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11. Impacts of food contact chemicals on human health: a consensus statement

Author

Muncke, Jane, Andersson, Anna-Maria, Backhaus, Thomas, Boucher, Justin M., Carney Almroth, Bethanie, Castillo Castillo, Arturo, Chevrier, Jonathan, Demeneix, Barbara A., Emmanuel, Jorge A., Fini, Jean-Baptiste, Gee, David, Geueke, Birgit, Groh, Ksenia, Heindel, Jerrold J., Houlihan, Jane, Kassotis, Christopher D., Kwiatkowski, Carol F., Lefferts, Lisa Y., Maffini, Maricel V., Martin, Olwenn V., Myers, John Peterson, Nadal, Angel, Nerin, Cristina, Pelch, Katherine E., Fernández, Seth Rojello, Sargis, Robert M., Soto, Ana M., Trasande, Leonardo, Vandenberg, Laura N., Wagner, Martin, Wu, Changqing, Zoeller, R. Thomas, and Scheringer, Martin

Published
2020
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15. NIEHS/FDA CLARITY-BPA research program update

Author

Heindel, Jerrold J., Newbold, Retha R., Bucher, John R., Camacho, Luísa, Delclos, K. Barry, Lewis, Sherry M., Vanlandingham, Michelle, Churchwell, Mona I., Twaddle, Nathan C., McLellen, Michelle, Chidambaram, Mani, Bryant, Matthew, Woodling, Kellie, Costa, Gonçalo Gamboa da, Ferguson, Sherry A., Flaws, Jodi, Howard, Paul C., Walker, Nigel J., Zoeller, R. Thomas, Fostel, Jennifer, Favaro, Carolyn, and Schug, Thaddeus T.

Published
2015
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17. European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation.

Author

Zoeller, R Thomas, Birnbaum, Linda S, Collins, Terrence J, Heindel, Jerrold, Hunt, Patricia A, Iguchi, Taisen, Kortenkamp, Andreas, Myers, John Peterson, Saal, Frederick S vom, Sonnenschein, Carlos, and Soto, Ana M

Abstract

The European Food Safety Authority (EFSA) has revised their estimate of the toxicity of bisphenol A (BPA) and, as a result, have recommended reducing the tolerable daily intake (TDI) by 20 000-fold. This would essentially ban the use of BPA in food packaging such as can liners, plastic food containers, and in consumer products. To come to this conclusion, EFSA used a systematic approach according to a pre-established protocol and included all guideline and nonguideline studies in their analysis. They found that Th-17 immune cells increased with very low exposure to BPA and used this endpoint to revise the TDI to be human health protective. A number of regulatory agencies including the European Medicines Agency (EMA) have written formal disagreements with several elements of EFSA's proposal. The European Commission will now decide whether to accept EFSA's recommendation over the objections of EMA. If the Commission accepts EFSA's recommendation, it will be a landmark action using knowledge acquired through independent scientific studies focused on biomarkers of chronic disease to protect human health. The goal of this Perspective is to clearly articulate the monumental nature of this debate and decision and to explain what is at stake. Our perspective is that the weight of evidence clearly supports EFSA's proposal to reduce the TDI by 20 000-fold. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement

Author

Solecki, Roland, Kortenkamp, Andreas, Bergman, Åke, Chahoud, Ibrahim, Degen, Gisela H., Dietrich, Daniel, Greim, Helmut, Håkansson, Helen, Hass, Ulla, Husoy, Trine, Jacobs, Miriam, Jobling, Susan, Mantovani, Alberto, Marx-Stoelting, Philip, Piersma, Aldert, Ritz, Vera, Slama, Remy, Stahlmann, Ralf, van den Berg, Martin, Zoeller, R. Thomas, and Boobis, Alan R.

Published
2017
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20. Correction to: Parma consensus statement on metabolic disruptors

Author

Heindel, Jerrold J., vom Saal, Frederick S., Blumberg, Bruce, Bovolin, Patrizia, Calamandrei, Gemma, Ceresini, Graziano, Cohn, Barbara A., Fabbri, Elena, Gioiosa, Laura, Kassotis, Christopher, Legler, Juliette, La Merrill, Michele, Rizzi, Laura, Machtinger, Ronit, Mantovani, Alberto, Mendez, Michelle A., Montanini, Luisa, Molteni, Laura, Nagel, Susan C., Parmigiani, Stefano, Panzica, Giancarlo, Paterlini, Silvia, Pomatto, Valentina, Ruzzin, Jérôme, Sartor, Giorgio, Schug, Thaddeus T., Street, Maria E., Suvorov, Alexander, Volpi, Riccardo, Zoeller, R. Thomas, and Palanza, Paola

Published
2017
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23. Gestational thyroid hormone concentrations and risk of attention‐deficit hyperactivity disorder in the Norwegian Mother, Father and Child Cohort Study.

