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Your search keyword '"RNA, Neoplasm biosynthesis"' showing total 21 results
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21 results on '"RNA, Neoplasm biosynthesis"'

1. [View of the inside: genetic circuits for the analysis of intracellular molecular profiles].

Author

Lapique N and Benenson Y

Subjects
Animals, Cell Compartmentation, Cell Line, Equipment Design, Gene Expression Profiling, Gene Expression Regulation, Neoplastic genetics, Gene Regulatory Networks, Humans, Intracellular Fluid metabolism, Models, Genetic, Neoplasms genetics, Neoplasms metabolism, Neoplasms pathology, RNA, Neoplasm biosynthesis, RNA, Neoplasm genetics, Repressor Proteins physiology, Synthetic Biology trends, Transcription Factors physiology, Transcription, Genetic genetics, Biosensing Techniques, Intracellular Fluid chemistry, MicroRNAs genetics, Synthetic Biology methods
Published
2015
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2. [Resveratrol acts by modulating miRNAs].

Author

Latruffe N

Subjects
Animals, Cell Line, Tumor, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, Cytokines biosynthesis, Cytokines genetics, Humans, Inflammation genetics, Inflammation metabolism, Inflammation Mediators metabolism, MicroRNAs genetics, Models, Biological, Neoplasm Proteins biosynthesis, Neoplasm Proteins genetics, Prostaglandins biosynthesis, Prostaglandins genetics, Proto-Oncogene Proteins c-jun physiology, RNA, Neoplasm biosynthesis, RNA, Neoplasm genetics, Reactive Oxygen Species metabolism, Resveratrol, Gene Expression Regulation drug effects, MicroRNAs biosynthesis, Stilbenes pharmacology
Published
2011
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3. [Molecular biology of lung cancer series].

Author

Hiret S, Senellart H, and Bennouna J

Subjects
Adjuvants, Immunologic, Antigens, Neoplasm analysis, Antigens, Neoplasm genetics, Biomarkers, Tumor, Bronchial Neoplasms immunology, Bronchial Neoplasms therapy, Cancer Vaccines therapeutic use, Carcinoma, Non-Small-Cell Lung immunology, Carcinoma, Non-Small-Cell Lung therapy, Clinical Trials, Phase III as Topic, Drug Delivery Systems, Female, HLA-A1 Antigen immunology, Humans, Immunotherapy methods, Lung Neoplasms therapy, Male, Neoplasm Proteins analysis, Neoplasm Proteins genetics, Predictive Value of Tests, Prognosis, RNA, Messenger biosynthesis, RNA, Neoplasm biosynthesis, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocytes, Cytotoxic immunology, Vaccination, Antigens, Neoplasm immunology, Lung Neoplasms immunology, Neoplasm Proteins immunology
Abstract

Introduction: MAGE-A3 (Melanoma Associated Antigen-A3) is expressed in cancer cells but not in normal tissues except male germ line cells which are devoid of Major Histocompatibility Complex molecules and therefore do not present MAGE-A3 antigens., Background: MAGE-A3 is expressed in 30 to 60% of non-small cell lung cancers but its function is unknown. Its recognition by cytotoxic T lymphocytes implies its presentation on the cell surface by HLA type A1 molecules that are absent from germ cells., Viewpoints: MAGE-A3 represents a good target for active anticancer immunotherapy. Some trials, which used MAGE-A3 and an adjuvant showed a strong antigen-specific T-cell response with, perhaps, an improved survival., Conclusion: This needs to be confirmed as an adjuvent therapy by current phase III randomized controlled trials., (Copyright © 2010 SPLF. Published by Elsevier Masson SAS. All rights reserved.)

Published
2010
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4. [The vascular endothelial growth factor (VEGF): a model of gene regulation and a marker of tumour aggressiveness. An obvious therapeutic target?].

