Avaliação laboratorial da toxicidade molecular em eritrócitos talassêmicos

Authors :: Naoum, Paulo Cesar
Querino, Sheldon S. S.
Cury, Nathália M.
Toledo, Cristiane G.
Naoum, Flávio Augusto
Source :: Revista Brasileira de Hematologia e Hemoterapia, Volume: 28, Issue: 4, Pages: 301-302, Published: DEC 2006
Publication Year :: 2006
Publisher :: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2006.
Abstract: Oxygen-derived free radical damage is associated with the molecular toxicity of hemoglobin. Especially in thalassemia syndromes, this toxicity has a relationship with "free" alpha globin concentrations. This study of beta thalassemia trait blood samples from 39 individuals shows that the evaluation of methemoglobin is a sensitive method of indicating molecular toxicity and the superoxide dismutase concentration revealing the intensity of oxidative stress of this process.

Subjects :: molecular toxicity
hemic and lymphatic diseases
Beta thalassemia
methemoglobin
superoxide dismutase

Language :: Portuguese
Database :: OpenAIRE
Journal :: Revista Brasileira de Hematologia e Hemoterapia, Volume: 28, Issue: 4, Pages: 301-302, Published: DEC 2006
Accession number :: edsair.od.......608..70825fdf36e2b0462f2648a5bbd9529a

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