaking activities (peer-to-peer talk, class discussion). In addition, collecting family history is yet another pragmatically feasible task to revise and study past tenses. The application of an activity-based approach to teaching the past tenses at a medical university is highly effective to foster essential job-related skills, experience and professional readiness. The authors believe that this, in turn, will promote academic mobility and scientific cooperation, thus contributing to the development of higher medical education in Ukraine, which renders the research relevant.

The main goal of the current overview is to assess major trends in studying of fine motor skills neurobiology.Materials and techniques. PubMed (MedLine), Embase databases have been used for Information search. Search depth is 5 years (2016 – 2021). 12 papers that are more relevant to the topic have been chosen from the primary paper array (n=49). MAXQDA (Verbi Software GmbH, Germany) has been used for content analysis.Results and discussion. The current state is characterized by interdisciplinary integration using both complex experimental laboratory models and modern bionic and information technologies.Conclusion. Contemporary trends in the problem studying is the widespread utilization of information technologies and the development of approaches to neurorehabilitation with motor deficiency consideration. Fine motor skills recovery in patients with CNS lesions requires further interdisciplinary integration.

Preparation of a product file (PF) for a biomedical cell product (BCP) is an important stage in the preparation of documents for marketing authorisation. The PF is the main document of a regulatory submission and is used as the basis for BCP quality control. The requirements for the content of a PF, including appropriate specifications, are laid out in the relevant laws and regulations that support Federal Law No. 180-FZ “On Biomedical Cell Products” of 23.06.2016. However, given the novelty of the Russian legislative framework for innovative products for human use represented by BCPs, the specificity of their composition (i.e., components based on viable human cells) which differs significantly from conventional medicines, and lack of marketing authorisation experience— there is a need to examine specific aspects of a BCP PF. The aim of the study was to formulate methodological approaches to the development and preparation of a BCP PF in accordance with the national legislation and taking into account the experience of foreign regulatory authorities in evaluation of regulatory submissions for BCP analogues. The paper summarises the national regulatory requirements for the description of quality characteristics of cell lines used as components in BCPs, as well as test methods and test procedures used for cell line quality control. These data are required both for quality control of BCP samples, and for preparation of the Expert Commission Conclusion. The paper looks into the content of cellular and process-related impurities in a cell line and a finished BCP, and presents considerations on the description of the viral safety strategy for the finished product and for the cells from the master and working cell banks. The approaches to the presentation of quality characteristics and quality control methods for a finished BCP and for the cell line used in its production could be used by BCP developers for preparation of a PF.

Typhoid fever is an acute infectious disease caused by Salmonella enterica subsp. enterica serovar Typhi (S. Typhi), which is still extremely common in endemic low- and middle-income countries of Asia and Africa. Industrialised countries may also be affected by typhoid fever outbreaks due to booming international tourism, and natural disasters. Given S. Typhi progressive resistance to antibiotics, high epidemiological burden, and lack of adequate sanitation and hygiene in a number of regions, the introduction of new treatment protocols and the improvement of preventive vaccination are critical tasks in global healthcare. The aim of the study was to highlight the main historical aspects of the typhoid vaccine development, to summarise data on the licensed vaccines and promising approaches to the development of new typhoid vaccines. The paper describes the current epidemiological situation of typhoid fever globally and in the Russian Federation. It dwells upon the global experience in typhoid vaccine development from the production of an inactivated vaccine to the development of conjugated vaccines. The paper summarises data on Russian and foreign-made typhoid fever vaccines currently available in the global pharmaceutical market. It outlines the main trends in the development of vaccines against the disease caused by S. Typhi. The paper demonstrates the need for improving the efficacy of existing vaccines and development of new typhoid combination vaccines.

Reconstruction of the anterior cruciate ligament (ACL) is a fairly successful surgical intervention that can achieve satisfactory results in 75-97 % of cases. In order to show the main categories of factors that can affect the functional outcomes of patients after ACL reconstruction and lead to unsatisfactory outcomes after surgery based on the literature data, we have run a search for English- and Russian-language publications in the electronic databases PubMed and RSCI for the period from 2000 to 2019 using the keywords: anterior cruciate ligament, ACL, revision, re-reconstruction, re-injury, re-rupture, graft failure. Out of 634 papers, 113 publications with the full text were selected. Inclusion criteria - more than 50 cases in the report; follow - up period of more than 2 years; the same groups of patients; assessment of knee joint function; application of various imaging options for the knee joint. 26 papers were included in this review. Based on the analysis of the multiple causes of failed ACL reconstruction outcomes were merged into four main groups: technical mistakes diagnosis and surgery (from 22 % to 79 %); re-injury (18 % to 79 %); biological factors (violation of the integration of the graft and its ligamental) (17 %); errors of rehabilitation and other (15 %). Thus, the review made it possible to systematize the causes of unsuccessful outcomes of ACL reconstruction and identify the most frequent.

