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Background & Aims: Education is the main factor of economic growth in a country, and the curriculum is the heart of any education system. As civilization makes the transition from the industrial era to one of sustainability, educational leaders around the globe ought to implement a learning system that prepares young people for life in a unified society. Every country that has experienced high growth for a long time makes great efforts to educate its nation and reinforce its human capital. In contrast, there is considerable evidence that many developing countries are not doing enough. Education has a legal claim on public funds for at least two obvious reasons. First, the social returns are likely to be greater than the private returns. Second, some families with low incomes and credit constraints may not be able to invest as much in education as they would like, even if a higher income is guaranteed for a diploma or university degree in the case of a successful job search. Therefore, public spending on education is established based on impartial opportunity and efficiency. This paper provides a starting point to explore what skills and concepts students should be studying to lead the future. The curriculum model provides an explicit outline of some of the competencies that will likely be required for whatever world scenario emerges. This study focuses on the key roles of education and its relation to economic development as well as the curriculum as a core part of the entire educational drive of nations. In particular, the aim of the present study was to study the goals and contents of the high school curriculum of Group 7 countries and Iran with a focus on the differences and similarities of cognitive and metacognitive skills, which were compared with Iran in order to reach an appropriate model. Methods: The method used in this study is qualitative, seeking to understand a research phenomenon in its usual environment that leads to a deep understanding of the studied phenomenon. In particular, this research is a documentary analytical research with a comparative approach. The statistical population of the research in the first study, which had a comparative approach, includes all documents, printed and electronic texts regarding the curriculum elements of the selected countries. It includes all articles, websites, studies, and research related to the research topic. In the Delphi method, the presence of experts and experts in the subject is emphasized. Statistical sample: In this research, in the first part, after searching the official portals of the countries and databases, all the documents that contain the content of the curriculum elements of these countries have been found. Data analysis in qualitative research is the process of classifying, describing, and combining data. In this section, after collecting the information and data, the contents were separated into 4 components: goal, content, method, and evaluation for each country. Then it was analyzed based on John Stuart Mill's agreement and difference model. The analysis in the quantitative part includes Kendall's coefficient and confirmatory factor analysis with the help of SPSS22 and Amos Graphics version 23 software. Meanwhile, Maxqda18 software was used in the qualitative part and model extraction. All documents were translated by translators from IACTI (Iranian Certified Translators and Interpreters). It must be acknowledged that the process of translating the documents was complicated and difficult due to the different languages and finding the appropriate equivalent in Persian. 212 participants, including secondary school teachers, university professors, and Ph.D. students in the fields of curriculum and education management helped to confirm and categorize the collected information. In the next step, the Delphi method was used to obtain the opinions of experts and reach a consensus about the studied components. With a 5-point Likert style scale 80% agreement was obtained, which was regarded as attaining a minimum acceptable interrater agreement. Results: This study was motivated by doubts that have been raised about the role of education and human capital in economic development. These doubts come from a variety of vantage points ranging from whether the research has correctly identified the impact of education to whether other institutional aspects of countries might be more important. They also encompass concerns about whether or not we really know how to change educational outcomes, particularly in developing countries. The eight studied countries were divided into two groups for comparison: (a) Group of Seven, and (b) Iran. The objectives and content included in the curricula of these countries were identified, and then similarities and differences between these two groups were analyzed. The results show the importance of both minimal and high-level skills, the complementarity of skills and the quality of economic institutions, and the robustness of the relationship between skills and growth. International comparisons incorporating expanded data on cognitive skills reveal much larger skill deficits in developing countries than generally derived from just school enrollment and attainment. The magnitude of change needed makes clear that closing the economic gap with developed countries will require major structural changes in schooling institutions. Moreover, the results of this research showed that the goals and content of the curriculum of these countries often emphasize the areas of work and employment and are somehow economy-oriented. In Iran, there is not much emphasis on these areas in Iran. Although the principles and teachings of Islam pay attention to work, there is a lack of attention to this issue in the goals and content of the curriculum. It is suggested that there is an emergency need to review the national curriculum in Iran. Taking help from religious foundations in this field, such as paying attention to work and effort in Islam, avoiding laziness, and contentment, paying attention to halal earning and sustenance, etc., is very beneficial and enlightening. Using the fundamentals of Islam only in prohibitions and outward criticisms and only paying attention to prayer and fasting not only makes students evasive but also limits the main mission of religion which enlightens the path of people's lives and can open a way in their social and economic life. Pointing to the fact that the longest verse of the Holy Quran is in the field of economic transactions is one of the examples of the importance of the field of economics in Islam and proof of this matter. The lack of economic attention and cultivating students’ cognitive as well as metacognitive is felt in terms of preparing people for the future, after graduating from secondary education. It seems that it is better for the planners to update and modify the secondary school curriculum in line with economic development and changes in psychological knowledge. [ABSTRACT FROM AUTHOR]

Background & Aims: Neural activation is associated with increasing energy requirements, and increasing peripheral Lactate (LA) concentration in response to severe exercise, enhances LA supply as an energy substrate to meet acute neurological needs. The acute speed and football exercises may affect cognitive function by increasing LA concentration and nervous activation. Increasing the neurocognitive performance of growing adolescent boy players an important role in their physical performance. Therefore, the aim of the present study was to investigate the effect of speed and plyometric training activity on the concentrations of nerve proteins in blood circulation. Although speed interval and plyometric training in football players may lead to progressive fatigue and activate the central nervous system and subsequent cognitive disorders, it may also positively increase neurotrophines such as BDNF or IGF-1 and affect brain neutrophils and neurological function. According to this evidence, we assumed that BDNF, BNG and IGF-1 increase in response to a football training session, which may be associated with increasing neurological function of adolescents. Therefore, the purpose of the present study was to investigate the effect of an acute speed and plyometric football-based exercise on plasma concentrations of BDNF, BNG and IGF-1 neural proteins, which may play an important role in enhancing cognitive abilities. And the effect of speed and plyometric training activity on the concentrations of nerve proteins in blood circulation. Methods: The present study is a semi-experimental type with a pre-test and post-test design, which was conducted in two sessions, including an intervention and control session. After calling in Tehran's schools, 20 adolescents 14-15 years of age were selected and accessible as a sample, and randomly participated in 2 sessions of speed and plyometric exercises and control sessions. All subjects are familiar with how to perform speed exercises (RAST Test) during a familiarization period (two sessions). On the day of the main test, after 12 hours of fasting, the test was referred to the test site and the first blood sample (5 cc) was taken from the antiquiobital vein. After the standard breakfast of the subjects, we were wearing sportswear and after ten minutes of general warming up the speed training included six times a maximum of 35 meters with a 10-second recovery between each run. After the test was performed, the plyometric exercise was executed, including a pair jump and one -foot barriers, jump on barriers with 180 degrees rotation, zigzag jump and one foot forward, jump on obstacles with both legs and legs Single-tofoot jumping on the barriers of single -foot and throwing a medicine ball, on the sides, with 12 repetitions. The active rest between turn was considered two to three minutes (29). The subject's heart rate was performed during the controlled exercise (Polar heart rate monitor) and the exercise in the range of 80-90 % of the heart rate. The second blood sample was taken immediately after the training session was completed. All sampling steps for each subject were performed under the same conditions and the BDNF and NGF levels were measured through the USA-made Kit. The IGF-I levels were measured through the ELISA methods and IGF-I Kit. Cognitive neurological function was also measured through the Stroop test (ST) before and after the training session. In this study, the Polish paper version of ST was used. ST consisted of 71 words written with colored ink. The task of the participants was to name the font color regardless of the written word. For statistical analysis, the research data are first described using the mean and standard deviation, then the changes before and after all the variables of the two sessions were calculated and analyzed using the dependent stroop test. A significant level was considered to be P≤0.05 and SPSS 16 was used to perform statistical calculations. Results: The mean and standard deviation of the somatic specifications of the research subjects was as follow: Weight (59.7±3.2), Body mass index (21.4±1.3), Fat percentage (21.7±2.8), and Fat free mase (41.10±4.1) The results of the present study showed that BDNF data changes were significantly different in training and control session (t19=12/89, p<0/001). In the exercise session, the BDNF rate increased by approximately 2.5 times compared with control session. NGF data also showed significant differences in both sessions before and after acute speed and Plyometric training (t19=4.89, p<0/001). Regarding the plasma levels of IGF-1 also the results showed a quite significant difference in comparison of two sessions (t19 =2.89, p=0.019). The time of implementation of the stroop test at two sessions of training and control in the preceding and later times also showed significant differences that in the exercise session the test was significantly reduced than the control session (t19 =3.89, p=0/009). The test time in the exercise session decreased from 59.3s to 53.1s. There was no significant change in the control session at the time of stroop performance (58.6 s and 59.3 s). These findings show that acute speeds and plyometric exercise are useful for improving post exercise cognitive performance in adolescent. Skeletal muscle contraction during high-intensity exercise increases BDNF levels in the brain, and the speed and plyeometric exercise protocol is a more effective and preferred intervention to raise BDNF levels than traditional exercise mode, with moderate intensity. Acute speed and plyometric exercises increase human cognitive function. Improvement of cognitive function may be the synthesis or release of neurological proteins that are adjusted by high blood LA after exercise. Conclusion: In summary, the current findings suggest that acute plyometric and speed training enhances human cognitive performance. The improvement in cognitive performance may be from the synthesis or release of neuroprotective proteins modulated by high blood LA concentrations after exercise. [ABSTRACT FROM AUTHOR]

Background and Aim: The aim of this study was to evaluate and compare the effect of curcumin and ibuprofen on pain control, in terms of pain intensity and duration of analgesia after extraction of the third molar of the mandible in the maxillofacial surgery department of the University School of Dentistry Islamic Azad Medical Sciences in the academic year 1400-1399. Material and Methods: The study was performed as a double-blind randomized clinical trial on 48 patients who were candidates for mandibular third molar surgery. they should also write their pain intensity one hour after taking the second dose of the drug after seeing the first symptoms of pain based on the VAS scale and the duration of their analgesia from the time of taking the drug (which was one hour before surgery for all patients) to the first signs of pain appeared on a piece of paper. Data analysis was performed using Two sample T test power analysis of PASS software version 22. Results: The results of our study showed that the duration of analgesia after Curcumin use is shorter compared to Ibuprofen (P<0.001). This difference was also statistically significant. Also, after taking the second dose of the drug, patients treated with ibuprofen reported less pain intensity, although this difference was not statistically significant (P=0.39) Conclusion: Ibuprofen compared to Curcumin further reduces patients' pain and also has a longer duration of pain for patients after extraction of the third molar of the mandible. [ABSTRACT FROM AUTHOR]

