1. New bioactive Δ11(17)-furanoeunicellins from an octocoral Cladiella sp.
- Author
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Chen, Ying-Fa, Chen, Wu-Fu, Wen, Zhi-Hong, Hwang, Tsong-Long, Zhang, Zhi-Jun, and Sung, Ping-Jyun
- Abstract
New bioactive Δ
11(17) -furanoeunicellins from an octocoral Cladiella sp. • New eunicellins were obtained from octocoral Cladiella sp. • Eunicellins showed anti-inflmmatory activity and cytotoxicity. • Setting of two oxygen bridges within the fused cyclodecanol B ring is natural. A new eunicellin diterpenoid, cladieunicellin U (1), along with a new natural eunicellin, cladieunicellin V (2), and two known analogues, sclerophytins A (3) and B (4), were obtained from an octocoral identified as Cladiella sp. The structures, including the absolute configurations, of eunicellins 1 – 4 were elucidated by using spectroscopic methods and compared with the spectroscopic and physical data reported in the literature. Eunicellins 1 , 3 and 4 decreased the release of elastase, while eunicellins 2 and 4 showed inhibitory effects in terms of the generation of superoxide anions by human neutrophils. Eunicellins 1 and 4 were found to show moderate cytotoxicity toward the leukemia K562 cells (IC 50 = 12.8, 11.4 μg/mL, respectively) and 2 exhibited moderate cytotoxicity toward the leukemia MOLT-4 cells (IC 50 = 18.8 μg/mL). [ABSTRACT FROM AUTHOR]- Published
- 2019
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