The paper dwells on methodical approaches that provide implementation of provisions fixed by the Federal Law No. 248 «On state control (surveillance) and municipal control on the Russian Federation» that comes into force on July 01, 2021. The Law has strengthened the significance of a risk-oriented model for control and stressed the necessity to assess surveillance efficiency as per criteria related to minimizing risks for protected values and to enhance digitalization and electronic communication between all the concerned parties in the sphere. Taking into account more specific list of objects that are subject to control fixed in the Law, we suggest a procedure for determining categories of health risks caused by specific industrial objects combined with determining a risk category for an economic activity performed by an economic entity. Risk is assessed as a combination of a probability that obligatory requirements are violated and severity of outcomes that result from such violations. The procedure allows optimal planning of control and surveillance activities regarding enterprises and organizations that perform their activities on multiple industrial sites (network companies, large holdings, etc.). We also considered an approach to creating dynamic risk-oriented checklists and suggested specific ranking for sanitary-epidemiologic requirements that were included into such checklists basing on frequency and history of violations that were committed by an object under surveillance regarding legislative requirements and risks that damage to health might occur due to such violations. The paper contains a description of methodical approaches to creating a statistic risk profile for an object under control. Creating a risk profile with mathematical procedures for data processing (including neural network modeling) allows achieving more qualitative risk detection, drawing up a maximum targeted program for a control activity, and operative reacting to types of violations that have not occurred previously. The paper describes a principle way for introducing forms and procedures for distance control into the sanitary-epidemiologic surveillance system. It is shown that efficient distance control should be based on digitalized documents required during control and surveillance activities; maximum possible use of data taken from state, municipal, and other data sources; intensified practices of remote hardware control; as well as development and scientific and methodical support provided for an intellectual information system within control and surveillance activities.

Prophylaxis against edema involves the removal of excess lymph fluid from a specific area of the body. The presence of lymph accumulation, is a sign of abnormalities in the functioning of the lymphatic system, which has lost the ability to properly transport lymph. Swelling otherwise known as lymphedema is among the chronic diseases that adversely affect the functioning of human systems. Lymphedema is one of the most common disorders of the lymphatic system. Its correct function is to drain lymph into the lymphatic vessels, and from there it travels to the lymph nodes. Its malfunction is the failure to drain the lymph into the lymphatic vessels or the lymph nodes. As a result of the abnormal lymph circulation, swelling usually occurs in the lower and upper extremities. The swelling at first appears to be painless, but over time it becomes hard thus reducing the functional capacity of the limbs. Over time, the skin and subcutaneous tissue can become infected, which can affect the formation of a cancer such as lymphosarcoma. Increasingly, so-called dynamic Plastering is being used to assist and alleviate lymphedema. Kinesiology Taping (KT) otherwise known as dynamic patching enables the reduction of swelling by elevating the skin, thus increasing the surface area between the skin and fascia. This results in body fluids having more room to flow freely to the lymph nodes, and this reduces our swelling and lymph accumulation in the extremities.[2] The purpose of this paper is to show the use of Kinesiology Taping to reduce lymphedema. The paper is based on a review of articles in reputable journals from past years.

Chronic diseases of the osteoarticular and muscular system belong to a group of health problems that lead to a limitation of the organism's efficiency, making it difficult or impossible for individuals to function normally. Of the forms of treatment used for chronic diseases of the osteoarticular system, rehabilitation is by far the most common. These activities are mainly financed by the National Health Fund, as well as by social insurance. A complementary role is played by local governments that finance medical rehabilitation for their residents in the form of health policy programmes, implemented as public health tasks. An important argument in favour of rehabilitation at the self-governmental level is the long waiting time for medical rehabilitation services financed by the National Health Fund. The aim of the paper was to show the role of local government in increasing access to therapeutic rehabilitation services for patients with musculoskeletal diseases. The paper discusses such issues as the importance of musculoskeletal diseases for the efficiency of individuals, organization and financing of guaranteed services in curative rehabilitation, as well as increasing access to these services at the local government level.

