150 results on '"Hasegawa N"'
Search Results
2. [A Case of Sarcoid‒Like Reaction with Multiple Lymphadenopathy by Rectal Cancer after an Operation].
- Author
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Hasegawa N, Uchima Y, Matsutani S, Iwauchi T, Tanaka H, Miyamoto H, Hirakawa T, Hirata K, Yamagata S, and Takeuchi K
- Subjects
- Aged, Female, Humans, Lymph Node Excision, Lymph Nodes surgery, Lymphatic Metastasis, Neoplasm Recurrence, Local, Lymphadenopathy etiology, Rectal Neoplasms surgery, Sarcoidosis diagnosis, Sarcoidosis surgery
- Abstract
We are reporting on a case of lymphadenopathy after surgery for rectal cancer. The case was a 66‒year‒old female. Laparoscopic high anterior resection(D3 dissection)was performed for rectal cancer(pT1bpN0M0, pStage Ⅰ)in April 2018, and she was followed up with on an outpatient basis. In July of the same year, a painless mass had formed in the right groin. An abdominal contrast‒enhanced CT showed lymph node swelling around the right groin and external iliac artery, but the tumor markers, CEA 2.3 ng/mL and CA19‒9 <2 U/mL, were within the standard values. An inguinal lymph node biopsy was performed during the same month. Pathological examination revealed no cancer cells and formation of epithelioid granuloma with giant cells. There was no suspicion of systemic sarcoidosis based on the test results and clinical findings. From the above, the patient was diagnosed with sarcoid reaction due to the tumor. Abdominal contrast‒enhanced CT scan 2 months after the biopsy showed lymph node shrinkage and there was no recurrence 2 years after the biopsy.
- Published
- 2021
3. [A Case of Adenosquamous Carcinoma of Pancreas Treated with Conversion Surgery after Systemic Chemotherapy].
- Author
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Komatsu H, Kashiwazaki M, Hasegawa N, Nishizawa Y, Nakatsuka R, Miyazaki S, Komori T, Motoori M, Yakushijin T, Fushimi H, Fujitani K, and Iwase K
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols, Gastrectomy, Humans, Male, Pancreatectomy, Carcinoma, Adenosquamous drug therapy, Carcinoma, Adenosquamous surgery, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms surgery
- Abstract
Case: A man in his 60s reported upper abdominal pain; close examination revealed a tumor in the body-tail of the pancreas that was suspected to be infiltrating the stomach. Multiple liver lesions(S3, S4)were also detected. Histological examination by EUS-FNA showed poorly-differentiated carcinoma; thus, this case was diagnosed with unresectable pancreatic cancer with liver metastases(cT3, cN1[No. 7], cM1[P0, H1], cStage Ⅳ: JPS 7th). After 2 kinds of systemic chemotherapy(9 courses of GEM plus nab-PTX and 9 courses of modified FOLFIRINOX), obvious distant metastases or local progression did not appear and conversion surgery was scheduled. Although a metastatic lesion was identified at S5 of the liver just before the surgery, it was assumed that an R0 resection could be achieved; therefore, the operation(distal pancreatectomy with combined proximal gastrectomy, left adrenalectomy, lymph node dissection, partial hepatectomy of S5, and cholecystectomy)was performed. Histopathological examination showed squamous metaplasia of the epithelial tissue combined with glandular formation. This case was, thus, diagnosed as adenosquamous carcinoma of pancreas. This patient was discharged 90 days after the operation. The patient is still alive 2 years and 2 months since the first diagnosis.
- Published
- 2019
4. [Bacteriocidal effects of introducing copper products on highly touched areas in hematology ward].
- Author
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Mori T, Kikuchi T, Sakurai M, Kato J, Koda Y, Abe R, Sumiya C, Yamazaki R, Sugita K, Hasegawa N, and Okamoto S
- Subjects
- Hospitals, Humans, Anti-Bacterial Agents pharmacology, Copper pharmacology, Cross Infection prevention & control, Equipment Contamination prevention & control, Hematology, Hospital Departments
- Abstract
Nosocomial infection via the hospital environment is a serious problem, and highly touched surfaces are the main route of transmission. Copper has been reported to possess bacteriocidal effects, and the introduction of copper-impregnated products is receiving attention as a potential component of hospital infection control. In this study, copper-impregnated door handles as highly touched areas were introduced in a hematology ward, and their bacteriocidal effects were evaluated in comparison with conventional products. All 12 samples obtained from conventional door handles were positive for bacterial cultures, whereas only 5 of 18 samples from copper-impregnated handles were positive (P<0.0001). The mean number of bacterial colonies per milliliter of sample was 300 (range: 40-1.1×10
6 ) in samples from conventional handles, but it was significantly lower in samples from copper-impregnated handles (0; range: 0-220, P<0.0001). While various types of bacteria grew on conventional handles, most of the bacteria on copper-impregnated handles were Bacillus subtilis. These results suggest that the introduction of copper-impregnated products would be useful for hospital infection control by reducing the bacterial burden on highly touched areas. However, the efficacy of this approach against spore-forming bacteria should be further investigated.- Published
- 2019
- Full Text
- View/download PDF
5. [MALT lymphoma accompanied by elevated serum IgM levels mimicking Waldenström's macroglobulinemia].
- Author
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Izumi S, Kimura K, Takeda Y, Tsukamoto S, Yamazaki M, Mishina T, Nagai Y, Takaishi K, Nagao Y, Oshima-Hasegawa N, Mitsukawa S, Mimura N, Takeuchi M, Ohwada C, Iseki T, Ota S, Nakaseko C, and Sakaida E
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cyclophosphamide therapeutic use, Diagnosis, Differential, Doxorubicin therapeutic use, Humans, Lymphoma, B-Cell, Marginal Zone blood, Male, Middle Aged, Mutation, Myeloid Differentiation Factor 88 genetics, Prednisone therapeutic use, Receptors, Interleukin-2 blood, Remission Induction, Rituximab therapeutic use, Vincristine therapeutic use, Waldenstrom Macroglobulinemia, Immunoglobulin M blood, Lymphoma, B-Cell, Marginal Zone diagnosis
- Abstract
A 60-year-old man with chronic hepatitis C was referred to our hospital with significantly elevated total protein and serum IgM (9,500 mg/dl) levels identified via a routine checkup. Blood examination revealed increased serum IgM-monoclonal protein and serum-soluble IL-2 receptor (sIL2R) levels. Computed tomography and fluorodeoxyglucose positron emission tomography revealed pulmonary masses, abnormal soft tissue masses surrounding the bilateral kidneys, and thickened mucous membrane of the bladder with high fluorodeoxyglucose uptake. Pathological examination of the pulmonary mass revealed infiltration of medium-sized lymphocytes and plasma cells. Immunohistochemical analysis revealed tumor cells positive for CD138 and IgM, with a low positive rate of Ki-67 expression. Notably, the tumor cell-surrounding lymphocytes were positive for CD20. Although the patient was initially regarded as having Waldenström's macroglobulinemia owing to the significantly increased serum IgM levels, based on positive IgH-MALT1 translocation and negative MYD88 L265P mutation findings, he was further diagnosed with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Complete remission was achieved following six cycles of rituximab + CHOP therapy. This study data suggest that analysis of the MYD88 L265P mutation in tumor cells is suitable for accurately diagnosing hematopoietic malignancies with increased IgM monoclonal protein.
- Published
- 2018
- Full Text
- View/download PDF
6. Susceptibility genes for nontuberculous mycobacterial disease.
- Author
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Namkoong H, Hasegawa N, and Betsuyaku T
- Subjects
- Animals, Cystic Fibrosis Transmembrane Conductance Regulator, Exome, HLA Antigens, High-Throughput Nucleotide Sequencing, Humans, Interferon-gamma, Interleukin-12, Microsatellite Repeats, Polymorphism, Single Nucleotide, Reproducibility of Results, Signal Transduction, Th1 Cells immunology, Toll-Like Receptor 2, Tuberculosis, Pulmonary genetics, Genetic Predisposition to Disease genetics, Mycobacterium Infections, Nontuberculous genetics
- Abstract
The number of patients with nontuberculous mycobacterial (NTM) disease is reportedly increasing both in Japan and worldwide. NTM diseases are classified into disseminated and pulmonary diseases based on their clinical characteristics. These two types of NTM diseases are thought to be controlled by different mechanisms. Disseminated NTM disease is caused by a defect in signal transduction of Th1 cellular immune responses, including the IFN-γ/IL-12 axis. The precise molecular mechanisms of disseminated NTM disease are understood in detail. Pulmonary NTM disease progression is associated with both bacterial factors as well as host factors. Furthermore, it is suggested that some susceptibility genes for NTM diseases may also exist. A previous study on the susceptibility genes for pulmonary NTM disease was performed using Single Nucleotide Polymorphism (SNP) analysis and microsatellite marker analysis. However, a number of challenges remain in terms of the reproducibility. The emergence of next generation sequencing enables genome-wide analysis, and further studies on the susceptibility genes for pulmonary NTM disease are expected in the future.
- Published
- 2017
- Full Text
- View/download PDF
7. Bacteremia due to Capnocytophaga species during chemotherapy-induced neutropenia in patients with hematological malignancies.
