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In the present study, the title compound named as 3-chloro-6-nitro-1-(prop-2-en-1-yl)-1Hindazole was synthesized by action of allyl bromide on 3-Chloro-6-nitroindazole. The structure of the compound obtained was established by single crystal X-ray analysis. The asymmetric unit of the title compound, C10H8ClN3O2, contains two independent molecules differing primarily in the orientations of the allyl substituents. The crystal packing involves slipped π-stacking of indazole units together with weak C—H···O and C—H···Cl hydrogen bonds., Journal Marocain de Chimie Hétérocyclique, Vol 17, No 1 (2018)

Objectifs Le cancer du rein (CCR) de stade pT3a s’accompagne d’un moins bon pronostic que les stades localises. Neanmoins, au moment de la decision therapeutique, la majorite des cas sont initialement consideres comme localises. L’objectif de notre etude etait de definir des facteurs de risque d’upstaging pathologique T3a. Methodes Une etude internationale multicentrique impliquant 17 centres et le reseau francais de recherche sur le cancer du rein UroCCR a ete conduite. Des cas de CCR ≤ cT2a operes entre 2005 et 2014 ont ete inclus. Les caracteristiques cliniques et tumorales ont ete recueillies et comparees en fonction du stade pT (localise vs pT3a) a l’aide des tests de Chi 2 , Fisher exact ou Wilcoxon. Les facteurs predictifs d’upstaging ont ete evalues en analyse uni- et multivariee (regression logistique). Resultats Un total de 3668 cas ≤ cT2a dont 472 (12,9 %) pT3a ont ete inclus. Dans le groupe pT3a, les patients etaient plus âges (64,7 vs.59,7, p ≤ 0,001), masculins (70,8 % vs.65,2 %, p = 0,0192), symptomatiques (40,5 % vs.24,7 %, p p p p p p p p p p d’upstaging : âge ( p p p = 0,009), symptomes generaux ( p = 0,028), RENAL Score 7–9 ( p = 0,003), situation tumorale anterieure ( p p = 0,001). Conclusion Dans notre cohorte de CCR ≤ cT2a, 12,9 % des cases etaient classes pT3a. Comparativement aux cas localises, les stades pT3a etaient associes a des facteurs de mauvais pronostic. Huit facteurs preoperatoires etaient predictifs du risque d’upstaging pathologique. Leur definition pourrait aider a apprecier l’agressivite tumorale et guider le choix therapeutique.

To describe the evaluation of our risk mapping methodology over the past two years.Based on the FMEA (failure mode effects analysis) method, some aspects have been adapted, e.g. the concept of risk control and effort scale, some others have been introduced, e.g. the concept of residual risk management. A weekly meeting is scheduled by a multidisciplinary team in order to support the different projects.Experiments and practice have led us to upgrade our scales of gravity and detectability, identify critical points and introduce the residual risk management concept. Some difficulties with regards to the multiplicity of scenarios still prevail.Risk mapping is an essential tool in the implementation of risk quality management, specifically when the methodology is progressive and takes into consideration all the members of a pluridisciplinary team.