Background & Aims: Cancer is one of the most important issues in the world which affects public health as an important problem. Cancer is the third cause of death in Iran with an annual occurrence of 51,000 new cases [1]. Previous studies demonstrated the considerable increasing trends in the mortality of gastrointestinal cancer in Iran, especially for Gastric cancer and colorectal cancer [2]. In general, incidence rates of these two cancers are high in Eastern Europe, Eastern Asia, and South America and the lowest rates are in North America, and most parts of Africa [3]. The most critical factors that increases the risk of gastrointestinal cancer are aging, inappropriate diet, biological factors, and infectious diseases which contribute to the cancer occurrence [4]. Colon cancer is studied to be one of the most critical digestive diseases and is the second leading cause of cancer deaths [5]. Gastric cancer is important cancer in the world and the prevalence of gastric cancer is raised with aging in both men and women [6]. Colon cancer is a disorder in which malignant cells form in the large intestinal tissues [7]. On the other hand, in gastric cancer the malignant cells form in the lining layer of the stomach caused it. The risk of gastric cancer is high in Iran, and unlike in Western countries it is not under the control, thus it is on a dramatically increasing trend in Iran [8]. Secondary metabolites and phenolic compounds of plants can play an important role in reducing the side effects of chemotherapy drugs and have some positive effects on cancer cells, as well as in the expression of apoptotic pathway genes [9]. Colutea persica was used in traditional medicine as an anti-inflammatory agent in gastrointestinal problems [10]. The aim of this study was to investigate the cytotoxic effects of aqueous and hydroalcoholic extracts of Colutea persica on gastric cancer (AGS), colon cancer (HT-29), and normal fibroblast (SKM) cell lines. Methods: Fresh Colutea persica leaves were collected from the Delfard region of Kerman province in 1399. Dried leaves of Colutea persica were ground into a fine powder by the electronic grinder. At the next step, the ground powder was extracted using ethanol by the maceration. Then, it was placed on a shaker at room temperature. After that, the collective extracted was filtered using a filter membrane. The solvent extracted was evaporated in the rotary evaporator. Finally, to completely remove the solvent, the extract was placed in an oven, and the hydroalcoholic extract was maintained at -20 °C until use. In order to measure the total flavonoid content (TFC) of the extracts the aluminum chloride complex-forming assay was applied. In this method, quercetin was applied as the standard which flavonoid content was distinguished based on the quercetin equivalent. Briefly, Colutea persica extract was added to the aluminum chloride hexahydrate and mixed with potassium acetate and distilled water. After 30 minutes, the absorbance of the reaction was checked using a UV-Vis spectrophotometer at 415 nm. The blank sample was made by replacing aluminum chloride with deionized water. Before measuring, all of the solutions were filtered by using Whatmann filter papers (number 41). Total flavonoid content in Colutea persica extract was measured using the standard calibration curve which is achieved from different concentrations of the standard reference. The total phenolic content (TPC) of organic crude extracts was calculated using the FolinCiocalteu reagent method. In this method, gallic acid was used as a reference standard (20-100 μg/mL) for plotting the calibration curve. 0.5 mL of the Colutea persica extract was added to 1.5 mL of Folin-Ciocalteu solution. Then, it was diluted (1:10) with deionized water and added to the sodium carbonate solution. The absorbance was recorded after one hour at 765 nm by using a UV-Vis spectrophotometer. Finally, the total phenolic content was calculated based on gallic acid equivalents (mgGAE/g). All the experiments were done in triplicate. Cytotoxic effects of 5, 10, 25, 50, 100 μg/ml concentrations of aqueous and hydroalcoholic extracts were evaluated on the cells for 24 hours using MTT assay. The apoptosis induction was monitored using flowcytometry by annexin-V FITC/PI doublestaining. Cells were seeded and after 24 h they were incubated with a 1.25 mg/ml concentration of the extract and for each treated cell line, one control cell was considered. The annexin V/PI assay was performed to confirm the cytotoxic activity of the plant extracts against AGS and HT-29 cell lines. Total RNA was isolated from cells using RNX-plus TM Reagent before and after treatment. Total RNA was reverse transcribed to cDNA using M-MuLV-RT and random hexamers. The cDNA was assayed by real-time PCR using primers for BAX and BCL-2 genes. Data were analyzed using SPSS software, one way ANOVA, Tukey test at p ≤0.05... Results: The MTT assay revealed the cytotoxicity against both two cell lines (HT29 and AGS) in comparison to the HT29 and AGS normal cell line (SKM). The expression level of BAX gene increased and BCL2 gene decreased in AGS cell line after treatment by plant extract. (p<0.05). The total phenolic content was expressed in terms of milligram gallic acid equivalent per gram dry weight of plant extract. The total phenolic content of hydroalcoholic and aqueous extracts of Colutea persica were 5.02±.05 and 5.85.±0.08 mgGAE/g respectively. Conclusion: In conclusion, our findings show that Colutea. persica has anti-cancer effects in vitro against AGS and HT-29 cancer cell lines. Induction of apoptosis by using plant extract was achieved by down-regulation of BCL2 and up-regulation of BAX. Finally, the current study suggests that Colutea. persica may have cancer-fighting properties and could be a promising new candidate in this field. Besides, the molecular target of Colutea. persica and its mechanism are unknown, and the author intends to use animal models and bioinformatics methods to discover the active ingredients of Colutea. persica. [ABSTRACT FROM AUTHOR]

Background and Aims: Dentistry is an important profession ensuring the health of body and soul, and has a special place in the scientific productions of medical disciplines. The purpose of this study was to analyze the co-citation and word co-occurrence of Iranian research papers in the field of dentistry based on indexed documents in Web of Science from 2014 to 2018. Materials and Methods: The present study follows the procedures related to quantitative research with a descriptive approach and a scientometric technique. Co-citation and cooccurrence analysis techniques were used. In this study, 1079 articles were reviewed from the Web of Science. Data analysis was performed Ucinet Software, and VOS viewer. Results: Iran has the highest level of international cooperation with the United States. The highest number of published articles in the Web of Science Database belongs to Vahid Derakhshani based on the highest degree of centrality, the Eigen centrality, and the Betweenness centrality. Naser Amin Abadi ranked first for the Closeness Centrality metric, and Massoud Peirokh with a citation weight of 20 had the highest citation. The field of surgery has received the most attention among dental and endodontics journal had the highest citation in the Iranian Dental Science Citation Network. Conclusion: The trend of publishing scientific articles in Iran in the field of dentistry has been increasing during the selected period. The keywords oral, dental, and pediatric surgery have the most effective and decisive role in the scientific network of dentistry. These keywords provided strong scientific communication amongst the dental scholars in Iran. [ABSTRACT FROM AUTHOR]

Background and Aims: Nowadays, the best choice for replacing missing teeth are dental implants, however, failure is not unexpected. One of the factors that plays an important role in the implant failure is bacterial microleakage which could cause biological complication. The aim of this study was to compare the bacterial microleakage between the two types of implants. Materials and Methods: In the present interventional study, SPI and Dentis implants were placed bilaterally in the premolar-molar area of the patients' mandible. One day and 14 days after the delivery of the crown, by removing the crown and removing the abutment, sampling was performed using a sterile paper cone from four areas. One day after sample culturing, the number of colonies was counted. All data were entered into SPSS 23 and were analyzed using independent samples t-test and paired t-test with a significance level of 0.05. Results: The amount of bacteria in implant sulcus was significantly different between the two types of implants (P=0.003). After 14 days, the amount of bacteria in SPI implant sulcus significantly decreased more than Dentis implant sulcus (P=0.001). After 14 days, the amount of bacteria also decreased in all other areas which there were no significant difference between the two types of implants (P>0.05). [ABSTRACT FROM AUTHOR]

Background and Aim Fibromyalgia syndrome is a chronic disease that causes widespread musculoskeletal pain. It primarily affects women and negatively impacts many aspects of a person’s psychological and social life. This study aimed to compare the effectiveness of cognitive therapy based on mindfulness and compassion therapy on automatic negative thoughts, psychological symptoms, pain intensity, and quality of life in patients with fibromyalgia syndrome. Methods & Materials This research is a quasi-experimental study with a pre-test-post-test design with two experimental and one control group. The statistical study population consisted of all individuals with fibromyalgia syndrome referred to Mehregan Pain Clinic in Mirdamad (District 3), Seyed Khandan Clinic (District 4), and Taleghani Hospital Pain Clinic (District 1) in Tehran City, Iran. Of them, 30 patients were randomly selected and divided into three groups of experimental 1, experimental 2, and control; each group will include 10 people. The instruments used in this study included the World Health Organization quality of life questionnaire (WHOQOL BREF), pain intensity questionnaire (PIS), psychological symptoms questionnaire (Anxiety, Stress and Depression [DASS]), and automatic negative thoughts (QNS). Ethical Considerations This study was approved by the Research Ethics Committee of Arak Branch, Islamic Azad University (Code: IR.IAU.ARAK.REC.1400.005). Results The analysis of covariance showed the effectiveness of both cognitive therapies based on mindfulness and compassion therapy on four variables of pain intensity, psychological symptoms, automatic negative thoughts, and quality of life (P<0.05). Comparing the two intervention methods showed that both therapies had almost the same effect on pain intensity, psychological symptoms, and automatic negative thoughts (P<0.05) but the effectiveness of mindfulness intervention on the quality of life was significantly higher than compassion intervention (P<0.05). Conclusion The results indicate that cognitive therapy based on mindfulness and compassion therapy are suitable for people with fibromyalgia under appropriate treatment. [ABSTRACT FROM AUTHOR]

Background and Aim MicroRNAs (miRNAs) are a class of small non-coding RNAs (17-25 nucleotides) that have been studied in many diseases. miRNAs studies in different cancers have shown that miRNAs may be considered oncogene or tumor suppressor. So far, many studies have shown that miR-17-5p and miR-93-5p are important regulatory molecules in some biological processes, such as cell proliferation, associated with cancer formation. This study aimed to investigate and compare the tissue and plasma expression levels of miR-17-5p and miR-93-5p in patients with ductal carcinoma breast cancer with the normal control group. Methods & Materials The total RNA (including miRNA) was extracted from breast and plasma tissue samples of cancerous and normal samples. The RNA concentration and purity were confirmed using optical absorbance measurements. cDNA was synthesized, and the expression levels of miR-17-5p and miR-93-5p were assessed semi-quantitatively by SYBR Green-based real-time RT-PCR assay in plasma and breast tissues of ductal carcinoma breast cancer compared with the control normal samples with SNORD47 as internal normalizer. Data were statistically evaluated using GraphPad Prism 8.0.2. Ethical Considerations This study was approved by the Ethics Committee of the institute (IRAN 52d/4922, 6.10.2016). All study individuals signed a consent form to use their clinical samples and personal data under the physician’s supervision. Results The expression level of miR-17-5p showed significantly higher expression in tissues and plasma of the cancer group compared with the control group (P<0.0001). It was also significantly associated with tumor stage and lymph node, and ER (estrogen receptor) and PR (progesterone receptor) status (P<0.0001). While decreased expression of miR-93-5p in plasma and tumor tissues was shown to be significantly associated with tumor stage and lymph node involvement (P<0.0001). Conclusion The data revealed that high expression of miR-17-5p and low expression of miR-93-5p in both plasma and breast tumor might be associated with poor prognosis in breast cancer. However, miR-17-5p, due to the greater change in expression and ease of plasma detection, may serve as a possible non-invasive biomarker for breast cancer’s poor prognosis. Further follow-up studies are required to confirm this finding. [ABSTRACT FROM AUTHOR]