- Author
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Murakami K, Mori T, Kato J, Shimizu T, Kohashi S, Sakurai M, Sugita K, Hasegawa N, Murata M, and Okamoto S
- Subjects
- Adult, Bacteremia diagnosis, Bacteremia drug therapy, Capnocytophaga drug effects, Hematologic Neoplasms diagnosis, Humans, Male, Middle Aged, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local drug therapy, Neutropenia diagnosis, Neutropenia drug therapy, Young Adult, Anti-Bacterial Agents therapeutic use, Bacteremia microbiology, Capnocytophaga isolation & purification, Hematologic Neoplasms drug therapy, Neoplasm Recurrence, Local microbiology, Neutropenia microbiology
- Abstract
The number of reported cases of infections due to Capnocytophaga species (spp.) is limited. We herein describe four cases developing bacteremia due to Capnocytophaga spp. during neutropenia after chemotherapy for hematological malignancies. At the onset of bacteremia, 3 of the 4 patients had oral mucositis, and 2 were co-infected with other bacteria. Two patients developed bacteremia while receiving fluoroquinolone as prophylaxis against bacterial infection. Bacteremia resolved with administration of antimicrobial agents in all patients and no recurrences were observed thereafter. The emergence of fluoroquinolone-resistant or beta-lactamase-producing Capnocytophaga spp. has recently been reported. Therefore, Capnocytophaga spp. could be causative pathogens in breakthrough and refractory infections under fluoroquinolone prophylaxis and empiric therapy, respectively, for febrile neutropenia. Capnocytophaga spp. should be recognized as one of the causative pathogens of febrile neutropenia. Furthermore, accumulation of cases and susceptibility data are required to establish an optimal treatment protocol.
- Published
- 2017
- Full Text
- View/download PDF
8. [Transmanubrial Osteomuscular-sparing Approach for Resection of Superior Mediastinal Schwannoma].
- Author
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Aragaki M, Iimura Y, Sato N, Fukuda N, Miyazaki D, Umemoto K, Yoshida Y, and Hasegawa N
- Subjects
- Aged, Female, Humans, Magnetic Resonance Angiography, Mediastinal Neoplasms diagnostic imaging, Mediastinum diagnostic imaging, Multimodal Imaging, Neurilemmoma diagnostic imaging, Positron-Emission Tomography, Thoracotomy, Tomography, X-Ray Computed, Treatment Outcome, Mediastinal Neoplasms surgery, Mediastinum surgery, Neurilemmoma surgery
- Abstract
Various approaches can be applied to resect superior mediastinal tumor. It is important to choose the procedure according to the location, size, and characteristics of the tumor in order to perform safe procedure surgery because of distinctive anatomy of this site. We hereby report on a case of Schwannoma of the superior mediastinum resected by the transmanubrial approach. A 67-year-old woman was referred to our department to examine an abnormal chest shadow found at a regular health checkup. Computed tomography revealed a tumor 58×52 mm in size extending from the left supraclavicular fossa to the upper border of the aortic arch. The surgery was performed under the diagnosis of neurogenic tumor using the transmanubrial approach. The tumor was resected safely and the pathological diagnosis was a Schwannoma. Transmanubrial approach was found to be quite useful in securing an adequate visual field and enabling the safe separation of blood vessels and nerves from the tumor.
- Published
- 2016
9. Severe stomatitis and ileocecal perforation developed after all-trans retinoic acid monotherapy in an HLA-B51-positive patient with acute promyelocytic leukemia.
- Author
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Kimura K, Takeuchi M, Hasegawa N, Togasaki E, Shimizu R, Kawajiri C, Muto T, Tsukamoto S, Takeda Y, Ohwada C, Sakaida E, Sakai S, Mimura N, Ota S, Iseki T, and Nakaseko C
- Subjects
- Adult, Antineoplastic Agents therapeutic use, Cecal Diseases pathology, HLA-B51 Antigen immunology, Humans, Leukemia, Promyelocytic, Acute immunology, Male, Tretinoin therapeutic use, Antineoplastic Agents adverse effects, Cecal Diseases chemically induced, Ileum pathology, Intestinal Perforation chemically induced, Leukemia, Promyelocytic, Acute drug therapy, Stomatitis chemically induced, Tretinoin adverse effects
- Abstract
A 34-year-old man who had been referred to our hospital was diagnosed with acute promyelocytic leukemia (APL). All-trans retinoic acid (ATRA), oral administration, was initiated. On day 25, he developed fever and respiratory distress with bilateral pulmonary infiltrates, suggesting differentiation syndrome (DS) caused by ATRA. These symptoms showed amelioration after discontinuing ATRA and initiating methylprednisolone. ATRA was re-started on day 29 at half the original dose because of residual APL blasts. The patient subsequently developed fever, severe stomatitis, and oropharyngeal ulcers, which persisted even after discontinuing ATRA. On day 48, he suddenly developed severe abdominal pain with free air, observable on an abdominal X-ray, and underwent emergency ileocecal resection. Pathological examination of the resected ileocecal intestines revealed multiple ulcers and perforations. No leukemic cell infiltration was observed. In this case, only ATRA was administered for APL treatment. These findings suggest that ileocecal ulcerations and perforations, as well as oropharyngeal ulcers, might have been caused by DS or ATRA. Furthermore, DNA typing of the HLA-B locus revealed that the patient had HLA-B51 associated with Behçet's disease. Therefore, hypercytokinemia with DS might have induced Behçet's disease-like symptoms, including stomatitis and ileocecal perforation, complications that are particularly observed in patients with HLA-B51.
- Published
- 2016
- Full Text
- View/download PDF
10. Chronic active Epstein-Barr virus infection with marked pericardial effusion successfully treated with allogeneic peripheral blood stem cell transplantation.
- Author
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Matsui S, Takeda Y, Isshiki Y, Yamazaki A, Nakao S, Takaishi K, Nagao Y, Hasegawa N, Togasaki E, Shimizu R, Kawajiri C, Sakai S, Mimura N, Takeuchi M, Ohwada C, Sakaida E, Iseki T, Imadome K, and Nakaseko C
- Subjects
- Chronic Disease, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections virology, Female, Humans, Transplantation, Homologous, Young Adult, Epstein-Barr Virus Infections therapy, Herpesvirus 4, Human physiology, Pericardial Effusion etiology, Peripheral Blood Stem Cell Transplantation
- Abstract
A 23-year-old woman presented with a persistent fever and shortness of breath. Computed tomography showed marked pericardial effusion, hepatosplenomegaly, and cervical and mediastinal lymph node swelling. Epstein-Barr virus (EBV) antibody titers were abnormally elevated, and the copy number of EBV-DNA was increased in peripheral blood. Based on these observations, she was diagnosed with chronic active EBV infection (CAEBV). The EBV-infected cells in her peripheral blood were CD4(+)T lymphocytes. Fever and pericardial effusion improved following treatment with a combination of prednisolone, etoposide, and cyclosporine; however, peripheral blood EBV-DNA levels remained high. The patient underwent allogeneic peripheral blood stem cell transplantation from an EBV-seronegative, HLA-matched sibling donor, with fludarabine and melphalan conditioning. The post-transplantation course was uneventful, except for mild skin acute graft-versus-host disease (grade 2). EBV-DNA became undetectable in peripheral blood 98 days post transplantation. She has since been in good health without disease recurrence. CAEBV is a potentially fatal disease caused by persistent EBV infection of T lymphocytes or natural killer cells, thus requiring prompt treatment and allogeneic transplantation. Pericardial effusion is rarely observed in CAEBV and can impede its diagnosis. Therefore, we should be aware that patients may present with marked pericardial effusion as an initial manifestation of CAEBV.
- Published
- 2016
- Full Text
- View/download PDF
11. [Antifungal Activity of Luliconazole Nail Solution on in vitro and in vivo Onychomycosis Model].
- Author
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Shimamura T, Hasegawa N, and Kubota N
- Subjects
- Adenosine Triphosphate metabolism, Administration, Topical, Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Resistance, Fungal, Humans, Male, Rabbits, Solutions, Treatment Outcome, Trichophyton metabolism, Antifungal Agents administration & dosage, Antifungal Agents pharmacology, Imidazoles administration & dosage, Imidazoles pharmacology, Onychomycosis drug therapy, Onychomycosis microbiology, Trichophyton drug effects
- Abstract
We evaluated luliconazole nail solution, originally generated formulation, for the topical treatment of onychomycosis by two infection models. First, a suspension of Trichophyton mentagrophytes was dropped onto the ventral layer of human nail plate and these nails were set in Franz diffusion cells. After 9-day culture, luliconazole nail solutions (1, 3, and 5%) were applied to the dorsal surface of the nails once a day for 7 days. After application, fungal viability was assessed by measuring the ATP contents of the samples. The dose-dependent efficacy was confirmed, with 3% and 5% luliconazole nail solutions producing significantly lower ATP levels at 7-day treatment. When 3% and 5% luliconazole nail solutions were evaluated in a rabbit model of onychomycosis, both concentrations completely inhibited the recovery of fungi on culture after 4-week treatment. We therefore think these results indicate that 5% luliconazole nail solution is sufficiently potent for treatment of onychomycosis.
- Published
- 2016
- Full Text
- View/download PDF
12. [Mediastinal Mature Teratoma Necessitating Resection of Superior Vena Cava].
