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1. An Introduction to Simulation Training Through the Lens of Experience and Activity Analysis

Author: Simon Flandin, Christine Vidal-Gomel, Raquel Becerril Ortega, Faculté de Psychologie et des Sciences de l'Education (FPSE), Université de Genève = University of Geneva (UNIGE), Laboratoire Recherche intervention formation et travail (RIFT), CRAFT, Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE), Nantes Université (Nantes Univ), Centre Interuniversitaire de Recherche en Education de Lille - ULR 4354 (CIREL), Université de Lille, Simon Flandin, Christine Vidal-Gomel, and Raquel Becerril Ortega
Subjects: ddc:370, [SHS.EDU]Humanities and Social Sciences/Education, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2022

2. Deposition of Extended Ordered Ultrathin Films of Au 38 (SC 2 H 4 Ph) 24 Nanocluster using Langmuir–Blodgett Technique

Author: Plinio Maroni, Alexis Chennevière, Mohammad M Dadras, Lay-Theng Lee, Michal Swierczewski, Thomas Bürgi, Department of Inorganic, Analytical and Applied Chemistry, Laboratory of Colloid and Surface Chemistry (LCSC), Université de Genève (UNIGE)-Université de Genève (UNIGE), LLB - Matière molle et biophysique (MMB), Laboratoire Léon Brillouin (LLB - UMR 12), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, University of Geneva [Switzerland], Université de Genève (UNIGE), Centre Suisse d'Electronique et de Microtechnique SA [Neuchatel] (CSEM), Centre Suisse d'Electronique et Microtechnique SA (CSEM), Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Université de Genève = University of Geneva (UNIGE)
Subjects: Materials science, Silicon, Atomic force microscopy, Scattering, Solid surface, chemistry.chemical_element, 02 engineering and technology, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Langmuir–Blodgett film, 0104 chemical sciences, Nanoclusters, Biomaterials, chemistry, Chemical engineering, Deposition (phase transition), General Materials Science, Mica, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS, Biotechnology
Abstract: International audience; Langmuir–Blodgett technique is utilized to deposit ultrathin films of Au$_{38}$(SC$_2$H$_4$Ph)$_{24}$ nanocluster onto solid surfaces such as mica and silicon. The morphologies of the films transferred at various surface pressures within the mono/bi/trilayer regime are studied by atomic force microscopy (AFM). The time spent on the water surface before the deposition has a decisive effect on the final ordering of nanoclusters within the network and is studied by fast AFM, X-ray reflectivity, and grazing-incidence wide-angle X-ray scattering.
Published: 2020

3. Implicit associations of teleology and essentialism concepts with genetics concepts among secondary school students

Author: Marine Delaval, Florian Stern, Kostas Kampourakis, Andreas Müller, University of Geneva [Switzerland], Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 (PSITEC), Université de Lille, Institut Universitaire de formation des enseignants (IUFE), Université de Genève (UNIGE), Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - ULR 4072, Université de Genève = University of Geneva [UNIGE], and Université de Genève = University of Geneva (UNIGE)
Subjects: Male, Heredity, Concept Formation, Social Sciences, medicine.disease_cause, Learning and Memory, Sociology, Psychological Attitudes, Psychology, Genetics, Multidisciplinary, Schools, 4. Education, 05 social sciences, Age Factors, 050301 education, Implicit-association test, School class, Professions, Teleology, Medicine, Female, Human learning, Research Article, Adolescent, Essentialism, Science, [SHS.EDU]Humanities and Social Sciences/Education, education, ddc:500.2, 050105 experimental psychology, Education, Genetic Determinism, Human Learning, Sex Factors, ddc:570, medicine, Learning, Humans, 0501 psychology and cognitive sciences, Association (psychology), Students, Cognitive Psychology, Biology and Life Sciences, Teachers, Human Genetics, Human genetics, Philosophy, People and Places, Cognitive Science, Population Groupings, 0503 education, Neuroscience
Abstract: International audience; In this article, we present the development and validation of an implicit association test for measuring secondary school students’ associations between genetics concepts and teleology concepts on the one hand, and between genetics concepts and essentialism concepts on the other hand. In total, 169 students from 16 school classes took part in the study, from January 2018 to May 2018. We investigated the strength of the aforementioned associations and the influence of various covariates such as gender, age, school class, or previous learning of biology on the association of teleology or essentialism concepts with genetics concepts through an analysis of covariance and a multi-level analysis. We found moderate associations between genetics and teleology concepts, as well as between genetics and essentialism concepts. These results might reflect a tendency of students of different ages and with various backgrounds to think about genes in terms of goals (teleology) and stability (essentialism), which should be investigated further in future research.
Published: 2020

4. Reconfigurable Digitalized and Servitized Production Systems: Requirements and Challenges

Author: Daniel Schneider, Damien Lamy, Hichem Haddou Benderbal, Gunther Reinhart, Xavier Boucher, Audrey Cerqueus, Magdalena Paul, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Institut Henri Fayol (FAYOL-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Département Génie mathématique et industriel (FAYOL-ENSMSE), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Institut Henri Fayol, Technologies de Formation et Apprentissage (TECFA), Faculté de Psychologie et des Sciences de l'Education (FPSE), Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE), Département Génie de l’environnement et des organisations (FAYOL-ENSMSE), Institut Henri Fayol-Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE), Bojan Lalic, Vidosav Majstorovic, Ugljesa Marjanovic, Gregor von Cieminski, David Romero, TC 5, WG 5,7, Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne-Institut Henri Fayol, Université de Genève (UNIGE)-Université de Genève (UNIGE), Institut Henri Fayol-Ecole Nationale Supérieure des Mines de St Etienne, and Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
Subjects: Flexibility (engineering), 0209 industrial biotechnology, Process management, 9. Industry and infrastructure, Computer science, Reconfigurability, 02 engineering and technology, Digitalization, 010501 environmental sciences, Manufacturing systems, 01 natural sciences, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Product demand, 020901 industrial engineering & automation, Sustainability, Key (cryptography), Production (economics), [INFO]Computer Science [cs], Adaptation (computer science), Servitization, 0105 earth and related environmental sciences
Abstract: International audience; Reconfigurable manufacturing systems (RMS) emerged in literature during the last two decades with the aim to respond to the rapid increase in product demand and variations. The implementation of such solutions in the industry is very recent and remains difficult. In this article, an analysis of the industrial requirements and challenges involving four key aspects of RDSS (reconfigurability, digitalization, servitization and sustainability) is based on semi-structured interviews conducted with representatives from the industry. Further, the identified requirements and challenges are compared to those extracted from an extensive literature review. The findings of the comparison are divided into technology and organization oriented issues and show a strong interconnection of the four key aspects: Digitalization offers possibilities for the implementation of sustainable systems, servitization creates the possibility for companies to achieve more flexibility through reconfigurable systems and the further development of RMS offers more possibilities for digitalization and thus a better adaptation to current requirements.
Published: 2020

5. Maternal stress programs accelerated aging of the basal ganglia motor system in offspring

Author: Marrocco, J., Verhaeghe, R., Bucci, D., Di Menna, L., Traficante, A., Bouwalerh, H., Van Camp, G., Ghiglieri, V., Picconi, B., Calabresi, P., Ravasi, L., Cisani, F., Bagheri, F., Pittaluga, A., Bruno, V., Battaglia, G., Morley-Fletcher, S., Nicoletti, F., Maccari, S., Rockefeller University [New York], Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fondazione Santa Lucia [IRCCS], Clinical and Behavioral Neurology [IRCCS Santa Lucia], Pharmacologie de la mort neuronale et de la plasticité cérébrale, IFR114-Université de Lille, Droit et Santé, Université de Genève (UNIGE), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], and Université de Genève = University of Geneva [UNIGE]
Subjects: Aging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Nigrostriatal development, Motor behavior, Adenosine receptors, Synaptic proteins, Integrated study, lcsh:QP351-495, lcsh:RC346-429, lcsh:RC321-571, Settore MED/26 - NEUROLOGIA, lcsh:Neurophysiology and neuropsychology, Original Research Article, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system
Abstract: Early-life stress involved in the programming of stress-related illnesses can have a toxic influence on the functioning of the nigrostriatal motor system during aging. We examined the effects of perinatal stress (PRS) on the neurochemical, electrophysiological, histological, neuroimaging, and behavioral correlates of striatal motor function in adult (4 months of age) and old (21 months of age) male rats. Adult PRS offspring rats showed reduced dopamine (DA) release in the striatum associated with reductions in tyrosine hydroxylase-positive (TH+) cells and DA transporter (DAT) levels, with no loss of striatal dopaminergic terminals as assessed by positron emission tomography analysis with fluorine-18-l-dihydroxyphenylalanine. Striatal levels of DA and its metabolites were increased in PRS rats. In contrast, D2 DA receptor signaling was reduced and A2A adenosine receptor signaling was increased in the striatum of adult PRS rats. This indicated enhanced activity of the indirect pathway of the basal ganglia motor circuit. Adult PRS rats also showed poorer performance in the grip strength test and motor learning tasks. The aged PRS rats also showed a persistent reduction in striatal DA release and defective motor skills in the pasta matrix and ladder rung walking tests. In addition, the old rats showed large increases in the levels of SNAP-25 and synaptophysin, which are synaptic vesicle-related proteins in the striatum, and in the PRS group only, reductions in Syntaxin-1 and Rab3a protein levels were observed. Our findings indicated that the age-dependent threshold for motor dysfunction was lowered in PRS rats. This area of research is underdeveloped, and our study suggests that early-life stress can contribute to an increased understanding of how aging diseases are programmed in early-life.
Published: 2020

6. First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities

Author: Madeleine Hill, Philippe Hubert, Katerina Plachka, Abhijit Tarafder, Adrien Raimbault, Benjamin Wuyts, Manish Grangrade, Niranjan Desphande, Andrew J. Aubin, Fabien Mauge, Vincent Desfontaine, Lucie Nováková, Erik L. Regalado, Mengling Wong, Sophie Bertin, Alexandre Grand-Guillaume Perrenoud, Julien Lefevre, Estelle Corbel, Caroline West, Elise Lemasson, Santosh Sadaphule, Dorina Kotoni, Brandon M. Jocher, Adrian Clarke, Marion Iguiniz, Eric Lesellier, Tomas Leek, Davy Guillarme, Debby Mangelings, Yvan Vander Heyden, Loic Villemet, Ravi Yadav, Nicolas Roques, Sabine Heinisch, Philippe Hennig, Luca Gioacchino Losacco, Isabelle François, Maxime Cazes, Nathalie Da Costa, Claudio Brunelli, Jean-Luc Veuthey, William Farrell, Kelly Zhang, Roland Djang’eing’a Marini, Christophe Desvignes, Shankar Shringare, Charlene Galea, Michael J. Gray, Amandine Dispas, Sandesh Rane, Lulu Dai, Morgan Sarrut, School of Pharmaceutical Science, University of Geneva [Switzerland]-Université de Lausanne (UNIL), Laboratoire De Chimie Analytique Pharmaceutique, Université de Genève (UNIGE)-Ecole de pharmacie Genève-Lausanne (EPGL), Special Pathogens, Public Health Agency of Canada-National Microbiology Laboratory, Chromatography & Hyphenated Techniques - Chromatographie et techniques couplées, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Sanofi R&D, Analyt Sci, Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tampere University of Technology [Tampere] (TUT), NASA Goddard Space Flight Center (GSFC), Oril Industrie, Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), Institut National de l'Environnement Industriel et des Risques (INERIS), Research grants from Walloon Region of Belgium and EU Commission (project FEDER-PHARE) to Amandine DISPAS are gratefully acknowledged. Waters (Milford, MA, USA) is acknowledged for supplying all columns used in this study. Novartis (Basel, Switzerland) is acknowledged for funding the EDQM standards sent to the participating laboratories. The author wants to thank M. Heptia and B. Dahmen for technical assistance and F. Bonivert for logistic help. K. Plachka and L. Novakova wish to gratefully acknowledge the grant project SVV No. 260412/2018 and the STARSS project (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000465) co-funded by ERDF. L. Montis (Waters) is acknowledged., Faculty of Medicine and Pharmacy, Pharmaceutical and Pharmacological Sciences, Chemical Engineering and Industrial Chemistry, Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, Université de Lausanne = University of Lausanne (UNIL)-Université de Genève = University of Geneva (UNIGE), Université de Genève = University of Geneva (UNIGE)-Ecole de pharmacie Genève-Lausanne (EPGL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS)
Subjects: Quality Control, spectroscopy, Salbutamol sulfate, International Cooperation, Transferability, Clinical Biochemistry, Pharmaceutical Science, Context (language use), Food company, 01 natural sciences, Analytical Chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Drug Discovery, Supercritical Fluid Chromatography (SFC), Inter-laboratory, Process engineering, Pharmaceutical impurities, Collaborative study, ddc:615, Reproducibility, 010405 organic chemistry, business.industry, Chemistry, 010401 analytical chemistry, Reproducibility of Results, Chromatography, Supercritical Fluid, Repeatability, 0104 chemical sciences, Supercritical fluid chromatography, Drug Contamination, business, Inter-laboratory study, Chromatography, Liquid
Abstract: International audience; Supercritical Fluid Chromatography (SFC) has known a strong regain of interest for the last 10 years, especially in the field of pharmaceutical analysis. Besides the development and validation of the SFC method in one individual laboratory, it is also important to demonstrate its applicability and transferability to various laboratories around the world. Therefore, an inter-laboratory study was conducted and published for the first time in SFC, to assess method reproducibility, and evaluate whether this chromatographic technique could become a reference method for quality control (QC) laboratories. This study involved 19 participating laboratories from 4 continents and 9 different countries. It included 5 academic groups, 3 demonstration laboratories at analytical instrument companies, 10 pharmaceutical companies and 1 food company. In the initial analysis of the study results, consistencies within- and between-laboratories were deeply examined. In the subsequent analysis, the method reproducibility was estimated taking into account variances in replicates, between-days and between-laboratories. The results obtained were compared with the literature values for liquid chromatography (LC) in the context of impurities determination. Repeatability and reproducibility variances were found to be similar or better than those described for LC methods, and highlighted the adequacy of the SFC method for QC analyses. The results demonstrated the excellent and robust quantitative performance of SFC. Consequently, this complementary technique is recognized on equal merit to other chromatographic techniques.
Published: 2018