Background and Aim Training clinical students who learn the theoretical lessons in hospitals in practice will play an important role in improving treatment processes and providing better services to patients. Therefore, the purpose of this study is to identify the factors affecting the quality of clinical education in hospitals in Saveh City. Methods & Materials This research is a combination of exploratory studies and exploratory projects. In the qualitative stage, the qualitative method of Grand Strauss and Corbyn 1998 was used to explain the quality of clinical training. Since the students who have taken clinical courses in the Faculty of Medical Sciences of Saveh Hospitals in 1398-1397 are about 200 people and the professors and educators who teach these people are about 20 people, which according to Karajsi and Morgan, the sample size should be 140, of which 20 were interviewed and 120 were filled out with paper and electronic questionnaires. In this study, semi-structured interviews, and a researcher-made questionnaire with Cronbach’s alpha coefficient of 0.598 were selected as the data collection method. This research was performed using the qualitative method and using MAZQDA 10 and SPSS 26 software, the items obtained from qualitative research were collected and exploratory factor analysis was used to identify the factors. Ethical Considerations Considering that this study is one of the research priorities of Saveh School of Medical Sciences, it has a research license letter (No. 24.127. D.99). Results The results showed that the factors affecting the quality of clinical education include five factors. The first factor is space and facilities, the second factor is the improvement of educational processes, the third factor is educational and managerial deficiencies, the fourth factor is the evaluation of the teacher and the fifth factor is the qualitative improvement of education. Conclusion According to the quantitative and qualitative results of this study and by interviewing twenty experienced professors and student representatives, the factors affecting the quality of clinical education in Saveh hospitals were identified. [ABSTRACT FROM AUTHOR]

Background and aim: Dental caries is a major health problem nowadays. polyphenolic compounds of tea can exert its anti-cariogenic effects by affecting the cariogenic Streptococcus Mutans bacteria. The aim of this study was to investigate the antimicrobial effect of ethanolic, methanolic and aqueous extracts of green tea in comparison with chlorhexidine on Iranian strain of this bacteria. Materials and Methods: 10 g of green tea powder was dissolved in 100 mg of ethanol, methanol and aqueous solvents separately. After one week, the obtained solutions were filtered and 100mg / ml solution was extracted. to evaluate the diameter of inhibition, zone The Swabs impregnated with suspension scrubbed on culture medium. the extracts were injected onto special paper discs and the impregnated disks were placed on the bacterial culture media, plates were kept in the incubator for 24 hours at 37 °C and then the diameter of inhibition zones was calculated. Using Muller Hinton Broth, herbal extracts were made at concentrations 1:2 (50 mg/ml) and 1:4 (25 mg/ml) and 1:8 (12.5 mg/ml) and 1:16 (6.25 mg/ml) and 1:32 (3.125 mg/ml). Then, 100 μl microbial suspensions made by standard McFarland 0.5 were transferred to all test tube. The test tubes were placed in an incubator at 37°C for 24 hours. After 1 day, contents of all test tubes were separately cultured on Muller Hinton Broth medium. The culture media were incubated at 37°C for 1 day. The results were evaluated in the form of growth or non-growth of bacterial colonies on culture media and MBC and MIC were determined. ANOVA and Post hoc test was used for statistical analyze with SPSS Software. Results: Experimental results after three iterations showed mean values of 16.16, 16.66, 12.5 and 17.5 mm for diameter of the inhibition zone of ethanolic, methanolic and aqueous extracts and chlorhexidine 0.2%, as control. Also, at the significant level of 0.05, there was no significant difference between the diameter of the inhibition zone of ethanol, methanol and chlorhexidine extracts. (p>0.05)The Aqueous Extract Showed Significant difference with other Extracts. MBC Reported 12.5mg/ml for Ethanolic and 50mg/ml for two other extracts. MIC Reported 6.25mg/ml for ethanolic and 25mg/ml for two other extracts. Conclusion: The results showed that the antimicrobial effects of ethanolic and methanolic extract of Iranian green tea are higher than aqueous extract and there is no significant difference between these two extracts with Chlorohexidine. [ABSTRACT FROM AUTHOR]

Introduction: The COVID-19 crisis exerts a marked impact on the quality of life of individuals experiencing grief. Therefore, the present study aimed to assess the effectiveness of life quality improvement treatment and emotion-focused therapy on the cognitive flexibility and vitality of individuals affected by grief due to COVID-19. Material & Methods: This research employed a quasi-experimental pretest-posttest design with two experimental groups and one control group. In 2021, 30 individuals affected by grief were purposefully selected and randomly assigned to three groups: life quality improvement treatment, emotion-focused therapy, and the control group. Data were collected using the Cognitive Flexibility Questionnaire and the Oxford Happiness Questionnaire. The first experimental group received emotion-focused therapy (Leslie Greenberg, 2012), while the second experimental group received life quality improvement treatment (Fresch, 2006). Data were analyzed in SPSS software (version 27) using analysis of covariance. Results: The results demonstrated that both emotion-focused therapy and therapy based on improving quality of life had a positive effect on behavioral flexibility and social vitality, and the effectiveness of therapy based on improving quality of life on the vitality of bereaved people was more than emotion-focused therapy. Discussion & Conclusion: Considering the effectiveness of both treatments on the flexibility of action and the effectiveness of the treatment to improve the quality of life and vitality of people with grief, psychotherapists can benefit from both two treatments to improve the quality of life and vitality of people with the experience of grief to take. [ABSTRACT FROM AUTHOR]

Introduction: 30 to 60% of patients admitted to non-psychiatric wards have at least one significant psychiatric illness. Objective: The aim of this study was to investigate the frequency, causes, and quality of psychiatric counseling requested. Materials and Methods: This descriptive study was carried out on all patients admitted to educational hospitals in Rasht, Iran from 2012 to 2014, for which psychiatric consultation was requested and their counseling sheets were available. Data were extracted based on the checklist. Assessment of the quality of the consultation request and the response quality of the counseling were done. Data were analyzed by SPSS21. Results: The frequency of psychiatric counseling application in this study was calculated to be 0/3%. A total of 905 counseling papers were reviewed. According to the data, 51/1% of patients were female and 48/9% were male, with the mean age of 45/7 years. For 54/7% of the patients, emergency counseling and for 45/3%, of them non-emergency counseling was requested. The most requesting counseling departments were surgery and internal medicine (14/6% and 12%, respectively). The lowest frequency of consultation requests was for anesthesiology department (0/1%). The most common reason for requesting psychiatric counseling was restlessness (26/75%) and then medication setting (14/45%). The most common diagnostic suspicion in response to counseling was delirium and the average duration for requesting counseling was 2.9 days after admission. Conclusion: Considering the relatively low frequency and quality of counseling in this study, more attention to the use of psychiatric counseling in medical patients and coherent training of assistants to improve the quality of counseling seem necessary. [ABSTRACT FROM AUTHOR]

Introduction: It has been demonstrated that cytokines are important factors in the progression of periodontitis and some of them have an important role in the pathogenesis of periodontal disease. The aim of this study was to compare IL-23 levels in gingival crevicular fluid of patients with chronic periodontitis and healthy subjects. In addition, the relationship between IL-23 levels and probing pocket depths was assessed. Materials & Methods: In this in vitro study, samples were collected from the gingival crevicular fluid of 19 patients with chronic periodontitis and 19 healthy subjects, using paper points. The samples were transferred to the laboratory in transfer vials. IL-23 levels were determined using ELISA reader. The relation between IL-23 levels and probing depths was assessed. Data were analyzed with SPSS 20 using independent t-test and Pearson’s correlation coefficient (α = 0.05). Results: The results showed statistically significant differences in IL-23 levels in GCF between healthy subjects and patients with chronic periodontitis, with higher IL-23 levels in patients with chronic periodontitis (p value < 0.001). In addition, there was a significant and direct correlation between IL-23 levels and pocket depths in patients with chronic periodontitis (p value < 0.001, r = 0.811) and healthy subjects (p value < 0.001, r = 0.858). Conclusion: Based on the results of the present study, IL-23 levels in gingival crevicular fluid can be used for the diagnosis of chronic periodontitis. [ABSTRACT FROM AUTHOR]

Background Depression is one of the most common psychological disorders that can affect a person’s mood and change his/her perception of the self and environment. Melilotus officinalis L. plant contains effective substances and antioxidant compounds. Objective The present study aims to investigate the antidepressant effects of alcoholic extract of Melilotus officinalis L. in male rats. Methods In this experimental research, 42 male rats were divided into six groups of 7 including control (normal saline), negative control (reserpine), positive control (reserpine+fluoxetine) and three reserpine groups treated by intraperitoneal injection of 100, 200, 400 mg/kg doses of alcoholic extract of Melilotus officinalis L. Behavioral tests including forced swim test (FST) and tail suspension test (TST) were used to evaluate depression, and the antioxidant capacity and malondialdehyde level were also measured. The data were analyzed in SPSS software, version 20 using one-way analysis of variance. The significance level was set at P<0.05. Results The 200 mg/kg and 400 mg/kg doses of alcoholic extract significantly reduced the duration of immobility in the FST compared to the negative control. In the TST, the doses of 200 and 400 mg/kg showed a significant increase compared to the negative control. The doses of 200 and 400 mg/kg significantly increased the antioxidant capacity of the brain compared to the negative control. The doses of 200 and 400 mg/kg significantly reduced the antioxidant capacity of the brain compared to the negative control. Conclusion The alcoholic extract of Melilotus officinalis L has antidepressant effects similar to fluoxetine probably due to its antioxidant compounds. [ABSTRACT FROM AUTHOR]

