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[The vascular endothelial growth factor (VEGF): a model of gene regulation and a marker of tumour aggressiveness. An obvious therapeutic target?].
- Source :
-
Journal de la Societe de biologie [J Soc Biol] 2009; Vol. 203 (2), pp. 181-92. Date of Electronic Publication: 2009 Jun 16. - Publication Year :
- 2009
-
Abstract
- VEGF represents a model of gene expression regulation. RAS/RAF/MEK/ERK and PI3 Kinase pathways, activated in response to growth factors stimulation or by oncogenes, contribute to its expression by activating transcription factors or inactivating proteins implicated in degradation of its mRNA. These factors (Sp1/Sp3, HIF-1 and TTP) constitute molecular markers of tumor aggressiveness. VEGF is overexpressed in solid or hematologic tumors. Thus, numerous compounds regulating angiogenesis by targeting VEGF have been developed. However, their effects are not as spectacular as expected. The existence of anti-angiogenic isoforms of VEGF could be a cause of their less potent activity. These different points are discussed in this review article.
- Subjects :
- 3' Untranslated Regions genetics
Angiogenesis Inhibitors pharmacology
Antibodies, Monoclonal pharmacology
Antibodies, Monoclonal therapeutic use
Antibodies, Monoclonal, Humanized
Antineoplastic Agents pharmacology
Bevacizumab
Clinical Trials as Topic
Drug Delivery Systems
Humans
Intercellular Signaling Peptides and Proteins physiology
Neoplasm Invasiveness genetics
Neoplasm Proteins antagonists & inhibitors
Neoplasm Proteins biosynthesis
Neoplasm Proteins genetics
Neoplasms drug therapy
Neoplasms metabolism
Neovascularization, Pathologic drug therapy
Neovascularization, Pathologic physiopathology
Oncogene Proteins physiology
Promoter Regions, Genetic
Protein Isoforms antagonists & inhibitors
Protein Isoforms physiology
Protein-Tyrosine Kinases physiology
RNA, Messenger biosynthesis
RNA, Messenger genetics
RNA, Neoplasm biosynthesis
RNA, Neoplasm genetics
Receptors, Vascular Endothelial Growth Factor antagonists & inhibitors
Receptors, Vascular Endothelial Growth Factor physiology
Signal Transduction drug effects
Signal Transduction genetics
Signal Transduction physiology
Vascular Endothelial Growth Factor A antagonists & inhibitors
Vascular Endothelial Growth Factor A biosynthesis
Vascular Endothelial Growth Factor A genetics
Angiogenesis Inhibitors therapeutic use
Antineoplastic Agents therapeutic use
Gene Expression Regulation
Neoplasm Invasiveness physiopathology
Neoplasm Proteins physiology
Neoplasms blood supply
Vascular Endothelial Growth Factor A physiology
Subjects
Details
- Language :
- French
- ISSN :
- 1295-0661
- Volume :
- 203
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal de la Societe de biologie
- Publication Type :
- Academic Journal
- Accession number :
- 19527632
- Full Text :
- https://doi.org/10.1051/jbio/2009022