Author

Engel, Stephanie M., Villanger, Gro D., Herring, Amy, Nethery, Rachel C., Drover, Samantha S. M., Zoeller, R. Thomas, Meltzer, Helle M., Zeiner, Pal, Knudsen, Gun Peggy, Reichborn‐Kjennerud, Ted, Longnecker, Matthew P., and Aase, Heidi

Subjects
ATTENTION-deficit hyperactivity disorder, THYROID hormones, LOGISTIC regression analysis, MISSING data (Statistics), THYROTROPIN receptors, THYROID hormone receptors, COHORT analysis, FETAL development, ODDS ratio
Abstract

Background: Maternal thyroid function plays an important role in foetal brain development; however, little consensus exists regarding the relationship between normal variability in thyroid hormones and common neurodevelopmental disorders, such as attention‐deficit hyperactivity disorder (ADHD). Objective: We sought to examine the association between mid‐pregnancy maternal thyroid function and risk of clinically diagnosed ADHD in offspring. Methods: We conducted a nested case–control study in the Norwegian Mother, Father and Child Cohort Study. Among children born 2003 or later, we randomly sampled singleton ADHD cases obtained through linkage with the Norwegian Patient Registry (n = 298) and 554 controls. Concentrations of maternal triiodothyronine (T3), thyroxine (T4), T3‐Uptake, thyroid‐stimulating hormone (TSH) and thyroid peroxidase antibody (TPO‐Ab) were measured in maternal plasma, collected at approximately 17 weeks' gestation. Indices of free T4 (FT4i) and free T3 (FT3i) were calculated. We used multivariable adjusted logistic regression to calculate odds ratios and accounted for missing covariate data using multiple imputation. We used restricted cubic splines to assess non‐linear trends and provide flexible representations. We examined effect measure modification by dietary iodine and selenium intake. In sensitivity analyses, we excluded women with clinically significant thyroid disorders (n = 73). Results: High maternal T3 was associated with increased risk of ADHD (5th vs 1st quintile odds ratio 2.27, 95% confidence interval 1.21, 4.26). For FT4i, both the lowest and highest quintiles were associated with an approximate 1.6‐fold increase in risk of ADHD, with similar trends found for T4. The FT4i association was modified by dietary iodine intake such that the highest risk strata were confined to the low intake group. Conclusions: Both high and low concentrations of maternal thyroid hormones, although within population reference ranges, increase the risk of ADHD in offspring. Increased susceptibility may be found among women with low dietary intake of iodine and selenium. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A

Author

Myers, John Peterson, Saal, Frederick S. vom, Akingbemi, Benson T., Arizono, Koji, Belcher, Scott, Colborn, Theo, Chahoud, Ibrahim, Crain, D. Andrew, Farabollini, Francesca, Guillette,, Louis J., Hassold, Terry, Ho, Shuk-mei, Hunt, Patricia A., Iguchi, Taisen, Jobling, Susan, Kanno, Jun, Laufer, Hans, Marcus, Michele, McLachlan, John A., Nadal, Angel, Oehlmann, Jörg, Olea, Nicolás, Palanza, Paola, Parmigiani, Stefano, Rubin, Beverly S., Schoenfelder, Gilbert, Sonnenschein, Carlos, Soto, Ana M., Talsness, Chris E., Taylor, Julia A., Vandenberg, Laura N., Vandenbergh, John G., Vogel, Sarah, Watson, Cheryl S., Welshons, Wade V., and Zoeller, R. Thomas

Published
2009
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27. The Price We Pay for the Convenience of Plastics.