Author

Grépin R and Pagès G

Subjects
3' Untranslated Regions genetics, Angiogenesis Inhibitors pharmacology, Antibodies, Monoclonal pharmacology, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized, Antineoplastic Agents pharmacology, Bevacizumab, Clinical Trials as Topic, Drug Delivery Systems, Humans, Intercellular Signaling Peptides and Proteins physiology, Neoplasm Invasiveness genetics, Neoplasm Proteins antagonists & inhibitors, Neoplasm Proteins biosynthesis, Neoplasm Proteins genetics, Neoplasms drug therapy, Neoplasms metabolism, Neovascularization, Pathologic drug therapy, Neovascularization, Pathologic physiopathology, Oncogene Proteins physiology, Promoter Regions, Genetic, Protein Isoforms antagonists & inhibitors, Protein Isoforms physiology, Protein-Tyrosine Kinases physiology, RNA, Messenger biosynthesis, RNA, Messenger genetics, RNA, Neoplasm biosynthesis, RNA, Neoplasm genetics, Receptors, Vascular Endothelial Growth Factor antagonists & inhibitors, Receptors, Vascular Endothelial Growth Factor physiology, Signal Transduction drug effects, Signal Transduction genetics, Signal Transduction physiology, Vascular Endothelial Growth Factor A antagonists & inhibitors, Vascular Endothelial Growth Factor A biosynthesis, Vascular Endothelial Growth Factor A genetics, Angiogenesis Inhibitors therapeutic use, Antineoplastic Agents therapeutic use, Gene Expression Regulation, Neoplasm Invasiveness physiopathology, Neoplasm Proteins physiology, Neoplasms blood supply, Vascular Endothelial Growth Factor A physiology
Abstract

VEGF represents a model of gene expression regulation. RAS/RAF/MEK/ERK and PI3 Kinase pathways, activated in response to growth factors stimulation or by oncogenes, contribute to its expression by activating transcription factors or inactivating proteins implicated in degradation of its mRNA. These factors (Sp1/Sp3, HIF-1 and TTP) constitute molecular markers of tumor aggressiveness. VEGF is overexpressed in solid or hematologic tumors. Thus, numerous compounds regulating angiogenesis by targeting VEGF have been developed. However, their effects are not as spectacular as expected. The existence of anti-angiogenic isoforms of VEGF could be a cause of their less potent activity. These different points are discussed in this review article.

Published
2009
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5. [Demonstration by stereological methods of pre-prophase doubling of the number of ribosomes in Ehrlich tumor cells].

Author

Lepoint A and Courrier MR

Subjects
Animals, DNA, Neoplasm biosynthesis, Male, Mice, Prophase, RNA, Neoplasm biosynthesis, Carcinoma, Ehrlich Tumor ultrastructure, Ribosomes ultrastructure
Abstract

Homogeneous populations of G1, S or G2 Ehrlich tumor cells are analysed by stereological methods at the ultrastructural level. This analysis demonstrates that the number of cytoplasmic ribosomes is doubled before the prophase.

Published
1978

8. [Estradiol and in vitro RNA biosynthesis in isolated nuclei of healthy and tumoral epithelial cells from the uterine cervix].

Author

Raynal F, Mousseron-Canet M, and Borgna JL

Subjects
Cell Nucleus metabolism, Cervix Uteri drug effects, DNA-Directed RNA Polymerases metabolism, Female, Humans, In Vitro Techniques, Oxidative Phosphorylation, Receptors, Cell Surface, Tritium, Uracil Nucleotides metabolism, Cervix Uteri metabolism, Estradiol pharmacology, HeLa Cells metabolism, RNA biosynthesis, RNA, Neoplasm biosynthesis, Uterine Cervical Neoplasms metabolism
Published
1972

10. [In vivo study of DNA and RNA kinetics of various normal and cancerous human cell populations].

