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7 results on '"Boveri E"'

2. Primary cutaneous large B-cell lymphoma of the leg: Histogenetic analysis of a controversial clinicopathologic entity

Author

Mario Lazzarino, Marco Paulli, Emilio Berti, Giovanni Borroni, Gianluca Gaidano, Davide Rossi, Marco Lucioni, Daniela Capello, Mario Bellosta, P Incardona, Emanuela Boveri, Roberta Riboni, Alessandra Viglio, Umberto Magrini, Elvio Alessi, Ester Orlandi, Daniela Vivenza, Paulli, M, Viglio, A, Vivenza, D, Capello, D, Rossi, D, Riboni, R, Lucioni, M, Incardona, P, Boveri, E, Bellosta, M, Orlandi, E, Borroni, G, Lazzarino, M, Berti, E, Alessi, E, Magrini, U, and Gaidano, G

Subjects
Male, Pathology, medicine.medical_specialty, Lymphoma, B-Cell, Skin Neoplasms, Population, DNA Mutational Analysis, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Histogenesis, Pathology and Forensic Medicine, immune system diseases, hemic and lymphatic diseases, Proto-Oncogene Proteins, MED/35 - MALATTIE CUTANEE E VENEREE, medicine, Biomarkers, Tumor, Humans, molecular analysis, primary cutaneous B-cell lymphoma, education, B-cell lymphoma, Aged, Aged, 80 and over, education.field_of_study, Leg, business.industry, Large-cell lymphoma, Germinal center, Gene rearrangement, DNA, Neoplasm, medicine.disease, Lymphoma, DNA-Binding Proteins, immunohistochemistry, Proto-Oncogene Proteins c-bcl-6, Female, Lymphoma, Large B-Cell, Diffuse, business, Diffuse large B-cell lymphoma, Transcription Factors
Abstract

This study analyzes the pathologic and molecular features of 5 cases of primary cutaneous large B-cell lymphoma of the leg (PCLBCL-leg), recently included in the European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphoma. PCLBCL-leg accounts for 5% to 10% of all primary cutaneous B-cell lymphoma (PCBCL), usually affects elderly patients and carries a worse prognosis than other forms of PCBCL. It has been proposed that the malignant cells of PCLBCL-leg originate from germinal center (GC)-related cells, but their effective normal counterpart is unclear, and the rationale behind the inclusion of this lymphoma as a separate entity is based on its prognosis rather than on its proved histogenesis. All of our cases of PCLBCL-leg morphologically resembled diffuse large B-cell lymphoma (DLBCL), but to better define their histogenesis, we also analyzed various phenotypic and genotypic markers, including mutations of the Ig and of BCL,6 genes, as well as expression of the bcl-6, MUM1, and CD138/syndecan-1 proteins. Immunohistochemically, all of our cases stained for the 1,26/CD20cy and CD79a antigens and expressed the bcl-2, bcl-6, and MUM-1 proteins but were negative for both the CD10/CALLA and CD138 antigens. With respect to molecular analysis, the lymphoma population of all PCLBCL-leg carried hypermutation of Ig genes, and all but I case also harbored mutations of the BCL-6 gene. Our results indicate that PCLBCL-leg are similar both under the morphofunctional and molecular profiles to most DLBCL of other sites. Thus, caution seems justified before definitely considering PCLBCL of the leg as a distinct entity. Copyright 2002, Elsevier Science (USA). All rights reserved.

Published
2002

3. [Castleman's disease: update].

Author

Magrini U, Lucioni M, Incardona P, Boveri E, and Paulli M

Subjects
Castleman Disease classification, Humans, Castleman Disease pathology
Published
2003

4. [Primary CD30+ large-cell non-Hodgkin's lymphoma of the soft tissues. Clinico-pathologic study of a case].

Author

Ciserani G, Paulli M, Boveri E, Kindl S, Gianelli U, Rosso R, and Magrini U

Subjects
Aged, Female, Humans, Lymphoma, Large-Cell, Anaplastic pathology, Soft Tissue Neoplasms pathology
Abstract

The authors report a single case of primary soft tissue CD30+ non anaplastic non-Hodgkin's lymphoma. The clinical, histological and immunohistochemical features of this peculiar lymphoma type are discussed. Within extranodal lymphomas, a primary soft tissue involvement is rare and the literature lacks exhaustive data on the clinical behaviour of these malignancies. In our case, the prognosis appeared more closely related to the clinical stage of the disease than to histology.

Published
1994

5. [Primary non-Hodgkin's lymphoma of the breast. Clinico-pathologic study of 2 cases].

Author

De Medici A, Venegoni A, Cabano F, Kindl S, Boveri E, and Paulli M

Subjects
Female, Humans, Middle Aged, Breast Neoplasms pathology, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Lymphoma, B-Cell pathology
Abstract

The authors describe two cases of malignant non-Hodgkin's lymphoma in a mammary site observed at IRCCS Policlinico San Matteo (Pavia). Histologic, immunohistochemical and clinical features are illustrated. Correct diagnosis is essential so that appropriate multidisciplinary treatment may be applied.

Published
1993

6. [Our experience in the treatment of upper digestive bleeding due to a nonvaricose lesion].

Author

Perduca G, Tava P, Rapella P, Amato G, Boveri E, Pacquola MG, and Costa G

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Emergencies, Endoscopy, Digestive System, Female, Gastrointestinal Hemorrhage diagnosis, Gastrointestinal Hemorrhage etiology, Hemostasis, Surgical methods, Humans, Male, Middle Aged, Gastrointestinal Hemorrhage surgery
Abstract

The authors examine the causes and incidence of upper digestive bleeding by no variceal lesions, emphasizing the better and better results obtained by endoscopic management of this surgical emergency. Personal experience with urgent endoscopic sclerotherapy of these haemorrhages and the good results obtained are then reported.

Published
1991

7. [Complicated diverticular disease].

Author

Feltri R, Tava P, Boveri E, Franzosi W, Pacquola MG, Prete R, and Allegrina S

Subjects
Adult, Aged, Aged, 80 and over, Colectomy, Colostomy, Diverticulum, Colon surgery, Emergencies, Female, Humans, Male, Middle Aged, Postoperative Complications, Diverticulum, Colon complications
Published
1988

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