The aim of this paper was to prove the relationship between motor skills and anthropometric characteristics as a predictive system with effectiveness and results in running the discipline at 400 meters as situational-motor variables of the criteria system. The research was done by testing 60 samples of men 18 years old, ± 6 months, of the Faculty of Physical Education and Sports in Prishtina. Regarding the anthropometric variable, bigger correlation has been shown by the variable dermal tipple of the arm (AMTP) which correlate positively with running in 400 meter, from which we can conclude that the fullest in the upper limbs are students, the more slowly realize running in the 400 meters and conversely. The measurements were executed during September in the hall of the Faculty, in 400 meter runs in the stadium "FadilVokrri" Prishtina. The only condition that was used during the determination of the sample was: that the students are involved in regular physical education classes (and on the day of the measurement be healthy, without the flu, cold or other symptoms). The variables which are applied in this research have been 8 anthropometric variables and 1 motor-specific variables. The results obtained after their processing indicate that the impact of anthropometric variables is higher in running 400 meters. Short distance running and long distance running reduces the impact of anthropometric parameters whereas the influence of metabolic factors of energy production is increased. These results were also confirmed using regression analysis, so that groups of predictors of anthropometric characteristics, specific motor skills that statistically significantly influenced each variable of individual criteria. The results obtained from regression analysis indicate that in the variable 400 m running from low start (MV400MU) does not affect any anthropometric variables applied.We can emphasize that the test (F-test) is more valuable if the multiple correlation is greater, in the concrete case of this paper is significant (Sig = 0.645), because the value of the F-test is = 0.753.

Surgery of meningiomas of the posterior cranial fossa, due to its small volume and close anatomical relationship of neoplasms with the brain stem, cranial nerves, main arteries and venous collectors, remains one of the urgent problems of neurooncology. Despite the improvement of microsurgical techniques and neurophysiological control, maintaining a high level of quality of life after radical removal of meningiomas is still far from desired. Purpose of the study. Retrospective analysis and generalization of clinical results of surgical treatment of patients with meningiomas of the posterior cranial fossa. Material and methods. The paper analyzes the results of surgical treatment of 101 patient with meningiomas of the posterior cranial fossa of various localization (80 women (79.2 %) and 21 men (20.7 %), age 58.26 ± 1.00 years). According to the localization of meningiomas, they were distributed as follows: convexital – 49 (48.5 %), cerebellopontine angle – 22 (21.8 %), jugular foramen – 4 (4 %), petroclival – 16 (15.8 %), foramen magnum – 10 (9.9 %). Results. All patients underwent surgical removal of the formation. In 99 (98 %) one-stage and in 2 (1.9 %) cases of additional surgical intervention, in the form of external drainage according to Arendt and ventriculoperitoneal shunting, due to frolicking liquorodynamic disorders. Radical removal of meningioma (grade I according to Simpson scale) was achieved in 72 (71.3 %) of cases, tumor resection with coagulation of the tumor matrix zone (Simpson II) – in 21 (20.8 %), removal without resection and coagulation of the matrix, or leaving the extradural component of meningiomas (Simpson III) – in 8 (7.9 %). Conclusions. The results obtained on the basis of the complex use of modern neuroimaging diagnostic tools, microneurosurgery, optimal surgical approaches in combination with the mandatory intraoperative physiological control of the function of the brain stem and cranial nerves in the early postoperative period indicate an improvement in the functional state, and sometimes complete regression of the neurological symptoms in 58 (57.4 %) of operated patients. Complete regression of symptoms and restoration of the functional state was achieved in 30 (29.7 %) of cases, deterioration was noted in 17 (16.8 %) of the operated patients, mortality was 4.95 % (n = 5).