7. How do perturbation training contribute to safety? The unexpected and the unthought as means to design perturbations in safety training

Author: Flandin, Simon, Poizat, Germain, Institut français de l'Education (IFÉ), École normale supérieure - Lyon (ENS Lyon), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Activité, Connaissance, Transmission, éducation (ACTé ), Université de Genève (UNIGE), Faculté de Psychologie et des Sciences de l'Education (FPSE), Laboratoire Recherche intervention formation et travail (RIFT), CRAFT, Université de Genève (UNIGE)-Université de Genève (UNIGE), FONCSI, Flandin, Simon, École normale supérieure de Lyon (ENS de Lyon), Université de Genève = University of Geneva (UNIGE), and Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE)
Subjects: safety, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [SHS.EDU]Humanities and Social Sciences/Education, [SHS.EDU] Humanities and Social Sciences/Education, sensemaking, [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], enaction, perturbation training
Abstract: International audience; Perturbation is a training design principle that consists in disrupting standard workflow with the introduction of a significant event. Mostly used in safety-concerned organizations, it is quite widespread in practices like crisis exercises, but weakly theorized in an educational perspective. Extending Weick’s descriptive theory (1995), perturbation should be aimed at developing the trained actors’ ability to make sense under uncertain conditions, and at encouraging them to invent and perform novel actions and coordination to achieve their objective (Flandin, Poizat, & Durand, in press). Most of empirical research on perturbation training focus on its influence on team coordination (e.g., Gorman, Cooke, & Amazeen, 2010) and we don’t know much about its influence on individual and collective sensemaking, though this seems to be a crucial ability for safety ensuring and recovering (Maitlis & Christianson, 2014). We conducted an exploratory study of a watch officer’s sensemaking (concerns, expectations, perceptions, emotions, meanings, decisions, and actions) during a perturbation training simulating a “beyond behind basis” accident in a gas plant. We used ergonomics methods (direct observations, field notes, and retrospective interviews) to collect data, and the enactive framework of the course of experience (Poizat, Flandin, Sève, Durand, & Theureau, submitted) to process it. We found that the perturbation led successively the watch officer (i) to an initial state of bewilderment and collapse of sensemaking as the situation got unexpected, (ii) to accept his state of uncertainty and to look for ways to achieve his objective, even though it involved moving away from the procedure, (iii) to make several wrong hypotheses before finally understanding what happened. We analyse the most plausible training outcomes regarding the officer’s abilities of anticipation, understanding, reactivity, and invention. Our analysis suggests that the unexpected (events whose realization is predictable, but whose moment of occurrence is not) and the unthought (events that are unprecedented and highly unlikely) may be two promising perturbation areas for safety training. We make propositions for innovative design and future research, especially regarding the fact that evidence is lacking concerning the impact of perturbation training in terms of occupational activity transformation and development.
Published: 2018

8. Reduced maternal behavior caused by gestational stress is predictive of life span changes in risk-taking behavior and gene expression due to altering of the stress/anti-stress balance

Author: Sara Morley-Fletcher, Lucie Deruyter, Hammou Bouwalerh, Ferdinando Nicoletti, Stefania Maccari, Jean Marc Lo Guidice, Gilles Van Camp, Eleonora Gatta, Jordan Marrocco, Jérôme Mairesse, CNRS, Université de Lille, University of Illinois [Chicago] [UIC], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Université de Genève = University of Geneva [UNIGE], Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], Rockefeller University [New York], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS], Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.], University of Illinois [Chicago] (UIC), University of Illinois System, Université de Genève (UNIGE), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Genève = University of Geneva (UNIGE), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)
Subjects: 0301 basic medicine, Agonist, medicine.medical_specialty, medicine.drug_class, Offspring, Receptor expression, Receptor, Metabotropic Glutamate 5, [SDV]Life Sciences [q-bio], Gene Expression, Gestational Age, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Maternal behavior, Risk-taking behavior, Oxytocin receptor agonist, Transcriptomics, Early-Life stress, Hippocampus, Oxytocin, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Risk-Taking, Internal medicine, medicine, early-life stress, hippocampus, maternal behavior, oxytocin receptor agonist, risk-taking behavior, transcriptomics, neuroscience (all), toxicology, Animals, Receptor, Pregnancy, ddc:618, business.industry, General Neuroscience, Postpartum Period, medicine.disease, Oxytocin receptor, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, 030104 developmental biology, Endocrinology, Receptors, Oxytocin, Carbetocin, Female, business, 030217 neurology & neurosurgery, Stress, Psychological, medicine.drug
Abstract: Exposure of the mother to adverse events during pregnancy is known to induce pathological programming of the HPA axis in the progeny, thereby increasing the vulnerability to neurobehavioral disorders. Maternal care plays a crucial role in the programming of the offspring, and oxytocin plays a key role in mother/pup interaction. Therefore, we investigated whether positive modulation of maternal behavior by activation of the oxytocinergic system could reverse the long-term alterations induced by perinatal stress (PRS; gestational restraint stress 3 times/day during the last ten days of gestation) on HPA axis activity, risk-taking behavior in the elevated-plus maze, hippocampal mGlu5 receptor and gene expression in Sprague-Dawley rats. Stressed and control unstressed dams were treated during the first postpartum week with an oxytocin receptor agonist, carbetocin (1 mg/kg, i.p.). Remarkably, reduction of maternal behavior was predictive of behavioral disturbances in PRS rats as well as of the impairment of the oxytocin and its receptor gene expression. Postpartum carbetocin corrected the reduction of maternal behavior induced by gestational stress as well as the impaired oxytocinergic system in the PRS progeny, which was associated with reduced risk-taking behavior. Moreover, postpartum carbetocin had an anti-stress effect on HPA axis activity in the adult PRS progeny and increased hippocampal mGlu5 receptor expression in aging. In conclusion, the activation of the oxytocinergic system in the early life plays a protective role against the programming effect by adverse experiences and could be considered as a novel and powerful potential therapeutic target for stress-related disorders. 66
Published: 2018

9. Improving resilience in high-risk organizations: principles for the design of innovative training situations

Author: Marc Durand, Simon Flandin, Germain Poizat, Institut français de l'Education (IFÉ), École normale supérieure - Lyon (ENS Lyon), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Activité, Connaissance, Transmission, éducation (ACTé ), Université de Genève (UNIGE), Faculté de Psychologie et des Sciences de l'Education (FPSE), Laboratoire Recherche intervention formation et travail (RIFT), CRAFT, Université de Genève (UNIGE)-Université de Genève (UNIGE), École normale supérieure de Lyon (ENS de Lyon), Université de Genève = University of Geneva (UNIGE), and Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE)
Subjects: Value (ethics), Organizational Behavior and Human Resource Management, Organizational architecture, Process management, Computer science, media_common.quotation_subject, [SHS.EDU]Humanities and Social Sciences/Education, Library and Information Sciences, 03 medical and health sciences, 0302 clinical medicine, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Originality, 0502 economics and business, Resilience (network), Risk management, media_common, Event (computing), business.industry, 4. Education, 05 social sciences, 030208 emergency & critical care medicine, Sensemaking, [INFO.EIAH]Computer Science [cs]/Technology for Human Learning, business, 050203 business & management, Autonomy
Abstract: Purpose Safety and organizational research indicates that fostering resilience in organizations is a promising way for improving safety, albeit concrete means to implement resilience are still lacking, especially in the educational field. The purpose of this paper is to propose four principles for training design derived from past and current studies the authors conduct in high-risk organizations. Design/methodology/approach Training for resilience is considered within an enactive approach of human activity building on its properties of autonomy, structural coupling, self-organization, emergence, sensemaking, and metastability. Findings The article describes four educational design principles aiming at improving individual, collective, and organizational resilience: encourage mimetic experiences; pay attention to attention and concernedness; perturb and turn into an event; support participatory-sensemaking and collective sensemaking. Research limitations/implications The training program the authors propose may be challenging to assess. Besides, the most durable solutions to improve safety through resilience are to be found at the crossroad between organizational design and training/development policies. Future research should determine the implementability criteria which are likely to support the use of the principles the authors propose, and contribute to enrich this educational foundation. Originality/value Education and training are conceived herein as high-order means to improve safety through resilience in high-risk organizations, fostering the capacity of the operators and organization to develop efficiently and in the long run. We provide independent but complementary training principles that cannot be hierarchized, but that can be locally prioritized in organizations.
Published: 2018

10. Referentiality in Secondary Teachers' Video Observation of Others' Teaching

Author: Lussi Borer, Valérie, Flandin, Simon, MULLER, Alain, Université de Genève (UNIGE), Institut français de l'Education (IFÉ), École normale supérieure - Lyon (ENS Lyon), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Activité, Connaissance, Transmission, éducation (ACTé ), Faculté de Psychologie et des Sciences de l'Education (FPSE), Laboratoire Recherche intervention formation et travail (RIFT), CRAFT, Université de Genève (UNIGE)-Université de Genève (UNIGE), Flandin, Simon, Université de Genève = University of Geneva (UNIGE), École normale supérieure de Lyon (ENS de Lyon), and Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE)
Subjects: ddc:370.71, [SHS.EDU]Humanities and Social Sciences/Education, [SHS.EDU] Humanities and Social Sciences/Education, instructional design, [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], video, experience, [INFO.EIAH] Computer Science [cs]/Technology for Human Learning, ddc:370, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], ComputingMilieux_COMPUTERSANDEDUCATION, Enseignement secondaire, [INFO.EIAH]Computer Science [cs]/Technology for Human Learning, Vidéo-formation, teacher education
Abstract: International audience; This article presents a study of individual video-based educational sessions with secondary trainee teachers (N = 30) observing others' teaching. Within a Peircian semiotic framework, the study was designed to deepen the researchers' understanding of video-enhanced experience in educational settings beyond the usual research areas of noticing, interpreting and reflecting. Facilitated think-aloud protocols were used, the trainees' verbalizations were transcribed and the data were coded using semiotic schemes. The analysis revealed eight referentiality items jointly underlying the teachers' activities of description, interpretation, and evaluation while video observing. The results suggest the need to acknowledge the dimension of referentiality in video observation as a legitimate object of research, instructional design, and facilitation in the field of teacher video-enhanced education, especially during the induction period.
Published: 2018

11. Special Issue: Considering experience to advance research in video-enhanced teacher learning

Author: Flandin, Simon, Lussi Borer, Valérie, Gaudin, Cyrille, Institut français de l'Education (IFÉ), École normale supérieure - Lyon (ENS Lyon), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Activité, Connaissance, Transmission, éducation (ACTé ), Université de Genève (UNIGE), Faculté de Psychologie et des Sciences de l'Education (FPSE), Laboratoire Recherche intervention formation et travail (RIFT), CRAFT, Université de Genève (UNIGE)-Université de Genève (UNIGE), Education et Diversité en Espaces Francophones (FRED), Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Université de Limoges (UNILIM), Association for the Advancement of Computing in Education, École normale supérieure de Lyon (ENS de Lyon), Université de Genève = University of Geneva (UNIGE), and Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE)
Subjects: Experience, Instructional design, Teacher education, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [SHS.EDU]Humanities and Social Sciences/Education, ComputingMilieux_COMPUTERSANDEDUCATION, Teacher professional development, [INFO.EIAH]Computer Science [cs]/Technology for Human Learning, video
Abstract: International audience; Recent literature reviews in the field of video-enhanced teacher learning (e.g. Gaudin & Chaliès, 2015) show that video viewing has been increasingly used over the past 10 years in teacher education and professional development in all subject areas, at all grade levels, and all over the world. Three main reasons are identified: (i) video is an “artifact of practice” that helps create a link between the traditional theoretical education at the university and classroom practice; (ii) video viewing has been greatly eased by technical progress (e.g., digitalization, storage, edition, annotation); (iii) video viewing is a means to facilitate the implementation of institutional reforms.The effects of video on the development of teachers’ abilities (e.g., noticing relevant features, reflecting on practice) are well documented. However, little is known about teacher and facilitator experience in video-enhanced educational situations and about how to develop user/learner experience design for video-enhanced teacher learning. How do teachers’ video-enhanced experiences improve their capacity to perform effective teaching in their classroom? How can we design better programs enabling (i) teachers to live such constructive experiences and (ii) facilitators to enact more efficient educational practices? Improving our knowledge on these two specific points holds promises for the design of new programs and can be a very valuable and innovative “research and design” area.This special issue addresses such questions within different disciplinary and content-related contexts, using a variety of focus and methods to elicit teacher experience and/or facilitator experience in video-enhanced educational settings.
Published: 2018