- Author
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Aragaki M, Iimura Y, Hasegawa N, and Kaga K
- Subjects
- Adult, Brachiocephalic Veins surgery, Female, Heart Atria surgery, Humans, Mediastinal Neoplasms surgery, Teratoma surgery, Vena Cava, Superior surgery
- Abstract
A 43-year-old woman was referred to our hospital for an abnormal shadow on chest X-ray. Computed tomography revealed a tumor with calcification of 9.8 cm in size at the anterior mediastinum. The infiltration into the left brachiocephalic vein and superior vena cava by tumor was suspected. Surgery was performed under a diagnosis of mature teratoma. The tumor was found to adhere firmly to superior vena cava (SVC), left brachiocephalic vein, right phrenic nerve, and the arch of the azygos vein. To ensure the blood flow, an artificial blood vessel was placed between left brachiocephalic vein and right atrium. Then SVC was clamped and the tumor was resected with the part of SVC.
- Published
- 2015
13. [Bacteremia due to Rothia mucilaginosa after chemotherapy for myeloid malignancies].
- Author
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Kohashi S, Mori T, Koda Y, Kikuchi T, Kato J, Shimizu T, Sugita K, Hasegawa N, Murata M, and Okamoto S
- Subjects
- Adult, Bacteremia microbiology, Female, Humans, Male, Middle Aged, Anti-Bacterial Agents therapeutic use, Antineoplastic Agents therapeutic use, Bacteremia drug therapy, Bone Marrow Neoplasms drug therapy, Leukemia, Myeloid, Acute drug therapy, Micrococcaceae isolation & purification, Sarcoma drug therapy
- Abstract
The number of reported cases of bacteremia due to Rothia mucilaginosa (R. mucilaginosa), a component of the normal flora of human gastrointestinal tract mucosa, is limited. We encountered three cases of bacteremia due to R. mucilaginosa during neutropenia after chemotherapy for myeloid malignancies. Although all three patients were successfully treated with antimicrobial agents, one patient developed disseminated lesions in the lungs and soft tissue. The portal of R. mucilaginosa bacteremia is reportedly mucositis or dental disorders; however, no such complications were identified in our patients. Even in the absence of a preexisting portal, R. mucilaginosa should be recognized as a potential causative pathogen of bacteremia during neutropenic periods. Accumulations of cases and isolates are required to further elucidate the risk factors for developing R. mucilaginosa bacteremia, its clinical course, and the optimal antimicrobial treatment.
- Published
- 2015
- Full Text
- View/download PDF
14. [Autism spectrum disorders in elderly].
- Author
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Hasegawa N and Yamamoto Y
- Subjects
- Aged, Child Development Disorders, Pervasive therapy, Humans, Child Development Disorders, Pervasive diagnosis
- Abstract
Autism spectrum disorders (ASD) have been largely neglected in the field of elderly psychiatry. ASD were characterized by a triad of qualitative impairments in the aspects of social interaction, communication, and restricted patterns of behavior and interests. The prevalence of ASD was not clearly estimated in elderly. In clinical practice, elderly patients with confirmed ASD were not usually diagnosed properly earlier in life for various reasons. However, the understanding of characteristic with ASD is useful for clinicians, because we can arrange a suitable environment for patients with ASD. We tend to make overdiagnoses of ASD because of paying attention to only frontal lobe syndrome. We should exclude neurodegenerative disease, especially frontotemporal lobar degeneration.
- Published
- 2013
15. [Antibacterial activity for clinical isolates from pediatric patients of clavulanic acid/amoxicillin (1: 14) -outcomes of special drug use investigation on antibacterial activity (annual changes)].
- Author
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Ishida A, Hasegawa N, Okano H, Hara T, and Yoshida P
- Subjects
- Bacteria drug effects, Child, Humans, Microbial Sensitivity Tests, Amoxicillin-Potassium Clavulanate Combination pharmacology, Anti-Bacterial Agents pharmacology
- Abstract
As a special drug use investigation, we monitored and assessed trends in antibacterial activity of clavulanic acid/amoxicillin (1:14) (hereafter, "CVA/AMPC (1:14)") and other antimicrobial agents for clinical isolates from pediatric patients with otitis media or respiratory, skin, and urinary tract infections. Against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis isolated and identified from otorrhea, epipharynx and rhinorrhea of pediatric patients with otitis media, the MIC90s of CVA/AMPC (1:14) in five years between 2006-2010 were 1 microg/mL for S. pneumoniae and 8 microg/mL for H. influenzae and 0.25-0.5microg/mL for M catarrhalis. The changes of MIC90s of CVA/AMPC (1:14) for penicillin-resistant S. pneumoniae (PRSP) and beta-lactamase non-producing H. influenzae were two times, and no decrease in drug susceptibility was found in the period of the present investigation. In addition, the MIC changes of other antimicrobial agents for these three organisms were approximately two to four times as well. Against organisms isolated and identified from pus, sputum, pharynx, skin and urine of pediatric patients with respiratory, skin, and urinary tract infections, the MIC90s of CVA/AMPC (1:14) in four years between 2008-2011 were 1 microg/mL for S. pneumoniae, < or =0.06microg/mL for penicillin susceptible S. pneumoniae (PSSP) without any change, 0.5-1 microg/mL for penicillin intermediate resistant S. pneumoniae (PISP) with a twofold change and 1 microg/mL for PRSP with no change. The MIC90s of CVA/AMPC (1:14) were 2-8 microg/mL for S. aureus with a fourfold change, 2 microg/mL for methicillin-sensitive S. aureus without any change, 4-8 microg/mL for H. influenzae with a twofold change. Against beta-lactamase non-producing H. influenzae, MIC90s of CVA/AMPC (1:14) were 1 microg/mL for beta-lactamase negative ampicillin susceptible (BLNAS), 8 microg/mL for beta-lactamase negative ampicillin resistant (BLNAR), showing no change. Neither Streptococcus pyogenes or Klebsiella pneumoniae demonstrated any change and M. catarrhalis and Escherichia coli showed twofold changes of MIC90s of CVA/AMPC (1: 14). In the present investigation conducted to monitor annual changes in antibacterial activity intended for pediatric patients with otitis media or other infections, there was no significant change in antibacterial activity of CVA/AMPC (1: 14).
- Published
- 2013
16. [Survey of integrated medical care for dementia in Hyogo Prefecture: comparison in two areas].
- Author
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Maeda K, Kakigi T, Kashibayashi T, Yamamoto Y, and Hasegawa N
- Subjects
- Data Collection, Humans, Japan, Physicians, Primary Care, Rural Health Services, Urban Health Services, Delivery of Health Care, Integrated trends, Dementia therapy
- Abstract
Objective: To assess the attitude of medical care for dementia among the primary care physicians (PCP) in two different areas in Hyogo Prefecture and compare it., Methods: A 15-item questionnaire related medical care for dementia was developed and sent it by mail to the PCP in December, 2011., Results: One area is an urban area and the other is a rural area. The response rates were 42.9% and 36.7%, respectively. The rate of the PCP in the urban area who was interested to care dementia elderly was higher, compared to the rural area. The integrated medical care net work was well functioning in the urban area. The rate of PCP in the urban area who wanted to have training for dementia care was higher than in the rural area., Conclusions: Although the rate of elderly in the population in the rural area is higher, the PCP in the rural area seemed not to be interested in dementia care.
- Published
- 2012
17. [Administration of sugammadex to a patient with myasthenia gravis with fade of the train-of-four ratio].
- Author
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Sugawara A, Sasakawa T, Hasegawa N, Takahata O, and Iwasaki H
- Subjects
- Anesthesia, General, Humans, Male, Middle Aged, Myasthenia Gravis physiopathology, Sugammadex, Thymectomy, Myasthenia Gravis surgery, Neuromuscular Blocking Agents administration & dosage, gamma-Cyclodextrins administration & dosage
- Abstract
A 50-year-old man (weight 87 kg, height 171 cm) with myasthenia gravis (MG) was scheduled for extended thymectomy under general anesthesia. His preanesthetic train-of-four ratio (T4/T1) was 59%. The first twitch of the train-of-four (T1) was 130% after calibration. We administered rocuronium 10 mg (0.11 mg x kg(-1)) for tracheal intubation. Maximal suppression was achieved in 50 seconds. During the operation, we did continuous infusion of rocuronium to maintain T1 at 10%. We discontinued rocuronium infusion before the end of surgery. In patients with MG, deep levels of neuromuscular block can be achieved with less rocuronium. We hypothesized that the requirement of sugammadex in a patient with MG is less than that in normal patients. Therefore, we administered 0.5 mg x kg(-1) of sugammadex. After 5 min, T4/T1 had reached 54%, but T1 had not reached the control value; therefore, we administered additional 1.5 m x kg(-1) of sugammadex. Subsequently, T1 reached 120%. Patients with MG with fade on T4/T1 require a full dose of sugammadex, identical to the dose administered to normal patients.
- Published
- 2011
18. [Acute lung injury/acute respiratory distress syndrome: progress in diagnosis and treatment. Topics: III. Treatment; 2. Current status and future direction of pharmacological treatments for acute respiratory distress syndrome].
- Author
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Hasegawa N
- Subjects
- Humans, Respiratory Distress Syndrome drug therapy
- Published
- 2011
- Full Text
- View/download PDF
19. [Mood disorders and dementia].
- Author
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Maeda K, Hasegawa N, Yamane Y, and Kakigi T
- Subjects
- Aged, Aged, 80 and over, Dementia complications, Female, Humans, Male, Middle Aged, Mood Disorders complications, Dementia diagnosis, Mood Disorders diagnosis
- Published
- 2011
20. [Lung transplantation for secondary interstitial pneumonitis caused by treatment for primary mediastinal diffuse large B-cell lymphoma].