Author

Zoeller, R Thomas

Subjects
PLASTICS, FLUOROALKYL compounds, MARKETING, ENDOCRINE disruptors
Abstract

A recent study published in the Journal of the Endocrine Society estimates that the healthcare costs associated with chemicals in plastics in the United States amount to approximately $250 billion per year, or 1.22% of the country's gross domestic product. However, this figure is considered to be a significant underestimate. Plastics are widely used in single-use packaging, construction materials, medical devices, and various industries. Plastics contain thousands of chemicals that can leach into products and pose risks to human health. The study highlights the need to reduce the production of new plastics in order to mitigate the disease burden and economic costs associated with plastic use. [Extracted from the article]

Published
2024
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28. Meeting Report: Moving Upstream-Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making

Author

Woodruff, Tracey J., Zeise, Lauren, Axelrad, Daniel A., Guyton, Kathryn Z., Janssen, Sarah, Miller, Mark, Miller, Gregory G., Schwartz, Jackie M., Alexeeff, George, Anderson, Henry, Birnbaum, Linda, Bois, Frederic, Cogliano, Vincent James, Crofton, Kevin, Euling, Susan Y., Foster, Paul M. D., Germolec, Dori R., Gray, Earl, Hattis, Dale B., Kyle, Amy D., Luebke, Robert W., Luster, Michael I., Portier, Chris, Rice, Deborah C., Solomon, Gina, Vandenberg, John, and Zoeller, R. Thomas

Published
2008
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29. Toward the Production of Safer Chemicals: A new protocol for safer chemical design is helping to overcome gaps in 'traditional' toxicology and improve upon federal regulations for endocrine-disrupting chemicals.

Author

Zoeller, R. Thomas and Myers, Pete

Subjects
ENDOCRINE disruptors, FEDERAL regulation, MEDICAL sciences, CHEMICAL testing, CHEMICAL engineering, THYROID hormone receptors
Abstract

The Tiered Protocol for Endocrine Disruption (TiPED) is a new protocol being developed to improve regulations for endocrine-disrupting chemicals (EDCs). These chemicals can have harmful effects on human health and the environment, even at low concentrations. TiPED consists of five testing tiers to evaluate the potential endocrine disruption of chemicals, saving time and resources by only conducting expensive testing on a small fraction of chemicals. The proposed European "Chemical Strategy for Sustainability" also emphasizes the need for safer chemicals and supports funding for sustainable replacements for hazardous chemicals. [Extracted from the article]

Published
2022

39. Parma consensus statement on metabolic disruptors

Author

Heindel, Jerrold J., vom Saal, Frederick S., Blumberg, Bruce, Bovolin, Patrizia, Calamandrei, Gemma, Ceresini, Graziano, Cohn, Barbara A., Fabbri, Elena, Gioiosa, Laura, Kassotis, Christopher, Legler, Juliette, La Merrill, Michele, Rizzir, Laura, Machtinger, Ronit, Mantovani, Alberto, Mendez, Michelle A., Montanini, Luisa, Molteni, Laura, Nagel, Susan C., Parmigiani, Stefano, Panzica, Giancarlo, Paterlini, Silvia, Pomatto, Valentina, Ruzzin, Jérôme, Sartor, Giorgio, Schug, Thaddeus T., Street, Maria E., Suvorov, Alexander, Volpi, Riccardo, Zoeller, R. Thomas, and Palanza, Paola

Published
2015
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40. Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project

Author

Kortenkamp, Andreas, Axelstad, Marta, Baig, Asma H., Bergman, Ake, Bornehag, Carl-Gustav, Cenijn, Peter, Christiansen, Sofie, Demeneix, Barbara, Derakhshan, Arash, Fini, Jean-Baptiste, Fraedrich, Caroline, Hamers, Timo, Hellwig, Lina, Koehrle, Josef, Korevaar, Tim I. M., Lindberg, Johan, Martin, Olwenn, Meima, Marcel E., Mergenthaler, Philipp, Nikolov, Nikolai, Du Pasquier, David, Peeters, Robin P., Platzack, Bjorn, Ramhoj, Louise, Remaud, Sylvie, Renko, Kostja, Scholze, Martin, Stachelscheid, Harald, Svingen, Terje, Wagenaars, Fabian, Wedebye, Eva Bay, Zoeller, R. Thomas, Physiologie moléculaire et adaptation (PhyMA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), E&H: Environmental Health and Toxicology, AIMMS, and Internal Medicine

Subjects
Project Report, endocrine system, Thyroid Hormones, [SDV]Life Sciences [q-bio], education, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy), brain development, Test method development, In Vitro Techniques, lcsh:Chemistry, test method validation, SDG 17 - Partnerships for the Goals, Naturvetenskap, Drug Discovery, Animals, Humans, Thyroid hormone system, test method development, lcsh:QH301-705.5, Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci), Endocrine disruptors, health care economics and organizations, Risk assessment, Internet, Brain, risk assessment, Brain development, High-Throughput Screening Assays, endocrine disruptors, lcsh:Biology (General), lcsh:QD1-999, thyroid hormone system, Blood-Brain Barrier, Test method validation, Natural Sciences
Abstract

