1. [Evaluation of the prognostic significance of P53 mutation in patients with non-small cell lung cancer].
- Author
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Jassem E, Rosell R, Jassem J, Monzo M, Kobierska G, Badzio A, Roszkiewicz A, Skokowski J, and Szulc A
- Subjects
- Adult, Aged, Base Sequence, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung surgery, DNA, Neoplasm analysis, Female, Humans, Lung Neoplasms mortality, Lung Neoplasms pathology, Lung Neoplasms surgery, Male, Middle Aged, Mutation, Neoplasm Staging, Prognosis, Survival Rate, Carcinoma, Non-Small-Cell Lung genetics, Genes, p53 genetics, Lung Neoplasms genetics
- Abstract
Prognostic value of p53 gene mutation was determined in 95 radically operated non small cell lung cancer patients (78 males and 17 females, mean age 57.8 years). Study group included 62 cases of squamous cell carcinoma, 30--adenocarcinoma and 3--large cell carcinoma. There were 52 patients in stage I disease, 16--in stage II, 26--in stage IIIa and one--in stage IIIb. Paraffin-embedded samples of resected tumors were assayed for p53 mutations with the use of PCR/SSCP analysis. p53 mutation were present in 22 cases (23%). The median survival in patients with and without p53 mutations were 49 and 75 months (p = 0.46), respectively, and the five-year survival rate 53% and 50%, respectively. In stage I disease the median survival for patients with p53 mutation was 53 months and for those without mutations the median survival could not be determined as more then a half of them were alive. Median survival in stage II patients with and without mutations was 35 months and 44 months (p = 0.62), and in stage IIIA--9.5 months and 17 months, respectively (p = 0.37). The results of this study indicate that p53 gene mutation is not correlated with prognosis in non-small cell lung cancer patients.
- Published
- 1998