- Author
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Kohno M, Hasegawa N, Okamoto S, Kondo T, and Nomori H
- Subjects
- Female, Humans, Lymphoma, Large B-Cell, Diffuse complications, Middle Aged, Lung Diseases, Interstitial etiology, Lung Diseases, Interstitial surgery, Lung Transplantation, Lymphoma, Large B-Cell, Diffuse therapy
- Abstract
A 34-year-old woman was diagnosed as primary mediastinal diffuse large B-cell lymphoma, treated by cyclophosphamide, doxorubicin, vincrisitne, prednisolone (CHOP) chemotherapy and radiation therapy, and received high-dose ranimustine, cytarabine, etoposide, cyclophosphamide (MCVAC) chemotherapy with autologous peripheral blood stem cell transplantation. Seven years after complete remission was achieved, she recognized dyspnea and was diagnosed secondary interstitial pneumonitis caused by chemotherapy and/or radiotherapy. Because her symptoms and pulmonary function got worsen gradually, she underwent lung transplantation from a brain death donor when she was 47-year-old. She has successfully rehabilitated and returned to her life without oxygen inhalation therapy.
- Published
- 2010
21. [A case of bisphosphonate-associated osteonecrosis of the jaw in a patient with bone metastasis of breast cancer].
- Author
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Iimura Y, Kaneko H, Hasegawa N, Takahashi Y, Shoji Y, and Kawabata M
- Subjects
- Bone Neoplasms secondary, Diphosphonates therapeutic use, Female, Humans, Jaw Diseases diagnostic imaging, Jaw Diseases surgery, Middle Aged, Osteonecrosis diagnostic imaging, Osteonecrosis surgery, Radiography, Bone Neoplasms drug therapy, Breast Neoplasms pathology, Diphosphonates adverse effects, Jaw Diseases chemically induced, Osteonecrosis chemically induced
- Abstract
A 5 6-year-old woman underwent modified radical mastectomy for left breast cancer in 2002. Bone metastases developed in November 2005, and she received pamidronate from February 2006. Pamidronate was changed to zoledronate in November 2006. In November 2007, she was referred to a dentist for pain and swelling of the right lower gum. Conservative therapy with local irrigation and antibiotics was performed, but the lesion progressed and showed ulceration with exposed bone. She was diagnosed as bisphosphonate-associated osteonecrosis of the jaws, and zoledronate was withdrawn in January 2008. Conservative therapy was continued but the necrotic lesion caused pathological fracture and fistula. In February 2009, surgical intervention was performed for the improvement of her QOL.
- Published
- 2010
22. [Primary malignant melanoma of the esophagus--detection of circulating tumor cells].
- Author
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Fujii K, Goto A, Matsunaga Y, Hasegawa Y, Sukawa Y, Suzuki K, Yonezawa K, Abe T, Itoh A, Shinomura Y, Iimura Y, Hasegawa N, Nakamura H, and Yoshida Y
- Subjects
- Aged, Biopsy, Esophageal Neoplasms diagnostic imaging, Esophageal Neoplasms drug therapy, Esophageal Neoplasms surgery, Fatal Outcome, Female, Gene Expression Regulation, Neoplastic, Humans, Melanoma diagnostic imaging, Melanoma drug therapy, Melanoma surgery, Recurrence, Tomography, X-Ray Computed, Esophageal Neoplasms pathology, Melanoma pathology, Neoplastic Cells, Circulating
- Abstract
Primary malignant melanoma of esophagus (PMME) is a rare tumor; therefore, the prognostic factors, predictive factors, and difference in biological behaviors of cutaneous melanoma and primary esophageal squamous cell carcinoma remain uncertain. Although we did not adopt a standard therapeutic strategy, we performed surgical resection, chemotherapy, immunotherapy, and radiotherapy either alone or in combination; all procedures resulted in poor outcomes. A 67-year-old woman presented with a swallowing disorder. An esophagogastroduodenoscopy was performed, leading to diagnosis of PMME. According to the Japanese Classification of Esophageal Cancer, the pathological stage was T1b, ly0, v0, N0, M0, stage I . KIT immunostaining was focally positive. After subtotal esophagectomy, adjuvant chemotherapy was performed, but the malignant melanoma relapsed in the mediastinum and the patient died 10 months after diagnosis. We serially monitored the patient using several new modalities, including PET/CT, metabolites of melanin: 5-S-CD, and circulating tumor cells (CTCs) by reverse transcription-polymerase chain reaction to identify the melanoma-specific gene. To our knowledge, this is the first report of a case in which CTCs in PMME were detected.
- Published
- 2010
23. [Case of dementia with Lewy bodies showing cervical dystonia after donepezil administration].
- Author
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Hasegawa N, Shimada K, Yamamoto Y, and Maeda K
- Subjects
- Aged, Donepezil, Electromyography, Female, Humans, Torticollis diagnosis, Indans adverse effects, Lewy Body Disease drug therapy, Piperidines adverse effects, Torticollis chemically induced
- Abstract
We reported a patient with probable dementia with Lewy bodies (DLB) showing cervical dystonia during treatment with donepezil. A 78-year-old female had been treated with donepezil 5 mg/day for 18 months. The patient admitted to our hospital because of severe antecollis. Antecollis disappeard three weeks after discontinuation of donepezil. Five months later the patient received donepezil 3-5 mg/day for disease progression. The patient showed laterocollis again after a month-treatment with donepezil. Physical examination and labolatory tests were nomal. Magnetic resonance imaging of the neck showed no abnormal finding, but electromyography revealed dystonic changes in the neck muscles. Three weeks after discontinuation of donepezil, laterocollis disappeared. These findings suggest that treatment with donepezil induced cervical dystona in a patient with DLB.
- Published
- 2010
- Full Text
- View/download PDF
24. [Long-term treatment with a humanized anti-interleukin-6 receptor antibody (tocilizumab), improving interstitial pneumonia in a patient with multicentric Castleman disease].
- Author
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Harada N, Sayama K, Tanaka K, Hasegawa N, Okamoto S, Hayashi Y, and Ishizaka A
- Subjects
- Antibodies, Monoclonal, Humanized, Humans, Male, Middle Aged, Antibodies, Monoclonal administration & dosage, Castleman Disease complications, Lung Diseases, Interstitial drug therapy
- Abstract
A 46-year-old man was admitted for the evaluation of a dry cough and dyspnea on exertion. Laboratory tests revealed anemia, elevated CRP, polyclonal hyperimmunoglobulinemia, and an elevated interleukin-6 level. Radiological examination of the chest showed peribronchovascular consolidations, ground glass opacities, small nodular opacities, and interlobular septal thickenings in the lungs, accompanied with hilar and mediastinal lymphadenopathies. A video-assisted thoracoscopic lung and mediastinal lymph node biopsy revealed plasmacytic and lymphocytic infiltration around the bronchovascular bundles of the lungs, and plasmacytic infiltration in the interfollicular areas of the nodes. Based on these findings, a diagnosis of multicentric Castleman disease was confirmed. The patient received a humanized anti-interleukin-6 receptor antibody, (tocilizumab, 8 mg/kg), every 2 weeks for 3 years, during which time, his PaO2 level improved from 64.1 Torr to 83.4 Torr, vital capacity increased from 2.53 L to 3.95 L, and radiological abnormalities in the lungs gradually improved, suggesting that tocilizumab is effective for interstitial pneumonia in patients with multicentric Castleman disease.
- Published
- 2010
25. [Two cases of breast cancer responding to primary systemic chemotherapy containing trastuzumab without surgery].
- Author
-
Konishi K, Hasegawa N, Kaneko H, Iimura Y, Shoji Y, and Kawabata M
- Subjects
- Adult, Antibodies, Monoclonal, Humanized, Combined Modality Therapy, Female, Humans, Trastuzumab, Antibodies, Monoclonal administration & dosage, Antineoplastic Agents administration & dosage, Breast Neoplasms drug therapy, Carcinoma, Ductal, Breast drug therapy, Carcinoma, Lobular drug therapy
- Abstract
The first case was a 40-year-old woman who was referred to our hospital with a complaint of left breast tumor. She was diagnosed as invasive ductal carcinoma (T2N0M0, Stage IIA). The tumor was ER-negative, PR-negative and HER2-positive. After primary systemic chemotherapy with 6 courses of 5-fluorouracil+epirubicin+cyclophosphamide(FEC)and 3 courses of weekly paclitaxel (PTX)+trastuzumab, the efficacy of chemotherapy was judged as a complete response (CR). After chemotherapy, radiotherapy for her left breast was performed without surgery. At 21 months after CR, local efficacy was judged as CR, but liver and bone metastases appeared, and were treated by capecitabine and trastuzumab. The efficacy of chemotherapy was judged as a partial response (PR). The second case was a 26-year-old woman referred to our hospital with a complaint of right breast tumor. She was diagnosed as invasive lobular carcinoma (T2N0M0, Stage IIA). The tumor was ER-positive, PR-negative and HER2-positive. After primary systemic chemotherapy with 4 courses of FEC and 6 courses of docetaxel+trastuzumab, the efficacy of chemotherapy was judged as CR. Then, 4 courses of weekly PTX+trastuzumab were performed. After chemotherapy, radiotherapy for her right breast was performed without surgery. The efficacy of treatment was judged as CR for 15 months.
- Published
- 2010
26. [Nutritional state and prognosis in elderly people].
