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During the autumn season, it is common for mushroom pickers to eat poisonous mushrooms. This is due to many reasons, including the ignorance of pickers. The most common is the misidentification of inedible species as edible mushrooms. The result is poisoning, which in many cases requires hospitalization. This paper presents a case report of toadstool poisoning by a 62-year-old female patient. In addition, other relevant publications on intoxication, diagnostic methods and treatment are reviewed. The purpose of this paper is to present the management and treatment of a case of toadstool poisoning. The effects of mushroom poisoning can range from mild disorders, mainly gastrointestinal to organ failure and even death. Significant elevations of liver enzymes and prothrombin time are important in laboratory tests in cases of intoxication. Treatment most often involves specific antidotes, such as Sylimarin, Acetylcysteine. The diagnosis in most cases is made on the basis of the clinical picture and a thorough interview with the patient, and the diagnosis is established by detecting toxins in a urine test. The prognosis is better if patients with toadstool poisoning are admitted to the hospital early. It is worth noting that gastrointestinal syndromes can also result from eating raw or inadequately cooked mushrooms, and by eating them excessively or too often. Proper diagnosis and treatment of mushroom poisoning can save lives. It is very important to raise public awareness of mushroom poisoning, as well as early detection of potential signs of intoxication. Cooperation with the poison center and mycologists is very important, especially in high-risk cases.

Copyright of Studia z Dziejów Panstwa i Prawa Polskiego is the property of Andrzej Frycz Modrzewski Krakow University, AFM Publishing Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper studies the effect of Mandarin proficiency on poverty reduction and its mechanism. The China General Social Survey (CGSS) is taken as the data source. From the perspective of social integration, the poverty reduction effect of Putonghua and its mechanism are empirically studied from the perspective of social interaction, social fairness, and social trust. The findings showed that improving the ability to listen and speak Mandarin positively affects social interaction, social trust, and social fairness. It showed that Putonghua proficiency positively correlates with the suppression of economic poverty. After the occurrence of poverty, whether a sample of absolute poverty or relative poverty, the ability to listen and speak in Mandarin has a specific inhibitory effect on social interaction, social trust, and social fairness. After the occurrence of poverty, the frequency of social interaction, social trust, and social public since have been reduced to a certain extent. Specifically, the ability to express Mandarin has shown remarkable results in improving social interaction, and the ability to listen among ordinary people has shown remarkable results in enhancing social fairness. The results of this paper provide empirical evidence of poverty alleviation in China via Improving Mandarin Proficiency. This research is also of great significance for optimizing poverty alleviation paths through language in the post-poverty alleviation era.

The main goal of the current overview is to assess major trends in studying of fine motor skills neurobiology.Materials and techniques. PubMed (MedLine), Embase databases have been used for Information search. Search depth is 5 years (2016 – 2021). 12 papers that are more relevant to the topic have been chosen from the primary paper array (n=49). MAXQDA (Verbi Software GmbH, Germany) has been used for content analysis.Results and discussion. The current state is characterized by interdisciplinary integration using both complex experimental laboratory models and modern bionic and information technologies.Conclusion. Contemporary trends in the problem studying is the widespread utilization of information technologies and the development of approaches to neurorehabilitation with motor deficiency consideration. Fine motor skills recovery in patients with CNS lesions requires further interdisciplinary integration.

The theme of the paper is the issue of fluency disorders, mediating the approach to a girl with cluttering. Cluttering, as a central speech disorder, can affect the entire personality of a person and his/her surroundings. Cluttering affects communication pathways, thus becoming a barrier to interpersonal interaction, and at the same time is an opportunity to explore support possibilities. The text offers the concept of Speech and Language Therapy in a girl of early school age, with regard to the analysis of semantic, syntactic and phonetic expressions. The paper illustrates the focus of the therapeutic process on the area of respiration, concentration of attention, structuring of speech and text work. Following identifiable difficulties, the case report captures the importance of cooperation with the girl and her mother.

Prophylaxis against edema involves the removal of excess lymph fluid from a specific area of the body. The presence of lymph accumulation, is a sign of abnormalities in the functioning of the lymphatic system, which has lost the ability to properly transport lymph. Swelling otherwise known as lymphedema is among the chronic diseases that adversely affect the functioning of human systems. Lymphedema is one of the most common disorders of the lymphatic system. Its correct function is to drain lymph into the lymphatic vessels, and from there it travels to the lymph nodes. Its malfunction is the failure to drain the lymph into the lymphatic vessels or the lymph nodes. As a result of the abnormal lymph circulation, swelling usually occurs in the lower and upper extremities. The swelling at first appears to be painless, but over time it becomes hard thus reducing the functional capacity of the limbs. Over time, the skin and subcutaneous tissue can become infected, which can affect the formation of a cancer such as lymphosarcoma. Increasingly, so-called dynamic Plastering is being used to assist and alleviate lymphedema. Kinesiology Taping (KT) otherwise known as dynamic patching enables the reduction of swelling by elevating the skin, thus increasing the surface area between the skin and fascia. This results in body fluids having more room to flow freely to the lymph nodes, and this reduces our swelling and lymph accumulation in the extremities.[2] The purpose of this paper is to show the use of Kinesiology Taping to reduce lymphedema. The paper is based on a review of articles in reputable journals from past years.

Chronic diseases of the osteoarticular and muscular system belong to a group of health problems that lead to a limitation of the organism's efficiency, making it difficult or impossible for individuals to function normally. Of the forms of treatment used for chronic diseases of the osteoarticular system, rehabilitation is by far the most common. These activities are mainly financed by the National Health Fund, as well as by social insurance. A complementary role is played by local governments that finance medical rehabilitation for their residents in the form of health policy programmes, implemented as public health tasks. An important argument in favour of rehabilitation at the self-governmental level is the long waiting time for medical rehabilitation services financed by the National Health Fund. The aim of the paper was to show the role of local government in increasing access to therapeutic rehabilitation services for patients with musculoskeletal diseases. The paper discusses such issues as the importance of musculoskeletal diseases for the efficiency of individuals, organization and financing of guaranteed services in curative rehabilitation, as well as increasing access to these services at the local government level.

Hallux valgus (HV) and hallux rigidus (HR) are common foot conditions that lead to deterioration of health status. This review aims to summarize and update information on the currently published research explicitly related to the influence of HV and HR surgeries on lower extremity gait biomechanics. A review of papers published from 1999 to 2020 has been conducted. The databases searched included Science Direct, PubMed Central, PubMed and EBSCO. After HV surgeries, most of patients’ spatio-temporal parameters remain the same as they were before them. Changes in plantar pressure parameters of the hallux region are inconclusive and depend on a study. In patients after HR surgeries, such as cheilectomy and Ist metatarsophalangeal joint (MTP I) arthrodesis, they do not affect knee or hip kinematics. The influence of MTP I arthrodesis on ankle joint kinematics is unclear. Cheilectomy in most cases increases MTP I motion in the sagittal plane. The HV angle and the intermetatarsal angle have significantly decreased after surgeries in all papers. American Orthopedic Foot and Ankle Society MTP–IP score results are also much better than their pre-operative values in patients after HV and HR surgeries. Surgical treatment decreases pain and allows patients to perform activities of daily living, but it does not normalize gait parameters. Further research on a large group of patients is needed to comprehensively assess kinetic, kinematic and plantar pressure parameters as well as muscle activity after HV and HR surgeries.