12. The Holocene history of grapevine (Vitis vinifera) and viticulture in France retraced from a large-scale archaeobotanical dataset

Author: Bouby, Laurent, Chabal, Lucie, Bonhomme, Vincent, Baly, Isabelle, Battentier, Janet, Ben Makhad, Sammy, Bonnaire, Emmanuelle, Cabanis, Manon, Callou, Cécile, Cenzon-Salvayre, Carine, Coubray, Sylvie, Daoulas, Geneviève, Delhon, Claire, Derreumaux, Marie, Dhesse, Priscille, Dietsch Sellami, Marie-France, Dufraisse, Alexa, Durand, Aline, Durand, Frédérique, Figueiral, Isabel, Flottes, Laurie, Gillot, Isabelle, Hallavant, Charlotte, Henry, Auréade, Jeanty, Angèle, Jedrusiak, Florian, Liottier, Léonor, Marinval, Philippe, Martin, Lucie, Neveu, Elsa, Paradis, Laure, Pinaud-Querrac'H, Rachël, Poirier, Philippe, Pradat, Bénédicte, Preiss, Sidonie, Rovira, Núria, Ros, Jérôme, Salavert, Aurélie, Schaal, Caroline, Thiébault, Stéphanie, Tillier, Margaux, Toulemonde, Françoise, Vaschalde, Christophe, Wiethold, Julian, Ruas, Marie-Pierre, Matterne, Véronique, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Bases de données sur la Biodiversité, Ecologie, Environnement et Sociétés (BBEES), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Institut national de recherches archéologiques préventives (Inrap), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre de Recherche en Archéologie, Archéosciences, Histoire (CReAAH), Le Mans Université (UM)-Université de Rennes (UR)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Nantes Université - UFR Histoire, Histoire de l'Art et Archéologie (Nantes Univ - UFR HHAA), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés (TRACES), École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Hadès - Bureau d'Investigations Archéologiques, Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Archéologie des Sociétés Méditerranéennes (ASM), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), University College of London [London] (UCL), Institut Royal des Sciences Naturelles de Belgique (IRSNB), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Trajectoires - UMR 8215, Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Archéologie Médiévale et Moderne en Méditerranée (LA3M), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Archéologie, Terre, Histoire, Sociétés [Dijon] (ARTeHiS), Ministère de la Culture et de la Communication (MCC)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), This research was funded by French National Agency, ANR-16-CE27-0013 'Vignes et vins en France du Néolithique au Moyen Âge. Approche intégrée en archéosciences' and ANR-22-CE27-0026 'Modelling interactions between climate change and agriculture in the ancient west'. It also received support from the CNRS GDR 3644 Bioarcheodat, Opération 4 «Recherches collaboratives et thématiques»., ANR-16-CE27-0013,VINICULTURE,Vignes et vins en France du Néolithique au Moyen Age. Approche intégrée en archéosciences(2016), and ANR-22-CE27-0026,MICA,Modéliser les Interactions entre changement Climatique et Agriculture en Occident ancien(2022)
Subjects: Domestication, Diffusion, Biogeography, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Charcoal, Paleontology, Seed/fruit, Human-plant interaction, Archaeobotany, Oceanography, Ecology, Evolution, Behavior and Systematics, Earth-Surface Processes, Diet
Abstract: Grapevine and wine have deeply shaped the landscapes, economy and cultures of Europe and the Mediterranean. In France, it is considered that viticulture started in the south via contacts with Mediterranean populations (Greeks, Etruscans, Phoenicians), during the second half of the 1st millennium BCE, and spread further with the Romans. Wild grapevines were nevertheless present in various areas of the country all through the Holocene. No archaeological or historical source allows us to follow the history of grapevine and viticulture over the entire Holocene period and over the whole territory.In this paper we investigate the potential of archaeological plant macroremains (seed/fruits and wood) to trace the history of the vine on a large scale. We have assembled the largest possible database of published and unpublished archaeobotanical data, comprising 4449 site-phases for seed and fruits and 1356 site-phases for wood remains. In spite of taphonomic discrepancies and imbalances in the datasets, the different types of macroremains and modes of preservation produce consistent patterns. They provide the first comprehensive picture of the spread of grapevine, fluctuations in the economic role of viticulture and grape uses over time, although some periods and regions are less documented.Grapevine remains are regularly recorded from the Mesolithic to the Iron Age in most regions showing that human societies were already familiar with the wild plant and its fruits, especially in the Mediterranean. In this region, Vitis remains become considerably more frequent and numerous during the Iron Age, from around 500 BCE onwards, testifying to the rapid and strong implantation of viticulture. Grapevine macroremains confirm that the spread of viticulture outside the Mediterranean area occurred mainly during the Roman period. However, this expansion was limited and mainly focused on the South. The main expansion into the temperate zone took place during the Middle Ages. However, the more detailed fluctuations of viticulture, particularly in relation to climate oscillations are still difficult to follow. Pip remains are mainly associated with urban sites. This is a consequence of the actual consumption of grapes and may be evidence of a viticulture centered around urban areas.
Published: 2023

13. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Author: Mark K. Bakker, Jos P. Kanning, Gad Abraham, Amy E. Martinsen, Bendik S. Winsvold, John-Anker Zwart, Romain Bourcier, Tomonobu Sawada, Masaru Koido, Yoichiro Kamatani, Sandrine Morel, Philippe Amouyel, Stéphanie Debette, Philippe Bijlenga, Takiy Berrandou, Santhi K. Ganesh, Nabila Bouatia-Naji, Gregory Jones, Matthew Bown, Gabriel J.E. Rinkel, Jan H. Veldink, Ynte M. Ruigrok, Anne Hege Aamodt, Anne Heidi Skogholt, Ben M Brumpton, Cristen J Willer, Else C Sandset, Espen S Kristoffersen, Hanne Ellekjær, Ingrid Heuch, Jonas B Nielsen, Knut Hagen, Kristian Hveem, Lars G Fritsche, Laurent F Thomas, Linda M Pedersen, Maiken E Gabrielsen, Oddgeir L Holmen, Sigrid Børte, Wei Zhou, Shérine Abboud, Massimo Pandolfo, Vincent Thijs, Didier Leys, Marie Bodenant, Fabien Louillet, Emmanuel Touzé, Jean-Louis Mas, Yves Samson, Sara Leder, Anne Léger, Sandrine Deltour, Sophie Crozier, Isabelle Méresse, Sandrine Canaple, Olivier Godefroy, Maurice Giroud, Yannick Béjot, Pierre Decavel, Elizabeth Medeiros, Paola Montiel, Thierry Moulin, Fabrice Vuillier, Jean Dallongeville, Antti J Metso, Tiina Metso, Turgut Tatlisumak, Caspar Grond-Ginsbach, Christoph Lichy, Manja Kloss, Inge Werner, Marie-Luise Arnold, Michael Dos Santos, Armin Grau, Martin Dichgans, Constanze Thomas-Feles, Ralf Weber, Tobias Brandt, Alessandro Pezzini, Valeria De Giuli, Filomena Caria, Loris Poli, Alessandro Padovani, Anna Bersano, Silvia Lanfranconi, Simone Beretta, Carlo Ferrarese, Giacomo Giacolone, Stefano Paolucci, Philippe Lyrer, Stefan Engelter, Felix Fluri, Florian Hatz, Dominique Gisler, Leo Bonati, Henrik Gensicke, Margareth Amort, Hugh Markus, Jennifer Majersik, Bradford Worrall, Andrew Southerland, John Cole, Steven Kittner, Evangelos Evangelou, Helen R Warren, He Gao, Georgios Ntritsos, Niki Dimou, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian’an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, John Connell, Renée de Mutsert, Alex SF Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola Del Greco M, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin Lehne, Terho Lehtimäki, David CM Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, YongMei Liu, Ruth JF Loos, Lorna M Lopez, Yingchang Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O’Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Aarno Palotie, Alison Pattie, Brenda WJH Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Quang Tri Nguyen, Olli T Raitakari, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Ried, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniela Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Reinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Snieder, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Maciej Tomaszewski, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Daniel I Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna MM Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Olle Melander, Dennis O Mook-Kanamori, Colin NA Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Daniel Levy, Patricia B Munroe, Christopher Newton-Cheh, Morris J Brown, Andres Metspalu, Bruce M. Psaty, Louise V Wain, Paul Elliott, Mark J Caulfield, Padhraig Gormley, Verneri Anttila, Priit Palta, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, Juho Wedenoja, David A Hinds, Julie E Buring, Markus Schürks, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson, Susan M Ring, Brenda W J H Penninx, Markus Färkkilä, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Rainer Malik, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Mart Kals, Kalle Pärn, Eija Hämäläinen, Hailiang Huang, Andrea E Byrnes, Lude Franke, Jie Huang, Evie Stergiakouli, Phil H Lee, Cynthia Sandor, Caleb Webber, Zameel Cader, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Johan G Eriksson, Kauko Heikkilä, Elizabeth Loehrer, Andre G Uitterlinden, Lynn Cherkas, Audun Stubhaug, Christopher S Nielsen, Minna Männikkö, Evelin Mihailov, Hartmut Göbel, Ann-Louise Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, Thomas Werge, Jaakko Kaprio, Arpo J Aromaa, Olli Raitakari, M Arfan Ikram, Tim Spector, Marjo-Riitta Järvelin, Christian Kubisch, Michel D Ferrari, Andrea C Belin, Maija Wessman, Arn M J M van den Maagdenberg, George Davey Smith, Kari Stefansson, Nicholas Eriksson, Mark J Daly, Benjamin M Neale, Jes Olesen, Dale R Nyholt, Masato Akiyama, Varinder S. Alg, Joseph P. Broderick, Ben M. Brumpton, Jérôme Dauvillier, Hubert Desal, Christian Dina, Christoph M. Friedrich, Emília I. Gaál-Paavola, Jean-Christophe Gentric, Sven Hirsch, Isabel C. Hostettler, Henry Houlden, Juha E. Jääskeläinen, Marianne Bakke Johnsen, Liming Li, Kuang Lin, Antti Lindgren, Olivier Martin, Koichi Matsuda, Iona Y. Millwood, Olivier Naggara, Mika Niemelä, Joanna Pera, Richard Redon, Guy A. Rouleau, Marie Søfteland Sandvei, Sabine Schilling, Eimad Shotar, Agnieszka Slowik, Chikashi Terao, W. M. Monique Verschuren, Robin G. Walters, David J. Werring, Cristen J. Willer, Daniel Woo, Bradford B. Worrall, Sirui Zhou, Biological Psychology, Amsterdam Reproduction & Development, APH - Mental Health, APH - Methodology, AMS - Sports, AMS - Ageing & Vitality, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Systems Ecology, Sociology and Social Gerontology, Bakker, Mark K., Kanning, Jos P., Abraham, Gad, Martinsen, Amy E., Winsvold, Bendik S., Zwart, John-Anker, Bourcier, Romain, Sawada, Tomonobu, Koido, Masaru, Kamatani, Yoichiro, Morel, Sandrine, Amouyel, Philippe, Debette, Stéphanie, Bijlenga, Philippe, Berrandou, Takiy, Ganesh, Santhi K., Bouatia-Naji, Nabila, Jones, Gregory, Bown, Matthew, Rinkel, Gabriel J. E., Veldink, Jan H., Ruigrok, Ynte M., Girotto, G., All-In Stroke, Hunt, Group, Cadisp, Consortium for Blood Pressure, International, Headache Genetics Consortium, International, Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, International, Utrecht University [Utrecht], Baker Heart and Diabetes Institute (AUSTRALIA), University of Melbourne, University of Oslo (UiO), Norwegian University of Science and Technology (NTNU), Oslo University Hospital [Oslo], Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), The University of Tokyo (UTokyo), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Hôpital Universitaire de Genève = University Hospitals of Geneva (HUG), Université de Genève = University of Geneva (UNIGE), Excellence Laboratory LabEx DISTALZ, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, University of Otago [Dunedin, Nouvelle-Zélande], University of Leicester, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure, International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group: Anne Hege Aamodt, Anne Heidi Skogholt, Ben M Brumpton, Cristen J Willer, Else C Sandset, Espen S Kristoffersen, Hanne Ellekjær, Ingrid Heuch, Jonas B Nielsen, Knut Hagen, Kristian Hveem, Lars G Fritsche, Laurent F Thomas, Linda M Pedersen, Maiken E Gabrielsen, Oddgeir L Holmen, Sigrid Børte, Wei Zhou, Shérine Abboud, Massimo Pandolfo, Vincent Thijs, Didier Leys, Marie Bodenant, Fabien Louillet, Emmanuel Touzé, Jean-Louis Mas, Yves Samson, Sara Leder, Anne Léger, Sandrine Deltour, Sophie Crozier, Isabelle Méresse, Sandrine Canaple, Olivier Godefroy, Maurice Giroud, Yannick Béjot, Pierre Decavel, Elizabeth Medeiros, Paola Montiel, Thierry Moulin, Fabrice Vuillier, Jean Dallongeville, Antti J Metso, Tiina Metso, Turgut Tatlisumak, Caspar Grond-Ginsbach, Christoph Lichy, Manja Kloss, Inge Werner, Marie-Luise Arnold, Michael Dos Santos, Armin Grau, Martin Dichgans, Constanze Thomas-Feles, Ralf Weber, Tobias Brandt, Alessandro Pezzini, Valeria De Giuli, Filomena Caria, Loris Poli, Alessandro Padovani, Anna Bersano, Silvia Lanfranconi, Simone Beretta, Carlo Ferrarese, Giacomo Giacolone, Stefano Paolucci, Philippe Lyrer, Stefan Engelter, Felix Fluri, Florian Hatz, Dominique Gisler, Leo Bonati, Henrik Gensicke, Margareth Amort, Hugh Markus, Jennifer Majersik, Bradford Worrall, Andrew Southerland, John Cole, Steven Kittner, Evangelos Evangelou, Helen R Warren, He Gao, Georgios Ntritsos, Niki Dimou, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, John Connell, Renée de Mutsert, Alex Sf Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola Del Greco M, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin Lehne, Terho Lehtimäki, David Cm Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, YongMei Liu, Ruth Jf Loos, Lorna M Lopez, Yingchang Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Aarno Palotie, Alison Pattie, Brenda Wjh Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Quang Tri Nguyen, Olli T Raitakari, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Ried, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniela Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Reinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Snieder, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Maciej Tomaszewski, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Daniel I Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna Mm Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Olle Melander, Dennis O Mook-Kanamori, Colin Na Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Daniel Levy, Patricia B Munroe, Christopher Newton-Cheh, Morris J Brown, Andres Metspalu, Bruce M Psaty, Louise V Wain, Paul Elliott, Mark J Caulfield, Padhraig Gormley, Verneri Anttila, Priit Palta, Tonu Esko, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, Terho Lehtimäki, Antti-Pekka Sarin, Juho Wedenoja, David A Hinds, Julie E Buring, Markus Schürks, Paul M Ridker, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson, Susan M Ring, Jouke-Jan Hottenga, Brenda W J H Penninx, Markus Färkkilä, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Rainer Malik, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Mart Kals, Reedik Mägi, Kalle Pärn, Eija Hämäläinen, Hailiang Huang, Andrea E Byrnes, Lude Franke, Jie Huang, Evie Stergiakouli, Phil H Lee, Cynthia Sandor, Caleb Webber, Zameel Cader, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Johan G Eriksson, Veikko Salomaa, Kauko Heikkilä, Elizabeth Loehrer, Andre G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Lynn Cherkas, Linda M Pedersen, Audun Stubhaug, Christopher S Nielsen, Minna Männikkö, Evelin Mihailov, Lili Milani, Hartmut Göbel, Ann-Louise Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, Thomas Werge, Jaakko Kaprio, Arpo J Aromaa, Olli Raitakari, M Arfan Ikram, Tim Spector, Marjo-Riitta Järvelin, Andres Metspalu, Christian Kubisch, David P Strachan, Michel D Ferrari, Andrea C Belin, Martin Dichgans, Maija Wessman, Arn M J M van den Maagdenberg, Dorret I Boomsma, George Davey Smith, Kari Stefansson, Nicholas Eriksson, Mark J Daly, Benjamin M Neale, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Aarno Palotie, Masato Akiyama, Varinder S Alg, Sigrid Børte, Joseph P Broderick, Ben M Brumpton, Jérôme Dauvillier, Hubert Desal, Christian Dina, Christoph M Friedrich, Emília I Gaál-Paavola, Jean-Christophe Gentric, Sven Hirsch, Isabel C Hostettler, Henry Houlden, Kristian Hveem, Juha E Jääskeläinen, Marianne Bakke Johnsen, Liming Li, Kuang Lin, Antti Lindgren, Olivier Martin, Koichi Matsuda, Iona Y Millwood, Olivier Naggara, Mika Niemelä, Joanna Pera, Richard Redon, Guy A Rouleau, Marie Søfteland Sandvei, Sabine Schilling, Eimad Shotar, Agnieszka Slowik, Chikashi Terao, W M Monique Verschuren, Robin G Walters, David J Werring, Cristen J Willer, Daniel Woo, Bradford B Worrall, Sirui Zhou, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Admin, Oskar
Subjects: Advanced and Specialized Nursing, Incidence, risk assessment, Smoking/epidemiology, intracranial aneurysm, genetic heterogeneity, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Risk Factors, Intracranial Aneurysm/epidemiology, Humans, Subarachnoid Hemorrhage/epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, genetics, Neurology (clinical), aneurysmal subarachnoid hemorrhage, genetic, Cardiology and Cardiovascular Medicine
Abstract: Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics. Methods: A genetic risk score incorporating genetic association data for IA and 17 traits related to IA (so-called metaGRS) was created using 1161 IA cases and 407 392 controls from the UK Biobank population study. The metaGRS was validated in combination with risk factors blood pressure, sex, and smoking in 828 IA cases and 68 568 controls from the Nordic HUNT population study. Furthermore, we assessed association between the metaGRS and patient characteristics in a cohort of 5560 IA patients. Results: Per SD increase of metaGRS, the hazard ratio for ASAH incidence was 1.34 (95% CI, 1.20–1.51) and the odds ratio for IA presence 1.09 (95% CI, 1.01–1.18). Upon including the metaGRS on top of clinical risk factors, the concordance index to predict ASAH hazard increased from 0.63 (95% CI, 0.59–0.67) to 0.65 (95% CI, 0.62–0.69), while prediction of IA presence did not improve. The metaGRS was statistically significantly associated with age at ASAH (β=−4.82×10 −3 per year [95% CI, −6.49×10 −3 to −3.14×10 −3 ]; P =1.82×10 −8 ), and location of IA at the internal carotid artery (odds ratio=0.92 [95% CI, 0.86–0.98]; P =0.0041). Conclusions: The metaGRS was predictive of ASAH incidence, although with limited added value over clinical risk factors. The metaGRS was not predictive of IA presence. Therefore, we do not recommend using this metaGRS in daily clinical care. Genetic risk does partly explain the clinical heterogeneity of IA warranting prioritization of clinical heterogeneity in future genetic prediction studies of IA and ASAH.
Published: 2023