- Author
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Hasegawa N, Tanaka H, Yanagimachi M, Tando Y, and Nakamura M
- Subjects
- Aged, Female, Humans, Male, Prognosis, Hypoalbuminemia etiology, Hypoalbuminemia therapy, Nutritional Status
- Published
- 2010
- Full Text
- View/download PDF
27. [A case of premenopausal stage IV breast cancer responding to neoadjuvant endocrine therapy after chemotherapy with FEC].
- Author
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Konishi K, Hasegawa N, Kaneko H, Iimura Y, Shoji Y, and Kawabata M
- Subjects
- Adult, Cyclophosphamide therapeutic use, Epirubicin therapeutic use, Female, Fluorouracil therapeutic use, Humans, Mastectomy, Neoadjuvant Therapy, Premenopause, Antineoplastic Agents, Hormonal administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms therapy, Carcinoma, Ductal, Breast therapy, Goserelin administration & dosage, Tamoxifen administration & dosage
- Abstract
A 33-year-old woman was referred to our hospital with a complaint of left breast tumor. After examinations, she was diagnosed as invasive ductal carcinoma with sternum metastasis (T2N0M1(OSS), Stage IV). The tumor was hormone receptor- positive and HER2-negative. Primary systemic chemotherapy with FEC was performed. After four courses, the efficacy was judged as a partial response (PR). After chemotherapy, endocrine therapy with goserelin and tamoxifen was performed. The efficacy of endocrine therapy was as good as that of chemotherapy. After endocrine therapy for 13 months, breast conserving-surgery was performed. After surgery, radiotherapy for left breast and sternum was performed. She continues to undergo outpatient endocrine therapy with no detectable tumor. It is suggested that neoadjuvant endocrine therapy may be useful with consideration for treatment effectiveness and the patient's quality of life.
- Published
- 2010
28. [Effect of direct hemoperfusion with a polymyxin B immobilized fiber column in acute exacerbation of interstitial pneumonia and serum indicators].
- Author
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Miyamoto K, Tasaka S, Hasegawa N, Kamata H, Shinoda H, Kimizuka Y, Fujiwara H, Kotake Y, Takeda J, and Ishizaka A
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Lung Diseases, Interstitial blood, Male, Pulmonary Surfactant-Associated Protein D blood, Biomarkers blood, Hemoperfusion methods, Lung Diseases, Interstitial therapy, Polymyxin B
- Abstract
Acute exacerbation of interstitial pneumonia (IP-AE) can occasionally occur and has a poor prognosis. Direct hemoperfusion with a polymyxin B immobilized fiber column (PMX-DHP) has been shown to have a beneficial effect on acute respiratory distress syndrome, which has similar pathological features to that of IP-AE. This study was aimed to investigate the effects of PMX-DHP on IP-AE and serum indicators for epithelial damage. Nine patients with a clinical diagnosis of interstitial pneumonia, who developed acute exacerbation, were included in this study. Five patients had been given a diagnosis of idiopathic pulmonary fibrosis (IPF) and 3 cases were diagnosed as collagen vascular disease-associated interstitial pneumonia (CVD-IP). On days 30 and 60, 6 and 4 patients were surviving, respectively. On day 60, all 3 patients with CVD-IP were alive, while 4 of 5 patients with IPF had died. In 4 patients who survived for 60 days or longer, serum levels of LDH, CRP, and SP-D were significantly decreased after PMX-DHP, whereas KL-6 level was unchanged. In 5 patients, who died by day 60, no significant changes in the serum markers were observed. These data suggest that serum levels of LDH, CRP, and SP-D might be predictive of successful PMX-DHP treatment in cases of IP-AE.
- Published
- 2009
29. [A case of stage IV breast cancer with large cancer ulcer responding to combination therapy of capecitabine and medroxyprogesterone acetate and cyclophosphamide].
- Author
-
Konishi K, Hasegawa N, Kaneko H, Iimura Y, Shoji Y, and Kawabata M
- Subjects
- Adenocarcinoma, Scirrhous complications, Adenocarcinoma, Scirrhous pathology, Administration, Oral, Antimetabolites, Antineoplastic administration & dosage, Antineoplastic Agents, Alkylating administration & dosage, Antineoplastic Agents, Hormonal administration & dosage, Breast Neoplasms complications, Breast Neoplasms pathology, Capecitabine, Cyclophosphamide administration & dosage, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Female, Fluorouracil administration & dosage, Fluorouracil analogs & derivatives, Humans, Medroxyprogesterone Acetate administration & dosage, Middle Aged, Receptor, ErbB-2 analysis, Receptors, Estrogen analysis, Receptors, Progesterone analysis, Skin Ulcer etiology, Skin Ulcer pathology, Adenocarcinoma, Scirrhous drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy
- Abstract
A 53-year-old woman suffering from nausea and vomiting was admitted to our hospital. There was a large ulcer from her left anterior chest to her right side chest. After pathological examination from the ulcer, she was diagnosed as breast cancer, scirrhous carcinoma. The estrogen and progesterone receptors were positive in the tumor. HER2 score was 1+ in the tumor. The stage was T4bNxM1(OTH). Uterine metastases of the breast cancer caused obstructive nephropathy. Ureteral obstruction was treated by urinary tract catheter. After improvement of renal failure, chemotherapy with 5-FU+epirubicin+cyclophosphamide (FEC) and docetaxel was performed. The efficacy was judged as stable disease (SD). For third-line chemotherapy, she was then treated with oral combination chemoendocrine therapy with capecitabine and medroxyprogesterone acetate. After the combination chemoendocrine therapy, the local tumor was remarkably reduced. With added cyclophosphamide, the partial response (PR) continued for 19 months. She died of peritonitis carcinomatosa and pleuritis carcinomatosa. No adverse reactions occurred with the combination chemoendocrine therapy. It is suggested that this oral combination chemoendocrine therapy may be useful with consideration for treatment effectiveness and the quality of life of the patient.
- Published
- 2009
30. [Mohs' ointment use in controlling advanced head and neck cancer].
- Author
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Minami K, Hasegawa N, Fukuoka O, Miyajima C, Tsunoda R, and Fukaya T
- Subjects
- Humans, Male, Middle Aged, Ointments, Palliative Care, Chlorides administration & dosage, Head and Neck Neoplasms drug therapy, Skin Neoplasms drug therapy, Zinc Compounds administration & dosage
- Abstract
Mohs' chemosurgery, originally developed to treat skin cancer, uses zinc chloride in Mohs' ointment to fix tissues, and is applicable in different clinical settings. In advanced head and neck cancer, Mohs' chemosurgery relieves main skin-infiltration symptoms such as bleeding, infection, exudation, and severe pain. Mohs' chemosurgery conducted in two cases of advanced head and neck cancer yielded an acceptable result free of bleeding, pain, exudation, and infection. Steps in palliative care are repeated until the tumor surface is completely fixed. Using Mohs' ointment provides acceptable relief without technical complications. Although not a topical chemotherapeutic agent, it fixes the lesion well.
- Published
- 2009
- Full Text
- View/download PDF
31. [A case of bilateral T4 breast cancer with different responses to chemotherapy].
- Author
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Konishi K, Hasegawa N, Kawabata M, Kaneko H, Iimura Y, Yamamura Y, and Teramura K
- Subjects
- Aged, Biomarkers, Tumor blood, Breast Neoplasms blood, Breast Neoplasms diagnostic imaging, Breast Neoplasms surgery, Combined Modality Therapy, Female, Humans, Tomography, X-Ray Computed, Antineoplastic Agents therapeutic use, Breast Neoplasms drug therapy
- Abstract
It is recognized that hormone receptors and HER2 are important as prognostic factors in breast cancer. Moreover, it seems likely that hormone receptors and HER2 are important predictive factors for response to chemotherapy in breast cancer. We report a case of bilateral T4 breast cancer with different expression for hormone receptors and HER2. The patient was a 67-year-old woman. The Stage was T4bN2aM0, respectively. The right tumor was negative for hormone receptors and positive for HER2, while the left tumor was positive for hormone receptors and negative for HER2. After primary chemotherapy with FEC, paclitaxel and docetaxel, the efficacy for the right local tumor was judged as cCR. However, brain metastases appeared and were treated by resection and radiation. The efficacy for the left tumor was judged as PR. Modified radical mastectomy with axillary lymph node dissection was performed. The patient has survived with no recurrence.
- Published
- 2008
32. [Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells].
- Author
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Hasegawa N
- Subjects
- Cells, Cultured, Humans, Periodontal Ligament metabolism, Periodontitis etiology, Receptor for Advanced Glycation End Products, Receptors, Immunologic physiology, Toll-Like Receptor 2 physiology, Toll-Like Receptor 4 physiology, HMGB1 Protein pharmacology, HMGB1 Protein physiology, Interleukin-11 biosynthesis, Interleukin-6 biosynthesis, Periodontal Ligament cytology
- Abstract
The periodontal ligament (PDL) is a fibrous connective tissue that exists in the cementum and the alveolar bone. Periodontitis is a chronic inflammatory disease that is caused by a bacterial infection in the periodontal region. This infection increases the production of inflammatory cytokines and causes the destruction of periodontal tissue. High mobility group box 1 (HMGB1) is a nuclear nonhiston DNA-binding protein that is present in many eukaryotic cells. HMGB1 is released actively from macrophages and monocytes stimulated by lipopolysaccharide or tumor necrosis factor-alpha and passively from damaged cells and necrotic cells. Extracellular HMGB1 signals through a specialized receptor for advanced glycation end products (RAGE), toll-like receptor 2 (TLR2), and toll-like receptor 4 (TLR4). According to a recent report, HMGB1 is of concern in periodontitis. The purpose of this study was to examine the effect of HMGB1 in PDL cells. To investigate RAGE, TLR2 and TLR4 mRNA in PDL cells, reverse transcript-polymerase chain reaction experiments were performed. PDL cells were stimulated with HMGB1, with or without anti-RAGE, TLR2 and TLR4 antibodies. IL-6 and IL-11 production was measured using an enzyme-linked immunosorbent assay, and mRNA expression was quantified by real-time PCR. PDL cells expressed RAGE, TLR2 and TLR4 mRNA. Production and mRNA expression of IL-6 and IL-11 were augmented in PDL cells stimulated with HMGB1. In addition, they were also suppressed by anti-RAGE, TLR2 and TLR4 antibodies. In conclusion, PDL cells produce IL-6 and IL-11 in response to HMGB1 via RAGE, TLR2 and TLR4.
