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Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
- Source :
- Marine Drugs, Vol 12, Iss 4, Pp 2144-2155 (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI AG, 2014.
-
Abstract
- Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
- Subjects :
- eunicellin
Cladiella
cladieunicellin
cytotoxicity
Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 12
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Marine Drugs
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5adff2ddafd647499c55499bae3d21e1
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/md12042144