14. Gully evolution and geomorphic adjustments of badlands to reforestation

Author: David R. Montgomery, Markus Stoffel, J.F. Martín-Duque, Christophe Corona, J. A. Ballesteros Cánovas, Ana Lucía, José María Bodoque, Climatic Change and Climate Impacts Research Group, Institute for Environmental Sciences [Geneva] (ISE), University of Geneva [Switzerland]-University of Geneva [Switzerland], Department of Earth and Environmental Sciences, University of Geneva [Switzerland], Department of Geodynamics, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne (UCA)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Faculty of Sciences, Center for Applied Geosciences, Eberhard Karls University Tübingen, Free University of Bozen-Bolzano, University of Castilla-La Mancha (UCLM), Department of Earth and Space Sciences [Seattle], University of Washington [Seattle], Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE), Université de Genève = University of Geneva (UNIGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, and Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM)
Subjects: Mediterranean climate, ddc:333.7-333.9, geography, Multidisciplinary, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, Landform, Reforestation, Soil science, Vegetation, [SHS.GEO]Humanities and Social Sciences/Geography, 15. Life on land, 010502 geochemistry & geophysics, 01 natural sciences, Article, Aerial photography, Erosion, Afforestation, Physical geography, Channel (geography), Geology, 0105 earth and related environmental sciences
Abstract: Badlands and gullied areas are among those geomorphic environments with the highest erosion rates worldwide. Nevertheless, records of their evolution and their relations with anthropogenic land transformation are scarcer. Here we combine historical data with aerial photographs and tree-ring records to reconstruct the evolution of a badland in a Mediterranean environment of Central Spain. Historical sources suggest an anthropogenic origin of this badland landscape, caused by intense quarrying activities during the 18th century. Aerial photographs allowed detection of dramatic geomorphic changes and the evolution of an emerging vegetation cover since the 1960s, due to widespread reforestation. Finally, tree-ring analyses of exposed roots allowed quantification of recent channel incision of the main gully, and sheet erosion processes. Our results suggest that reforestation practices have influenced the initiation of an episode of incision in the main channel in the 1980s, through the hypothesized creation of disequilibrium in water-sediment balance following decoupling of hillslopes from channel processes. These findings imply an asymmetry in the geomorphic response of badlands to erosion such that in the early evolution stages, vegetation removal results in gullying, but that reforestation alone does not necessarily stabilize the landforms and may even promote renewed incision.
Published: 2017

15. Mixing of porpoise ecotypes in South Western UK waters revealed by genetic profiling

Author: Michael C. Fontaine, Rob Deaville, Paul Jepson, Nicolas Ray, Sylvain Piry, Nicholas J. Davison, Simon J. Goodman, Olivier Thatcher, Andrew Brownlow, Fontaine lab, Sch Biol, Fac Biol Sci, University of Leeds, Groningen Inst Evolutionary Life Sci GELIFES, University of Groningen, Inst. Zool., Zoological Society of London, Dept. Zool., University of Cambridge, EnviroSPACE Laboratory, Institute for Environmental Sciences [Geneva] (ISE), University of Geneva [Switzerland]-University of Geneva [Switzerland], Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Scottish Marine Animal Stranding Scheme, SRUC Veterinary Service, Scotland's Rural College (SRUC), Animal and Plant Health Agency [Addlestone, UK] (APHA), EnviroSPACE Laboratory, Institute for Environmental Sciences, University of Geneva, SRUC, Animal and Plant Health Agency (APHA), Fontaine, Michael C., Goodman, Simon J., and Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE)
Subjects: 0106 biological sciences, 0301 basic medicine, [SDV]Life Sciences [q-bio], Climate change, Phocoena, Admixture, Biology, 010603 evolutionary biology, 01 natural sciences, Molecular ecology, 03 medical and health sciences, biology.animal, ecotype specialization, 14. Life underwater, lcsh:Science, molecular ecology, dispersal, 030304 developmental biology, Isolation by distance, ddc:333.7-333.9, 0303 health sciences, Multidisciplinary, Ecotype, Ecology, Biology (Whole Organism), continuous population, Pelagic zone, Dispersal, Continuous population, biology.organism_classification, 030104 developmental biology, climate change, Ecotype specialization, Genetic structure, Microsatellite, Biological dispersal, admixture, lcsh:Q, Bay, Porpoise, Research Article
Abstract: Contact zones between ecotypes are windows for understanding how species may react to climate changes. Here, we analysed the fine-scale genetic and morphological variation in harbour porpoises (Phocoena phocoena) around the UK by genotyping 591 stranded animals at nine microsatellite loci. The data were integrated with a prior study to map at high resolution the contact zone between two previously identified ecotypes meeting in the northern Bay of Biscay. Clustering and spatial analyses revealed that UK porpoises are derived from two genetic pools with porpoises from the southwestern UK being genetically differentiated, and having larger body sizes compared to those of other UK areas. Southwestern UK porpoises showed admixed ancestry between southern and northern ecotypes with a contact zone extending from the northern Bay of Biscay to the Celtic Sea and Channel. Around the UK, ancestry blends from one genetic group to the other along a southwest--northeast axis, correlating with body size variation, consistent with previously reported morphological differences between the two ecotypes. We also detected isolation by distance among juveniles but not in adults, suggesting that stranded juveniles display reduced intergenerational dispersal. The fine-scale structure of this admixture zone raises the question of how it will respond to future climate change and provides a reference point for further study.
Published: 2017