Background Herb shops are important for preparing medicinal plants. Improper packaging can lead to contamination of these plants by various types of microorganisms, fungi and yeasts. Objective This study aims to investigate the prevalence of microbial and fungal contamination in four plants from the Lamiaceae family in herb shops in Rasht, Iran. Methods In this study, 15 samples from mint, rosemary, and wild mint plants, and 16 samples from lemon balm were collected. The samples were diluted and incubated for one hour, then transferred onto Tryptic soy agar culture medium for bacterial enumeration. The sabouraud dextrose agar culture medium was used to count total mold and yeast, while McConkey Broth culture medium was used for specific identification of Escherichia coli. Data analysis was conducted in SPSS software, version 16. For comparing the bacterial and fungal contamination levels in the plant samples with the Pharmacopeial quality standard values, the non-parametric Wilcoxon signed rank test was used. Results Out of 61 plant samples, 59 (73.7%) were contaminated with bacteria, and 60 samples (86.6%) were contaminated with fungi. The number of samples contaminated with Escherichia coli was 27 (44.2%). The mean counts of bacteria and fungi in the plant samples were 3.39×105 and 6.3×105, respectively. Conclusion The microbial contamination in most of the plant samples examined in this study is significantly higher than the permissible limit. It is necessary for health authorities to implement stricter policies for monitoring the quality of natural products in herb shops of Rasht, Iran. [ABSTRACT FROM AUTHOR]

Background Temporomandibular disorders (TMDs) are a group of conditions that cause dysfunction in the jaw joint, masticatory muscle pain and mouth opening limitations, and affects patients’ ability to eat, practice oral health, and perform other activities of daily living. The etiology of TMDs is not well-known. These disorders have a higher prevalence in women and younger people. Although the benefits of lowlevel laser therapy (LLLT) in treating TMD have been reported, the results vary from study to study. Objective The purpose of this study is to investigate the effectiveness of LLLT in the treatment of TMDs Methods In this narrative review study, a search was conducted in Google Scholar, PubMed, and Scopus databases for randomized clinical trials, case-control studies, and systematic reviews published from 1976 to 2023 using the keywords (Mesh terms) temporomandibular disorder, low-level laser therapy, LLLT, and myofascial pain. Results Of 271 found articles, only 8 were included in the study, of which 6 confirmed that the LLLT was effective in the treatment of TMDs. One article concluded that superluminous devices are more effective than LLLT and one article concluded that LLLT is not effective in treating TMDs. Conclusion The LLLT is effective in the treatment of TMDs and its related disorders, such as masticatory muscle disorder, temporal joint pain, and difficulty in jaw opening. The nuber of studies are limited and definite conclusions cannot be drawn. Therefore, further studies are needed in this field. [ABSTRACT FROM AUTHOR]

Introduction: Lupus is a chronic systemic disorder with a complex etiology, and viral infections have contributed to its development and progression. Human herpesvirus-8 (HHV-8) has been diagnosed in many patients with autoimmune disorders; however, its role in lupus has not been well investigated. The present study aimed to compare the frequency and viral load of HHV-8 in patients with lupus and healthy population. Material & Methods: In this cross-sectional study, 70 patients with lupus and 70 healthy individuals who were matched for gender and age were included. After the extraction of viral DNA, the HHV-8 viral load was measured using the Real-time polymerase chain reaction (PCR) technique, and the results were analyzed by SPSS software. Results: Patients with lupus consisted of 59 females (84.3%) and 11 males (15.7%) with a mean age of 31.1±8.4 years, and the control group consisted of 58 females (82.9%) and 12 males (17.1%) with a mean age of 33.5±11.2 years, none of them were positive for HHV-8 genome. Discussion & Conclusion: To date, there is no report in this field from Iran, and this study is the first survey. Regarding the high accuracy of the Real-time PCR technique and lack of HHV-8 genome in the blood samples of Iranian patients with lupus, it seems that none of the individuals, even in the case of viral infection, were infected with the active form of HHV-8, which is compatible with the previous studies. [ABSTRACT FROM AUTHOR]

Introduction: Autism is considered a neurodevelopmental disorder. Children with autism are known to have qualitative defects in communication and social interactions, as well as repetitive and limited behaviors. In addition, these children have deficits in joint attention. The present study aimed to determine the effectiveness of the joint attention training program on the neuropsychological abilities and mental flexibility of children with high-functioning autism aged 3 to 7 in Abadan City, Iran. Material & Methods: A semi-experimental design with pretest-posttest and a control group was conducted in 2021 for 30 children with high-functioning autism disorder in Fereshtagan and Noandish centers in Abadan, Iran. The sampling was performed in an accessible way and via the randomized balanced blocks method in the experimental and control groups. Moreover, the assignment and joint attention training program was implemented in the intervention group. The data were collected using the Autism Spectrum Screening Questionnaire (ASSQ, Ehlers and Gillberg, 1993), Continuous Performance Task (CPT, Connors, 2004), and Wisconsin Card Sorting Test (WCST, Grant and Berg, 1948). The obtained data were analyzed through the multivariate covariance test and at a significance level of 0.05 using the SPSS software. Results: In the intervention group, the mean (standard deviation) of neuropsychological abilities decreased from 7.82 (0.93) in the pre-test to 6.26 (0.84) in the post-test (P<0.001). In the intervention group, the mean (standard deviation) of cognitive flexibility decreased from 7.00 (1.00) in the pre-test to 6.22 (0.70) in the post-test (P<0.001). Discussion & Conclusion: Considering the effectiveness of the joint attention training program in improving neuropsychological abilities and mental flexibility, the implementation of this program is recommended for preschool counselors and psychologists to improve the conditions of children, especially those with high-functioning autism. [ABSTRACT FROM AUTHOR]

Introduction: The possible accidents for mountaineers and the importance of safety highlight the necessity of first aid training in the mountains. Therefore, the present study aimed to assess the impact of face-to-face, virtual, and integrated first aid training on the knowledge, attitude, and skills of mountaineers. Material & Methods: The present quasi-experimental study was conducted on 93 mountaineers using the available sampling method and random allocation using permutation blocks of six in three groups of virtual, face-to-face, and integrated training. The intervention was carried out for four weeks. Face-to-face and integrated training groups attended in-person classes, while the virtual training group received the content through WhatsApp messenger during the same period. Participants completed the demographic characteristic form, as well as knowledge, attitude, and skill questionnaires before the intervention and three weeks after its completion, and the data were analyzed in SPSS software (version 22) using descriptive and inferential statistical tests (P<0.05). Results: The mean scores of knowledge, attitude, and skills in the three groups before and after the intervention had a significant difference and increased after the intervention (P<0.001). In the inter-group comparison, the face-to-face training group obtained higher scores in attitude (69.58±4.19) and skill (44.06±12.99) compared to the virtual and integrated education (P<0.000214). Discussion & Conclusion: There was a significant difference between the attitude, knowledge, and skill scores of mountaineers in all three groups of face-to-face, virtual, and integrated training before and after the intervention, and the mean scores increased. Nonetheless, the mean score of face-to-face training was higher than that of virtual and integrated training methods. It is suggested that face-to-face training be used to teach first aid to mountaineers. [ABSTRACT FROM AUTHOR]

Introduction: Domestic violence occurs in different ways in families. Parent abuse is a type of psychological, physical, or financial violence practiced by children against their parents. This study aimed to investigate the prevalence of parent abuse in high school boy students during the coronavirus pandemic. Material & Methods: The research method was descriptive-cross-sectional. The statistical population was all mothers of high school boy students in Khuzestan, Iran, in the academic year 2020-2021, of which 676 were selected by multistage cluster sampling. In this study, the Parent Abuse Scale (boy version) and demographic inventory were used. The data were analyzed with descriptive statistics (mean, standard deviation, and percentage) and t-test using SPSS software (version 22). Results: The findings of this study showed that the prevalence of physical abuse is 6.2%, emotional abuse 5%, financial abuse 11.4% and parental abuse in Corona epidemics is 4.1%. In addition, the findings of this study compared to the studies before the Corona outbreak showed that the prevalence of parental abuse of high school boy students in Khuzestan province was lower in the context of the coronavirus epidemic. Discussion & Conclusion: Despite the fact that the number of parental abusesin Iranian society is significant, the rate of parental abuse in high school boy students during the Coronavirus in Khuzestan showed no increase. It is suggested to investigate strategies that have created and maintained positive interactions in the family. [ABSTRACT FROM AUTHOR]

Introduction: Mothers are more responsible for raising their children, and they are usually the main caregivers of disabled children. The present study aimed to determine the effectiveness of behavioral activation therapy on social avoidance in mothers of children with cerebral palsy. Material & Methods: This study with a quasi-experimental research design had a pretest, post-test, and a control group. The research sample consisted of 40 mothers referred to Occupational Therapy Centers in Ilam, Iran, in 2021. Then, they were randomly assigned into an experimental group (n=20) and a control group (n=20). The experimental group received behavioral activation group therapy based on the protocol provided by Kanter, Bush, and Rush during eight 90-minute sessions in one group session per week[S1]. Information was collected using a social phobia questionnaire (SPI) by Connor et al. (2000) in two stages of pre- and post-interventions. Covariance analysis and SPSS software (version 27) were used for data analysis. Results:Based on the obtained results, at the end of the treatment, the social avoidance scores of the intervention group were significantly reduced compared to the control group (P<0.05). Discussion & Conclusion: The study showed that behavioral activation therapy has a favorable effect on reducing the severity of symptoms of social avoidance disorder in mothers of children with cerebral palsy. Therefore, this treatment is suggested as a complementary treatment along with drug treatments to improve psychological symptoms in these people. [ABSTRACT FROM AUTHOR]

Introduction: One of the problems of the elderly is a decrease in balance and quality of life of senior citizens. Therefore, the present study aimed to assess the effect of fatigue on balance, motor function, lower limb strength, and quality of life of the two groups of elderly people at home and in a nursing home. Material & Methods: The present study was conducted based on a prospective quasiexperimental design. For this purpose, 35 elderly women at home and 35 elderly women in nursing homes in Miyaneh were selected via available sampling. To carry out the fatigue protocol, the subjects performed sitting and standing movements with their hands on their chests. Subjects were administered the relevant tests under normal conditions and without fatigue. In the second session, which was held 48 hours later, the subjects performed the fatigue protocol and then performed balance, motor function (TUG), and lower limb strength tests (number of takeoff and landing chairs). The quality of life in both groups was assessed using the Leipad Elderly Quality of Life questionnaire. Data were analyzed in SPSS software (version 24) using independent and dependent t-tests. Results: The results demonstrated a significant difference (P=0.001) between the two groups of elderly women in nursing homes and those living at home in terms of motor function, strength, and quality of life. Nonetheless, there was no significant difference (P=0.127) in the balance of the two elderly groups. Discussion & Conclusion: As evidenced by the results of this study, the quality of life of the elderly in nursing homes was lower than that of the elderly at home, and fatigue can exert a more marked effect on the motor function and strength of these people. Therefore, it is recommended to prioritize the design of exercise interventions with the approach of increasing the fatigue threshold to improve the parameters related to the quality of life of the elderly. [ABSTRACT FROM AUTHOR]