The aim of this paper was to prove the relationship between motor skills and anthropometric characteristics as a predictive system with effectiveness and results in running the discipline at 400 meters as situational-motor variables of the criteria system. The research was done by testing 60 samples of men 18 years old, ± 6 months, of the Faculty of Physical Education and Sports in Prishtina. Regarding the anthropometric variable, bigger correlation has been shown by the variable dermal tipple of the arm (AMTP) which correlate positively with running in 400 meter, from which we can conclude that the fullest in the upper limbs are students, the more slowly realize running in the 400 meters and conversely. The measurements were executed during September in the hall of the Faculty, in 400 meter runs in the stadium "FadilVokrri" Prishtina. The only condition that was used during the determination of the sample was: that the students are involved in regular physical education classes (and on the day of the measurement be healthy, without the flu, cold or other symptoms). The variables which are applied in this research have been 8 anthropometric variables and 1 motor-specific variables. The results obtained after their processing indicate that the impact of anthropometric variables is higher in running 400 meters. Short distance running and long distance running reduces the impact of anthropometric parameters whereas the influence of metabolic factors of energy production is increased. These results were also confirmed using regression analysis, so that groups of predictors of anthropometric characteristics, specific motor skills that statistically significantly influenced each variable of individual criteria. The results obtained from regression analysis indicate that in the variable 400 m running from low start (MV400MU) does not affect any anthropometric variables applied.We can emphasize that the test (F-test) is more valuable if the multiple correlation is greater, in the concrete case of this paper is significant (Sig = 0.645), because the value of the F-test is = 0.753.

Walker orthoses are one of the most popular substitutes to regular cast. They are used by people who have experienced acute trauma to the ankle complex. This review aimed to summarize and update information on the currently published research explicitly related to the application of ankle-foot orthoses and to help improve the understanding of how orthoses influence gait pattern, in particular the kinematics, kinetics, and muscle activity parameters. A review of papers published from 1999 to 2019 was conducted. The databases searched included PubMed Central, PubMed, ScienceDirect and EBSCO, a total of 546 articles were found. The review is based on 11 articles that were selected for further analysis. Kinematics parameters were described in 8 papers, kinetics parameters in 6 papers, the effect of a Walker orthosis on muscle activity in 2 papers, and the effects of a Walker boot on energy cost, pain and balance were discussed in 3 papers. A Walker orthosis significantly reduces ankle joint motion and significantly reduces lower leg muscle activity. On the other hand, it may cause secondary site pain due to leg length differences and increase in energy expenditure. A Walker orthosis is a useful tool replacing total contact casts and allowing earlier weight bearing and rehabilitation. It is important to use it for the shortest possible period of time and to always use compensation of leg length discrepancy.

Teresiński in his studies, both older ones, published in 2013 [1, 2] and the recent one from 2019 [3] as a follow-up to the earlier studies, discusses “acceleration” as a criterion of selective verification of the sequelae of whiplash injury. In principle, the approach outlined in the cited studies is correct, but it lacks an explicit definition of what precisely is meant by “acceleration”. In the 2013 papers, the author failed to give any indication as to what type of “acceleration” was discussed, while in his latest publication he stated that “acceleration” referred to the “acceleration of the centre of gravity of the vehicle in which the victim was travelling”, which is also an insufficiently precise definition. More detailed information on the topic can be found in the paper by Kędzierski [4], written from the perspective of an engineer and complementary to Teresiński’s study [3], which was published in the same issue of Archives of Forensic Medicine and Criminology, but the aspect is not highlighted enough among the abundance of information presented there.

Introduction. The development of pneumatic shooting has led to the construction of technologically advanced devices with discharge energies similar to those of firearms. The pneumatic weapons ammunition market offers a variety of shot which varies in penetration properties and the extent of gunshot damage. In view of the ease of „tuning” of air rifles, a study was conducted of the inlet damage to the anterior femoral surface after pneumatic gunshots. The paper shows the differences in damage parameters depending on the type of shot. Material and methods. In the study, Air Arms Hi-Power Xtra FAC cal. 5.5 mm and FX Bobcat Mk II cal. 6.35 mm pneumatic carbines were used and lead shot by Haendler&Natterman’s Spitzkugel type, Hollow Point and Baracuda cal. 5.5 mm and 6.35 mm, as well as lead-free shot Excite Apollo cal. 5.5 mm and Black Max Lead-Free cal. 6.35 mm. Measurements were taken of the extent of inlet damage to the anterior surface of the femoral shaft with X-ray and CT imaging. Results. HollowPoint shot caused the greatest range of gunshot penetration damage in both bone and periosteum, Apollo lead-free shot caused the least. At the same time, HollowPoint shot showed the greatest susceptibility to ricocheting. Conclusions: 1. The type of shot used influences diversified morphology of the holes and the nature of gunshot damage to the femoral shaft. The differences concern both the gunshot holes and the nature, course and extent of associated fractures. 2. The smallest inlet holes and damage to the periosteum with a regular shape are caused by gunshots with pointed and pointed tip pellets. The greatest extent of bone and periosteum inlet damage was observed in gunshots with Hollow Point type shot due to its predisposition to deformation and fragmentation. 3. Radio-imaging studies are a valuable complement to macroscopic visual assessment providing a useful value for identifying the type of shot used.

This paper presents the results of genetic testing in two cases of shared paternity between half-siblings. In the first example, the research was based on the analysis of half-siblings and their mothers with respect to 21 autosomal markers. In the second, the research was based on both the analysis of 30 autosomal markers and X chromosome markers in putative sisters and the mother of one of them. Selected examples are presented to illustrate how the use of different research strategies affects the outcome of the likelihood ratio and the ability to make inferences in complex kinship cases.

The present article deals with the possibilities of diagnosing social pragmatic communication disorder (SPCD), focusing on questionnaire methods, test methods and assessment scales. Abroad, diagnosis of this disorder is often done through a combination of interviews, questionnaires, rating scales, observations and other methods. The aim of this paper was to create an integrative overview, i.e. to summarise questionnaire methods, rating scales and test methods that are aimed at diagnosing pragmatic language. For this purpose, seven methods were selected that deal with the recognition of deficits in pragmatic language, developed between 1989 and 2023. The individual methods were evaluated in terms of age range, focus, content, norms, and time duration. These categories were followed for foreign diagnostic methods, since no materials of this type are yet available in the Czech Republic.

