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[Evaluation of the prognostic significance of P53 mutation in patients with non-small cell lung cancer].
- Source :
-
Pneumonologia i alergologia polska [Pneumonol Alergol Pol] 1998; Vol. 66 (5-6), pp. 290-6. - Publication Year :
- 1998
-
Abstract
- Prognostic value of p53 gene mutation was determined in 95 radically operated non small cell lung cancer patients (78 males and 17 females, mean age 57.8 years). Study group included 62 cases of squamous cell carcinoma, 30--adenocarcinoma and 3--large cell carcinoma. There were 52 patients in stage I disease, 16--in stage II, 26--in stage IIIa and one--in stage IIIb. Paraffin-embedded samples of resected tumors were assayed for p53 mutations with the use of PCR/SSCP analysis. p53 mutation were present in 22 cases (23%). The median survival in patients with and without p53 mutations were 49 and 75 months (p = 0.46), respectively, and the five-year survival rate 53% and 50%, respectively. In stage I disease the median survival for patients with p53 mutation was 53 months and for those without mutations the median survival could not be determined as more then a half of them were alive. Median survival in stage II patients with and without mutations was 35 months and 44 months (p = 0.62), and in stage IIIA--9.5 months and 17 months, respectively (p = 0.37). The results of this study indicate that p53 gene mutation is not correlated with prognosis in non-small cell lung cancer patients.
- Subjects :
- Adult
Aged
Base Sequence
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Non-Small-Cell Lung surgery
DNA, Neoplasm analysis
Female
Humans
Lung Neoplasms mortality
Lung Neoplasms pathology
Lung Neoplasms surgery
Male
Middle Aged
Mutation
Neoplasm Staging
Prognosis
Survival Rate
Carcinoma, Non-Small-Cell Lung genetics
Genes, p53 genetics
Lung Neoplasms genetics
Subjects
Details
- Language :
- Polish
- ISSN :
- 0867-7077
- Volume :
- 66
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Pneumonologia i alergologia polska
- Publication Type :
- Academic Journal
- Accession number :
- 9857649