Copyright © 2020 by the authors. The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood–brain and blood–placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation. EU Horizon 2020 programme, grant number 825161

Published
2020

42. Contributors

Author

Abu Dayyeh, Barham K., Agostini, Maura, Aiello, Lloyd Paul, Alicic, Radica Z., Anawalt, Bradley D., Ang, Lynn, Angelidi, Angeliki M., Antonio, Leen, Armstrong, David G., Arner, Peter, Assié, Guillaume, Athonvarangkul, Diana, Auchus, Richard J., Avery, Michael B., Avram, Anca M., Baloch, Zubair W., Bancos, Irina, Barb, Diana, Barkhoudarian, Garni, Basaria, Shehzad, Basham, Kaitlin J., Bashari, Waiel, Bastepe, Murat, Batterham, Rachel L., Bauer, Elizabeth M., Bellin, Melena D., Bertherat, Jérôme, Berthon, Annabel, Bhasin, Shalender, Bilezikian, John P., Billington, Emma O., Boelen, Anita, Bouillon, Roger, Brada, Michael, Brent, Gregory A., Broekmans, Frank J., Bronstein, Marcello D., Brown, Edward M., Bulun, Serdar E., Burch, Henry B., Burghard, Anne Claire, Burney, Richard O., Pop-Busui, Rodica, Cagliero, Enrico, Cameron, Sharon, Caoili, Elaine M., Carmeliet, Geert, Cavallerano, Jerry D., Chatterjee, Krishna, Chen, Zi-Jiang, Cheung, N. Wah, Christian, Helen C., Cidlowski, John A., Clavijo, Leonardo C., Clifton-Bligh, Roderick J., Considine, Robert V., Conti, Marco, Copps, Kyle D., Corcuff, Jean- Benoît, D’Alessio, David, Dattani, Mehul T., Davey, Rachel A., Davis, Stephen N., De Felice, Mario, de Kretser, David, DeFranco, Donald B., Demay, Marie B., DeMayo, Francesco J., De Santis, Pascual, Deutsch, Madeline B., Dhatariya, Ketan, Dhillon, Vaninder K., Di Lauro, Roberto, Dillon, Joseph S., Dinneen, Sean F., Doherty, Gerard M., Donahoo, William Troy, Econs, Michael J., Egan, Aoife M., Ehrhardt, Nicole, Ehrmann, David A., Eisenhofer, Graeme, El-Khairi, Ranna, Elisei, Rossella, Else, Tobias, Erickson, Lori A., Erinjeri, Neeta J., Eszlinger, Markus, Eugster, Erica A., Evert, Alison B., Faix, James D., Farooqi, I. Sadaf, Fassnacht, Martin, Fauser, Bart C.J.M., Findlay, David M., Fliers, Eric, Freeman, Mason W., Frydenberg, Mark, Fuller, Peter J., Gagliano-Jucá, Thiago, Gardella, Thomas J., Garrahy, Aoife, Garvey, W. Timothy, German, Michael S., Gershengorn, Marvin C., Gild, Matti, Gilliam, Lisa K., Giudice, Linda C., Glezer, Andrea, Glorieux, Francis H., Goodpaster, Bret H., Grinman, Diego Y., Guasti, Leonardo, Gurnell, Mark, Habra, Mouhammed Amir, Haddad, Nadine G., Halperin, Daniel M., Hammes, Stephen R., Hardman, Sarah, Harmon, Jamie S., Haugen, Bryan R., Hebrok, Matthias, Hedger, Mark P., Heindel, Jerrold J., Hirsch, Irl B., Hobbs, Robin M., Hollenberg, Anthony N., Hruska, Keith A., Husebye, Eystein, Iacovazzo, Donato, Ilie, Mirela Diana, Imel, Erik A., Isaac, Adam L., Jameson, J. Larry, Jasuja, Ravi, Jayasena, Channa N., Johannsson, Gudmundur, Jones, Glenville, Jonklaas, Jacqueline, Jørgensen, Niels, Jüppner, Harald, Juul, Anders, Kahaly, George J., Karavitaki, Niki, Katugampola, Harshini, Keevil, Brian, Kelley, David E., Kellogg, Todd Andrew, Kelly, David F., Klein, Ronald, Kleinau, Gunnar, Koniares, Katherine, Kopp, Peter, Korbonits, Márta, Korevaar, Tim I.M., Koulouri, Olympia, Krausz, Csilla, Kronenberg, Henry M., La