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[Alzheimer's disease: cellular and molecular aspects].
- Source :
-
Bulletin de l'Academie nationale de medecine [Bull Acad Natl Med] 2008 Feb; Vol. 192 (2), pp. 323-31; discussion 331-2. - Publication Year :
- 2008
-
Abstract
- Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.
- Subjects :
- Alzheimer Disease pathology
Amyloid beta-Protein Precursor genetics
Calcium Signaling
Cyclin-Dependent Kinase 5 metabolism
Glycogen Synthase Kinase 3 metabolism
Glycogen Synthase Kinase 3 beta
Humans
Neurofibrillary Tangles pathology
Neurons metabolism
Phosphorylation
Plaque, Amyloid pathology
Protein Structure, Tertiary
Alzheimer Disease metabolism
Amyloid beta-Peptides metabolism
Amyloid beta-Protein Precursor metabolism
Neurofibrillary Tangles chemistry
Plaque, Amyloid chemistry
Protein Processing, Post-Translational
tau Proteins metabolism
Subjects
Details
- Language :
- French
- ISSN :
- 0001-4079
- Volume :
- 192
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bulletin de l'Academie nationale de medecine
- Publication Type :
- Academic Journal
- Accession number :
- 18819686