- Published
- 2008
- Full Text
- View/download PDF
33. [Effects of processing and cooking on the levels of pesticide residues in rice samples].
- Author
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Saka M, Iijima K, Nishida M, Koma Y, Hasegawa N, Sato K, and Kato Y
- Subjects
- Chromatography, High Pressure Liquid, Gas Chromatography-Mass Spectrometry, Cooking, Food Handling, Oryza chemistry, Pesticide Residues analysis
- Abstract
The effects of processing and cooking on the levels of pesticide residues in rice samples were investigated for 11 pesticides in pre-harvest (9 pesticides) and post-harvest (4 pesticides) samples. In the polishing process, the transfer ratio (%, total pesticide residue amount in product/that in brown rice) of rice bran ranged from 40% to 106%, and the transfer ratio of polished rice ranged from 9% to 65% in pre-harvest samples. These values varied from pesticide to pesticide. The processing factor (the concentration (mg/kg) of pesticide in product/that in the brown rice) of polished rice ranged from 0.11 to 0.73. The loss of pesticides during processing and/or cooking did not correlate to any single physical or chemical property. Investigation of changes of pesticide residues during processing and/or cooking is useful not only to establish MRLs, but also to recognize actual levels of pesticide residues in food.
- Published
- 2008
- Full Text
- View/download PDF
34. [Effects of processing and cooking on the levels of pesticide residues in wheat samples].
- Author
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Saka M, Iijima K, Nishida M, Koma Y, Hasegawa N, Sato K, and Kato Y
- Subjects
- Dietary Fiber analysis, Cooking, Food Handling, Pesticide Residues analysis, Triticum chemistry
- Abstract
The effects of processing and cooking on the levels of pesticide residues in wheat samples were investigated for 13 pesticides in pre-harvest (Pre, 9 pesticides) and post-harvest (Post, 6 pesticides) samples. In the milling process, the transfer ratios (%, total pesticide residue amount in product/that in wheat grain) of wheat bran were greater than 70% and 80% for pre-harvest and post-harvest samples, respectively. The transfer ratios of flour ranged from 1.7% to 23% (Pre) and 4.0% to 11% (Post). There was no significant difference in transfer ratio among the pesticides investigated. The processing factors (Pf, the concentration (mg/kg) of pesticide in product/that in the wheat grain) of flour ranged from 0.030 to 0.40 (Pre) and 0.069 to 0.18 (Post). The values in pre-harvest samples were higher than those in post-harvest samples. Investigation of changes of pesticide residues during processing and/or cooking is useful not only to establish MRLs, but also to recognize actual levels of pesticide residues in food.
- Published
- 2008
- Full Text
- View/download PDF
35. [Effects of processing and cooking on the levels of pesticide residues in soybean samples].
- Author
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Saka M, Iijima K, Nishida M, Koma Y, Hasegawa N, Sato K, and Kato Y
- Subjects
- Cooking, Food Handling, Pesticide Residues analysis, Glycine max chemistry
- Abstract
The effects of processing and cooking on the levels of pesticide residues in soybean samples were investigated for 14 pesticides in pre-harvest samples. On soaking, the transfer ratios (%, total pesticide residue amount in product/that in soybean) of soaked soybean were greater than 60% for most of the pesticides investigated. The transfer ratio of soymilk ranged from 37% to 92%, and that of tofu ranged from 7% to 63%. The processing factor (Pf, the concentration (mg/kg) of pesticide in product/that in soybean) of tofu ranged from 0.026 to 0.28. These values varied among pesticides. There was a high correlation between the log P(ow) and the transfer ratio of tofu. The test described here should be useful to obtain the transfer ratios of pesticide residues in processing and/or cooking steps.
- Published
- 2008
- Full Text
- View/download PDF
36. [Progress in the treatment of ARDS].
- Author
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Ishizaka A, Hasegawa N, and Miyamoto K
- Subjects
- Adult, Humans, Respiratory Distress Syndrome therapy
- Published
- 2008
- Full Text
- View/download PDF
37. [Peculiar "chestnuts in burrs" formation in MGIT cultures of pulmonary Mycobacterium xenopi cases].
- Author
-
Abe K, Yamazato M, Ohtani S, Shinozawa Y, Nakamura H, Miura T, Hasegawa N, and Hara M
- Subjects
- Aged, Culture Media, Female, Humans, Male, Middle Aged, Mycobacterium xenopi isolation & purification, Tuberculosis, Pulmonary microbiology, Mycobacterium xenopi growth & development
- Abstract
We report 3 patients whose sputum and bronchoalveolar lavage fluid (BALF) cultures for acid fast bacteria in MGIT liquid media grew colonies of Mycobacterium xenopi (M. xenopi) with a characteristic chestnut burr like appearance. Patients I, II, and III were a 74-year-old man, 47-year-old woman, and 62-year-old woman, respectively. Chest X ray showed a pulmonary cavity in each case. Patient I had a history of pulmonary and renal tuberculosis. The past medical history of patient II was unremarkable. Patient III had a history of lung cancer. Eight sputum samples and 4 BALF samples from patient I, 3 sputum samples and 1 BALF sample from patient II, and 4 sputum samples from patient III were positive for acid fast bacteria, and the organism was identified as M. xenopi in 9 samples. Smears of these MGIT-positive cultures were stained by the Ziehl Neelsen method, and examined under a microscope. Large and small, spherical shaped, 15-100 microm clusters of thin, elongated bacteria, with a chestnut burr-like or spherical moss like and partly budding appearance, were scattered throughout the smear preparation. Although only 34 cases of M. xenopi infection were reported in Japan between 1984 and 2005, the number of reported cases has been on the increase in recent years. Since no report from Japan, Europe, or the United States have noted the characteristic appearance of M. xenopi in cultures, we consider that the feature described in this communication is useful to presumptively identify M. xenopi.
- Published
- 2007
38. [A case of recurrent breast cancer with multiple liver metastases responding to combination therapy of capecitabine and MPA].
- Author
-
Konishi K, Hasegawa N, Kawabata M, Abeshima S, Ichimura T, Kaneko H, and Nakayama T
- Subjects
- Aged, Antimetabolites, Antineoplastic administration & dosage, Antineoplastic Agents, Hormonal administration & dosage, Capecitabine, Combined Modality Therapy, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Female, Fluorouracil administration & dosage, Fluorouracil analogs & derivatives, Humans, Medroxyprogesterone Acetate administration & dosage, Neoplasm Recurrence, Local, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms pathology, Breast Neoplasms therapy, Liver Neoplasms secondary
- Abstract
The patient was a 68-year-old woman who underwent left partial mastectomy on February 1999. The stage was T2N1. There were positive for estrogen and progesterone receptors in the tumor. After operation, adjuvant therapy consisting of oral administration of tamoxifen and radiation was performed. On February 2005, she felt dyspnea and right femoral pain. After examinations, she was diagnosed as recurrent breast cancer with pleuritis carcinomatosa and bone metastasis. The patient was treated with oral administration of anastrozole and pamidronate disodium 90 mg intravenously every 4 weeks, radiation of her right femur, and OK-432 injection into the intrapleural cavity. On November 2005, she felt general fatigue and anorexia. CT examination revealed multiple liver metastases. She was treated with oral combination chemoendocrine therapy with capecitabine (2,400 mg/day) and MPA (600 mg/day). After the four courses, multiple liver metastases were remarkably reduced in the CT findings. After twelve courses, the partial response continued. No adverse reactions occurred except for gain in weight of grade 1. It is suggested that this oral combination chemoendocrine therapy may be useful for recurrent breast cancer with consideration for treatment effectiveness and the quality of life of the patient.
- Published
- 2007
39. [Simultaneous renal cell carcinoma and urothelial carcinoma in ipsilateral kidney, report of two cases].
- Author
-
Sasaki H, Hasegawa N, Ikemoto I, and Egawa S
- Subjects
- Aged, Carcinoma surgery, Carcinoma, Renal Cell surgery, Humans, Kidney Neoplasms surgery, Male, Neoplasms, Multiple Primary surgery, Carcinoma pathology, Carcinoma, Renal Cell pathology, Kidney Neoplasms pathology, Neoplasms, Multiple Primary pathology
- Abstract
Two cases of simultaneously developed renal tumors (renal cell carcinoma and renal pelvic urothelial carcinoma) in the ipsilateral kidney are reported. These underwent radical surgery under the diagnosis of renal cell carcinoma or renal pelvic urothelial carcinoma, respectively. The risk of incorrect preoperative diagnosis is discussed in terms of insufficient surgical margins. The liberal use of frozen section diagnosis and more radical resection if applicable may be the key to solve such dilemmas.