Greca, Amanda, Lamos, Elizabeth M., Lebovitz, Harold E., Hong Lee, Alan Chun, Legro, Richard S., Lenders, Jacques W.M., Lerario, Antonio M., Lernmark, Åke, Lightman, Stafford L., Lin, David S., Liu, Eva S., Lo, Janet, Loomba, Lindsey A., Loveland, Kate L., Lue, Tom F., Lundgren, Markus, MacFarlane, James Robert, Magee, Gregory A., Maes, Christa, Maharaj, Avinaash, Main, Katharina M., Makaronidis, Janine M., Malina, Robert, Mannstadt, Michael, Manohar, Paul, Mantzoros, Christos S., Marazuela, Mónica, Matrone, Antonio, Maxwell, Jessica E., McCartney, Christopher R., McGee, Elizabeth A., Melanson, Edward L., Melmed, Shlomo, Mendelson, Carole R., Merke, Deborah P., Mesiano, Sam, Metherell, Louise A., Miller, Barbra S., Mizokami-Stout, Kara, Mohan, Dipika R., Molitch, Mark E., Moran, Carla, Moravek, Molly B., Neumann, Susanne, Neumiller, Joshua J., Newell-Price, John D.C., Newey, Paul J., Norwitz, Errol R., O’Donnell, Liza, O’Rahilly, Stephen, Oakley, Robert H., Oberfield, Sharon E., Orellana, Minerva, Mete, Ozgur, Pacak, Karel, Pace-Asciak, Pia, Page, Stephanie T., Paschke, Ralf, Pasquel, Francisco J., Pearce, Elizabeth N., Peters, Anne L., Pook, David W., Potts, Callum A., Potts, John T., Jr, Purcell, Sarah A., Raff, Hershel, Ragnarsson, Oskar, Rajpert-De Meyts, Ewa, Ramos-Levi, Ana M., Rao, Sarika N., Rastrelli, Giulia, Raverot, Gérald, Ray, David W., Razavi, Christopher R., Reed-Maldonado, Amanda B., Reid, Ian R., Retnakaran, Ravi, Rickels, Michael R., Riddell, Michael Charles, Rinaudo, Paolo, Risbridger, Gail P., Robertson, R. Paul, Robinson, Bruce G., Rogol, Alan D., Romei, Cristina, Rosenfelder, Nicola, Rowen, Tami S., Ruderman, Neil B., Rushing, John, Russell, Jonathon O., Russo, Jose, Rydén, Mikael, Santoro, Nanette, Schlegel, Peter N., Schoenmakers, Erik, Schoenmakers, Nadia, Senanayake, Russell Martin, Shaear, Mohammad, Shalev, Anath, Shields, James, Shimy, Kim, Shindel, Alan W., Shulman, Gerald I., Silva, Paolo S., Simmons, David, Simon, James A., Singer, Frederick R., Sipos, Jennifer A., Skaznik-Wikiel, Malgorzata E., Smallridge, Robert C., Smith, Christopher J., Smith, Roger, Smith, Ulf, Snyder, Peter J., Solda, Francesca, Speiser, Phyllis W., St-Arnaud, René, Stewart, Elizabeth A., Stowasser, Michael, Straseski, Joely, Strauss, Jerome F., III, Styne, Dennis M., Swerdloff, Ronald S., Tabarin, Antoine, Tanavde, Ved, Taïeb, David, Thakker, Rajesh V., Thompson, Christopher J., Timmers, Henri J.L.M., Toppari, Jorma, Torpy, David J., Tsang, Venessa, Tsoukas, Michael A., Tufano, Ralph P., Tuttle, Katherine R., Udelsman, Robert, Umpierrez, Guillermo, Upton, Thomas J., Vaidya, Anand, Val, Pierre, Vasiljevic, Alexandre, Vaughan, Denis A., Vella, Adrian, Verlinden, Lieve, Vietor, Nicole O., Viglianti, Benjamin L., Vilain, Eric, Barisson Villares Fragoso, Maria Candida, Visser, W. Edward, Walford, Geoffrey, Walker, Marcella D., Wang, Christina, Weetman, Anthony P., Wei, Daimin, White, Kenneth E., White, Morris F., White, Perrin C., Whyte, Michael P., Williams, Matthew James, Witchel, Selma Feldman, Wong, Ka Kit, Wu, Frederick C.W., Wysolmerski, John J., Young, Morag J., Zennaro, Maria-Christina, Zimmerman, Michael B., and Zoeller, R. Thomas

Published
2023
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