16. Rare pathogenic variants in WNK3 cause X-linked intellectual disability

Author: Sébastien Küry, Jinwei Zhang, Thomas Besnard, Alfonso Caro-Llopis, Xue Zeng, Stephanie M. Robert, Sunday S. Josiah, Emre Kiziltug, Anne-Sophie Denommé-Pichon, Benjamin Cogné, Adam J. Kundishora, Le T. Hao, Hong Li, Roger E. Stevenson, Raymond J. Louie, Wallid Deb, Erin Torti, Virginie Vignard, Kirsty McWalter, F. Lucy Raymond, Farrah Rajabi, Emmanuelle Ranza, Detelina Grozeva, Stephanie A. Coury, Xavier Blanc, Elise Brischoux-Boucher, Boris Keren, Katrin Õunap, Karit Reinson, Pilvi Ilves, Ingrid M. Wentzensen, Eileen E. Barr, Solveig Heide Guihard, Perrine Charles, Eleanor G. Seaby, Kristin G. Monaghan, Marlène Rio, Yolande van Bever, Marjon van Slegtenhorst, Wendy K. Chung, Ashley Wilson, Delphine Quinquis, Flora Bréhéret, Kyle Retterer, Pierre Lindenbaum, Emmanuel Scalais, Lindsay Rhodes, Katrien Stouffs, Elaine M. Pereira, Sara M. Berger, Sarah S. Milla, Ankita B. Jaykumar, Melanie H. Cobb, Shreyas Panchagnula, Phan Q. Duy, Marie Vincent, Sandra Mercier, Brigitte Gilbert-Dussardier, Xavier Le Guillou, Séverine Audebert-Bellanger, Sylvie Odent, Sébastien Schmitt, Pierre Boisseau, Dominique Bonneau, Annick Toutain, Estelle Colin, Laurent Pasquier, Richard Redon, Arjan Bouman, Jill. A. Rosenfeld, Michael J. Friez, Helena Pérez-Peña, Syed Raza Akhtar Rizvi, Shozeb Haider, Stylianos E. Antonarakis, Charles E. Schwartz, Francisco Martínez, Stéphane Bézieau, Kristopher T. Kahle, Bertrand Isidor, Clinical Genetics, Clinical sciences, Medical Genetics, Reproduction and Genetics, Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), University of Exeter, MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), The Greenwood Genetic Center, GeneDx [Gaithersburg, MD, USA], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Pontchaillou [Rennes], Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Genève = University of Geneva (UNIGE), Yale School of Medicine [New Haven, Connecticut] (YSM), This work was granted by the French network of University Hospitals HUGO ('Hôpitaux Universitaires du Grand Ouest'), the French Ministry of Health, and and the Health Regional Agencies from Poitou-Charentes (represented by Frédérique Allaire), Bretagne, Pays de la Loire, and Centre-Val de Loire (HUGODIMS, 2013, RC14_0107). W.K.C. was supported by grants from Simons Foundation Autism Research Initiative, United
Subjects: MESH: Symporters, Exome sequencing, Male, KCC2, Mutation, Missense, MESH: Catalytic Domain, Neurodevelopmental disease, Protein Serine-Threonine Kinases, X-linked intellectual disability, MESH: Brain, WNK3, SDG 3 - Good Health and Well-being, Loss of Function Mutation, Catalytic Domain, MESH: Mental Retardation, X-Linked, Humans, Phosphorylation, MESH: Hemizygote, Genetics (clinical), Hemizygote, MESH: Mutation, Missense, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Phosphorylation, Symporters, Brain, MESH: Loss of Function Mutation, MESH: Protein Serine-Threonine Kinases, MESH: Male, Mental Retardation, X-Linked, Maternal Inheritance, MESH: Maternal Inheritance
Abstract: PURPOSE: WNK3 kinase (PRKWNK3) has been implicated in the development and function of the brain via its regulation of the cation-chloride cotransporters, but the role of WNK3 in human development is unknown. METHOD: We ascertained exome or genome sequences of individuals with rare familial or sporadic forms of intellectual disability (ID). RESULTS: We identified a total of 6 different maternally-inherited, hemizygous, 3 loss-of-function or 3 pathogenic missense variants (p.Pro204Arg, p.Leu300Ser, p.Glu607Val) in WNK3 in 14 male individuals from 6 unrelated families. Affected individuals had identifier with variable presence of epilepsy and structural brain defects. WNK3 variants cosegregated with the disease in 3 different families with multiple affected individuals. This included 1 large family previously diagnosed with X-linked Prieto syndrome. WNK3 pathogenic missense variants localize to the catalytic domain and impede the inhibitory phosphorylation of the neuronal-specific chloride cotransporter KCC2 at threonine 1007, a site critically regulated during the development of synaptic inhibition. CONCLUSION: Pathogenic WNK3 variants cause a rare form of human X-linked identifier with variable epilepsy and structural brain abnormalities and implicate impaired phospho-regulation of KCC2 as a pathogenic mechanism.
Published: 2022

17. What is the Functional Role of iEEG Oscillations in Neural Processing and Cognitive Functions?

Author: Proix, Timothée, Mégevand, Pierre, Giraud, Anne-Lise, Department of Basic Neuroscience, Université de Genève = University of Geneva (UNIGE), Institut de l'Audition [Paris] (IDA), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and Nikolai Axmacher
Subjects: [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Abstract: International audience; Oscillations of the electric field generated by neuronal populations are often observed in intracranial EEG recordings from human cortical and subcortical brain regions. The functional relevance of these oscillations for neural processing and cognitive functions remains a debated issue in modern neuroscience. In this chapter, we review evidence that iEEG oscillations constitute a key mechanism in the functional integration of neuronal activity across temporal and spatial scales. We focus on the potential role of cortical oscillations in cognitive processes, and particularly speech perception and production, which involve diverse brain regions and temporal scales in a structured hierarchy, as an ideal testbed for outlining the possible insights that iEEG oscillations offer on cognitive functions.
Published: 2023

18. C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3 -Mutant Leukemia

Author: Marie Sabatier, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Lea Goupille, Ismael Boussaid, Mael Heiblig, Emeline Boet, Ambrine Sahal, Estelle Saland, Juliana C. Santos, Marc Armengol, Miranda Fernandez-Serrano, Thomas Farge, Guillaume Cognet, Federico Simonetta, Corentin Pignon, Antoine Graffeuil, Celine Mazzotti, Herve Avet-Loiseau, Oceane Delos, Justine Bertrand-Michel, Amelie Chedru, Vilma Dembitz, Paolo Gallipoli, Natasha S. Anstee, Sun Loo, Andrew H. Wei, Martin Carroll, Armelle Goubard, Remy Castellano, Yves Collette, Francois Vergez, Veronique Mansat-De Mas, Sarah Bertoli, Suzanne Tavitian, Muriel Picard, Christian Recher, Nathalie Bourges-Abella, Fanny Granat, Olivier Kosmider, Pierre Sujobert, Benoit Colsch, Carine Joffre, Lucille Stuani, Johannes V. Swinnen, Herve Guillou, Gael Roue, Nawad Hakim, Anne S. Dejean, Petros Tsantoulis, Clement Larrue, Didier Bouscary, Jerome Tamburini, Jean-Emmanuel Sarry, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Faculté de médecine [Genève], Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne = University of Lausanne (UNIL), Leuven Cancer Institute [Leuven, Belgium] (LKI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Josep Carreras Leukaemia Research Institute (IJC), MetaboHUB-MetaToul, MetaboHUB-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Queen Mary University of London (QMUL), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Peter MacCallum Cancer Center, Perelman School of Medicine, University of Pennsylvania, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales (CREFRE), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Leuven Cancer Institute (LKI), Leuven, Belgium, ToxAlim (ToxAlim), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université de Genève = University of Geneva (UNIGE), and 2018/Ligue Nationale de Lutte contre le Cancer C57799/A27964/Cancer Research UK (CRUK) Institut National Du Cancer (INCa)
Subjects: Oncology, [SDV]Life Sciences [q-bio]
Abstract: Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely unknown in cancer. Here, multiomics analyses uncovered a coordinated activation of C/EBPα and Fms-like tyrosine kinase 3 (FLT3) that increased lipid anabolism in vivo and in patients with FLT3-mutant acute myeloid leukemia (AML). Mechanistically, C/EBPα regulated the fatty acid synthase (FASN)–stearoyl-CoA desaturase (SCD) axis to promote fatty acid (FA) biosynthesis and desaturation. We further demonstrated that FLT3 or C/EBPα inactivation decreased monounsaturated FA incorporation to membrane phospholipids through SCD downregulation. Consequently, SCD inhibition enhanced susceptibility to lipid redox stress that was exploited by combining FLT3 and glutathione peroxidase 4 inhibition to trigger lipid oxidative stress, enhancing ferroptotic death of FLT3-mutant AML cells. Altogether, our study reveals a C/EBPα function in lipid homeostasis and adaptation to redox stress, and a previously unreported vulnerability of FLT3-mutant AML to ferroptosis with promising therapeutic application. Significance: FLT3 mutations are found in 30% of AML cases and are actionable by tyrosine kinase inhibitors. Here, we discovered that C/EBPα regulates FA biosynthesis and protection from lipid redox stress downstream mutant-FLT3 signaling, which confers a vulnerability to ferroptosis upon FLT3 inhibition with therapeutic potential in AML. This article is highlighted in the In This Issue feature, p. 1501
Published: 2023

19. Spatio-temporal dynamics of habitat use by fish in a restored alluvial floodplain over two decades

Author: Bouloy, Anaëlle, Olivier, Jean-Michel, Riquier, Jérémie, Castella, Emmanuel, Marle, Pierre, Lamouroux, Nicolas, RiverLy - Fonctionnement des hydrosystèmes (RiverLy), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ecologie et de Biologie Aquatique - LEBA (Genève, Suisse), Université de Genève = University of Geneva (UNIGE), RhônEco, Observatoire Hommes Milieux (OHM) Vallée du Rhône, and Zone Atelier Bassin du Rhône (ZABR)
Subjects: [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences
Abstract: International audience; Floodplain channels of rivers can serve as reproduction, nursery or refuge areas for fish. Although the complementary use of floodplain and main channels is known, few studies attempted to quantify this use and even fewer analysed its controlling factors. The objectives of this study are (1) to describe the spatio-temporal use of floodplain habitats and to identify their roles as complementary habitats for fish and (2) to analyse how abiotic variations and their modifications under restoration impact habitat use by fish. To meet these objectives, we analysed multi-site data collected over 20 years in eight restored sectors of the Rhône River. Results show that habitat use by fish is mainly related to spatial effects. As expected, rheophilic species were more abundant in lotic stations and limnophilic species in lentic ones. In addition, we identified an euryecious guild, grouping youngs of the year taxa, that used all types of habitats and particularly lentic floodplain channels with short life-span. Temporal effects combine (1) the effect of restoration, particularly in floodplain channels for which the connectivity regime was modified, (2) the effect of high flows upon the habitat use by fish that reinforces the nursery and refuge functions of floodplain channels. To conclude, our results demonstrate the importance of restoring habitat diversity and connectivity because habitats may have complementary functions for fish. Furthermore, our results also highlight that it is essential to account for temporal variations in order to better estimate the potential effects of restoration on river and their floodplains.
Published: 2023

20. Functional trait-based approaches as a common framework for aquatic ecologists: Synthesis and recent results

Author: Martini, Séverine, Larras, Floriane, Boyé, Aurélien, Faure, Emile, Aberle, Nicole, Archambault, Philippe, Bacouillard, Lise, Beisner, Beatrix, Bittner, Lucie, Castella, Emmanuel, Danger, Michael, Gauthier, Olivier, Karp-Boss, Lee, Lombard, Fabien, Maps, Frédéric, Stemmann, Lars, Thiébaut, Éric, Usseglio-Polatera, Philippe, Vogt, Meike, Laviale, Martin, Ayata, Sakina‐dorothée, Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Institut des Sciences de la MER de Rimouski (ISMER), Université du Québec à Rimouski (UQAR), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire d'Ecologie et de Biologie Aquatique - LEBA (Genève, Suisse), Université de Genève = University of Geneva (UNIGE), Laboratoire Interdisciplinaire des Environnements Continentaux (LIEC), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Terre et Environnement de Lorraine (OTELo), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Maine, Laboratoire d'océanographie de Villefranche (LOV), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Global Oceans Systems Ecology & Evolution - Tara Oceans (GOSEE), Université de Perpignan Via Domitia (UPVD)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Aix Marseille Université (AMU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Université de Toulon (UTLN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche pour le Développement (IRD [France-Nord])-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-European Molecular Biology Laboratory (EMBL)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université australe du Chili, Takuvik International Research Laboratory, Université Laval [Québec] (ULaval)-Centre National de la Recherche Scientifique (CNRS), Institute of Biogeochemistry and Pollutant Dynamics [ETH Zürich] (IBP), Department of Environmental Systems Science [ETH Zürich] (D-USYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Zone Atelier du Bassin de la Moselle [LTSER France] (ZAM), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Association for the Sciences of Limnology and Oceanography (ASLO)
Subjects: aquatic ecology, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, functional traits
Abstract: International audience; Aquatic ecologists face challenges in identifying the general rules of the functioning of ecosystems. A common framework, including freshwater, marine, benthic, and pelagic ecologists, is needed to bridge communication gaps and foster knowledge sharing. This framework should transcend local specificities and taxonomy in order to provide a common ground and shareable tools to address common scientific challenges. In a recent review paper published in Limnology and Oceanography (Martini et al., 2021), we advocated the use of functional trait-based approaches (FTBAs) for aquatic ecologists and proposed concrete paths to go forward. In this presentation, we will first present an overview of this synthesis work. Then, using a few examples of recent results, including from quantitative imaging, genomics, and machine learning, we will then concretely illustrate how FTBAs can allow aquatic ecologists to tackle some of the scientific challenges identified in the paper.
Published: 2023

21. Mechano-optical couplings in an oxynitride glass-ceramic

Author: Duval, Alexis, Rocquefelte, Xavier, Suffren, Yan, Benabdesselam, Mourad, Ryan, Dominic, Gueguen, Yann, Célarié, Fabrice, Houizot, Patrick, Rouxel, Tanguy, Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Département de chimie physique [Genève], Université de Genève = University of Geneva (UNIGE), Département de chimie [UdeM-Montréal], Université de Montréal (UdeM), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA), Institut de Physique de Nice (INPHYNI), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and McGill University = Université McGill [Montréal, Canada]
Subjects: oxynitride glasses, [PHYS]Physics [physics], Luminescence, mechanoluminescence, glass-ceramics, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [PHYS.MECA]Physics [physics]/Mechanics [physics]
Abstract: International audience
Published: 2023

22. Carrier-Density Control of the Quantum-Confined 1$T$-TiSe$_2$ Charge-Density-Wave

Author: Jaouen, T., Pulkkinen, A., Rumo, M., Kremer, G., Salzmann, B., Nicholson, C. W., Mottas, M. -L., Giannini, E., Tricot, S., Schieffer, P., Hildebrand, B., Monney, C., Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Department of Physics [Fribourg], Université de Fribourg = University of Fribourg (UNIFR), Fribourg Center for Nanomaterials (FriMat), University of West Bohemia [Plzeň ], Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Max Planck Society, Department of Quantum Matter Physics [Geneva] (DQMP), Université de Genève = University of Geneva (UNIGE), and This project was supported by the Fonds National Suisse pour la Recherche Scientifique through Div. II. Skillful technical assistance was provided by F. Bourqui, B. Hediger, and O. Raetzo.
Subjects: Superconductivity (cond-mat.supr-con), [PHYS]Physics [physics], Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons, Strongly Correlated Electrons (cond-mat.str-el), Condensed Matter - Superconductivity, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat]
Abstract: Using angle-resolved photoemission spectroscopy, combined with first principle and coupled self-consistent Poisson-Schr\"odinger calculations, we demonstrate that potassium (K) atoms adsorbed on the low-temperature phase of 1$T$-TiSe$_2$ induce the creation of a two-dimensional electron gas (2DEG) and quantum confinement of its charge-density-wave (CDW) at the surface. By further changing the K coverage, we tune the carrier-density within the 2DEG that allows us to nullify, at the surface, the electronic energy gain due to exciton condensation in the CDW phase while preserving a long-range structural order. Our study constitutes a prime example of a controlled exciton-related many-body quantum state in reduced dimensionality by alkali-metal dosing., Comment: 6 pages, 3 figures, accepted for publication in Physical Review Letters
Published: 2023