Introduction: Urinary control disorder is one of the most common disorders in children, which has important psychological consequences such as reducing selfconfidence, anxiety, etc. This research was conducted with the aim of evaluating aggression in children with daily urinary disorders. Material & Methods: This case-control study was conducted on 200 children aged 5 to 12 years in two groups (50 girls and 50 boys) and control (50 girls and 50 boys) who referred to the pediatric clinic of Amirkabir Arak Hospital in 1401 and with random sampling. Easy randomization and using Shahim's aggression questionnaire, the level of aggression was measured in two groups of cases and controls, and the data were analyzed using SPSS version 23 software. Results: In this study, 200 children, including 100 in the case group and 100 in the control group, with an average age of 7.17 years (±2.17) participated. No significant relationship was found between the two groups in terms of parents' education, place of residence, socio-economic status, number of children in the family, and history of mental illnesses in the parents. (P>0.05). The mean total score of aggression in the case group (±8.18) was 34.41 and in the control group (±5.17) it was 27.80. The total score of aggression and the mean score of reactive-overactive aggression and Physical aggression and relational aggression were significantly higher in the case group than in the control group (P<0.05). Discussion & Conclusion: In this study, children with daily urinary disorders were more aggressive than non-diseased children. Therefore, screening children with urinary disorders and, if necessary, psychiatric interventions such as teaching anger management methods are very important. [ABSTRACT FROM AUTHOR]

Introduction: Psychological well-being is of paramount imporance for cancer patients and is affected by various factors, such as personality traits. The present study aimed to predict psychological well-being based on resilience and personality type D in cancer patients. Material & Methods: The current research was conducted based ona descriptivecorrelatioal design. The statistical population of this research was made up of all cancer patients who were members of Maxa in Isfahan in 2021. The research sample included 220 cancer patients who were selected via aailable sampling. The data collection tools were demographic characteristics questionaire, psychological well-being questionnaire by Riff (1995), personality type D by Denault (2005), and resilience by Connor and Davidson (2003). The data were analyzed in SPSS software (version 24). Descriptive statistics included mean, standard deviation, and percentage, while inferential statistics including Pearson's correlation coefficient and multiple regression analysis. The significance level was considered to be 0.05. Results: The correlation matrix illustrated that psychological well-being had a significant positive correlation with the total score of resilience (r= 0.701; P=0.001) and a significant negative correlation with personality type D (r= -0.517; P=0.001). Moreover, according to the results of multiple regression analysis, 38% of the variance of psychological well-being can be predicted based on resilience and personality type D variables (P=0.001). Resilience with beta 0.38 (P=0/001; T=0.639) positively and significantly and personality type D with beta -0.25 (P=0/001; T=-1.607) can negatively and significantly predict the psychological well-being of cancer patients. Discussion & Conclusion: Resilience and personality type D can predict the psychological well-being of cancer patients; Therefore, the psychological well-being of cancer patients can be affected by carrying out interventions related to resilience and D personality type. [ABSTRACT FROM AUTHOR]

Introduction: Exercise training and vegetarian diets have been accepted as suitable and non-pharmacological methods for improving lifestyle and mitigating obesity, and related metabolic diseases. The aim of this study was to investigate the combined effect of aerobic training and vegetarian diet on lipid profile of adults. Material & Methods: A comprehensive search of English and Persian articles was conducted on databases including PubMed, Web of Science, Scopus, SID, Magiran, and Google Scholar, up to February 2023. Meta-analyses were conducted to compare the effects of aerobic exercise and vegetarian diet on body weight, as well as lipid profile parameters (low-density lipoprotein, high-density lipoprotein, triglyceride and total cholesterol). Standardized mean differences (SMD), weighted mean differences (WMD), and 95% confidence interval (CI) were calculated using a random effect model. Additionally, the I2 test was assessed the heterogeneity, and Funnel plots and Egger tests at a (significance level: 0.1) were employed to identify publication bias. Results: The meta-analysis, comprising 36 studies with 10,795 adults, showed that aerobic exercise and vegetarian diet significantly decreased body weight [WMD=-4.5, (CI: -5.68 to -3.31), p=0.001], low-density lipoprotein [SMD=-0.35, (CI: -0.44 to - 0.26), p=0.001], high-density lipoprotein [SMD=-0.16, (CI: -0.29 to -0.03), p=0.01], triglyceride [SMD=-0.11, (CI: -0.17 to -0.05), p=0.001], and total cholesterol [SMD=- 0.44, (CI: -0.57 to -0.32), p=0.001]. Data analysis utilized Comperhensive Metaanalysis software version 2. Discussion & Conclusion: The findings of the present meta-analysis showed the important role of exercise and vegetarian diet in improving lipid profiles. Therefore, aerobic exercise and vegetarian diet are recommended as non-pharmacogloical strategies for reducing body weight and improving lipid profiles in adults. [ABSTRACT FROM AUTHOR]

Introduction: It seems that education focusing on the perceived threat is effective in informing people about water scarcity. Therefore, due to the position of educated people as role models in society, the present study aimed to assess the effect of education based on the perceived threat on water conservation behavior of students of Behbahan Faculty of Medical Sciences. Material & Methods: This quasi-experimental study was conducted on 62 operating room students of Behbahan Faculty of Medical Science in the academic year of 2017- 2018, selected via multistage random sampling. The data collection tool was a researcher-made questionnaire assessing demographic characteristics, perceived threats, and water conservation behavior which was completed by students before the intervention. Thereafter, written and visual messages based on the perceived threat were prepared and presented in PowerPoint format with the cooperation of professors for four sessions in the last minutes of the classroom, and an opportunity was given for group discussion and exchange of opinions. In addition, message posters were installed in appropriate places, such as restrooms, and were sent to students using the SMS system. Two months later, the questionnaires were completed again. The data were analyzed in SPSS software (version 15) using the Paired t-test, Covariance analysis, and Pearson correlation coefficient. A p-value less than 0<0.05 was considered statistically significant. Results: The mean age of participants was 20.61±1.32 years. There were 32 (51.6%) female and 30 (48.4%) male students. Before the training, the mean water conservation behaviors, susceptibility, and severity scores were 47.98±16.36, 61.74±21.23, and 59.03±21.09, respectively. After training, the aforementioned mean scores increased significantly to 77.55±14.59, 86±0.54, and 83.38±8.53, and there was a significant relationship between the variables (P<0.05). Discussion & Conclusion: The education caused an increase in students' perceived threat to the water shortage crisis and promoted water conservation behavior. It is suggested that similar studies be carried out in other groups to check the generalizability of the results at the community level. [ABSTRACT FROM AUTHOR]

Introduction: Considering the broad spectrum of using nanoparticles in food coatings as a potent antimicrobial agent and their possible cytotoxic effects and accidental consumption of these toxic materials, this study was performed. The present study aimed to investigate the cytotoxicity of chitosan and nano-chitosan in vitro. Material & Methods: This cross-sectional study was conducted in 2019 in the Laboratory of the Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. The XRD and FITR techniques were employed to study the characteristics of these nanoparticles. Moreover, two cell lines, HT-29 and Vero, were used to study the cytotoxic effects of chitosan and nanochitosan by MTT assay, acridine orange, and ethidium bromide staining. One-way ANOVA and independent t-test were used to analyze the collected data with the help of SPSS software (version 19). Results:Based on the obtained findings, the maximum values of XRD at the angle of θ2 were observed at 20°. The highest peak appeared at 1530 cm-1, which was associated with tensile vibration of N-P-N. The spectrum diagram of chitosan due to the tensile vibration of synthetic nanochitosan of N-H bound appeared at 1646 cm-1. The results showed a proportional increase in the cytotoxicity with time and concentration of nanoparticles in the cells. Discussion & Conclusion: Since by increase in time and concentration of nanoparticles, toxicity was observed in cells; therefore, the time and concentration of chitosan nanoparticles are important in causing cytotoxicity. Considering the toxic effects of these nanocomposites on cancer cells, they can be used in cancer treatment, which requires further studies. [ABSTRACT FROM AUTHOR]

Introduction: Feeling alone and enduring distress are risk factors for suicidal thoughts, while parental bonds are protective factors. However, the complex mechanisms behind these factors have not been identified among people with a history of suicide attempts. Therefore, the present study aimed to predict suicide attempts through distress tolerance, feeling alone, and parental bonds in people with a history of suicide attempts. Material & Methods: The current research is a descriptive-correlational study, and the statistical population included all people with a history of suicide attempts in Isfahan, Iran, from among whom 120 people were selected through convenience sampling. The research tools included parental bond questionnaires by Parker et al. (1979), distress tolerance by Simmons and Gaher (2005), feelings of loneliness by Russell et al. (1980), and attempted suicide was made by the researcher. The collected data was analyzed using descriptive methods, including Mean and Standard deviation and inferential statistics (e.g., Pearson's correlation coefficient and stepwise regression analysis) using the SPSS software (version 27) and PLS3 statistical software. Results: The results showed that among the predictor variables, feeling alone had the highest predictive power (64.7%), and in the second step, with the addition of parental bond with the mother, it increased to 0.701%, and in the third step, with the addition of Parenting bond with father reached 0.729%, and in fourth step with the addition of distress tolerance, it reached 0.743%, all of which are statistically significant. Discussion & Conclusion: Based on the findings of the present research, we can point out the influential role of feeling alone in predicting suicide attempts, and the need for families and policy-makers to pay attention to this prominent factor can play a major role in reducing suicide rate. [ABSTRACT FROM AUTHOR]

Introduction: The extraction of chemical compounds from plants is influenced by various factors, such as methodology and duration of extraction, sample preparation, and the type and concentration of solvent used. This study was performed to investigate the effect of extraction time and type of solvent on the contents of phenolic compounds, flavonoids, and antioxidant activity of Digitalis purpurea L. plant. Material & Methods: An experiment based on a completely randomized design in a factorial arrangement with three replications was conducted at the Horticulture Laboratory at the University of Zanjan, Zanjan, Iran, in 2021. The experimental treatments included two levels of extraction duration (24 and 48 h) as the main factor, and two levels of methanol, ethanol, and acetone solvents (100% and 80%), compared with the control (distilled water), as sub-factors. Extraction of purple foxglove leaf powder was done by macerating 24 or 48 h using two levels of methanol, ethanol, or acetone as solvents (100%, 80%, and distilled water for the control). Evaluation of phenolic compounds, flavonoids, and antioxidant activity was performed. The resulting data were analyzed in SAS software version 9, and mean comparisons were performed by Duncan's Multi-Range Tests at the 1% and 5% probability levels. To determine the correlation between parameters, Pearson's correlation coefficient was checked using SPSS version 20 software. Results: The results showed that there was a significant difference between 24 and 48 h of maceration to extract chemical compounds (P<0.01). The highest amounts of total phenol (24.75 mg GAE/g dw) and antioxidant activity (71.36%) were obtained in 80% acetone extract, and the maximum flavonoid content (6.03 mg Q/g dw) was achieved in 80% ethanol and 48 h maceration time. Generally, increasing the maceration time from 24 h to 48 h caused a significant rise in the extraction of phenolic compounds, flavonoids, and antioxidant activity. Moreover, there was a positive correlation between flavonoid content (P=0.86) and phenolic content (P=0.82) with antioxidant activity. Discussion & Conclusion: According to the results, increasing the extraction time and also utilizing hydroalcoholic solvents were more effective in extracting these compounds than pure alcohols. [ABSTRACT FROM AUTHOR]