In this paper we discuss the InterACT - Attitude Change & Tolerance programme (Weidner, 2015) for preschool and younger school-age children, as well as the process of its adaptation into Polish (2019) and Slovak (2019-2023) languages. The programme builds on several research studies that have investigated children's attitudes towards stuttering and the possibilities of early exposure to relevant information about stuttering. Research has confirmed the need to address changing attitudes towards stuttering already at pre-school age. Statistically, the InterACT programme has been shown to be effective in improving children's attitudes toward stuttering and teaching how to appropriately interact with children with stuttering (Wesierska and Weidner, 2022). The programme is conceptualised in a way that it can be translated into other languages, with consideration of cultural contexts. As Slovakia is close in terms of language, culture and historical context to Poland, where the effectiveness of the programme is confirmed, we find the application of the results from their research relevant for Slovakia as part of speech therapy prevention and effective support of the process of anti-stigmatisation of stuttering.

Tethered oral tissues can be considered as an issue that belongs under the scope of many specialists, such as paediatricians, lactation consultants, dentists, speech therapists, orthodontists, physiotherapists, ENT doctors and others. It is necessary to look at tethered oral tissues comprehensively in a broader timeframe. The article summarises the impact of tethered oral tissues on the patient throughout their development and highlights areas that could provide diagnostic clues to detect tethered oral tissues and their management from a multidisciplinary team perspective. The older the patient, the more specialists will be involved in their treatment. With this paper, we aim to arouse interest about the issue among different professionals and to prevent adverse effects on the health of the individual. Although tethered oral tissues are short stretches of tissue, they can have a very negative impact on the quality of life.

The paper focuses on practices in medicine conducted by the authorities of Vilnius University at the beginning of the nineteenth century. The author analyzes institutional and scientific meaning of these practices, claiming that they are main reason for emerging animal magnetism in Vilnius. Emerging of mesmerism was caused first of all by depersonalizing medical treatment and secondly by peculiar interpretation of electricity as a vital force. The author shows that the latter was common for mesmerists and scientific establishments and thus mesmerists proved the credibility of their science. Therefore he states that animal magnetism in polish culture should not be consider as an epidemic of irrational pseudoscience, but rather a logical consequence of the biopolitical and scientific practices of University. [ABSTRACT FROM AUTHOR]

Copyright of Archives of the History & Philosophy of Medicine / Archiwum Historii i Filozofii Medycyny is the property of Polskie Towarzystwo Historii Medycyny i Farmacji and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Communication management in sports organizations requires not only the use of formal tools, such as an official website, fan page or official TV channel. Effective communication should also be based on informal methods, in which the main role is played by interactions between the sports organization and its stakeholders. One such form is viral marketing, which involves sharing files with humorous, social or image content on social networks, messengers, blogs and e-mail. In the case of such forms, due to the wide range and speed of spreading opinions, especially negative ones, about the company, its services or products, it becomes necessary to control the emerging opinions. Management of information with a viral potential allows you to reach stakeholders in an informal way, influencing the building of a positive image, response in crisis situations or creating communities. The purpose of this paper is to analyze the degree of viral marketing use in sports clubs. The research was conducted in October 2021 on different social media. However, due to the extensive scope of the research, this paper focuses on the social network Facebook. The research is concerned with determining the use of viral marketing potential in information management and identifying the characteristics of this form of influencing stakeholders. Due to the limited volume of the article, the main subject of the study is the Polish clubs of the highest level of competition against the background of examples from abroad. The main hypothesis of this article assumes that Polish clubs do not fully use the viral potential and communication activities are based on official messages. Communication management is based on peer benchmarking and replication of what others are doing. It is also assumed that departments responsible for communication in sports clubs do not fully use foreign models.

Today’s economic reality requires entrepreneurs to introduce many changes, especially those of an organisational nature. The period following COVID-19 pandemic will require organizations to create new values, and a broader view of responsibility, to build mutual trust, and to adapt to the new reality. This paper introduces the principles of Corporate Social Responsibility (CSR), with a focus on ecology as one of the areas of CSR. It can be seen that the pandemic has accelerated environmental targets in many companies. This is due not only to the regulations aligned with the governmental environmental policy, but to an increasing extent also with changing social expectations. The aim of the article was to demonstrate the applicability of ecological, environment-friendly solutions as an example of CSR in the management of sports and leisure enterprises. CPOR studies show that most young people take responsibility for the state of their environment. The training of the test subjects also plays an important role here (CBOS, Environmental Awareness of Poland, 2020) It is assumed that the introduction of eco-friendly solutions in the operation of sports and leisure businesses is noticed and appreciated only by young participants in physical activity. The survey focuses on specific environmental solutions to create a socially responsible corporate image and how these companies operate in a changing environment. The results of the studies carried out for this paper are intended to help answer the question of the importance of emphasising environmental aspects and adapting to change by integrating eco-innovation into the CSR strategies of sports and leisure companies, whether these solutions are perceived by the purchasers of sports and leisure services, as they affect their image. and whether they lead to better relations with market participants.

Purpose: The aim of the paper is to present the economic situation of two publicly listed companies: GKS Katowice (Poland) and Olympique Lyonnais (France). Both enterprises have different ownership models: Olympique Lyonnnais is a privately owned club, and GKS Katowice belongs to a municipal government. However, both clubs operate in the realities of different market economic system (Poland and France) and also at a different level of economic development. It is common that football companies function under uncertainty and risk. This is heightened by additional characteristic factors for this type of activity such as uncertainty of outcome in sports competition. The adoption of professional sport activities also automatically runs to the risk, but this is not the only problem that the company has to face. In addition, both clubs had to deal with new challenges: COVID-19 pandemic and lockdowns. The paper presented the functioning of both football companies during the COVID-19 pandemic and lockdowns. Methodology: The first part of this research study discusses some particular points of the business strategy and risk management in the context of football companies’ management. The economic and financial situation of two football companies is presented, namely: Olympique Lyonnais and GKS Katowice. The focus is on sports, economic and financial criteria to assess the standing of football companies. This paper combines the conclusions from secondary data analysis, content analysis of web­sites as well as qualitative and quantitative analysis. The study also employs a comparative analysis. Research and practical limitations: Football companies are in the need to take several actions: a) continuously search for new sources of financing and diversification of activities, b) conclude long sponsorship agreements. Building a solid financial foundation and looking into the future can help football companies get through times of various crises and the COVID-19 pandemic.