Author

Duprez A, Bessot M, and Florentin P

Subjects
Aged, Biopsy, Carcinoma, Hepatocellular pathology, Deoxyribonucleases metabolism, Female, Gallbladder Neoplasms pathology, Humans, Liver Neoplasms pathology, Male, Methods, Middle Aged, Phosphorus Isotopes, Radiometry, Rectal Neoplasms pathology, Ribonucleases metabolism, Thymidine metabolism, Tritium, Uridine metabolism, DNA biosynthesis, DNA, Neoplasm biosynthesis, RNA biosynthesis, RNA, Neoplasm biosynthesis
Published
1969

11. [Determination, on histologic sections, of specific activities of H3-DNA and H3-RNA synthesized in vivo by normal and cancerous human tissues].

Author

Duprez A, Bessot M, and Stempfler A

Subjects
Carcinoma, Hepatocellular metabolism, Gallbladder Neoplasms, Humans, Neoplasm Metastasis, Phosphorus Isotopes, Thymidine metabolism, Tritium, Uridine metabolism, DNA biosynthesis, DNA, Neoplasm biosynthesis, Liver metabolism, Liver Neoplasms metabolism, RNA biosynthesis, RNA, Neoplasm biosynthesis
Published
1969

12. [Electron microprobe measurement of nuclear phosphorus in human cells].

Author

Duprez A

Subjects
DNA biosynthesis, DNA, Neoplasm biosynthesis, Electron Probe Microanalysis, Humans, Leydig Cells cytology, Male, RNA biosynthesis, RNA, Neoplasm biosynthesis, Spectrum Analysis, Astrocytoma, Cell Nucleus analysis, Phosphorus analysis, Testis cytology
Published
1967

13. [Low molecular weight nuclear na from KB cells].

Author

Larsen CJ, Galibert F, Hampe A, and Boiron M

Subjects
Carcinoma, Cell Line, Chromatography, Gel, Chromatography, Ion Exchange, Cytoplasm analysis, Electrophoresis, Escherichia coli metabolism, Humans, Molecular Weight, Mouth Neoplasms, Nucleotides analysis, Phosphorus Isotopes, RNA, Bacterial analysis, RNA, Neoplasm biosynthesis, Cell Nucleus analysis, RNA, Neoplasm analysis
Published
1969

14. [Kinetics of the incorporation of uridine ( 3 H) in subnucleolar fractions of rat ascites hepatoma cells].

Author

Bachellerie JP, Martin-Prevel C, and Zalta JP

Subjects
Animals, Centrifugation, Density Gradient, Female, Heparin pharmacology, In Vitro Techniques, Kinetics, Leucine metabolism, Neoplasms, Experimental metabolism, Nucleoproteins isolation & purification, Rats, Ribosomes drug effects, Tritium, Carcinoma, Hepatocellular metabolism, Cell Nucleolus metabolism, Liver Neoplasms metabolism, RNA, Neoplasm biosynthesis, Uridine metabolism
Published
1971
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16. [Persistence and role of oncogenic RNA viruses in transformed cells].

Author

Vigier P

Subjects
Animals, Cell Membrane, Chickens, Cricetinae, Culture Techniques, DNA, Neoplasm biosynthesis, Fibroblasts, Genotype, Humans, Mice, Mutation, Neoplasm Metastasis, Phenotype, RNA, Neoplasm biosynthesis, RNA, Viral biosynthesis, Rats, Cell Transformation, Neoplastic, Oncogenic Viruses pathogenicity, RNA Viruses pathogenicity
Published
1970

17. [Characteristics of RNA synthesized in the presence of actinomycin D in mouse plasmacytoma].

Author

Kempf J and Mandel P

Subjects
Animals, Centrifugation, Density Gradient, DNA, Neoplasm, Dactinomycin administration & dosage, Gammaretrovirus enzymology, Kinetics, Mice, Nucleic Acid Denaturation, Nucleotides analysis, Phosphoric Monoester Hydrolases, Phosphorus Isotopes, RNA, Neoplasm analysis, RNA, Transfer biosynthesis, Ribosomes, Spectrophotometry, Time Factors, Tritium, Ultracentrifugation, Uridine metabolism, Dactinomycin pharmacology, Plasmacytoma metabolism, RNA, Neoplasm biosynthesis
Published
1969

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