- Published
- 2006
40. [Small cell lung cancer with Sjögren's syndrome and Lambert-Eaton myasthenic syndrome].
- Author
-
Nishimura T, Tasaka S, Yamada W, Hasegawa N, Soejima K, Sayama K, Asano K, and Ishizaka A
- Subjects
- Aged, Carcinoma, Small Cell diagnosis, Carcinoma, Small Cell therapy, Combined Modality Therapy, Humans, Lambert-Eaton Myasthenic Syndrome diagnosis, Lambert-Eaton Myasthenic Syndrome therapy, Lung Neoplasms diagnosis, Lung Neoplasms therapy, Male, Sjogren's Syndrome diagnosis, Sjogren's Syndrome therapy, Carcinoma, Small Cell complications, Lambert-Eaton Myasthenic Syndrome etiology, Lung Neoplasms complications, Sjogren's Syndrome complications
- Abstract
A 72-year-old man was admitted to our hospital with complaints of dry mouth, muscle weakness of the lower limbs and gait disturbance. The patient had dry mouth, dry eyes, positive anti-SS-B antibody and salivary gland inflammation. Sjögren's syndrome was diagnosed. Since muscle weakness of the lower limbs and gait disturbance were not compatible with Sjögren's syndrome, we considered the possibility of paraneoplastic syndrome. Serum levels of CEA, NSE and ProGRP were elevated. Chest roentgenogram and CT showed a nodular lesion in the right upper lobe of the lung and swollen lymph nodes in the hilum and mediastinum. Small cell lung cancer was diagnosed by bronchoscopy. Anti-P/Q-type Ca2+ channel antibody was positive. Electromyogram showed a reduction in the amplitude of the evoked muscle action potential response after slow repetitive stimulation and did not show a reduction after rapid repetitive stimulation. Based on these findings, we made a diagnosis of Lambert-Eaton myasthenic syndrome (LEMS). Concurrent chemoradiotherapy induced an improvement of muscle weakness of the lower limbs. LEMS is frequently associated with a malignant tumor and an autoimmune disorder. We thought that in this patient, the presentation of LEMS was apparent because he had both Sjögren's syndrome and small cell lung cancer.
- Published
- 2006
41. [Clinical features of Pneumocystis pneumonia in patients with systemic lupus erythematosus].
- Author
-
Tasaka S, Hasegawa N, Yamada W, Saito F, Nishimura T, and Ishizaka A
- Subjects
- Adult, Aged, Bronchoalveolar Lavage Fluid microbiology, Female, Humans, Immunocompromised Host, Male, Middle Aged, Pneumonia, Pneumocystis diagnosis, Lupus Erythematosus, Systemic complications, Pneumonia, Pneumocystis etiology
- Abstract
Systemic lupus erythematosus (SLE) is often associated with various opportunistic infections, particularly during treatment with corticosteroids or immunosuppressants. We studied the clinical characteristics of 15 patients with SLE who underwent diagnostic bronchoalveolar lavage (BAL) and compared 6 patients with confirmed Pneumocystis pneumonia (PcP+), with 9 patients without Pneumocystis pneumonia (PcP-). The serum concentrations of beta-D-glucan and KL-6 were significantly higher in PcP+ than in PcP- patients, whereas serum LDH was similar in both groups. The serum concentrations of complement, a marker of SLE activity, and of IgG did not predict the presence of PcP. In all patients, the overall cell and lymphocyte counts were increased in the BAL fluid, without any significant difference between the PcP+ and PcP- groups. Ground-glass opacities on chest computed tomography, and oxygenation impairment (PaO2/FiO2<200Torr) were more common in PcP+ than PcP- patients. We concluded that, in patients with SLE, serum beta-D-glucan and KL-6 might be useful in the diagnosis of PcP, particularly when severe hypoxemia precludes BAL.
- Published
- 2006
42. [A case of rectal cancer with multiple liver metastases responding to TS-1].
- Author
-
Konishi K, Kaneko H, Ichimura T, Abeshima S, Hasegawa N, Kawabata M, and Yoshida Y
- Subjects
- Adenocarcinoma secondary, Adenocarcinoma surgery, Ambulatory Care, CA-19-9 Antigen blood, Carcinoembryonic Antigen blood, Drug Administration Schedule, Drug Combinations, Female, Humans, Liver Neoplasms drug therapy, Middle Aged, Rectal Neoplasms pathology, Rectal Neoplasms surgery, Adenocarcinoma drug therapy, Antimetabolites, Antineoplastic administration & dosage, Biomarkers, Tumor blood, Liver Neoplasms secondary, Oxonic Acid administration & dosage, Rectal Neoplasms drug therapy, Tegafur administration & dosage
- Abstract
A 63-year-old woman was referred to our hospital with complaints of anal pain, constipation and abdominal distention caused by a rectal tumor. After examinations, she was diagnosed as rectal cancer with multiple liver metastases. The CEA level was 70.0 ng/ml and the CA19-9 level was more than 5,000 U/ml at admission. To prevent bowel obstruction, low anterior resection of the rectum was performed. At 34 days after operation, TS-1 chemotherapy was started as outpatient treatment (each course consisted of daily oral administration of 100 mg TS-1 for 4 weeks followed by 2 drug-free weeks). After the first course, the CEA level was reduced to 3.3 ng/ml and the CA19-9 level to 15 U/ml, both under the normal value. After the second course, administration was discontinued due to diarrhea, and restarted as a daily oral administration of 80 mg TS-1. After the five courses, the CEA level was 4.0 ng/ml and the CA19-9 level was 4 U/ml, both under the normal value. Multiple liver metastases had remarkably reduced in the CT findings. The patient continues to undergo outpatient treatment with good QOL.
- Published
- 2006
43. [Cell transplantation for periodontal diseases. A novel periodontal tissue regenerative therapy using bone marrow mesenchymal stem cells].
- Author
-
Kawaguchi H, Hayashi H, Mizuno N, Fujita T, Hasegawa N, Shiba H, Nakamura S, Hino T, Yoshino H, Kurihara H, Tanaka H, Kimura A, Tsuji K, and Kato Y
- Subjects
- Humans, Periodontium physiology, Regeneration physiology, Tissue Engineering, Mesenchymal Stem Cell Transplantation methods, Periodontal Diseases therapy
- Abstract
A major goal of periodontal therapy is to reconstruct healthy periodontium destroyed by periodontal diseases. Basic studies have revealed that transplantation of mesenchymal stem cells (MSC) into periodontal defects promotes regeneration of periodontal tissue. We have developed a novel method for periodontal therapy using MSC. Human bone marrow cells are obtained from the iliac crest and expanded in vitro at Cell and Tissue Engineering Center in Hiroshima University Hospital. MSC are, then, isolated and mixed with Atelocollagen at final concentrations of 2 x 10(7) cells/mL. These MSC in Atelocollagen are transplanted into periodontal osseous defects at the periodontal surgery. The results in all seven patients who received the own MSC transplantation have shown good clinical course. Further basic studies and the continuous clinical trial are needed to prove the effectiveness of the clinical application.
- Published
- 2005
- Full Text
- View/download PDF
44. [Usefulness of QuantiFERON TB-2G in contact investigation of a tuberculosis outbreak in a university].
- Author
-
Funayama K, Tsujimoto A, Mori M, Yamamoto H, Fujiwara K, Nishimura T, Hasegawa N, Horiguchi I, Mori T, and Marui E
- Subjects
- Adult, Contact Tracing methods, Humans, Tuberculin Test, Universities, Antigens, Bacterial immunology, Disease Outbreaks statistics & numerical data, Interferon-gamma blood, Mycobacterium tuberculosis immunology, Tuberculosis, Pulmonary diagnosis
- Abstract
Purpose: This study examined the usefulness of QuantiFERON TB-2G (QFT) i.e., a novel technique for detecting tuberculosis infection based on the whole blood interferon-gamma response to specific antigens, in the investigation of a tuberculosis outbreak among university students., Subjects and Method: One university student was diagnosed as smear-positive pulmonary tuberculosis. In order to determine the extent of tuberculosis infection among contact students, tuberculin skin tests and QFT were performed on the close-contact group (220 people), as well as on the non-close-contact group (242 people)., Results: Nine students were found to be TB either clinically or on the X-ray screening in the contact investigation. In the close-contact group, the QFT-positive rate was 32.7%. The proportion of those exhibiting tuberculin reactions with erythema diameters of 30 mm or larger was 57.7%. In the non-close-contact group, the QFT-positive rate was only 0.8 %, as expected from the current healthy Japanese youths of this age. In contrast, strong tuberculin reactions with erythema of 30 mm or larger were seen in 18.2% in the latter group, most likely due to the previous history of BCG vaccination., Conclusion: QFT was clearly demonstrated to be a useful method for diagnosing tuberculosis infection, especially among subjects who show tuberculin reactivity due to past BCG vaccination. At the same time, the current criteria for the indication of chemoprophylaxis based on the strong tuberculin reaction were considered to be unreliable, causing many subjects with strong reactions to be given unnecessary preventive medications.
- Published
- 2005
45. [Primary, nonviral, hepatocellular carcinoma in patients with prostate cancer treated by hormone therapy: 2 case reports].