Introduction and Purpose Brain tumors cause a variety of somatic and psychiatric symptoms, which vary depending on the age of the patient and the location and type of tumor. Symptomatology includes both physical symptoms, such as headache, nausea, seizures and weakness, and psychiatric symptoms, including mood, personality and cognitive dysfunction. In children, the clinical picture is more complex and includes specific developmental difficulties. The purpose of this paper is to analyze the various symptoms accompanying brain tumors in order to detect them early and enable faster diagnosis. Material and Methods A comprehensive literature review was conducted using the PubMed database, focusing on articles published until the end of 2023.The search included the keywords: "brain tumors" "symptoms" "headache" and "psychiatric" in various combinations. Relevant studies were selected based on criteria such as somatic and psychiatric symptoms and early diagnosis of brain tumors. Results Accumulating data show the diversity of symptoms associated with brain tumors. Somatic symptoms such as headache, optic disc swelling, nausea, and seizures depend on intracranial pressure and tumor location. Psychiatric symptoms, including personality changes, mood disorders, and cognitive impairment, pose a significant diagnostic challenge in adult patients. In children, brain tumors can cause developmental delay and atypical neurological symptoms. Conclusions The symptoms of brain tumors are highly variable and difficult to diagnose, which significantly delays proper diagnosis of the disease. Its early detection is crucial as it improves the prognosis of patients, significantly improves their quality of life, and allows for the introduction of effective therapeutic interventions.

Liposuction is one of the most commonly performed procedures in aesthetic surgery, with an increasing variety of available methods that enhance both the effectiveness and safety of this treatment. The aim of this paper is to analyze and compare three primary techniques: ultrasonic, laser, and traditional liposuction, as well as to highlight potential directions for the development of this procedure. Based on available literature and research findings, both the effectiveness and potential risks associated with each of these methods will be assessed, allowing for the identification of optimal solutions tailored to the individual needs of patients.

Introduction and purpose: Over the past two decades, the management of severe asthma shifted from high doses of inhaled and oral corticosteroids to targeted biologic agents. Adverse effects of treatment with monoclonal antibodies are not yet fully characterised. The aim of this paper is to provide a comprehensive review of the adverse effects of the FDA-approved monoclonal antibodies in the treatment of moderate-to-severe asthma, including omalizumab, benralizumab, dupilumab, mepolizumab, reslizumab, tezepelumab. Material and methods of research: A thorough literature review was performed using PubMed Web of Science and Embase, employing key words related to monoclonal antibodies, asthma and adverse effects. Description of the state of knowledge: Omalizumab and mepolizumab have black box warning on the risk of anaphylaxis. Due to scarcity of data, no causal association between the use of monoclonal antibodies and risk of malignancy can be established. The most common adverse effects of biologic agents in severe asthma include upper respiratory tract infections, nasopharyngitis and asthma worsening. Conclusions: Overall, monoclonal antibodies have a favourable safety profile, with certain risk of side effects remains present, and is variable for the different molecules. More studies of asthmatic patients treated with monoclonal antibodies are needed to spot rare adverse events and those developing over longer time.

Migraine, a complex neurological disorder, affects a significant portion of the population and presents both medical and societal challenges. The aim of this paper is to provide a detailed review and analysis of available therapeutic methods for patients suffering from migraines, considering both pharmacological and non-pharmacological therapies. The approaches presented include acute treatment with triptans and nonsteroidal anti-inflammatory drugs (NSAIDs), as well as preventive therapies, such as beta-blockers and antiepileptic drugs. The section on non-pharmacological therapies focuses on cognitive-behavioral therapy (CBT), biofeedback, and lifestyle recommendations, including diet and sleep hygiene. A review of the literature indicates that integrating pharmacological and non-pharmacological approaches can significantly improve treatment effectiveness and the quality of life for patients with migraines.

Introduction: Neuroendocrine tumors (NETs) are a diverse group of tumors that arise from neuroendocrine cells and can synthesize and secrete neuropeptides or hormones. Although NETs usually originate from the gastrointestinal tract or bronchopulmonary tree, they can affect various organs, including the eye. The majority of ocular association with neuroendocrine tumors results from metastasis that affects the orbit, however, primary ocular tumors have been reported. Purpose of the study: The article reviews the presentation of ocular manifestations in neuroendocrine tumors including pheochromocytoma, ocular paraganglioma, gastrointestinal and bronchial NETs, Merkel cell carcinoma and neuroendocrine metastasis. Materials and methods: In order to summarize the current knowledge on the topic, a literature review of English language papers with a focus on the most current literature was performed. The review was conducted with the PubMed database with 43 works used, accessed before September 2024. Conclusions: Instances of neuroendocrine tumors leading to ocular manifestations have become increasingly prevalent. These nonspecific symptoms can make it challenging to diagnose ocular NETs. Ocular manifestations are not typically the primary symptom, but patients with tumors located in the eye may experience symptoms such as eye pain, blepharitis or exophthalmos. Ocular motility and vision may also be affected. It is crucial to study the association between those symptoms and NETs, in order to develop a more comprehensive understanding of the matter.

Diabetic retinopathy, also defined as diabetic eye disease is one of the main causes of eye complications and blindless in the world therefore leads to irreversible vision disorder and vision loss. A pregnant women as a patient is always a real challenge for doctors of various specialties. During this period, numerous systemic changes occur, such as increased blood pressure in the third trimester, increased blood volume insulin resistance with worsening glycemic control and excessive coagulation. The above complication may be reflected in the image of the fundus of the eye. Pregnancy may induce retinal disease such as diabetic retinopathy. This review article presents the incidence, pathogenesis and risk factors associated with diabetic retinopathy during pregnancy. More over in the following paper discussed management of diabetic retinopathy in pregnancy and guidelines are recommended based on the achievable evidence.

This paper presents the diagnostic and therapeutic challenges encountered in an older woman with advanced HIV infection. Upon admission, the patient exhibited severe symptoms of interstitial pneumonia and cachexia. During hospitalization, the patient was diagnosed with SARS-CoV-2 infection and a wide spectrum of opportunistic pulmonary infections, including Pneumocystis jiroveci, Candida krusei, and Staphylococcus haemolyticus. Another major diagnostic challenge posed the patient’s prolonged fever, which persisted despite comprehensive treatment. This report underscores the importance of considering new HIV infections in older patients presenting complex clinical pictures, its significant mortality risk in older individuals, and the need for timely initiation and adjustment of antiretroviral therapy.

Scars are a natural consequence of the wound healing process, but excessive scarring can lead to aesthetic and functional concerns. This paper aims to review current scar treatment methods, including modern techniques such as laser therapies, microneedling, corticosteroid injections, and silicone dressings. Special attention is given to the treatment of hypertrophic scars and keloids, which present significant challenges in contemporary medicine. An analysis of recent studies highlights the effectiveness of these methods in improving scar appearance and reducing discomfort associated with scars. Additionally, emerging experimental therapies, such as the use of stem cells and monoclonal antibody treatments, are discussed. The findings suggest that early intervention and individualized treatment approaches are crucial for achieving optimal aesthetic and functional outcomes.

