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47. Value of MRI for the diagnosis of cardiac involvement in sarcoidosis

Author

Dhôte, R., Vignaux, O., Blanche, P., Duboc, D., Dusser, D., Brezin, A., Devaux, J.-Y., Christoforov, B., and Legmann, P.

Subjects
*MAGNETIC resonance imaging, *SARCOIDOSIS, *ECHOCARDIOGRAPHY
Abstract

Purpose. – The aim of the study was to assess the place of cardiac Magnetic Resonance Imaging (MRI) in patients with sarcoidosis with or without cardiac involvement.Material and methods. – Fifty patients with histologically-proven sarcoidosis underwent initial cardiac evaluation including MRI, ECG, holter ECG, echocardiography. Seven of them had cardiac involvement (cardiac insufficiency, auriculo-ventricular block, bundle-branch block). Fiveteen patients had a second evaluation at 10-month follow-up. MRI was classified in three stages, on the base of literature data (stage 1 “granulomatous”, stage 2 “exsudative”, stage 3 “fibrotic”).Results. – A good correlation between the type of the sarcoidosis and MRI was observed: patients with cardiac involvement had all stage 2 MRI; patients with quiescent sarcoidosis had normal or stage 3 MRI; patients without cardiac involvement had all stages on MRI. A good correlation was observed between cardiac MRI abnormalities and evolution of sarcoidosis. Patients under corticoid, with or without cardiac involvement all had regression of MRI lesions and sarcoidosis. In 2 cases, MRI was predictive of clinical cardiac involvement.Conclusion. – Cardiac MRI is a useful non-invasive method for the early diagnosis and follow-up of cardiac sarcoidosis. [Copyright &y& Elsevier]

Published
2003
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48. [White card to the Hôpital Cochin].

Author

Dusser D

Subjects
Adult, Cystic Fibrosis genetics, Hospital Units, Humans, Paris, Biomedical Research trends, Hospitals, University organization & administration, Pulmonary Medicine organization & administration, Pulmonary Medicine standards, Pulmonary Medicine trends
Published
2018
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49. [Small airway diseases and immune deficiency].

Author

Burgel PR, Bergeron A, Knoop C, and Dusser D

Subjects
Bronchial Diseases epidemiology, Bronchial Diseases immunology, Bronchial Diseases pathology, Bronchiolitis Obliterans epidemiology, Bronchiolitis Obliterans etiology, Hematopoietic Stem Cell Transplantation adverse effects, Humans, Immunologic Deficiency Syndromes epidemiology, Immunologic Deficiency Syndromes pathology, Lung Transplantation adverse effects, Bronchial Diseases etiology, Immunologic Deficiency Syndromes complications
Abstract

Introduction: Innate or acquired immune deficiency may show respiratory manifestations, often characterized by small airway involvement. The purpose of this article is to provide an overview of small airway disease across the major causes of immune deficiency., Background: In patients with common variable immune deficiency, recurrent lower airway infections may lead to bronchiolitis and bronchiectasis. Follicular and/or granulomatous bronchiolitis of unknown origin may also occur. Bronchiolitis obliterans is the leading cause of death after the first year in patients with lung transplantation. Bronchiolitis obliterans also occurs in patients with allogeneic haematopoietic stem cell transplantation, especially in the context of systemic graft-versus-host disease., Viewpoint and Conclusion: Small airway diseases have different clinical expression and pathophysiology across various causes of immune deficiency. A better understanding of small airways disease pathogenesis in these settings may lead to the development of novel targeted therapies., (Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.)

Published
2016
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