23. Water discharge variations control fluvial stratigraphic architecture in the Middle Eocene Escanilla formation, Spain

Author: Nikhil Sharma, Alexander Whittaker, Stephen Watkins, Luis Valero, Jean Vérité, Cai Puigdefàbregas, Thierry Adatte, Miguel Garcés, François Guillocheau, Sebastien Castelltort, Université de Genève = University of Geneva (UNIGE), Imperial College London, Université du Maine [Le Mans - Laval], Universitat de Barcelona (UB), Université de Lausanne = University of Lausanne (UNIL), Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), and Swiss National Science Foundation (SNSF Grant No. 200020_182017: Earth Surface Signaling Systems 2)
Subjects: Huesca (Aragon), Multidisciplinary, Osca (Aragó), Eocene Epoch, Estratigrafia, [SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/Stratigraphy, Fluvial geomorphology, Geomorfologia fluvial, Eocè, Stratigraphic geology
Abstract: Ancient fluvial deposits typically display repetitive changes in their depositional architecture such as alternating intervals of coarse-grained highly amalgamated (HA), laterally-stacked, channel bodies, and finer-grained less amalgamated (LA), vertically-stacked, channels encased in floodplain deposits. Such patterns are usually ascribed to slower, respectively higher, rates of base level rise (accommodation). However, “upstream” factors such as water discharge and sediment flux also play a potential role in determining stratigraphic architecture, yet this possibility has never been tested despite the recent advances in the field of palaeohydraulic reconstructions from fluvial accumulations. Here, we chronicle riverbed gradient evolution within three Middle Eocene (~ 40 Ma) fluvial HA-LA sequences in the Escanilla Formation in the south-Pyrenean foreland basin. This work documents, for the first time in a fossil fluvial system, how the ancient riverbed systematically evolved from lower slopes in coarser-grained HA intervals, and higher slopes in finer-grained LA intervals, suggesting that bed slope changes were determined primarily by climate-controlled water discharge variations rather than base level changes as often hypothesized. This highlights the important connection between climate and landscape evolution and has fundamental implications for our ability to reconstruct ancient hydroclimates from the interpretation of fluvial sedimentary sequences.
Published: 2023

24. Action of the Euclidean versus Projective group on an agent's internal space in curiosity driven exploration: a formal analysis

Author: Sergeant-Perthuis, Grégoire, Rudrauf, David, Ognibene, Dimitri, Tisserand, Yvain, OUtils de Résolution Algébriques pour la Géométrie et ses ApplicatioNs (OURAGAN), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Complexité, Innovation, Activités Motrices et Sportives (CIAMS), Université d'Orléans (UO)-Université Paris-Saclay, Dipartimento di Psicologia, Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Swiss Center for Affective Sciences (CISA), and Université de Genève = University of Geneva (UNIGE)
Subjects: FOS: Computer and information sciences, Computer Science - Artificial Intelligence, Spatial Cognition, Systems and Control (eess.SY), Electrical Engineering and Systems Science - Systems and Control, Mathematical Consciousness, [SCCO]Cognitive science, [SPI]Engineering Sciences [physics], Artificial Intelligence (cs.AI), Curiosity, FOS: Biological sciences, Quantitative Biology - Neurons and Cognition, Intentionality, FOS: Electrical engineering, electronic engineering, information engineering, Neurons and Cognition (q-bio.NC), [INFO]Computer Science [cs]
Abstract: In human spatial awareness, information appears to be represented according to 3-D projective geometry. It structures information integration and action planning within an internal representation space. The way different first person perspectives of an agent relate to each other, through transformations of a world model, defines a specific perception scheme for the agent. In mathematics, this collection of transformations is called a `group' and it characterizes a geometric space by acting on it. We propose that imbuing world models with a `geometric' structure, given by a group, is one way to capture different perception schemes of agents. We explore how changing the geometric structure of a world model impacts the behavior of an agent. In particular, we focus on how such geometrical operations transform the formal expression of epistemic value in active inference as driving an agent's curiosity about its environment, and impact exploration behaviors accordingly. We used group action as a special class of policies for perspective-dependent control. We compared the Euclidean versus projective groups. We formally demonstrate that the groups induce distinct behaviors. The projective group induces nonlinear contraction and dilatation that transform entropy and epistemic value as a function of the choice of frame, which fosters exploration behaviors. This contribution opens research avenues in which a geometry structures \textit{a priori} an agent's internal representation space for information integration and action planning.
Published: 2023

25. Effects of Malocclusion on Maximal Aerobic Capacity and Athletic Performance in Young Sub-Elite Athletes

Author: El Mokhtar El Ouali, Hassane Zouhal, Loubna Bahije, Azeddine Ibrahimi, Bahae Benamar, Jihan Kartibou, Ayoub Saeidi, Ismail Laher, Sanae El Harane, Urs Granacher, Abdelhalem Mesfioui, École nationale des sciences appliquées [Kenitra] (ENSA), Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut International des Sciences du Sport (2I2S), Université Mohammed V de Rabat [Agdal] (UM5), University of British Columbia [Vancouver], Université de Genève = University of Geneva (UNIGE), University of Freiburg [Freiburg], and The authors acknowledge the support of the Deutsche Forschungsgemeinschaft (DFG) and Open Access Publishing Fund of the University of Freiburg, Germany.
Subjects: endurance, exercise, training, running, orthodontic pathologies, [SDV]Life Sciences [q-bio], Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine
Abstract: Oral pathologies can cause athletic underperformance. The aim of this study was to determine the effect of malocclusion on maximal aerobic capacity in young athletes with the same anthropometric data, diet, training mode, and intensity from the same athletics training center. Sub-elite track and field athletes (middle-distance runners) with malocclusion (experimental group (EG); n = 37; 21 girls; age: 15.1 ± 1.5 years) and without malocclusion (control group (CG); n = 13; 5 girls; age: 14.7 ± 1.9 years) volunteered to participate in this study. Participants received an oral diagnosis to examine malocclusion, which was defined as an overlapping of teeth that resulted in impaired contact between the teeth of the mandible and the teeth of the upper jaw. Maximal aerobic capacity was assessed using the VAMEVAL test (calculated MAS and estimated VO2max). The test consisted of baseline values that included the following parameters: maximum aerobic speed (MAS), maximal oxygen uptake (VO2max), heart rate frequency, systolic (SAP) and diastolic arterial pressure (DAP), blood lactate concentration (LBP), and post-exercise blood lactate assessment (LAP) after the performance of the VAMEVAL test. There were no statistically significant differences between the two study groups related to either anthropometric data (age: EG = 15.1 ± 1.5 vs. CC = 14.7 ± 1.9 years (p = 0.46); BMI: EG = 19.25 ± 1.9 vs. CC = 19.42 ± 1.7 kg/m2 (p = 0.76)) or for the following physical fitness parameters and biomarkers: MAS: EG = 15.5 (14.5–16.5) vs. CG = 15.5 (15–17) km/h (p = 0.47); VO2max: EG = 54.2 (52.5–58.6) vs. CG = 54.2 (53.4–59.5) mL/kg/min (p = 0.62) (IQR (Q1–Q3)); heart rate before the physical test: EG = 77.1 ± 9.9 vs. CG = 74.3 ± 14.0 bpm (p = 0.43); SAP: EG = 106.6 ± 13.4 vs. CG = 106.2 ± 14.8 mmHg (p = 0.91); DAP: EG = 66.7 ± 9.1 vs. CG = 63.9 ± 10.2 mmHg (p = 0.36); LBP: EG = 1.5 ± 0.4 vs. CG = 1.3 ± 0.4 mmol/L (p = 0.12); and LAP: EG = 4.5 ± 2.36 vs. CG = 4.06 ± 3.04 mmol/L (p = 0.60). Our study suggests that dental malocclusion does not impede maximal aerobic capacity and the athletic performance of young track and field athletes.
Published: 2023

26. An interdisciplinary approach of the family in East Africa: insights from past and current research

Author: Clémentine Rossier, Valérie Golaz, Yonatan Nissim Gez, Yvan Droz, Université de Genève = University of Geneva (UNIGE), Institut national d'études démographiques (INED), Laboratoire Population-Environnement-Développement (LPED), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)
Subjects: literature review, Kinship, General Engineering, Family, East Africa, [SHS]Humanities and Social Sciences
Abstract: International audience; This paper presents an overview of the literature on the family in East Africa over the past several decades. The recent literature on family and kinship in this region is rather scant. Moreover it is anchored in different disciplinary approaches, each implying specific sources, methods, and geographies. While this diversity is enriching, it complicates cross-disciplinary and cross-national comparisons, slowing the identification of common trends and local specificities. As rapid social change is underway across East Africa, knowledge on new family configurations and family-related vulnerabilities is needed. One promising avenue in this regard consists in redefining the objects of analysis through an interdisciplinary lens and working at different scales.
Published: 2023

27. Investigation of Dengue Infection in Asymptomatic Individuals during a Recent Outbreak in La Réunion

Author: Olga De Santis, Emilie Pothin, Nicolas Bouscaren, Seth R. Irish, Marie-Christine Jaffar-Bandjee, Luce Menudier, Julie Ramis, Cédric Schultz, Florence Lamaurt, Ania Wisniak, Antoine Bertolotti, Sarah Hafsia, Philippe Dussart, Laurence Baril, Patrick Mavingui, Antoine Flahault, Centre d'Investigation Clinique de La Réunion - INSERM (CIC 1410), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Université de Genève = University of Geneva (UNIGE), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), and This research was funded mainly by the Swiss National Foundation for Scientific Research, grant number 179532. The first author, Olga DE SANTIS, was also funded by the GlobalP3HS program for Global Ph.D. Fellowship in Public Health Sciences, funded by Marie Sklodowska-Curie Actions (Horizon 2020–COFUND). INSERM Reacting contributed to the funding of the research. Part of the blood analyses was funded by the European Regional Development Fund through RUNDENG project number RE0022937.
Subjects: dengue, asymptomatic infections, La Réunion, cluster study, dengue outbreak, Infectious Diseases, Virology, [SDV]Life Sciences [q-bio]
Abstract: International audience; The number of dengue cases has increased dramatically over the past 20 years and is an important concern, particularly as the trends toward urbanization continue. While the majority of dengue cases are thought to be asymptomatic, it is unknown to what extent these contribute to transmission. A better understanding of their importance would help to guide control efforts. In 2019, a dengue outbreak in La Reunion resulted in more than 18,000 confirmed cases. Between October 2019 and August 2020, 19 clusters were investigated in the south, west, and east of the island, enabling the recruitment of 605 participants from 368 households within a 200 m radius of the home of the index cases (ICs). No active asymptomatic infections confirmed by RT-PCR were detected. Only 15% were possible asymptomatic dengue infections detected by the presence of anti-dengue IgM antibodies. Only 5.3% of the participants had a recent dengue infection confirmed by RT-PCR. Although the resurgence of dengue in La Réunion is very recent (2016), the rate of anti-dengue IgG positivity, a marker of past infections, was already high at 43% in this study. Dengue transmission was focal in time and space, as most cases were detected within a 100-m radius of the ICs, and within a time interval of less than 7 days between infections detected in a same cluster. No particular demographic or socio-cultural characteristics were associated with dengue infections. On the other hand, environmental risk factors such as type of housing or presence of rubbish in the streets were associated with dengue infections.
Published: 2023
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28. Stereoisomer‐specific reprogramming of a bacterial flagellin sialyltransferase

Author: Nicolas Kint, Thomas Dubois, Patrick H Viollier, Université de Genève = University of Geneva (UNIGE), Unité Matériaux et Transformations - UMR 8207 (UMET), and Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: flagellum, Gglyco-profiling, General Immunology and Microbiology, glycosylation, General Neuroscience, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Flm, Molecular Biology, General Biochemistry, Genetics and Molecular Biology, sialic acids
Abstract: Glycosylation of surface structures diversifies cells chemically and physically. Nucleotide-activated sialic acids commonly serve as glycosyl donors, particularly pseudaminic acid (Pse) and its stereoisomer legionaminic acid (Leg), which decorate eubacterial and archaeal surface layers or protein appendages. FlmG, a recently identified protein sialyltransferase, O-glycosylates flagellins, the subunits of the flagellar filament. We show that flagellin glycosylation and motility in Caulobacter crescentus and Brevundimonas subvibrioides is conferred by functionally insulated Pse and Leg biosynthesis pathways, respectively, and by specialized FlmG orthologs. We established a genetic glyco-profiling platform for the classification of Pse or Leg biosynthesis pathways, discovered a signature determinant of eubacterial and archaeal Leg biosynthesis, and validated it by reconstitution experiments in a heterologous host. Finally, by rewiring FlmG glycosylation using chimeras, we defined two modular determinants that govern flagellin glycosyltransferase specificity: a glycosyltransferase domain that either donates Leg or Pse and a specialized flagellin-binding domain that identifies the acceptor.
Published: 2023