Introduction and purpose: Obesity affects every age group and is associated with many negative health effects. Various diets are used to remove excess body weight. Recently, popular became two diets - intermittent fasting and ketogenic diet. Material and Method: This paper reviews various types of research documents published since 2018. Its main aim is to summarize the latest knowledge of ketogenic diet and intermittent fasting, including contraindications, side effects, impact on body weight and many diseases. It is also aimed to highlight the need for future research of the effects of both diets on various diseases and body weight reduction. Results: Both diets may be effective in weight loss and show other health benefits. Both ketogenic diet and intermittent fasting have proven to be effective in weight reduction. In the case of intermittent fasting the biggest impact on weight loss is calorie restriction. Ketogenic diet is effective as a result of calorie restriction, increased gluconeogenesis and loss of free water through increased diuresis. They can be used in the prevention and treatment of many diseases, including cardiovascular disorders, neurological disorders or potentially cancer. However, they cannot be administered by everyone and may cause dangerous side effects. Conclusion: Ketogenic diet and intermittent fasting are successful strategies for body weight reduction. Moreover, both of them may be used as an additional therapy for various diseases. However, patients should be under supervision.

Introduction Alveolar osteitis is the most common postoperative complication of tooth extraction. This medical condition has been recognized for decades, however its treatment approach is diverse with varying outcome. Aim of the study The purpose of this review is to examine and discuss contemporary methods of treating dry socket. Through a synthesis of available studies, the paper aims to identify the most beneficial methods to deal with this post-extraction complication. Materials and methods An analysis of scientific articles available in Pubmed and Google Scholar databases was conducted. The study used publications from 2017 to 2024. The search process included the use of the following keywords: “dry socket”, “alveolar osteitis”, “alveolitis sicca dolorosa”, “socket pain treatment”. Results Thirty-five articles were selected and reviewed carefully and independently by all authors. The agents used in the treatment of dry socket were classified as: remedies, drugs and medications, blood products, and technologies. Each group of agents is described with a discussion of their therapeutic efficacy. Summary Dry socket is a common dental problem. Currently, non-invasive methods of treating this complication are preferred. Modern solutions can provide quick and effective therapy. The treatment should relieve discomfort and promote tissue regeneration. Despite various methods, there is still no clear opinion on the best way to treat dry socket.

Introdution: Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, characterized by the cyclical onset and resolution of symptoms. It is a progressive disease that leads to intestinal damage and even disability. This disease can occur in any segment of the digestive system, from the mouth to the anus. The typical symptom is segmental inflammation in the small or large intestine, which is separated by healthy sections. The inflammation usually starts in the mucosa but, over time, spreads to the entire thickness of the intestinal wall, which can lead to intestinal damage, scarring, and the subsequent formation of fistulas and strictures. Inflammatory lesions most often occur in the last segment of the ileum, followed in order by the small and large intestines and the large intestine itself. Aim of the study: The purpose of this paper is to provide a general overview of Crohn's disease, focusing on oral symptoms. Materials and methods: An analysis of scientific articles available in Pubmed and Google Scholar databases was conducted. The study used publications from recent years that were most pertinent to the topic under discussion. The search process consisted of using the following keywords: “crohn's disease”, “oral manifestations”, “oral healh”, “Crohn's disease symptoms”. Results: In addition to the classic intestinal symptomatology, Crohn's disease can also manifest in the oral cavity. Symptoms that appear in the oral cavity may be early harbingers of Crohn's disease, occur concurrently with its onset, or manifest themselves several years after the onset of the condition. They most commonly involve the lips, buccal mucosa and gums. According to Malins and colleagues, these lesions can be divided into specific and non-specific ones. Conclusions: Crohn’s disease diagnoses are increasing, and early awareness of symptoms is crucial for timely diagnosis and prevention of complications.

Introduction and purpose Achalasia is the most prevalent primary esophageal motility disorder, marked by improper relaxation of the lower esophageal sphincter (LES), increased resting pressure in the LES, and a lack of peristalsis in the esophagus. Symptoms include difficulty swallowing (dysphagia), regurgitation, chest pain, and weight loss. Due to the nonspecific nature of these symptoms, diagnosis can be delayed by several years. Since the underlying cause of achalasia is still unknown, treatment options focus on alleviating symptoms by targeting the lower esophageal sphincter. Materials and methods This paper is based on a literature review sourced from PubMed, using the following keywords: achalasia, POEM, laparoscopic cardiomyotomy, pneumatic dilation, and botulinum toxin injection. Results Various treatment options are available for achalasia, each offering unique features and results. The main approaches include Peroral Endoscopic Myotomy (POEM), Laparoscopic Myotomy (LM), Botulinum Toxin Injection, and Pneumatic Dilation (PD). Conclusion Each treatment differs in its level of invasiveness, duration of symptom relief, risk of complications, and the likelihood of requiring additional interventions. The selection of the most suitable option is influenced by individual patient factors, such as the type and severity of achalasia, overall health, and personal preference

Background: The purpose of this paper is to determine the impact of body development and composition on the depression level, and to determine which of the morphological and body composition parameters have higher impact on the manifestation of depression in women aged 19 to 30 years.Methods: The study was conducted on the sample of 50 voluntarily selected test subjects. From 83 women presented at the fitness center “Fitnes Center Mall” in the city of Gjakova for the purposes of this study are voluntarily involved 50 women aged 19 to 30 years with an average age of 23.2 years. For the purpose of this paper were applied 11 body composition variables and one test for measuring depression levels.Results: The obtained results show that the multiple correlation coefficient between the predictor and the criterion system is quite high R = 0.962. This relation shows that the common variability between the two systems is 93% (R Square = 0.926). Predictive variables that has the influence in the manifestation of depression level are: Height of the body body (HEIG) t=2.784; pBody mass index (BMI) t=2.908; pConclusions: The research results show that Height of the body, Body weight, and Body mass index affect in the rate of depression level. Research shows that although mental and physical health are two separate concepts, yet they are still in a strong relationship, physical condition affects in mental state.