Background The human immunodeficiency virus (HIV) infection is important because it can cause stigma and psychological, family, and social problems in affected people. Objective This study aims to investigate the effect of schema therapy on adaptive and maladaptive strategies of cognitive-emotion regulation in people with HIV. Methods This is an interventional study with a pretest-posttest design. Thirty people with HIV were selected by a convenience sampling method and randomly divided into two groups of intervention and control. Garnefski et al.’s cognitive-emotion regulation questionnaire - short form (CERQ-SF) was used to collect data. The intervention group received 10 two-hour sessions of group treatment based on Young’s schema therapy model. The data analysis was performed in SPSS software, version 26 using descriptive statistics (frequency, percentage, mean, standard deviation) and analysis of covariance (ANCOVA). The significance level was set at 0.05. Results The results ANCOVA showed that group schema therapy affected the use of adaptive strategies (acceptance, positive refocusing, refocusing on planning, positive reappraisal, and putting into perspective) and maladaptive strategies (self-blame and catastrophizing), (P<0.001). However, it had no significant effect on other-blame (P=0.033) and rumination (P=0.102). Conclusion Schema therapy can increase the use of adaptive strategies and reduce the use of maladaptive strategies (self-blame and catastrophizing) of cognitive-emotion regulation in people with HIV. [ABSTRACT FROM AUTHOR]

Background Cleft lip and cleft palate are the most common congenital anomalies in the head and neck region, which are affected by environmental and genetic factors. These anomalies can cause serious problems such as physical deformity, nutritional problems, respiratory problems, and problems in social interactions for affected people. Objective The current study aims to investigate the prevalence of lip and palate clefts and the related factors in infants born from 2014 to 2019 in Karaj, Iran. Methods This descriptive-analytical study was conducted on the data of 91,563 babes born from 2014 to 2019 in Kamali, Imam Ali, Maryam, and Ghaem hospitals in Karaj, Iran. The data were collected and analyzed in SPSS software, version 24. Results Of 91,563 cases, 46 were identified with various types of clefts. The overall prevalence was 0.5 per 1000 live births; 26.08 had cleft lip, 52.17% had cleft palate, and 21.73% had cleft lip and palate (P=0.024). Also, 56.52% of babies were male (P=0.37), 76.08% had mothers aged 20-30 years with a mean age of 24.4 years, 58.69% had first-time pregnancy mothers, 13.03% had parents with cousin marriage (P<0.001), and 37% had mothers with blood type A (P=0.11). Conclusion The prevalence of lip and palate clefts in babies born in Karaj is lower than the global prevalence and the prevalence in other cities of Iran. [ABSTRACT FROM AUTHOR]

Background: The Celiac National Institute has recently devised a diagnostic algorithm for celiac, which has been adopted from the most recent guidelines and articles worldwide. All Iranian provinces are requested to set all diagnoses based on the newest national protocol devised by the National Institute of Celiac Disease; however, some incompatibilities are observed. Therefore, this study was conducted to demonstrate these incompatibilities. Materials and Methods: In this descriptive-analytical study, we enrolled 250 cases of celiac disease referred to the province registry system and revised the diagnosis based on the national protocol for celiac disease diagnosis. All data were analyzed using SPSS software version 26. Results: Among the 250 patients diagnosed with celiac disease, 88 (35.2%) had incompatibility. The mean age of the patients was 37.19 years. 28 people (31.8 %) were men. Results indicated that in 40.9% of incompatibility cases, only pathology tests were performed, and in 52.3% of incompatibility cases, only serological tests were performed. In 6.8% of cases, both tests were performed, but the diagnosis was indefinite. Pathological results indicated that 0.5% of patients were in Marsh 1, 19% in Marsh 2, 35.7% in 3a, 23.8% in 3b, and 19% in Marsh 3c phases. Conclusion: There are cases of diagnostic incompatibilities between the most recent national protocol for celiac disease and physicians' practice. Therefore, it is vital that practitioners are trained with the national protocol for celiac disease diagnosis. [ABSTRACT FROM AUTHOR]

Background. Different shoe weights affect walking mechanics. Therefore, the purpose of this study was to determine the effect of sport shoe weight on lower extremity muscle activities in athletes with anterior cruciate ligament reconstruction during walking. It was hypothesized that reduced shoe weight results in decreased frequency content of selected muscles during walking. Methods. Twenty healthy males and athletes with ACL reconstruction volunteered and gave their written informed consent to participate in this study. Participants were male and physically active. Each participant performed three walking trials in each of the light (mass per shoe: 150 ± 18 g), medium (300 ± 18 g), and heavy (450 ± 18 g) conditions in a randomized order and electromyography were analyzed during walking. Results. EMG results showed that the increase in shoe weight was directly related to the increase in electrical activity of the muscles, but only in the swing phase was the electrical activity of the TA muscle decreased. Conclusion. Different shoe weights affect the electrical activity of the muscles and the walking speed. Therefore, lighter weight shoes are recommended for patients with ACL. Practical Implications. The results of this study show that light shoes are useful for patients with anterior cruciate ligament rupture and the use of lightweight shoes is recommended for people with anterior cruciate ligament rupture. [ABSTRACT FROM AUTHOR]

Background and Objectives Constant control of electrical panels is effective in ensuring the safety of users. This study was conducted during the years 2022-2023 to evaluate their structure in blood transfusion centers by ETBA method. Materials and Methods In this descriptive-analytical study with the ETBA method, the performance and quality of the grounding system, capacitor bank, connections, the location of the panels, the arrangement structure of the components, and their cleanliness and safety in the centers of Kermanshah, Hamadan, Ilam, Sanandaj, Arak, Karaj, Semnan, Bandar Abbas, Sari and Yazd were investigated. The obtained information was analyzed statistically with SPSS 25 software. Results The results showed 74.3% electrical panels with unprincipled volume and distribution of connections, 72.4% due to the selection of inappropriate location and distance from tools and devices, deployment in users' traffic area without provision of fence and safety devices, 70.5% not equipped with warning devices, 43.3% non-standard arrangement, 51.4% insufficient cleaning, 66.3% not having an active earth connection, and 60.3% not having a capacitor bank did not have reliable electrical safety. Conclusions Based on these results, the regular and continuous establishment and implementation of the medical equipment maintenance management system can be a fundamental and effective factor in identifying risks and the pertinent degree of risks and damages in the process of activity. [ABSTRACT FROM AUTHOR]

Background Infertility is a major crisis for couples, causing anxiety in them. Infertile couples experience more psychological, marital, family, and social problems. Objective This study aims to compare psychological well-being, moral foundations, and sense of humor between fertile and infertile couples in Rasht, Iran. Methods In this causal-comparative study, 212 couples (106 infertile and 106 fertile) referred to AlZahra Hospital in Rasht in 2022 participated. Ryff’s psychological well-being scale, moral foundations questionnaire, and multidimensional sense of humor scale were used to collect data. For data analysis, the analysis of covariance was used in SPSS software, version 28. Results There was a significant difference between infertile and fertile couples regarding self-acceptance, positive relations with others, autonomy, and personal growth dimensions of psychological well-being and its total score, and also in the sanctity/purity dimension of moral foundations and the humor creativity and uses of humor for social purposes dimension of sense of humor. Conclusion Fertile couples in Rasht have significantly higher scores in some dimensions of psychological well-being, moral foundations, and sense of humor than infertile couples. [ABSTRACT FROM AUTHOR]

Background Staff training in organizations is a measure for developing human capital. The pathology of this process needs to be assessed to understand the current situation and solve the challenges and limitations. Objective This study aims to assess the pathology of the training process for the incident command system (ICS) staff of hospitals in Guilan Province using the three-pronged approach. Methods This is a qualitative-quantitative study. The study population in the qualitative phase included experts in the hospital ICS. In the quantitative phase, the study population included all ICS managers and staff in the Guilan Province hospitals (n= 548). The data collection tool was a semi-structured interview in the qualitative phase and a researcher-made questionnaire in the quantitative phase. For data analysis, MAXQDA software, version 2020 was used in the qualitative phase and SPSS software, version 26 was used in the quantitative phase. Results The results in the qualitative phase showed the extraction of 55 open codes, 25 axial codes, and 6 selective codes in the form of three domains of processes, context, and structure. The results in the quantitative phase showed that among all the domains, the process domain-related factors with a percentage of variance (impact) of 0.262 were more harmful than context- and structure-related factors in the training process. Conclusion The pathology assessment based on the three-pronged model is an effective method for determining the training priorities for the hospital ICS staff. The use of this model during a crisis can be an effective step for identifying shortcomings to solve them and take appropriate measures for the ICS staff training. [ABSTRACT FROM AUTHOR]

Background As congenital gastrointestinal diseases are pretty common and can lead to fatal consequences when combined with congenital heart diseases, we conducted a study in Iran to explore the relationship and prevalence of these two conditions. Our objective was to identify the types and frequency of congenital heart diseases in children who also have gastrointestinal anomalies. Materials and Methods: This was a cross-sectional analytical study. The research population was the patients referred to the Gastrointestinal Clinic of Hazrat Masoumeh Children's Subspecialty Hospital during the 2011-2017. In this study, the echocardiography in the patients’ files performed by a pediatric heart specialist was examined, and in the next step, the patients were divided into two groups with and without heart disorders. Gastrointestinal abnormalities were also recorded in the relevant checklist. Finally, the recorded information was entered into SPSS software version 22, and Chi-square and Fisher exact tests were used to compare the qualitative findings. The significant level for all tests was considered to be 0.05. Results: The average age of the children in this study was 7.93±7.74 months. 105 boys (54.7%) and 87 girls (45.3%) were examined. 167 children (87%) had cardiovascular abnormalities and 25 children (13%) had no abnormalities. The most common types of cardiovascular abnormalities were 69 (35.9%) septal defects, 36 (18.8%) atrial septal defects, and 22 (11.5%) pulmonary valve stenosis. The least frequent abnormalities were cardiomyopathy in three (1.6%) and ventricular inter-atrial septal defects along with atrial septal defects in one (0.5%) patient There was not a significant correlation between congenital heart diseases and frequency of closed anus, rectovaginal fistula, Hirschsprung, anal stenosis, rectal prolapse, perianal fistula, esophageal atresia, pyloric hypertrophy, intestinal obstruction, annular pancreas, biliary atresia, diaphragmatic hernia, Meckel's diverticulum.(P>0.05). A significant relationship was found only between omphalocele and pyloric hypertrophy with the presence of cardiovascular disorders (P<0.05). Conclusion: The results showed that congenital heart diseases have a high prevalence in infants with gastrointestinal anomalies, so cardiac examination is mandatory in all infants with gastrointestinal anomalies. [ABSTRACT FROM AUTHOR]