- Author
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Hasegawa Y, Tomita M, Asano K, Hasegawa N, Ikemoto I, Onodera S, Ohishi Y, and Ishikawa T
- Subjects
- Aged, Carcinoma, Hepatocellular pathology, Drug Administration Schedule, Humans, Liver Neoplasms pathology, Male, Middle Aged, Neoplasms, Second Primary pathology, Prostatic Neoplasms pathology, Androgen Antagonists therapeutic use, Antineoplastic Agents, Hormonal therapeutic use, Carcinoma, Hepatocellular etiology, Diethylstilbestrol analogs & derivatives, Diethylstilbestrol therapeutic use, Liver Neoplasms etiology, Neoplasms, Second Primary etiology, Prostatic Neoplasms drug therapy
- Abstract
We studied two cases of primary, hepatocellular carcinoma (HCC) that occurred following hormone therapy (estrogen therapy in one case and total androgen blockade therapy in another) for stage D2 prostate cancer. Prostate cancer is considered to be hormone-dependent, and androgens appear to be important hormonal factors. However, hepatocellular carcinoma has been shown to have both estrogen and androgen receptors, suggesting that this may be dependent on estrogen or androgen. Reported here are two unique cases of hepatocellular carcinoma in patients with prostate cancer; the pathogenesis of HCC in these patients was suspected to be related to diethylstilbestrol (DES) therapy and antiandrogen therapy for their prostate cancer.
- Published
- 2005
- Full Text
- View/download PDF
46. [Urologic area].
- Author
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Hasegawa N, Kato N, Ohishi Y, and Fukuda K
- Subjects
- Humans, Female Urogenital Diseases diagnostic imaging, Image Processing, Computer-Assisted methods, Imaging, Three-Dimensional methods, Male Urogenital Diseases, Tomography, Spiral Computed methods, Urography methods
- Abstract
In this review, the clinical experience of a three-dimensional(3D) image at urologic area are described. There are some methods for reconstructive 3D image of Multi-slice CT. Maximum intensity projection (MIP) is usefulness for detection of vascular anatomy. Multi-planar reconstruction (MPR) is usefulness for relation with circumference organs. Therefore the opportunities of angiography decreased. It seems that an applied range of a 3D image spreads more in future.
- Published
- 2004
47. [Prostatic cancer in a young adult: a report of 2 cases].
- Author
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Sasaki H, Miki J, Hasegawa T, Hasegawa N, Ikemoto I, and Ohishi Y
- Subjects
- Adenocarcinoma pathology, Adenocarcinoma therapy, Adult, Age Factors, Biomarkers, Tumor blood, Combined Modality Therapy, Diagnostic Imaging, Humans, Male, Middle Aged, Prognosis, Prostate-Specific Antigen blood, Prostatic Neoplasms pathology, Prostatic Neoplasms therapy, Adenocarcinoma diagnosis, Prostatic Neoplasms diagnosis
- Abstract
Patients younger than 45 years with prostate cancer are rare. Between 1999 and 2002, we studied two cases of prostate cancer in men aged under 45 years. Case 1; a 45-year-old man admitted with the chief complaint of urination disorder. Serum level of prostate-specific antigen (PSA) was 5,000 ng/ml or higher. Transrectal needle biopsy of the prostate revealed moderately differentiated adenocarcinoma. Computed tomography (CT) and bone scan showed para-aorta lymph node metastasis and bone metastasis. Hormone therapy was performed. Case 2; a 37-year-old man admitted with the chief complaint of pollakisuria and sense of residual urine. Serum level of prostate-specific antigen (PSA) was 24 ng/ml. Magnetic resonance imaging (MRI) showed that the prostate tumor invaded the bladder wall. Transrectal needle biopsy revealed poorly differentiated adenocarcinoma. Hormone therapy and radiation therapy were performed. Twenty-one cases reported in Japan in addition to the present cases are reviewed.
- Published
- 2004
48. [Effects of docetaxel dosage in combination chemotherapy with carboplatin against advanced non-small cell lung cancer].
- Author
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Oyamada Y, Watanabe H, Fukunaga K, Nakamura H, Asano K, Hasegawa N, and Yamaguchi K
- Subjects
- Aged, Anemia chemically induced, Carboplatin administration & dosage, Docetaxel, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Leukopenia chemically induced, Male, Middle Aged, Neutropenia chemically induced, Taxoids adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, Taxoids administration & dosage
- Abstract
We retrospectively analyzed the effects of dosages of docetaxel (DOC) in combination chemotherapy with carboplatin (CBDCA) against advanced non-small cell lung cancer (NSCLC). Twenty-three cases of previously untreated NSCLC (stage III and IV, performance status: 0-1) that were pathologically or cytologically confirmed were divided into 2 groups (DOC-60, DOC-70) based on their received DOC doses (60 and 70 mg/m2, respectively). Both groups had similar patient characteristics and received similar treatment except for their DOC doses. Although not statistically significant, the response rates after the completion of whole cycles of the treatment (mean: 4 cycles) were 18.2% in DOC-60 and 41.6% in DOC-70. Leukocytopenia, neutropenia and anemia were observed similarly in both groups. However, while thrombocytopenia was not observed in DOC-70, it was found in 36.4% of the cases in DOC-60. In combination chemotherapy with carboplatin against advanced NSCLC, the use of DOC at 70 mg/m2 was rather protective against thrombocytopenia, keeping the response equivalent or possibly superior to that obtained in the patients treated with DOC at 60 mg/m2.
- Published
- 2003
49. [Mucinous adenocarcinoma of the prostate: a case report and review of 32 cases on immunohistochemical study of both PSA and CEA].
- Author
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Furuta A, Naruoka T, Hasegawa N, Suzuki Y, Ikemoto I, and Oishi Y
- Subjects
- Adenocarcinoma, Mucinous pathology, Antigens, Bacterial analysis, Humans, Immunohistochemistry, Male, Middle Aged, Prostate-Specific Antigen analysis, Prostatic Neoplasms pathology, Adenocarcinoma, Mucinous diagnosis, Biomarkers, Tumor analysis, Prostatic Neoplasms diagnosis
- Abstract
Mucinous adenocarcinoma of the prostate is extremely rare and its biological behavior is not well known. We report a case of mucinous adenocarcinoma of the prostate which stained positively for prostate specific antigen (PSA) and negatively for carcinoembryonic antigen (CEA) on immunohistochemical study. Our case contained conventional adenocarcinomas and no signet-ring cells. Thirty two cases of mucinous adenocarcinoma of the prostate which performed on immunohistochemical study of both PSA and CEA, including our case, were reviewed. 17 of the 23 cases of immunoreactive to PSA contained conventional adenocarcinomas, and 3 of the 10 cases of immunoreactive to CEA contained them, respectively. The 6 cases of immunoreactive to CEA only contained signet-ring cells. It indicated that there seemed to be the two types of mucinous adenocarcinoma of the prostate, the one which stained positively for PSA was the subtype of conventional adenocarcinomas, and the other which stained positively for CEA and negatively for PSA was derived from the intestinal metaplasia with atypia of the prostatic urethra.
- Published
- 2003
- Full Text
- View/download PDF
50. [Comparison and examination of stereotactic surgical complications in movement disorders].
- Author
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Terao T, Okiyama R, Takahashi H, Yokochi F, Taniguchi M, Hamada I, and Hasegawa N
- Subjects
- Adult, Aged, Brain Stem injuries, Cerebral Hemorrhage etiology, Electric Stimulation Therapy, Electrocoagulation, Female, Hallucinations etiology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Movement Disorders diagnosis, Movement Disorders therapy, Neurosurgical Procedures adverse effects, Tomography, X-Ray Computed, Treatment Outcome, Movement Disorders surgery, Neurosurgical Procedures methods, Stereotaxic Techniques adverse effects
- Abstract
The purpose of the present study was to determine exactly the incidence of surgical complications in patients for whom MRI-targeted, microelectrode recording (MER)-guided implantation of deep brain stimulation (DBS) or radiofrequency (RF)-coagulation surgery was performed. Between January, 1998 and September, 2002, a total of 110 stereotactic surgeries for movement disorders (57 RF-coagulations and 53 implantations of DBS) were performed. We investigated the type and number of complications for each of the following surgical targets; globus pallidus, thalamus, and subthalamic nucleus (STN). Twenty-four neurological complications in 22 patients and 16 radiological/instrumental complications in 16 patients were verified among the 110 surgeries. Among the neurological complications, hemiparesis and mental disturbances were observed at a high rate, while intraoperative hemorrhage frequently occurred among the radiological/instrumental complications. The rate of neurological and radiological/instrumental complications for each of the stereotactic targets; the globus pallidus, thalamus, and STN-targeted surgeries, was 32.4%, 16.7%, 18.8% and 16.2%, 20.0%, 12.5%, respectively. The reason for the high rate of intraoperative hemorrhage may be associated with technical problems resulting from the penetration of vessels by needles, as well as the destruction of small vessels due to heat ablation. As for the mental disturbances, visual hallucinations (VH) occurred a high rate, especially during STN-DBS. Peduncular damage and/or L-dopa toxicity due to STN-DBS may have been associated with VH, so the STN-DBS may therefore be thought to change the threshold of stimulus-induced hallucinations. We also found that the procedures for DBS surgery, especially in younger patients, have a lower risk of complication, while, on the other hand, coagulation surgery for elderly patients is accompanied by of high risks, from the standpoint of surgical complications.
- Published
- 2003
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