Senility is strongly associated with changes in body composition. Sarcopenic obesity (SO) consists of symptoms such as increased body fat mass and a reduction in muscle strength and/or mass. The review covered treatment methods and diagnostic criteria used in SO patients. Moreover, the impact of SO on the health of older people was reviewed. Papers from the Science Direct and PubMed databases were analysed. The following keywords were used: “sarcopenic obesity”, "diagnostic", "treatment", "elderly", and "physical therapy". The inclusion criteria encompassed research studies on SO in older people. To be precise, the review included papers from January 2015 to March 2020, and the review itself was carried out from March to April 2020. Out of over 1,200 SO articles, 18 met all inclusion and exclusion criteria. All of the chosen papers were divided into two main groups. The first group contained papers about SO’s impact on the health of older people. The second comprised works about SO treatment methods. The most commonly used SO diagnostic indicators were: BMI (25kg/m2-30kg/m2), BF% (27%-42%), SMI (x

The purpose of this paper is to provide a synthesis of the current international research evidence base regarding best practice in the diagnosis and treatment of children with language disorders. We begin with a discussion about the terminology used and how this relates to identification and diagnosis, and then describe assessment and treatment practices. The discussion of intervention and case management of these children focuses on the use of high quality evidence that presents an overview of treatment approaches, rather than specific treatment programmes that may not be relevant to all international practice settings. The paper sets the context of the wider international research evidence base: we also include commentary that may be more relevant to some countries across mainland Europe, and specifically to the Czech Republic context. Research studies that reflect local languages and culture are a highly important component of the evidence base for practice, but these should be considered in the context of international consensus evidence. In particular, some strategic recommendations are made to address the inherent challenges of sustaining best practice where open access to evidence sources may be constrained.

Introduction: Patients with maxillofacial and intraoral defects require orthognathic surgery to improve the appearance of the face and correct the occlusion. The number of orthognathic surgeries has been increasing in recent years. The motivation to undergo these surgeries is the possibility for patients to improve stomatognathic system functions i.e. chewing, swallowing and pronunciation, as well as aesthetic and psychosocial factors. Aim: The aim of the paper was to assess the occurrence of late postoperative complications and dysfunction of the stomatognathic system in patients after orthognathic surgeries such as Maxillary Lefort 1 Osteotomy and Bilateral Sagittal Split Osteotomy (BIMAX). Additionally, the paper emphasizes the necessity of quick activation of the stomatognathic system structures in patients after orthognathic surgeries in order to reduce the incidence of complications.Material and methods: The research was conducted with the help of the users of internet groups: "Progenia, mandibular prognathism, photos BEFORE and AFTER the operation :)" (in Polish: „Progenia, wysunięta szczęka, zdjęcia PRZED i PO operacji :)”) and "Suffering from progenia" („Progenicy”) as well as users of the Jawsurgeryforums.com online forum who have given their informed consent to participate in the survey. The analysis was carried out on a group of 92 people who underwent orthognathic surgery of Maxillary Lefort 1 Osteotomy and Bilateral Sagittal Split Osteotomy (BIMAX) type in the years 2004-2019. To assess the opinions of patients, a diagnostic questionnaire method was used, based on a proprietary electronic questionnaire, which consisted of three parts. The first part is metric, i.e.: age, gender and questions concerning the number of orthognathic surgeries performed, time of wearing intermaxillary traction wiring or splints, postoperative rehabilitation. The second part of the questionnaire consisted of 15 close-ended questions assessing the occurrence of symptoms of SS system disorders and functioning. The third part of the questionnaire consists of 20 questions concerning postoperative complications after 3 and 6 months from surgery and functioning of the dental system after surgery. The fourth part of the questionnaire consists of 5 close-ended questions concerning the evaluation of the overall impression after surgery and the most important effects of it. The test results were statistically analyzed using the correlation coefficient and Pearson's chi-squared test (p ≤ 0.05).Results: 92 people, of which 86 women (93.5%) and 6 men (6.5%), participated in the study. The most common ailments before the surgery—affecting more than half of the patients—were chewing impairment, speech defect, breathing problems and headaches. 3 months after the operation, facial neurosensory disturbances and facial swelling were the most frequent of the ailments reported by the patients (more than 70% of the respondents), limited jaw mobility, joint pains and chewing impairment were also frequent (more than 40%). 6 months after the surgery, the most frequent persisting ailments were facial neurosensory disturbances (> 60%), facial swelling and acoustic problems (> 30%), as well as pains of masticatory and mandibular muscles, headaches and limited joint mobility (> 20%). More than half of the patients (n=48) were satisfied with the surgery, the second largest group were patients delighted with the result (n=25). 4 people were dissatisfied and 3 very dissatisfied. 12 patients had difficulties in determining their satisfaction with the results of the surgery. 19 people (20.7%) did not report disturbances of somatosensory system in any of the facial areas, and among the patients experiencing ailments, 40 people (43.5%) reported problems in two areas, 27 people (29.3%) in one, 5 people (5.4%) in four and 1 person (1.1%) in three areas. In the 3rd month after the surgery it was observed that people who did not use physiotherapeutic treatment were 11.5% more likely to suffer from bone inflammation [X2(1)=4.359; p=0.037]. Two statistical tendencies were observed, suggesting that people using physiotherapy slightly less often showed limitations in mandibular mobility [by 17.6%; X2(1)=3.599; p=0.065] and by 4.7% less often experienced bone inflammation [X2(1)=1.238; p=0.076]. Conclusions: The most common postoperative complication is somatosensory system disturbance of the lower facial muscles. Orthognathic surgery contributes to the reduction of stomatognathic system ailments. Persons using physiotherapy suffer less frequently from bone inflammation and enjoy greater mobility of the temporomandibular joint.

Introduction and purpose: the Terminology Guidelines of the American Hippotherapy Association defines Equine Assisted Activities or Therapies (EAA/T) as a collection of different forms of contact between man and horse. EAA/T have become increasingly common interventions in the last decade, demonstrating therapeutic benefits in various areas of mental health. The aim of this report is to identify the forms and programmes of EAA/T that are used and to summarise and assess the latest available evidences of their clinical effectiveness in the treatment of symptoms of mental ilness and disorders such as autism spectrum disorders, post-traumatic stress syndrome or schizophrenia. In order to achieve the above mentioned objectives, a literature review has been conducted to summarise existing evidence relating to the subject matter of the study in a descriptive manner. Description of the state of knowledge: 13 findings were found in autism spectrum disorders (1 review paper and 5 research papers), post-traumatic stress syndrome (1 review paper and 4 research papers), schizophrenia (1 review paper), and children whose parents were addicted (1 research paper). Summary: the results of the research indicate that Equine Assisted Activities and Therapies (EAA/T), including horse riding, may be beneficial for people with mental illnesses and disorders, such as autism spectrum disorders, post-traumatic stress syndrome, schizophrenia, and for people whose parents were addicted.

