Descriptor: "Glycogen Synthase Kinase 3 metabolism" / Language: french - Searchworks@Jio Institute Digital Library Search Results

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Start Over Descriptor "Glycogen Synthase Kinase 3 metabolism" Language french

Author: Plouhinec JL and Taelman V
Subjects: Animals, Endocytosis physiology, Endosomes metabolism, Glycogen Synthase Kinase 3 antagonists & inhibitors, Glycogen Synthase Kinase 3 genetics, Humans, Models, Biological, Protein Transport, Glycogen Synthase Kinase 3 metabolism, Multivesicular Bodies metabolism, Wnt Signaling Pathway physiology
Published: 2011
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Author: Octave JN and Pierrot N
Subjects: Alzheimer Disease pathology, Amyloid beta-Protein Precursor genetics, Calcium Signaling, Cyclin-Dependent Kinase 5 metabolism, Glycogen Synthase Kinase 3 metabolism, Glycogen Synthase Kinase 3 beta, Humans, Neurofibrillary Tangles pathology, Neurons metabolism, Phosphorylation, Plaque, Amyloid pathology, Protein Structure, Tertiary, Alzheimer Disease metabolism, Amyloid beta-Peptides metabolism, Amyloid beta-Protein Precursor metabolism, Neurofibrillary Tangles chemistry, Plaque, Amyloid chemistry, Protein Processing, Post-Translational, tau Proteins metabolism
Abstract: Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.
Published: 2008

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