Introduction: Bacterial biofilm assumes importance across various contexts, including chronic human infections, dental plaque, and infections associated with foreign bodies such as catheters. Pseudomonas aeruginosa, recognized for its biofilm-forming capacity, is implicated in the onset of diverse infections. This study aims to explore the correlation between biofilm production and resistance to distinct classes of betalactam antibiotics. Material & Methods: In this cross-sectional investigation, 113 wound samples from burn patients admitted to Tehran and Ahvaz hospitals in 2020 were collected. Pseudomonas aeruginosa strains were identified using conventional biochemical and molecular methods. Antibiotic resistance profiles were elucidated employing the disk diffusion method, while beta-lactamase genes were identified through polymerase chain reaction (PCR). Statistical analysis was conducted using SPSS 20 software. Results: Forty isolates of P. aeruginosa, all exhibiting biofilm-producing capabilities, were identified. Carbapenem resistance manifested in 16 isolates, with the predominant beta-lactamase genes being blaTEM (15 isolates), blaVIM (12 isolates), and blaCTX-M (8 isolates). The highest resistance was observed against cefotaxime, cefazolin, meropenem, imipenem, and piperacillin, with 16 strains displaying resistance to these antibiotics. In the examination of carbapenemase-producing isolates (40% of the isolates), robust adhesion capabilities were consistently observed, and none lacked biofilm formation. Discussion & Conclusion: Significant antibiotic resistance, particularly carbapenem resistance, was identified among P. aeruginosa isolates causing burn wound infections. The combination of carbapenem resistance with biofilm production poses a formidable challenge in managing infectious diseases. It is suggested that, in addition to combating microbial resistance, efforts should be directed towards the eradication of bacterial biofilm for effective treatment. [ABSTRACT FROM AUTHOR]

Introduction: Energy homeostasis as a metabolic control pathway can be investigated from different dimensions. The present study aimed to assess the effect of eight weeks of aerobic and resistance training on adropin, spexin, and TNFa, as well as insulin resistance indices, in obese men with type 2 diabetes. Material & Methods: In this quasi-experimental study, 30 obese men with type 2 diabetes in khoy in 2022 were selected and randomly assigned to three groups: control, aerobic exercise, and resistance exercise. Aerobic and resistance training (three sessions per week) was performed for eight weeks. In the pre-test and posttest stages, the levels of serum adropin, spexin, and TNFa, as well as the indices of insulin resistance and insulin sensitivity, were measured. Data were analyzed in SPSS software (version 24) using Shapiro-Wilk, t-test correlated, and one-way analysis of variance test to investigate intra-group and inter-group effects, respectively. Results: Aerobic and resistance training causes significant changes in fat percentage, fasting blood sugar, cholesterol, triglyceride, HDL, and LDL in obese men with type 2 diabetes (P≤0/05). Moreover, in the between-group comparison, aerobic exercise causes significant changes in mean blood pressure, insulin, Insulin resistance index (HOMA-IR), adropin, and spexin levels in obese men with type 2 diabetes (P≤0/05). Conclusion: Participation in an aerobic exercise program with moderate intensity exerts more marked effects on adropin and spexin indices compared to resistance exercise. It is recommended to consider aerobic training programs in diabetic people as an effective factor in therapeutic intervention. [ABSTRACT FROM AUTHOR]

Introduction: Neurodevelopmental disorders begin in childhood and lead to a weakening of physical, cognitive, emotional and social skills in affected children. The aim of this study is to develop a multimedia educational program and to evaluate its effectiveness on problem solving in children with neurodevelopmental disorders. Material & Methods: In this study, a multimedia training program with a neuropsychological approach was first developed and the content validity of the tool was confirmed by experts. The effectiveness of the program was then evaluated in a quasi-experimental study with a pre-test, a post-tesand a follow-up phase. The participants in this study were children with neurodevelopmental disorders whose male students were studying in Tehran in the academic year of 1400-1401. The children were examined using the Tehran Stanford-Binet Intelligence Test, and 100 children with neurodevelopmental disorders were selected based on the available sampling method and randomly divided into two groups, the experimental group and the control group. The experimental group completed 24 -training sessions that focused on a multimedia training program with a neuropsychological approach. Each session took place five times a week and lasted 90 minutes. The instrument used in this research were London Tower Test (Shalis,1982), which was used as a pre-test, post-testand for the follow-up studies. The data were then analyzed using repeated measurement tests and multivariate analysis of variance (MANCOVA). Findings: The results showed that the multimedia training program can influence the problem-solving skills (p≤0/01) of children with neurodevelopmental disorders. It also showed that the effect of this instruction was constant even after 1/5 months. Conclusion: multimedia training program with Neuropsychological approach enhance problem solving of Children with neurodevelopmental disorders. [ABSTRACT FROM AUTHOR]

Introduction: Recurrent Pregnancy Loss and Recurrent Implantation Failure are major limiting factors in the establishment of pregnancy. Recurrent Pregnancy loss is defined as the failure of two or more clinically recognized pregnancies. A considerable proportion of infertile couples undergoing IVF treatment experiencing recurrent implantation failure (RIF) fail repeatedly to implant following at least three IVF cycles. MicroRNAs (miRNAs) can serve as reliable non-invasive diagnostic and prognostic biomarkers for pregnancy-related complications. Therefore, this study aimed to quantify miR-23a-3p expression level in the plasma of patients with idiopathic recurrent pregnancy loss (iRPL) and recurrent implantation failure compared to healthy subjects to evaluate its potential diagnostic value in iRPL and RIF patients. Material & Methods: This study is a cross-sectional descriptive study. A total of 120 plasma samples were obtained from 40 women with a history of at least two consecutive iRPL, 40 women with RIF, and 40 healthy women without a history of miscarriage to evaluate the expression level of the circulating miR-23a-3p by quantitative real-time polymerase chain reaction (qPCR) technique. All participants were recruited from Assisted Reproductive Technology (ART) and Stem Cell Research Center, Tabriz, Iran, September 2019-March 2020. Statistical analysis was performed using SPSS (version 22). Diagnostic efficiency of the circulating miRNAs was determined by Receiver Operatig Characteristic curve analysis using Graphpad Prism version 9.1.1. Findings: Our results showed that the miR-23a-3p expression level in plasma of iRPL patients was lower than those in healthy controls but without a statistically significant difference (P=0.113). We also found that miR-23a-3p plasma level in patients with RIF tended to be lower compared to healthy participants; however, it was not statistically significant (P=0.974). Discussion & Conclusion: The current study provides evidence indicating that downregulation of miR-23a-3p may be associated with iRPL and RIF. Therefore, further research is needed, such as using different geographic regions, large sample sizes, and other techniques (microarray). [ABSTRACT FROM AUTHOR]

Introduction: Squamous cell carcinoma accounts for about 90% of head and neck cancers. The present study aimed to investigate the epidemiology and anatomical involvement pattern of squamous cell carcinoma (SCC) in the head and neck region from 2013-2021 in Imam Khomeini Hospital, Kermanshah, Iran. Material & Methods: This descriptive cross-sectional study was conducted on all the patients with SCC of the head and neck treated at Imam Khomeini Medical Center in Kermanshah over a period of 10 years. Demographic and pathological information was extracted from the patients' medical records. Then, the obtained data was analyzed in SPSS software (version 23). Findings: Out of 299 patients identified with SCC, 236 (78.9%) were male, and the remaining were female. The majority of the patients (48.8%) fell within the age group of 55-72 years, with 57.9% reporting a history of smoking and 76.9% residing in urban areas. Among those studied, the most commonly affected site was the larynx, accounting for 49.5% (148) of cases. The highest incidence of head and neck cancers in both men and women was observed in 2019, with 15.9% and 15.7% of cases, respectively. Discussion & Conclusion: The results of this study showed that most patients were older men over 50, who mostly lived in the city and smoked. The most anatomical site of involvement was the larynx. Therefore, it is recommended to pay attention to these risk factors to prevent and control these cancers. [ABSTRACT FROM AUTHOR]

Background & aim: Cardiac arrest and heart attack are the most common cardiovascular diseases in the world. Most of the time, during a cardiac arrest, there is a person as an observer who can prevent brain death and save the patient's life in the golden time (first 4 to 6 minutes of cardiopulmonary arrest) by performing resuscitation. The aim of this study was to compare two methods of basic cardiopulmonary resuscitation training in person and virtual on the level of learning resuscitation skills (awareness and performance) in military families. Methods: In this clinical trial study, 100 people from families living in selected organizational areas were randomly assigned to two groups of face-to-face training (50 people) and virtual training (50 people). In the face-to-face training group, during a 2-hour session, cardiopulmonary resuscitation and how to deal with cardiac arrest victims were taught theoretically and practically (mannequins). In the virtual educational group, educational materials were presented by using virtual channels (once-up Weita platform) and sending animation videos, photos, short texts, and PDF files of educational booklets during two weeks. In order to collect data, a demographic form, an awareness questionnaire including 14 four-choice questions, and a performance assessment checklist including 13 items were used to assess the skill in cardiopulmonary resuscitation. At the end, the collected data were compared between the two groups. Results: Data related to age (P = 0.468), sex (P = 0.812), education (P = 0.307), occupation (P = 0.055) had no significant difference in the two groups. The U-Man-Whitney test showed that there was no statistically significant difference before the intervention between the two groups of face-to-face and virtual education in terms of knowledge and skill levels (P>0.05). Wilcoxon's statistical test showed that the difference in the mean score of knowledge and skill level before and after the intervention in both face-to-face and virtual education groups was statistically significant (P<0.05). Furthermore, the U-Man Whitney test showed that there is a statistically significant difference after the intervention between the two groups of face-to-face and virtual training in terms of knowledge and skill level (P<0.05). Conclusion: In this research, in both face-to-face and virtual training groups, the amount of knowledge and skill increased significantly compared to before and after the training. However, by comparing the two groups, it was observed that the amount of knowledge in the participants of the virtual training group was higher and the amount of skill in the participants of the face-to-face training group were more. Despite the belief of the effectiveness of face-to-face training, the findings of this research showed that virtual training can be as effective as face-to-face training. [ABSTRACT FROM AUTHOR]