Rehabilitation of patients with a diagnosed cancer poses a major challenge for physiotherapists (PT) due to the limited number of methods which may be used on every stage of cancer treatment (including convalescence). Kinesiology Taping (KT) is one of the few available options that enable pain and oedema reduction. Limited number of studies with significantly varied study methods makes it difficult to draw clear conclusions on the legitimacy of KT use. Aim of the review was to analyse available studies on the KT use in pain management and associated discomfort reported by cancer patients. Six papers met the criteria for the review and were included in the detailed pooled analysis (2 clinical studies and 4 case studies). Analysis emphasized papers describing analgesic effect of KT. On the basis of available studies, it proved to be beneficial for oncology patients (breast cancer, lung cancer, multiple myeloma). Additionally, studies reported an increased ability to carry out daily activities, decreased ‘psychological suffering’ and lower fatigue which directly resulted in the improvement of the quality of life (QoL) – a main goal of palliative care. The number of studies that evaluate the effectiveness of KT in pain reduction in oncology patients is scarce. Since KT has minor adverse effects it is recommended to be used as an adjunct analgesic therapy. Review supports the effectiveness of KT for pain management in oncologic patients. In order to confirm the efficacy of KT use in cancer patients, a greater number of randomized clinical trials, covering larger study groups, is required with special emphasis on malignant neoplasms.

IntroductionThe nurse provides medical care for the patient, including nursing, administering medicines and performing injections. She assists the doctor in the process of diagnosis and treatment. The definition of this profession changes as a result of the development of science and increasing expectations of health care. The development of this profession is evidenced by developed models of nursing, which will focus on the practical application of the acquired knowledge.Aim The aim of this work was to present the tasks and competences of nursing and the role of this profession in improving the quality of patient care.Material and methodThe paper uses the method of literature analysis. The material used in the paper comes from publications published in a compact form and scientific articles.ResultsThe review of the collected scientific material showed that nurses have a significant impact on the quality of health care and the functioning of the entire facility. Healthcare institutions belong to organizations in which the quality of services translates into the patient's health and life. Care should therefore be a priority for the entire staff, especially for the nurses who first meet the patient and spend a lot of time with him. Patients expect medical knowledge from nurses first and foremost, but also safety, trust and proper communication.ConclusionsIn recent years, nursing has been constantly changing, which means that people in this profession have to take various actions for their development. Patient expectations are also changing. Their opinion and satisfaction is important for success. A satisfied patient will surely use the services of the facility again.

Athletic operates on the basis of a particular system of knowledge that has in its contentthe theoretical and methodological foundations of sport training (Rashiti N, Nika F, Bekolli L, Heta G.) 2017. Athletic is one of the types of sports, with complex and applicable character, consisting of large groups, which include different athletic types, with similar characteristics among them; our treatment is athletic decathlon.(Dibra F.)2006. The decathlon is a complexcombined event in athletic consisting of ten track and field events.Olympic men’s decathlons are divided into a two-day competition. The evaluation is done by points.Men’s decathlonconsists of:100m,Long jump,Shot put,High jump, 400m (Day 1); 110m hurdles,Discus throw,Pole vault,Javelin throw,1500m(Day 2).The main purpose of this paper was to verify that from the disciplines of the Decathlon:Long jump,Shot put,High jump, Discus throw,Pole vault,Javelin throw and1500m,as predictor (independent) variables will have an impact on the performance of specific motor tasks, respectively the execution of disciplines pertaining to short-distance running:100m, 110m hurdles and 400mas well as to determine the impact of these short-distance running to the final result of the decathlon knowing that these disciplines in athletics are largely genetically determined.(Misja B.) 2012The sample for the purposes of this paper will include 10 first contestants of decathlons World Championship: September 27 and October 6, 2019 in Doha, Qatar.In this research, after obtaining a statistically significant multiple correlation (R = 0.936) it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor variable (independent) in the dependent or criterion variable 400m.We can emphasize that the test (F-test) is always more valuable if the multiplex correlation is greater, in this case it is significant (Sig = 0.000), because the value of the F-test is 15,347.A statistically significant multiple correlation was obtained (R = 0.958); it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor (independent) variable in the dependent variable or criterion 110 m.In this research, after obtaining a statistically significant multiple correlation (R = 0.958), it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor variable (independent) in the dependent or criterion variable) 100 m.

The presented paper is a review of selected alcoholism typologies, some of which include the relatively well-functioning type. The analysis covers widely known typologies, deeply grounded in addiction psychology, as well as other research, all of which consider the shared characteristics of high-functioning alcoholics. Thus, the aim of the paper is to provide an overview of these classifications of alcoholics, focusing on the groups whose traits are consistent with the image of high-functioning alcoholics described by Moss et al. (2007). It was found that the majority of classifications include a subtype showing features similar to high-functioning alcoholics (such as older age of alcohol use initiation, later onset of alcohol dependence, mild course of alcohol dependence, higher psychosocial functioning, low prevalence of familial alcoholism, low rates of comorbid psychiatric disorders, and lower level of withdrawal symptoms compared to other groups). However, there are significant differences in each of the mentioned typologies. Further research should expand on the subject, aiming to find particular personality and temperamental traits, personal resources and factors associated with undergoing addiction therapy/ treatment, its course and maintaining abstinence in high-functioning alcoholics. Moreover, negative consequences of alcohol abuse in high-functioning alcoholics should be assessed. Such research could have both practical (supporting the diagnosis and effective therapy) and theoretical implications (allowing for the development of a conceptual framework for highfunctioning alcoholics and the extent to which they differ from other types).

Introduction and aims of the study: The aim of this study is to present recent reports on the treatment and therapy of schizophrenia and bipolar disorder (ChAD). The current treatment of patients affected by these diseases is difficult and unsatisfactory, therefore it is necessary to find new therapeutic options that will improve the effectiveness of treatment For the purpose of this study, scientific papers were reviewed using the Google Scholar search engine covering studies from 2016 to 2021. A dozen papers covering the scope of the publication were selected. Results: In the treatment of schizophrenia, the use of cannabinoids is of greatest interest due to the action of the preparations on the endocannabinoid system. In the treatment of ChaD, promising reports have been published on the therapy with aripiprazole and the need to improve its use in the treatment of both akathisia and agitation. Furthermore, from the fact that abnormalities of calcium signalling are considered a possible pathophysiological process in ChAD, it has been suggested that calcium channel L antagonists may be potential therapeutic agents in bipolar affective disorder. One study also demonstrated the potential use of vortioxetine in the treatment of patients with a depressive episode. Conclusions: The results of recent studies on the treatment of schizophrenia and ChAD cited in this paper offer the prospect of creating treatment regimens that are more effective and targeted in the aforementioned diseases. However, further randomised trials are needed to confirm the effective use of the cited drugs in the treatment of these diseases.

The physiotherapy process in children is specific and requires much more patience and understanding than in adults. Working with a child is not only related to the physiotherapy of a small patient, but also in a very good cooperation between the parent-physiotherapist. The paper presents selected issues of children's therapy in the light of research papers published in renowned scientific journals dealing with medical issues.

