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بررسی اثرات ضد افسردگی و ضد اضطرابی عصاره الکلی شاه افسر در موشهای سوری تر.
- Source :
- Journal of Guilan University of Medical Sciences; Spring2024, Vol. 33 Issue 1, p46-54, 9p
- Publication Year :
- 2024
-
Abstract
- Background Depression is one of the most common psychological disorders that can affect a person’s mood and change his/her perception of the self and environment. Melilotus officinalis L. plant contains effective substances and antioxidant compounds. Objective The present study aims to investigate the antidepressant effects of alcoholic extract of Melilotus officinalis L. in male rats. Methods In this experimental research, 42 male rats were divided into six groups of 7 including control (normal saline), negative control (reserpine), positive control (reserpine+fluoxetine) and three reserpine groups treated by intraperitoneal injection of 100, 200, 400 mg/kg doses of alcoholic extract of Melilotus officinalis L. Behavioral tests including forced swim test (FST) and tail suspension test (TST) were used to evaluate depression, and the antioxidant capacity and malondialdehyde level were also measured. The data were analyzed in SPSS software, version 20 using one-way analysis of variance. The significance level was set at P<0.05. Results The 200 mg/kg and 400 mg/kg doses of alcoholic extract significantly reduced the duration of immobility in the FST compared to the negative control. In the TST, the doses of 200 and 400 mg/kg showed a significant increase compared to the negative control. The doses of 200 and 400 mg/kg significantly increased the antioxidant capacity of the brain compared to the negative control. The doses of 200 and 400 mg/kg significantly reduced the antioxidant capacity of the brain compared to the negative control. Conclusion The alcoholic extract of Melilotus officinalis L has antidepressant effects similar to fluoxetine probably due to its antioxidant compounds. [ABSTRACT FROM AUTHOR]
- Subjects :
- OXIDATION-reduction reaction
PHYSIOLOGIC salines
INTRAPERITONEAL injections
FLUOXETINE
BRAIN
RESERPINE
DESCRIPTIVE statistics
MOVEMENT disorders
PLANT extracts
ANTIDEPRESSANTS
RATS
EXPERIMENTAL design
DOSE-effect relationship in pharmacology
MEDICINAL plants
ANTIOXIDANTS
ANIMAL experimentation
ANIMAL behavior
COMPARATIVE studies
DATA analysis software
MENTAL depression
MALONDIALDEHYDE
PHARMACODYNAMICS
Subjects
Details
- Language :
- Persian
- ISSN :
- 20084048
- Volume :
- 33
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Guilan University of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 176414465
- Full Text :
- https://doi.org/10.32598/JGUMS.33.1.2107.1