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Diffuse large B cell lymphoma (Diffuse Large B-Cell Lymphoma = DLBCL), the most common type of non-Hodgkin lymphoma (NHL) is characterized by a great heterogeneity in terms clinico-evolutionary and molecular histology. We present results of a study of 98 patients diagnosed and treated for DLBCL. Two thirds of patients from urban areas (61.2%), with a predominance of males (M = 63.4%, F = 36.6%), with a ratio M/ F = 2/1. Median age was 61.5 years, half of the subjects with ages between 48.75 and 71.15.3% of patients in the study group at diagnosis associated viral infections, most type hepatitis (HCV- 46.7%, HBV- 33.3%). Extranodal determinations were highlighted in a third of patients, the most common being the bone marrow, the circle Waldayer, stomach, pleuro-pulmonary, soft tissue, bone, brain, etc.. Factors that adversely influenced survival were advanced clinical stage at diagnosis (median survival reached after 54 months compared to 82 months in cases diagnosed in the early stages, this symptom B (correlated with disease relapse P = 0.058), presence of extranodal determinations (median survival of 25 months compared with 33 months in their absence), high levels of serum LDH (P = 0.010), Ki67 proliferation index > 70% (correlated with elevated LDH, P = 0.05) and phenotype of non-germinal center proliferation of tumor (median survival was reached after 48 months compared with 86 months in cases of DLBCL with germinal center phenotype). Association of monoclonal antibodies to PCT significantly improved (P = 0.01) obtaining RC study group. NHL DLBCL remains a group characterized by a great diversity aspect that determines the need to identify new prognostic factors and impact of new therapeutic targets. [ABSTRACT FROM AUTHOR]

Eosinophils from patients with peripheral blood eosinophilia due to a spectrum of underlying causes (i.e. parasitic diseases) appear to be different than the ones from normal individuals with respect to a variety of parameters including morphological abnormalities. We evaluated morphological changes in peripheral blood eosinophils from patients with severe trichinosis in muscular phase. Abnormalities of the nuclei, cytoplasm vacuolation, degranulation and increased size were found and represent signs of eosinophil activation. [ABSTRACT FROM AUTHOR]

Hairy Cell Leukemia is a chronic B cell disorder, it is charactherized by the presence of typical Hairy cells in the perypheral blood and marrow, pancitopenia and a variable degree of splenomegaly. The standard therapy consists of the nucleosides analogs dCF (2'deoxycoformicyn) and CdA (2-chlorodeoxy-adenosine), wich produce complete and durable remissions in the majority of patients. Splenectomy may still be used for HCL in the under specific circum-stances. Molecular diagnosis-PCR (Polimerase Chain Reaction) is more sensitive than Flowcytometry in detecting the Minimal residual disease. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC) correlated with HBV infection is the 2nd cancerous death cause, after smoking. HBV increases HCC risk 200 times. Hepatocellular carcinoma associated with hepatic cirrhosis appears with an annual risk of 2-5%, but the HBV infected persons may also evolve towards HCC with an anual risk of 0,5%. (47, 48) Extrahepatic chronic diseases associated with HBV and HCV infection belong mainly to the autoimmune diseases and chronic lymphoproliferative syndromes. HBV infection prevalence to the patients with malignant non-Hodgkinian lymphoma (MNHL) ranges between 3-30%. HCV infection prevalence in patients with NHML B cell or other cronical limfoprolifertions ranges between 8-32%. [ABSTRACT FROM AUTHOR]

Many malignant disorders can induce hematological features that perfectly mimic a hematologic disease. We present the case of a 45 years old female patient in which although the preliminary investigation suggested the diagnosis of erythroleukemia, the more detailed subsequent assays revealed that the hematological picture was the consequence of another neoplastic disease. [ABSTRACT FROM AUTHOR]