Acne vulgaris is a chronic inflammatory skin condition with a high global prevalence. Light-based therapies can be used in acne treatment on account of their good safety profile, lack of potential for developing resistance, and mechanism of action. Despite variations in research methodologies and diverse findings among researchers, numerous clinical studies have shown a statistically significant improvement in the skin condition of acne patients treated with light. In the majority of studies, the follow-up period is comparatively short, preventing the evaluation of long-term effects of therapy. This paper examines the literature on the effects of various light therapies (based on LED devices, photodynamic therapy, intense pulsed light, and laser therapy), on the clinical signs of acne.

The most common type of arthritis that alters a joint's mechanical and structural properties is osteoarthritis (OA). Resistance training combined with blood flow restriction training (BFRT) is one of the new and promising non-pharmacological strategies for treating OA that has received attention recently. This paper aims to identify the outcomes and outcome measures used for BFRT in knee OA, evaluating BFRT intervention and cuff parameters. The Preferred Reporting Items for Systematic Reviews and Meta-analysis Extension for Scoping Reviews is followed while reporting on scoping reviews. The Cochrane Central Register of Controlled Trials, the Physiotherapy Evidence Database, and PubMed were among the databases that were searched for research. Eight studies were included. The range of outcomes used in the study were knee pain, function, strength, quadriceps cross-sectional area, quality of life, disease severity, growth hormone level, and Range of motion. The parameters that were used in the included studies ranged from 4-5 sets of 10-15 repetitions at 20%–30% of 1RM load; progressive blood restriction ranging from 30%–80% of arterial occlusion pressure occurred with placement of the cuff at the most proximal part of the thigh. Low-intensity exercise training combined with blood flow restriction (BFR) used with appropriate parameters is a viable alternative to traditional strategies for improving knee OA patients' pain, strength, muscle mass, hormones, functionality, range of motion, and overall quality of life.

The aim of the study was to determine the components of measurement uncertainty in the concentration of alcohol in exhaled breath and to determine the state of sobriety at the time of incident. Based on the literature review and the authors’ experience in providing opinions for law enforcement and the judiciary, the influence of various factors on the final interpretation of sobriety state is described on the basis of measurement uncertainty of breath analyzers, uncertainty of retrospective and prospective calculations, and uncertainty related to the conversion of alcohol concentrations detected during breath and blood tests. The paper pays particular attention to interpreting the concentrations of ethanol in exhaled breath close to the legal limits of the state of sobriety and the state after alcohol use, or the state after alcohol use and the state of insobriety. Analyzing the results of an exhaled breath test concerning concentrations close to the values of 0.1 mg/dm3 and 0.25 mg/dm3, it is necessary to take into account the factors affecting the measurements obtained, including the measurement uncertainty of the determination of alcohol in exhaled breath, the processes of absorption, distribution and metabolism of ethyl alcohol, and the possibility of the presence of alcohol lingering in the oral cavity. The incorrect execution of measurements of the tested person’s alcohol concentration is also a problematic issue. When determining sobriety state by means of retrospective and prospective calculations, it is important to remember that the uncertainty of the result is affected by a number of factors and depends, among other things, on the information provided by the suspect. Hence, the expert should draw conclusions particularly cautiously and any overestimation or underestimation of the components of uncertainty can lead to erroneous conclusions. Awareness of the uncertainties inherent in the results of a sobriety test or alcohol calculation allows for meaningful interpretation of test results and determination of the sobriety state of the person tested.

Introduction and purpose of paper: The aim of this paper was to present diagnostic and therapeutic difficulties in management of sinonasal tumors, which are extremely rare. First symptoms are not specific, that is why patients usually present with advanced tumors at the moment of diagnosis. Optimal treatment depends upon extent or stage of disease. State of knowledge: Tumors of nose cavity and paranasal sinuses affecting less than 1 in 100 000 people per year. They are result of abnormal proliferation of variety of structures in the nose. Tumors in sinonasal region grow slowly and may invade local structures, for example the skull base, orbit, or brain. Symptoms of tumors of this region are not specific. This is reason why they are often misdiagnosed by the doctors. Proper detection and diagnostic examination require histopathology examination and imaging test such as computed tomography and magnetic resonance imaging. Due to type and stage of tumor, the treatment options are surgery, radiation therapy and chemotherapy, used separate or in combination. Summary: Nasal cavity and paranasal sinus tumors are rare, with a wide spectrum of histological differentiation. The accurate diagnosis of tumor plays a significant role influencing the therapeutic conduct and prognosis.

This article is devoted to empirical research of adolescents’ suicidal thoughts in the context of the cognitive-behavioural approach. In Kazakhstan, this type of research is being conducted for the first time. The studies are conducted in general educational institutions of Kazakhstan with the consent of teachers, parents and participants themselves. The aim of this paper is to study irrational attitudes that generate cognitive distortions and become predictors for suicidal thoughts as well as adolescents’ attitude towards parents, family, teachers, the same and opposite sexes, to their doubts and fears, feelings of guilt, the past and future, and to life goals. Research methods applied in this paper are CP-45 by Yunatskevich, Irrational Beliefs Test (IBT) by Ellis, Sachs and Levy’s The Sentence Completion Test, and the psychological verbal and communicative method “Conversation.” Study results revealed the most commonly used cognitive distortions formed as irrational settings such as “Frustrating tolerance,” “Owes to yourself ”, “Owes to others” and “Catastrophisation,” which are the reasons for low self-esteem and irrational thinking to be generated. Other main reasons are negative attitude towards one’s own future or own past, and to their parents. In a risk group, adolescents represent dominance of irrational attitudes which are later transformed into a cognitive distortion of reality leading to suicidal thoughts. Suicide-oriented adolescents have a negative attitude to their own future and past and to their parents as well as socially oriented fears.

Insomnia is one of the most common disorders coexisting with depression, and sometimes precedes the development of depression by a number of months. During depressive episodes, insomnia affects 60–90% of patients. At the same time, insomnia is the most prevalent residual symptom of depression, which may persist after the resolution of depression itself in up to 40–50% of patients, causing significant distress. Consequently, normalisation of disturbed sleep is an important aspect of depression therapy. Inappropriate pharmacological treatment may significantly hinder the achievement of the desired therapeutic outcomes. The paper aims to address the recommended treatment of insomnia with coexisting depression, and to discuss the advantages and disadvantages of various pharmacotherapy options and non-pharmacological interventions. In addition, the paper summarises available data on the effect of agomelatine on sleep in patients with depression. Because of its melatoninergic activity the drug synchronises the disturbed circadian rhythm of numerous physiological processes including the sleep–wake cycle. Agomelatine is a particularly beneficial therapeutic choice for patients with depression and insomnia who are prescribed treatment with serotonin or serotonin and noradrenaline reuptake inhibitors, but are worried about the deterioration of sleep quality.