Search

Your search keyword '"Glycogen Synthase Kinase 3 beta"' showing total 4 results
Start Over Descriptor "Glycogen Synthase Kinase 3 beta" Language french
4 results on '"Glycogen Synthase Kinase 3 beta"'

1. [GSK-3beta: a central kinase for neurodegenerative diseases?]

Author

Agnès, Petit-Paitel

Subjects
Glycogen Synthase Kinase 3 beta, Models, Neurological, Presenilins, Brain, Apoptosis, Nerve Tissue Proteins, Neurodegenerative Diseases, Neurofibrillary Tangles, Parkinson Disease, Plaque, Amyloid, tau Proteins, Mitochondria, Amyloid beta-Protein Precursor, Glycogen Synthase Kinase 3, Alzheimer Disease, alpha-Synuclein, Humans, Lewy Bodies, Phosphorylation, Carrier Proteins, Protein Kinase Inhibitors, Protein Processing, Post-Translational
Abstract

Neurodegenerative diseases are more and more prevalent in our aging societies. There is strong evidence that glycogen synthase kinase (GSK)-3b plays a crucial role in Alzheimer's disease (AD). Indeed, it is involved in the regulation of the two major neuropathological hallmarks present in the brains of AD patients. Interestingly, the kinase has been implicated in multiple cellular processes and linked with the pathogenesis and neuronal loss in several neurodegenerative diseases, including Parkinson's and Huntington's diseases, in which abnormally elevated levels of GSK-3b activity have been reported. In this review, we will provide an overview of the current data pointing out the convergent role of GSK-3b in the neuropathological pathways of these diseases. We will also discuss the rationale for the development of specific inhibitors with therapeutic potentials for such devastating human diseases.

Published
2010

2. [Alzheimer's disease: cellular and molecular aspects]

Author

Jean-Noël, Octave and Nathalie, Pierrot

Subjects
Neurons, Amyloid beta-Peptides, Glycogen Synthase Kinase 3 beta, Cyclin-Dependent Kinase 5, Neurofibrillary Tangles, Plaque, Amyloid, tau Proteins, Protein Structure, Tertiary, Amyloid beta-Protein Precursor, Glycogen Synthase Kinase 3, Alzheimer Disease, Humans, Calcium Signaling, Phosphorylation, Protein Processing, Post-Translational
Abstract

Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.

Published
2008

3. [GSK-3beta: a central kinase for neurodegenerative diseases?].

Author

Petit-Paitel A

Subjects
Alzheimer Disease enzymology, Alzheimer Disease pathology, Amyloid beta-Protein Precursor physiology, Apoptosis physiology, Brain enzymology, Brain pathology, Carrier Proteins physiology, Glycogen Synthase Kinase 3 antagonists & inhibitors, Glycogen Synthase Kinase 3 beta, Humans, Lewy Bodies, Mitochondria physiology, Models, Neurological, Nerve Tissue Proteins antagonists & inhibitors, Neurodegenerative Diseases drug therapy, Neurodegenerative Diseases prevention & control, Neurofibrillary Tangles enzymology, Parkinson Disease enzymology, Phosphorylation, Plaque, Amyloid enzymology, Presenilins physiology, Protein Kinase Inhibitors therapeutic use, Protein Processing, Post-Translational, alpha-Synuclein physiology, tau Proteins metabolism, Glycogen Synthase Kinase 3 physiology, Nerve Tissue Proteins physiology, Neurodegenerative Diseases enzymology
Abstract

Neurodegenerative diseases are more and more prevalent in our aging societies. There is strong evidence that glycogen synthase kinase (GSK)-3b plays a crucial role in Alzheimer's disease (AD). Indeed, it is involved in the regulation of the two major neuropathological hallmarks present in the brains of AD patients. Interestingly, the kinase has been implicated in multiple cellular processes and linked with the pathogenesis and neuronal loss in several neurodegenerative diseases, including Parkinson's and Huntington's diseases, in which abnormally elevated levels of GSK-3b activity have been reported. In this review, we will provide an overview of the current data pointing out the convergent role of GSK-3b in the neuropathological pathways of these diseases. We will also discuss the rationale for the development of specific inhibitors with therapeutic potentials for such devastating human diseases.

Published
2010
Full Text
View/download PDF

4. [Alzheimer's disease: cellular and molecular aspects].

Author

Octave JN and Pierrot N

Subjects
Alzheimer Disease pathology, Amyloid beta-Protein Precursor genetics, Calcium Signaling, Cyclin-Dependent Kinase 5 metabolism, Glycogen Synthase Kinase 3 metabolism, Glycogen Synthase Kinase 3 beta, Humans, Neurofibrillary Tangles pathology, Neurons metabolism, Phosphorylation, Plaque, Amyloid pathology, Protein Structure, Tertiary, Alzheimer Disease metabolism, Amyloid beta-Peptides metabolism, Amyloid beta-Protein Precursor metabolism, Neurofibrillary Tangles chemistry, Plaque, Amyloid chemistry, Protein Processing, Post-Translational, tau Proteins metabolism
Abstract

Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results