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1. Avaliação laboratorial da toxicidade molecular em eritrócitos talassêmicos

Author

Naoum, Paulo Cesar, Querino, Sheldon S. S., Cury, Nathália M., Toledo, Cristiane G., and Naoum, Flávio Augusto

Subjects
molecular toxicity, hemic and lymphatic diseases, Beta thalassemia, methemoglobin, superoxide dismutase
Abstract

Oxygen-derived free radical damage is associated with the molecular toxicity of hemoglobin. Especially in thalassemia syndromes, this toxicity has a relationship with "free" alpha globin concentrations. This study of beta thalassemia trait blood samples from 39 individuals shows that the evaluation of methemoglobin is a sensitive method of indicating molecular toxicity and the superoxide dismutase concentration revealing the intensity of oxidative stress of this process.

Published
2006

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