29. Ten years of INTEGRAL observations of the hard X-ray emission from SGR 1900+14

Author: Lorenzo Ducci, Andrea Santangelo, D. Gotz, Sandro Mereghetti, Institut für Astronomie und Astrophysik [Tübingen] (IAAT), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, INTEGRAL Science Data Center (ISDC), Geneva Observatory, University of Geneva [Switzerland]-University of Geneva [Switzerland], Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano (IASF-MI), Istituto Nazionale di Astrofisica (INAF), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), and Eberhard Karls Universität Tübingen
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Photon, X-ray, FOS: Physical sciences, Flux, Astronomy and Astrophysics, Astrophysics, gamma rays: general, pulsars: individual: SGR 1900+14, 01 natural sciences, Power law, Luminosity, 010309 optics, Space and Planetary Science, pulsars: general, 0103 physical sciences, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics
Abstract: We exploited the high sensitivity of the INTEGRAL IBIS/ISGRI instrument to study the persistent hard X-ray emission of the soft gamma-ray repeater SGR 1900+14, based on ~11.6 Ms of archival data. The 22-150 keV INTEGRAL spectrum can be well fit by a power law with photon index 1.9 +/- 0.3 and flux F_x = (1.11 +/- 0.17)E-11 erg/cm^2/s (20-100 keV). A comparison with the 20-100 keV flux measured in 1997 with BeppoSAX, and possibly associated with SGR 1900+14, shows a luminosity decrease by a factor of ~5. The slope of the power law above 20 keV is consistent within the uncertainties with that of SGR 1806-20, the other persistent soft gamma-ray repeater for which a hard X-ray emission extending up to 150 keV has been reported., Comment: Accepted for publication in Astronomy & Astrophysics. 4 pages
Published: 2015

30. The student-institution fit at university: interactive effects of academic competition and social class on achievement goals

Author: MickaÃ«l Jury, Nicolas Sommet, Gabriel Mugny, Alain Quiamzade, Université de Genève (UNIGE), Université de Lausanne (UNIL), Laboratoire de psychologie sociale et de psychologie cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Université de Genève = University of Geneva [UNIGE], Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC], Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), and Université de Lausanne = University of Lausanne (UNIL)
Subjects: student-institution fit, media_common.quotation_subject, lcsh:BF1-990, Identity (social science), [SHS.PSY]Humanities and Social Sciences/Psychology, 050109 social psychology, Context (language use), Bachelor, Social class, Competition (economics), ddc:150, First- and continuing-generation students, academic competition, Institution, Mathematics education, achievement goals, first-and continuing-generation students, Psychology, 0501 psychology and cognitive sciences, Curriculum, achievement gap, first- and continuing-generation students, General Psychology, media_common, Original Research, 4. Education, 05 social sciences, 050301 education, Achievement gap, Achievement goals, Academic competition, lcsh:Psychology, social class, [SCCO.PSYC]Cognitive science/Psychology, Student-institution fit, 0503 education, Graduation
Abstract: International audience; As compared to continuing-generation students, first-generation students are struggling more at university. In the present article, we question the unconditional nature of such a phenomenon and argue that it depends on structural competition. Indeed, most academic departments use harsh selection procedure all throughout the curriculum, fostering between-student competition. In these departments, first-generation students tend to suffer from a lack of student-institution fit, that is, inconsistencies with the competitive institution's culture, practices, and identity. However, one might contend that in less competitive academic departments continuing-generation students might be the ones experiencing a lack of fit. Using a cross-sectional design, we investigated the consequences of such a context-and category-dependent lack of fit on the endorsement of scholastically adaptive goals. We surveyed N = 378 first-and continuing-generation students from either a more competitive or a less competitive department in their first or final year of bachelor's study. In the more competitive department, first-to-third year decrease of mastery goals (i.e., the desire to learn) was found to be steeper for first-than for continuing-generation students. In the less competitive department, the reversed pattern was found. Moreover, first-to-third year decrease of performance goals (i.e., the desire to outperform others) was found to be steeper within the less competitive department but did not depend on social class. This single-site preliminary research highlights the need to take the academic context into account when studying the social class graduation gap.
Published: 2015
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31. Judgment of musical emotions after cochlear implantation in adults with progressive deafness

Author: Emmanuèle eAmbert-Dahan, Anne-Lise eGiraud, Olivier eSterkers, Séverine eSamson, Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE), Chirurgie otologique mini-invasive robotisée, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 (PSITEC), Université de Lille, Université de Lille, LillOA, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Genève = University of Geneva (UNIGE), Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - EA 4072, Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - ULR 4072, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab], Université de Genève = University of Geneva [UNIGE], and Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC]
Subjects: medicine.medical_specialty, media_common.quotation_subject, medicine.medical_treatment, lcsh:BF1-990, acquired deafness, emotion, Musical, Audiology, behavioral disciplines and activities, Arousal, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, Rhythm, arousal, Cochlear implant, medicine, otorhinolaryngologic diseases, Psychology, music, Original Research Article, Valence (psychology), valence, 030223 otorhinolaryngology, 10. No inequality, General Psychology, media_common, cochlear implant, [SCCO] Cognitive science, humanities, ddc:616.8, Sadness, lcsh:Psychology, Happiness, Emotion, Social psychology, Timbre, 030217 neurology & neurosurgery
Abstract: While cochlear implantation is rather successful in restoring speech comprehension in quiet environments (Nimmons et al., 2008), other auditory tasks, such as music perception, can remain challenging for implant users. Here, we tested how patients who had received a cochlear implant (CI) after post-lingual progressive deafness perceive emotions in music. Thirteen adult CI recipients with good verbal comprehension (dissyllabic words ≥ 70%) and 13 normal hearing participants matched for age, gender, and education listened to 40 short musical excerpts that selectively expressed fear, happiness, sadness, and peacefulness (Vieillard et al., 2008). The participants were asked to rate (on a 0 to 100 scale) how much the musical stimuli expressed these four cardinal emotions, and to judge their emotional valence (unpleasant-pleasant) and arousal (relaxing-stimulating). Although CI users performed above chance level, their emotional judgments (mean correctness scores) were generally impaired for happy, scary, and sad, but not for peaceful excerpts. CI users also demonstrated deficits in perceiving arousal of musical excerpts, whereas rating of valence remained unaffected. The current findings indicate that judgments of emotional categories and dimensions of musical excerpts are not uniformly impaired after cochlear implantation. These results are discussed in relation to the relatively spared abilities of CI users in perceiving temporal (rhythm and metric) as compared to spectral (pitch and timbre) musical dimensions, which might benefit the processing of musical emotions (Cooper et al., 2008).
Published: 2015

32. CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells

Author: Bellec, Jessica, Bacchetta, Marc, Losa, Davide, Anegon, Ignacio, Chanson, Marc, Nguyen, Tuan, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), laboratory of clinical investigation III [Geneva, Switzerland], Geneva University Hospitals - HUG [Switzerland]-University of Geneva [Switzerland], laboratory of clinical investigation III, University of Geneva [Switzerland], Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Genève = University of Geneva (UNIGE)-Geneva University Hospitals - HUG [Switzerland], Université de Genève = University of Geneva (UNIGE), and Le Bihan, Sylvie
Subjects: Cystic Fibrosis, [SDV]Life Sciences [q-bio], Genetic Vectors, Respiratory System, Cystic Fibrosis Transmembrane Conductance Regulator, Gene Expression, Primary cells, Cystic fibrosis, Cell Line, RNA interference, Cell Movement, Humans, Clustered Regularly Interspaced Short Palindromic Repeats, RNA, Small Interfering, CFTR, Cell Proliferation, Genome, ddc:618, Interleukin-8, Lentivirus, Epithelial Cells, Genetic Therapy, [SDV] Life Sciences [q-bio], RNA Interference, Lentiviral vector, CRISPR-Cas9, Biotechnology
Abstract: © 2015 Bentham Science Publishers. Background: Polarized airway epithelial cell cultures modelling Cystic Fibrosis Transmembrane conductance Regulator (CFTR) defect are crucial for CF and biomedical research. RNA interference has proven its value to generate knockdown models for various pathologies. More recently, genome editing using CRISPR-Cas9 artificial endonuclease was a valuable addition to the toolbox of gene inactivation. Methods: Calu-3 cells and primary HAECs were transduced with HIV-1-derived lentiviral vectors (LVV) encoding small hairpin RNA (shRNA) sequence or CRISPR-Cas9 components targeting CFTR alongside GFP. After sorting of GFP-positive cells, CFTR expression was measured by RT-qPCR and Western blot in polarized or differentiated cells. CFTR channel function was assessed in Ussing chambers. Il-8 secretion, proliferation and cell migration were also studied in transduced cells. Results: shRNA interference and CRISPRCas9 strategies efficiently decreased CFTR expression in Calu-3 cells. Strong CFTR knockdown was confirmed at the functional level in CRISPR-Cas9-modified cells. CFTR-specific shRNA sequences did not reduce gene expression in primary HAECs, whereas CRISPR-Cas9-mediated gene modification activity was correlated with a reduction of transepithelial secretion and response to a CFTR inhibitor. CFTR inactivation in the CRISPR-Cas9-modified Calu-3 cells did not affect migration and proliferation but slightly increased basal interleukin-8 secretion. Conclusion: We generated CFTRinactivated cell lines and demonstrated that CRISPR-Cas9 vectorised in a single LVV efficiently promotes CFTR inactivation in primary HAECs. These results provide a new protocol to engineer CF primary epithelia with their isogenic controls and pave the way for manipulation of CFTR expression in these cultures.
Published: 2015