Background and Aims: Hydroxyapatite coating has allocated a special place in dentistry due to its biocompatibility and bioactivity. The purpose of this study was to evaluate the relation between the hydroxyapatite thickness and stress distribution by using finite element method. Materials and Methods: In this paper, the effect of hydroxyapatite coating thickness on dental implants was studied using finite element method in the range between 0 to 200 microns. A 3D model including one section of mandible bone was modeled by a thick layer of cortical surrounding dense cancellous and a Nobel Biocare commercial brand dental implant was simulated and analyzed under static load in the Abaqus software. Results The diagram of maximum von Mises stress versus coating thickness was plotted for the cancellous and cortical bones in the range between 0 to 200 microns. The obtained results showed that the magnitude of maximum von Mises stress of bone decreased as the hydroxyapatite coating thickness increased. Also, the thickness of coating exhibited smoother stress distribution and milder variations of maximum von Mises stress in a range between 60 to 120 microns. Conclusion: In present study, the stress was decreased in the mandible bone where hydroxyapatite coating was used. This stress reduction leads to a faster stabilization and fixation of implant in the mandible bone. Using hydroxyapatite coating as a biocompatible and bioactive material could play an important role in bone formation of implant-bone interface. [ABSTRACT FROM AUTHOR]

Introduction: A standardized questionnaire is the principal tool for assessing individuals' knowledge. Since no standard questionnaire is available for assessing elementary school hygiene instructors' knowledge about dental taumas the aim of this study was to design and standardize such a questionnaire with acceptable validity and reliability. Materials and methods: In the present descriptive study in order to design a standard questionnaire, existing questions about individuals' knowledge on dental trauma were evaluated from papers published in English and 42 questions were selected. The English questions were translated into Persian in a linguistic style. The validity of the questions was fully evaluated by experts in epidemiology, Persian language, pedodontists and endodontics, considering the target group and a Persian questionnaire was prepared. In order to evaluate the reliability of the designed questionnaire, 30 hygiene instructors from Shiraz elementary schools were asked to answer the questionnaire. Inter-item correlation, Cronbach's alpha and alpha when the item was deleted, were used along with intra-class correlation test with SPSS 18. All the necessary changes were made and validity and reliability tests were repeated until appropriate results were achieved. Results: Assessment of the reliability of the questionnaire was carried out twice, which resulted in a questionnaire with 19 multiple choice questions. Cronbach's alpha of the final questionnaire was 0.887 and ICC was 0.716. No significant change was observed after deleting each question. Conclusion: Under the limitations of the present study, it can be concluded that a standardized Persian questionnaire, including 19 questions with acceptable validity and reliability is now available to evaluate school hygiene instructors' knowledge about dental trauma and can be used in other similar studies in Iran. [ABSTRACT FROM AUTHOR]

Introduction: We aimed to assess the outcomes of critical appraisal method beside lecturing versus lecturing method regarding theoretical sections among the student of msc of nutritional science. methods: This semi-experimental study was undertaken on 8 students of nutritional science in two semesters during 2009-2010. Some sections were taught via using critique of original articles, but others were taught using exclusive lecturing method. We assessed student's Knowledge by using a written examination, attitude via a 5 item-questionnaire and Skill via writing a review paper. SPSS software was used to analysis of data and student t test was used to compare the scores in two sections. Results: The mean of knowledge, attitude and skill grades in post-test were significantly higher in the critical appraisal sections (18.1±4.2 vs 15.9± 3.5; P=0.03, 4.0±3.5 vs 1.0±0.2; P=0.02 and 18.5±2.5 vs 15.0±3.5; P=0.04, respectively). Conclusion: teaching the theoretical sections beside criticizing of papers improves the knowledge, attitude and skill grades. [ABSTRACT FROM AUTHOR]

Introduction: Echinococcus granulosus is the causative agent of hydatid cysts, which are distributed worldwide. Nowadays, much research is being done to inactivate hydatid cyst protoscoleces. This study was conducted with the aim to compare the scolicidal effect of two chemical compounds 12 and 2 on hydatid cyst protoscoleces in vitro. Material & Methods: The scolicidal activity of two amini-hydrox-phenylcoumarin and amini-bromo-phenylcoumarin at concentrations of 1.2, 1.5, 1.10 and 1.100 after 15, 30 and 60 minutes of incubation was tested separately and each of the experiments was repeated three times. The viability of protoscoleces was checked with 0.1% eosin dye under a light microscope. Subsequently data were analyzed using GraphPad version 5 software and two-way repeated measures ANOVA and values (P > 0.05) was considered a significant level. Findings: The results of this study showed that the chemical compound aminibromophenylcoumarin at a concentration of 1.10 destroyed 100% of protoscoleces after 60 minutes of exposure compared to the control group, but amini-hydroxophenylcoumarin, at a concentration of 1.100 could destroy 98% of protoscolecia after 60 minutes of exposure. Discussion & Conclusion: The results of the present study showed that aminibromophenylcoumarin had stronger protoscolicidal effects than aminihydroxophenyl-coumarin. However, further studies and in vivo studies are needed to evaluate the efficacy of these chemical compounds. [ABSTRACT FROM AUTHOR]

Introduction: The infant mortality rate is one of the most important parameters for evaluating the health index in societies. The present study aimed to investigate the mortality rate of infants hospitalized in the neonatal intensive care unit (NICU) (Ayatollah Taleghani Hospital, Ilam) from 2018-2019. Material & Methods: This cross-sectional descriptive study was conducted on infants hospitalized in the NICU department of Ayatollah Taleghani Hospital in Ilam, from April 2018 to March 2019. The sampling was performed using the census method. The data collection tools included a demographic questionnaire and a researcher-made checklist. The collected data were analyzed in SPSS software (version 26) using chisquare and independent t-tests at a significance level (P<0.05). Findings: In the current study, the total number of infants hospitalized in the NICU was 83, and 28 infants died, of whom 11 (30.6%) cases were girls and 17 (36.2%) neonates were boys. The mean age of deceased infants was 32.67 weeks. The most common type of disease at the time of death in these infants was asphyxia, with a frequency of 35.7% (n=10). Age and gender showed no significant relationship with mortality (P>0.05). Discussion & Conclusion: Due to the high mortality rate in premature neonates with less than 32 weeks of gestation, effective measures should be put on the agenda to prevent premature birth and respiratory distress syndrome. [ABSTRACT FROM AUTHOR]

Introduction: Ciprofloxacin antibiotic is used in the treatment of retinal toxicity or retinopathy. The present study aimed to assess the effect of ciprofloxacin on rhodopsin protein structure and the stability or instability of this protein in the presence of this medicine. The type of drug and protein binding is effective in the elimination or interaction of the medicine with the target tissues. Material & Methods: Thermodynamic components can be obtained in the interactions between rhodopsin protein and ciprofloxacin using docking software. Docking studies were performed by AutoDock 4.2 software. Pymol, Ligplot, and VMD graphic software packeages were used to observe the docking performed. Findings:Based on the results obtained from docking studies, the most important bond involved in the binding of ciprofloxacin drug with rhodopsin protein is hydrophobic bonds and hydrogen bonds. The estimate of Gibbs free energies (kcal/mol) for the best docking model is equal to -6.5. This model with the lowest level of binding energy has the greatest tendency to bind to rhodopsin amino acids, and negative values of ΔG° are indicative of a spontaneous process. Discussion & Conclusion: Based on the docking results, the A position of the rhodopsin protein is a suitable place for ciprofloxacin to bind to this protein, and the complex of ciprofloxacin with the rhodopsin protein can cause rhodopsin to regenerate so that it can start the process of seeing normally. In fact, the strong hydrogen bond between the nitrogen atom in the ciprofloxacin structure and the amino acid arginine plays a key role in stabilizing the complex. [ABSTRACT FROM AUTHOR]

Introduction: The increasing prevalence of obesity has affected millions of people across the globe, leading to various diseases, such as prediabetes, diabetes, cardiovascular diseases, cancer, and muscle disorders. One of the therapeutic interventions in the prevention of diabetes is the use of herbal supplements, such as green coffee and its phenolic compounds, including chlorogenic acid, due to its antioxidant, anti-inflammatory, and insulin-sensitive properties. Therefore, the present study aimed to investigate the effect of green coffee and chlorogenic acid on glycogen content in the muscles of prediabetic mice. Material & Methods: A total of 20 male C57BL/6 mice were randomly assigned to two groups: normal diet mice (5 mice) and high-fat diet mice (15 mice), which were fed for 12 weeks. After the induction of prediabetes by Fasting blood sugar (FBS) and Glucose tolerance test (GTT) tests, this group was divided into three subgroups: prediabetes mice (5 cases), prediabetes mice with diabetes with green coffee consumption (Prediabetes - Green Coffee, 5 cases) and prediabetes with chlorogenic acid consumption (Prediabetes - Chlorogenic Acid, 5 cases) which were treated for 10 weeks. In the end, the mice were sacrificed, and the relative level of expression of genes involved in the glycogen content of the Gastrocnemius muscle, including PI3K, AKT, GSK3, GYS1, as well as the LRRC8A gene, was measured through the Real-Time PCR technique. The data were analyzed using the one-way analysis of variance test by GraphPad Prism software (version 8). Findings: The results pointed to a significant increase in the blood glucose level in the HFD group (129.9±5.4 mg/dL) compared to ND (95±3.3 mg/dL) and a significant decrease in the PD-GC group (103.5±8.16 mg/dL) and PD-CA (99±8 mg/dL) compared to the PD group (129.5±9.4 mg/dL) (P<0.001). The periodic acid-Schiff (PAS) staining technique demonstrated a significant decrease in the level of glycogen content in the rats of the PD group compared to the ND group. While in the treatment groups, a significant increase was observed in muscle glycogen accumulation compared to the PD group (P<0.001). The expression level of PI3K, AKT, LRRC8A, and GYS1 genes decreased, and GSK3 significantly increased in the PD group compared to the ND group (P<0.001), indicating a disturbance in the signaling pathway of glycogen content in the PD group. Nonetheless, in the treated groups, a significant increase was observed in the expression level of PI3K, AKT, LRRC8A, and GYS1 genes compared to the PD group (P<0.001). Discussion & Conclusion: Considering the complications caused by prediabetes disease, in addition to early diagnosis of prediabetes, it seems to control weight and increase insulin sensitivity, the consumption of green coffee and chlorogenic acid can improve the prediabetic condition caused by the signaling pathway of glycogen synthesis in the muscle tissue of prediabetic rats. [ABSTRACT FROM AUTHOR]