Background. Functional processes in the female organism at the stage of reproductive function failure in menopause attract considerable interest of researchers. The paper presents a study of great medical, biological and social importance into reproductive function failure in women living in the territories with permanent military operations for a long time and, thus, suffering from post-traumatic syndrome, which significantly affects the character of menopause. Objectives. To identify the features of menopausal syndrome in women who have been living under chronic stress (6–8 years) in the zone of ongoing military operations, namely in the Donetsk and Luhansk People’s Republics, and in women from Rostov Oblast — the region free from active military operations.Methods. An observational cohort study involved 60 women (refugees), long-term residents of the territories with ongoing military operations and 60 long-term residents of the territories without military operations, aged 50–65 years, with clinical manifestations of menopausal syndrome; all women were patients of the Research Institute of Obstetrics and Pediatrics, Rostov State Medical University. In accordance with the Stages of Reproductive Aging Workshop (STRAW+10) classification and clinical manifestations of menopause, two clinical groups (n = 30) were formed from the representatives of each region of residence. Group I included 30 women, aged 50–55, from the Donetsk and Luhansk People’s Republics, who had late menopausal transition (stage -1 of STRAW+10) and menopausal syndrome. Group II involved 30 postmenopausal patients (stages +1 and +2 of STRAW+10), aged 60–65, with menopausal syndrome. Group 1 enrolled 30 residents of Rostov Oblast, aged 50–55, who had late menopausal transition (stage -1 of STRAW+10) and menopausal syndrome, group 2 included 30 postmenopausal patients (stages +1 and +2 of STRAW+10), aged 60–65, with menopausal syndrome. Modified menopausal index was considered as the main indicator of the study. Statistical data processing was carried out by means of Statistica 10.01 (StatSoft, USA), Microsoft Excel 2010 (Microsoft, USA), IBM SPSS 24.0 (IBM, USA), and MedCalc (MedCalc Software, Belgium).Results. Long-term female residents of the territories with ongoing military operations were reported to develop menopausal syndrome more often. Rostov Oblast female residents in the late menopausal transition revealed a statistically significant prevalence of a mild degree of menopausal syndrome in 63.3 % of cases compared to 36.7 % of a similar severity of menopausal syndrome in residents of the Donetsk and Luhansk People’s Republics. Meanwhile, women from the Donetsk and Luhansk People’s Republics were indicated with moderate menopausal syndrome in 50.0 % of cases in late menopausal transition and severe syndrome in 33.3 % in postmenopause versus 23.4 % and 10 % of women from Rostov Oblast, respectively. The intensity of neurovegetative and psycho-emotional disorders in women of both regions increases with the aging process of the reproductive system and appears most pronounced in the postmenopausal period.Conclusion. Residents of the Donetsk and Luhansk People’s Republics, who live in the war zone and are exposed to constant threat to life, develop post-traumatic syndrome which significantly intensifies and modulates the already existing functional and hormonal restructuring in the brain subsystems during perimenopause. Non-uniform functional shifts at different levels of the central nervous system under conditions of chronic stress lead to a significant change in intracerebral processes and to an increase in the occurrence and severity of various dysfunctional deviations.

Introduction. Given the ongoing war in Ukraine, innovative solutions are needed to ensure students’ access to quality education. This paper explores the benefits of applying a Learning Management System (LMS) at a medical university in Ukraine. The aim of the study was to evaluate the results of the implementation of the educational platform in the educational process of the second educational level (master's degree) in the specialty 221 Dentistry on the example of the educational component «Propedeutics of Internal Medicine». Materials and methods. Using Moodle, we developed a training course for an Introduction to Internal Medicine for dental students. The student population consisted of 54 2nd-year students and 77 3rd-year students. The student academic performance during the academic years 2021-22 and 2022-23 was analysed statistically. We also conducted a questionnaire-based survey to assess student satisfaction. Results. The study found that the end-of-module assessment scores in the 2nd year of study significantly increased in the 2022-23 academic year. A questionnaire survey found that most students were familiar with the subject, were satisfied with the forms and methods of teaching and considered that they had sufficient information and support to achieve the expected learning outcomes. Discussion. The use of the LMS helped control the negative impact of the war on education. The introduction of the LMS into the dentistry curriculum has ensured the quality of education, improved academic performance, and allowed for a more accurate assessment of student knowledge.

This study explores the impact of ozone treatment on a 0.05% chlorhexidine gluconate solution, focusing on potential changes in molecular structure and corresponding crystallographic transformations at the regularity level following the completion of the wedge dehydration process. The aim of this study is to assess the effect of ozone treatment on a 0.05% chlorhexidine solution, especially focusing on determining the optimal time for ozonation process performance and the period of its effect duration based on the results of crystallography. The methodology employed involves an open-air thesis and subsequent microscopic examination of crystal formation results. The ImageJ software (Wayne Rasband, USA) was applied to study morphological changes in the crystal formation process through a structured algorithm of sequential actions. Micrograph analysis led to the identification of five characteristic crystal morphotypes, which can be categorized based on the increasing complexity of crystal element shapes. Result. The study explored the potential application of ozonated chlorhexidine in dental protocols. This paper presented a comprehensive analysis of the general crystallographic characteristics of chlorhexidine in a 0.05% solution, demonstrated changes in crystallograms found in samples of ozonated chlorhexidine, investigated the impact of ozone treatment time on crystal formation features, as well as explored the duration of the ozonation effect on 0.05% chlorhexidine gluconate solution based on crystallographic results. Conclusions. Ozone treatment of a 0.05% solution of chlorhexidine bigluconate changes the process of crystal formation towards its activation, promotes the clustering of small crystals, the formation of crystals of the second type and the development of complex structures. These morphological changes lead to a decrease in the fractal index of crystals. Changes in the fractal index remain noticeable for 7 days after ozone treatment, indicating that the activation of crystal formation is irreversible. This opens up the possibility of using a solution of ozonated chlorhexidine 0.05% in dental protocols.