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Primary cutaneous large B-cell lymphoma of the leg: Histogenetic analysis of a controversial clinicopathologic entity
- Publication Year :
- 2002
- Publisher :
- W.B. Saunders, 2002.
-
Abstract
- This study analyzes the pathologic and molecular features of 5 cases of primary cutaneous large B-cell lymphoma of the leg (PCLBCL-leg), recently included in the European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphoma. PCLBCL-leg accounts for 5% to 10% of all primary cutaneous B-cell lymphoma (PCBCL), usually affects elderly patients and carries a worse prognosis than other forms of PCBCL. It has been proposed that the malignant cells of PCLBCL-leg originate from germinal center (GC)-related cells, but their effective normal counterpart is unclear, and the rationale behind the inclusion of this lymphoma as a separate entity is based on its prognosis rather than on its proved histogenesis. All of our cases of PCLBCL-leg morphologically resembled diffuse large B-cell lymphoma (DLBCL), but to better define their histogenesis, we also analyzed various phenotypic and genotypic markers, including mutations of the Ig and of BCL,6 genes, as well as expression of the bcl-6, MUM1, and CD138/syndecan-1 proteins. Immunohistochemically, all of our cases stained for the 1,26/CD20cy and CD79a antigens and expressed the bcl-2, bcl-6, and MUM-1 proteins but were negative for both the CD10/CALLA and CD138 antigens. With respect to molecular analysis, the lymphoma population of all PCLBCL-leg carried hypermutation of Ig genes, and all but I case also harbored mutations of the BCL-6 gene. Our results indicate that PCLBCL-leg are similar both under the morphofunctional and molecular profiles to most DLBCL of other sites. Thus, caution seems justified before definitely considering PCLBCL of the leg as a distinct entity. Copyright 2002, Elsevier Science (USA). All rights reserved.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Lymphoma, B-Cell
Skin Neoplasms
Population
DNA Mutational Analysis
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Histogenesis
Pathology and Forensic Medicine
immune system diseases
hemic and lymphatic diseases
Proto-Oncogene Proteins
MED/35 - MALATTIE CUTANEE E VENEREE
medicine
Biomarkers, Tumor
Humans
molecular analysis
primary cutaneous B-cell lymphoma
education
B-cell lymphoma
Aged
Aged, 80 and over
education.field_of_study
Leg
business.industry
Large-cell lymphoma
Germinal center
Gene rearrangement
DNA, Neoplasm
medicine.disease
Lymphoma
DNA-Binding Proteins
immunohistochemistry
Proto-Oncogene Proteins c-bcl-6
Female
Lymphoma, Large B-Cell, Diffuse
business
Diffuse large B-cell lymphoma
Transcription Factors
Subjects
Details
- Language :
- Italian
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9ccf0b1e35a49f714e1ff15ebd8fc5ee