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In vitro perfusions of the fetal part of 15 placentas were performed. An arterial system was singularly injected by 0.75 mg of PGE2 (Prostin-Upjohn). Persistent effect of a perfusion pressure increase reflecting the placenta vessels resistance was observed.

In this paper, basing on recently published data, the influence of growth factors on small intestine epithelium regeneration after irradiation is presented. Our knowledge of growth control in the small intestine mucosa may become an accepted mode of radio-, chemotherapy and the treatment of acute radiation sickness in the future. Results of recent studies suggest that there are different factors which can modulate the process of epithelium regeneration. Some of them such as gastrin, enteroglucagon, CCK, EGF, FGF, TGF and IL-11 are able to enhance this process. In addition, other factor-PGE-2 is responsible for not only stimulation of small intestine epithelium growth but radioprotection as well.

The influence of local intracervical application of PGE2 (Prostin E2-Upjohn) on collagenolytic activity as well as extracellular matrix components of human cervix during parturition has been analyzed. The content and extractability of collagen as well as concentration of glycosaminoglycans and hyaluronic acid were investigated. Since we did not find any statistical changes in DNP-peptide collagenolytic activity and investigated extracellular macromolecules of cervical connective tissue we presumed that cervical ripening after local prostaglandin application closely resembles that occurring spontaneously.

Physiological, experimental and theoretical aspects concerning haemopoietic inhibitors are reviewed. In the paper there are also discussed future research directions of this branch of haematology.