33. The JEM-EUSO mission : an introduction

Author: J. Karczmarczyk, A. Haungs, T. Murakami, Tomás Belenguer, Piero Vallania, M. D. Sabau, M. Serra, J. Bayer, C. de la Taille, K. Katahira, Luis A. Anchordoqui, T. Batsch, D. Supanitsky, Hanna Rothkaehl, R. Nava, N. Sakaki, Y. Karadzhov, I. Kaneko, K. Mase, J. Watts, L. Valore, Rossella Caruso, H. J. Crawford, C. Pennypacker, I. Rodríguez, Shoichi Ogio, Patrick J. Reardon, Toshiki Tajima, G. Siemieniec-Oziȩbło, G. Masciantonio, Hitoshi Ohmori, Yoshiya Kawasaki, D. Allard, G. Castellini, M. E. Bertaina, Ken'ichi Nomoto, Silvia Ferrarese, Toshiyuki Nonaka, P. Prat, R. Young, M. Sakata, A. Guzmán, I. V. Yashin, T. Shirahama, T. Shibata, Alberto Cellino, P. Picozza, J. Lee, I. Fernández-Gómez, P. Baragatti, L. Marcelli, Ralph Engel, M. Karus, G. Sáez Cano, M. Nagata, A. Ebersoldt, L. Villaseñor, A. Bruno, Jeong-Sook Kim, L. R. Wiencke, J. Błȩcki, Karl Mannheim, D. Ikeda, D. Monnier-Ragaigne, A. Segreto, F. Tajima, Lech Wiktor Piotrowski, M. Rybczyński, Michael S. Briggs, A. J. de Castro, F. Sarazin, Domenico Finco, H. Lim, Frederic Trillaud, P. Gorodetzky, Dmitry V. Naumov, R. Bechini, Marc Weber, Katsuaki Asano, G. Cordero, M. C. Maccarone, Piotr Orleanski, N. Blanc, S. Piraino, J.N. Capdevielle, T. Patzak, S. Yoshida, J. Szabelski, Francesco Fenu, Yoshiki Tsunesada, Hiroyuki Sagawa, M. Wille, Andrii Neronov, Y. Uchihori, R. Matev, G. Giraudo, M. Suzuki, Satoshi Wada, H. Sato, C. De Donato, Markus Roth, J. N. Albert, T. Ogawa, Hajime Takami, B. A. Khrenov, G. Distratis, Fausto Guarino, O. Martinez, Masaki Fukushima, Thomas Schanz, Soon-Wook Kim, Takuji Nakamura, Jianyi Yang, Yoshitaka Itow, Shigeto Watanabe, H. Miyamoto, D. Maravilla, P. von Ballmoos, M. Ricci, K. Shinozaki, Angela V. Olinto, Fernando López, Andrea Santangelo, S. Selmane, Livio Conti, J. Fujimoto, A. Anzalone, Barbara Szabelska, T. Peter, David B. Cline, A. Zuccaro Marchi, Maxim Gonchar, Hirohiko M. Shimizu, M. D. Rodríguez Frías, F. Cafagna, G. Modestino, E. Joven, D. Campana, Francesco Isgrò, F. Dulucq, Z. Plebaniak, J. Blümer, Valentina Scotti, B. Keilhauer, Graciela B. Gelmini, M. Flamini, P. L. Biermann, Jörn Wilms, Javier Licandro, M. I. Panasyuk, J. F. Valdés-Galicia, L. G. Tkachev, O. A. Saprykin, Michiyuki Chikawa, B. Mot, Y. Hachisu, Inkyu Park, Frederic Jean Ronga, M. Dupieux, S. Csorna, T. Napolitano, S. Perez Cano, Y. Takizawa, L. Santiago Crúz, M. Putis, Humberto Ibarguen Salazar, Y. Arai, G. Vankova, I. Rusinov, A. Sobey, Y. Miyazaki, S. Blin-Bondil, C. De Santis, H. Tokuno, Y. Yamamoto, A. Insolia, M. Kleifges, Yukihiro Takahashi, B. Pastirčák, E. G. Judd, T. Pierog, M. Ave Pernas, Katsuhiko Tsuno, H. Prieto, R. Cremonini, S. Biktemerova, J. Watanabe, Pierre Barrillon, Mark Christl, O. Tibolla, Osvaldo Catalano, Gali Garipov, K. Kawai, I. Kreykenbohm, Sergei A. Sharakin, R. Tsenov, Vladimir Andreev, Marcos Reyes, Marco Casolino, Claudio Fornaro, K. Belov, C. Catalano, A. Pollini, J. Hernández Carretero, Pavel Klimov, M. Unger, C. Lachaud, S. Dagoret-Campagne, M. Di Martino, A. Marini, Toshikazu Ebisuzaki, T. J. Weiler, G. Osteria, S. Sánchez, S. Ahmad, Yoshimasa Kurihara, T. Tymieniecka, J. Sledd, H. Schieler, Mitsuteru Sato, C. González Alvarado, Alfonso Monaco, C. Blaksley, N. Tone, Ke Fang, M. Nagano, Taka Tomida, Daisuke Yonetoku, Roberto Bellotti, Andreas A. Berlind, M. Sanz Palomino, Tokonatsu Yamamoto, James H. Adams, M. Yu. Zotov, D. Kolev, Valerie Connaughton, H. H. Silva Lopez, Susana Briz, S. Falk, H. Ikeda, V. S. Morozenko, Hajime Yano, A. Dell’Oro, Toshitaka Kajino, K. Higashide, C. Moretto, P. Galeotti, C. Tenzer, T. Sugiyama, Tadeusz Wibig, K. Kudela, G. Roudil, B. Harlov, Carlo Vigorito, N. Tajima, M. Takeda, Shigehiro Nagataki, Guillaume Prévôt, M. Bogomilov, F. Kajino, H. W. Park, Massimiliano Bonamente, E. Kuznetsov, Alexander Kusenko, K. Słomińska, Akinori Saito, Ovidiu Vaduvescu, M. Lacombe, Claudio Cassardo, Dmitri Semikoz, Sug-Whan Kim, T. Mernik, Z. Włodarczyk, Simona Toscano, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Pavol Bobik, J. A. Morales de los Ríos, Susumu Inoue, A. Jung, T. Paul, K. Yoshida, G. Medina-Tanco, J. Geary, N. De Simone, Yoshihiko Mizumoto, Organisation de Micro-Électronique Générale Avancée (OMEGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratori Nazionali del Sud (LNS), Istituto Nazionale di Fisica Nucleare (INFN), Division of Biology, Kansas State University, Kansas State University, CTC, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astrofisico di Torino (OATo), Istituto Nazionale di Astrofisica (INAF), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Universities Space Research Association (USRA), Regione Emilia Romagna, Servizio Tecnico Bacini Enza e sinistra Secchia, Institute for Data Processing and Electronics (IPE), Karlsruhe Institute of Technology (KIT), Institute for Ecology, Universität Greifswald - University of Greifswald, Tokushima research center, Department of Physics and Astronomy [UCLA, Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Istituto Nazionale di Fisica Nucleare, Sezione di Torino (INFN, Sezione di Torino), Institute of Applied Biotechnology and Basic Sciences, Rzeszow University, Department of Mechanical System (Hiroshima University), Hiroshima University, Nagoya University, Department of Pathology, Ludwig-Maximilians-Universität München (LMU), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Institute of Experimental Physics of Kosice, Slovak Academy of Sciences (SAS), KEK (High energy accelerator research organization), iMagX/MIRO, Université Catholique de Louvain = Catholic University of Louvain (UCL), Instituto de Astrofisica de Canarias (IAC), The Open University of Japan [Chiba] (OUJ), Tohoku University [Sendai], Department of Earth and Planetary Science [Tokyo], Graduate School of Science [Tokyo], The University of Tokyo (UTokyo)-The University of Tokyo (UTokyo), Department of Electrical Engineering and Computer Sciences, University of Hyogo, INTEGRAL Science Data Center (ISDC), Geneva Observatory, Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE), Service de dermatologie et vénéréologie (CHUV Lausanne), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institute for Surgical Technology and Biomechanics [Bern] (ISTB), University of Bern, Centre IRMf de Marseille, Université de la Méditerranée - Aix-Marseille 2, Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Centre d'étude spatiale des rayonnements (CESR), Center for Mathematics and Physics, University of Aizu, Centre de recherche sur la Paléobiodiversité et les Paléoenvironnements (CR2P), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Colorado School of Mines, Department of Physics (Department of Physics), Tokyo Metropolitan University [Tokyo] (TMU), Department of Radiation-Oncology, Università degli Studi di Firenze = University of Florence (UniFI), Graduate School of Materials Science, Nara Institute os Science and Technology, Observatoire océanologique de Banyuls (OOB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Kernphysik (MPIK), Max-Planck-Gesellschaft, Vrije Universiteit Brussel (VUB), Laboratoire de Génie Electrique de Grenoble (G2ELab), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Institute of Sensor and Actuator Systems, Vienna University of Technology (TU Wien), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Luxembourg Institute of Science and Technology (LIST), Dr. Karl-Remeis-Sternwarte, Erlangen Centre for Astroparticle Physics (ECAP), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Kyoto University, University of Connecticut (UCONN), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), National Institute for Nuclear Physics (INFN), University of Bari and INFN section of Bari, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), University of California-University of California, Université Catholique de Louvain (UCL), The University of Tokyo, University of Geneva [Switzerland]-University of Geneva [Switzerland], Polska Akademia Nauk (PAN), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Tokyo Metropolitan University [Tokyo], University of Florence (UNIFI), High Energy Accelerator Research Organization (KEK), University of Tsukuba, Vrije Universiteit [Brussels] (VUB), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Technical University of Vienna [Vienna] (TU WIEN), PSL Research University (PSL)-PSL Research University (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Kyoto University [Kyoto], Adams, J. H., Ahmad, S., Albert, J. N., Allard, D., Anchordoqui, L., Andreev, V., Anzalone, A., Arai, Y., Asano, K., Ave Pernas, M., Baragatti, P., Barrillon, P., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Blaksley, C., Blanc, N., Błȩcki, J., Blin Bondil, S., Blã¼mer, J., Bobik, P., Bogomilov, M., Bonamente, M., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J. N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Cline, D., Connaughton, V., Conti, L., Cordero, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Dell’Oro, A., De Simone, N., Di Martino, M., Distratis, G., Dulucq, F., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., FernÃ¡ndez GÃ³mez, I., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Franceschi, A., Fujimoto, J., Fukushima, M., Galeotti, P., Garipov, G., Geary, J., Gelmini, G., Giraudo, G., Gonchar, M., GonzÃ¡lez Alvarado, C., Gorodetzky, P., Guarino, Fausto, Guzmã¡n, A., Hachisu, Y., Harlov, B., Haungs, A., HernÃ¡ndez Carretero, J., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgro', Francesco, Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Keilhauer, B., Khrenov, B. A., Kim, Jeong Sook, Kim, Soon Wook, Kim, Sug Whan, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lee, J., Licandro, J., Lim, H., Lã³pez, F., Maccarone, M. C., Mannheim, K., Maravilla, D., Marcelli, L., Marini, A., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Medina Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier Ragaigne, D., Morales de los RÃos, J. A., Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Panasyuk, M. I., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Perez Cano, S., Peter, T., Picozza, P., Pierog, T., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Prat, P., Prã©vã´t, G., Prieto, H., Putis, M., Reardon, P., Reyes, M., Ricci, M., Rodrãguez, I., Frãas, M. D. RodrÃguez, Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., SÃ¡ez Cano, G., Sagawa, H., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sã¡nchez, S., Santangelo, A, Santiago CrÃºz, L., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec Oziȩbło, G., Silva LÃ³pez, H. H., Sledd, J., Słomińska, K., Sobey, A., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Trillaud, F., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., ValdÃ©s Galicia, J. F., Vallania, P., Valore, Laura, Vankova, G., Vigorito, C., Villaseã±or, L., von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zotov, M. Y. u., Zuccaro Marchi, A., École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Università degli studi di Bari Aldo Moro (UNIBA), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo (UTokyo), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: Photon, Aperture, Ciencias Físicas, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Cosmic ray, ultra-high energy cosmic rays, Astrophysics, law.invention, Telescope, Atmosphere, law, International Space Station, Neutrino, Ultra-high energy cosmic rays, Neutrinos, Neutrinos, Ultra-high energy cosmic ray, ComputingMilieux_MISCELLANEOUS, media_common, Physics, [PHYS]Physics [physics], Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, neutrinos, Astronomy and Astrophysics, Ultra-high energy cosmic rays, Astronomy and Astrophysic, Universe, Astronomía, Space and Planetary Science, Physics::Space Physics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], CIENCIAS NATURALES Y EXACTAS
Abstract: 注記: The JEM-EUSO Collaboration 288名 [所属. 宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS) 池田, 博一; 鈴木, 睦; 矢野, 創], Accepted: 2015-10-19, Note: The JEM-EUSO Collaboration 288members [Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS) Ikeda, Hirokazu; Suzuki, Makoto; Yano, Hajime], 資料番号: SA1150231000
Published: 2015

34. Reflection-in-Action Markers for Reflection-on-Action in Computer-Supported Collaborative Learning Settings

Author: Gaëlle Molinari, Yannick Prié, Elise Lavoué, Safè Khezami, Situated Interaction, Collaboration, Adaptation and Learning (SICAL), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Université Lumière - Lyon 2 (UL2), Centre de Recherche Magellan, Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut d'Administration des Entreprises (IAE) - Lyon, Technologies de Formation et Apprentissage (TECFA), Faculté de Psychologie et des Sciences de l'Education (FPSE), Université de Genève (UNIGE)-Université de Genève (UNIGE), Laboratoire d'Informatique de Nantes Atlantique (LINA), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Information, Milieux, Médias, Médiations - EA 3820 (I3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Recherche Magellan, Université de Genève = University of Geneva (UNIGE)-Université de Genève = University of Geneva (UNIGE), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
Subjects: FOS: Computer and information sciences, General Computer Science, Exploratory research, 050109 social psychology, Education, Computer Science - Computers and Society, Computers and Society (cs.CY), 0501 psychology and cognitive sciences, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], Group work, Reflection (computer graphics), Set (psychology), distance education and telelearning, computer-mediated communication, Reflection in action, 4. Education, 05 social sciences, 050301 education, Action (philosophy), Computer-supported collaborative learning, [INFO.EIAH]Computer Science [cs]/Technology for Human Learning, Computer-mediated communication, Psychology, 0503 education, Social psychology, cooperative/collaborative learning, Cognitive psychology
Abstract: We describe an exploratory study on the use of markers set during a synchronous collaborative interaction (reflection-in-action) for later construction of reflection reports upon the collaboration that occurred (reflection-on-action). During two sessions, pairs of students used the Visu videoconferencing tool for synchronous interaction and marker setting (positive, negative or free) and then individual report building on the interaction (using markers or not). A quantitative descriptive analysis was conducted on the markers put in action, on their use to reflect on action and on the reflection categories of the sentences in these reports. Results show that the students (1) used the markers equally as a note-taking and reflection means during the interaction, (2) used mainly positive markers both to reflect in and on action; (3) paid more attention in identifying what worked in their interaction (conservative direction) rather than in planning on how to improve their group work (progressive direction); (4) used mainly their own markers to reflect on action, with an increase in the use of their partners's markers in the second reflection reports; (5) reflected mainly on their partner in the first reflection reports and more on themselves in the second reports to justify themselves and to express their satisfaction., Accepted for publication by Computers & Education
Published: 2015

35. Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish

Author: Deepak Khatri, Audrey Putoux, Audric Cologne, Sophie Kaltenbach, Alicia Besson, Eloïse Bertiaux, Justine Guguin, Adèle Fendler, Marie A. Dupont, Clara Benoit-Pilven, Leila Qebibo, Samira Ahmed-Elie, Séverine Audebert-Bellanger, Pierre Blanc, Thomas Rambaud, Martin Castelle, Gaëlle Cornen, Sarah Grotto, Agnès Guët, Laurent Guibaud, Caroline Michot, Sylvie Odent, Lyse Ruaud, Elise Sacaze, Virginie Hamel, Rémy Bordonné, Anne-Louise Leutenegger, Patrick Edery, Lydie Burglen, Tania Attié-Bitach, Sylvie Mazoyer, Marion Delous, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Genève = University of Geneva (UNIGE), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Hôpital Morvan [Brest], CH Morlaix, Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Hôpital Louis Mourier - AP-HP [Colombes], Université de Lyon, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Hôpital Robert Debré, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), This work was supported by CNRS, Inserm, Université de Montpellier, Université Paris 7 and Université Lyon 1 through recurrent funding, the Fondation Maladies Rares ('Small Animal Models and Rare Diseases' program, no. 20161207), the Agence Nationale de la Recherche (no. ANR-18CE12-0007-01), and the Fondation pour la recherche sur le Cerveau « Espoir en tête » (confocal microscope). E.B. was supported by an European Molecular Biology Organization long-term fellowship (ALTF-284-2019) and the Novartis Foundation for medical-biological Research (18B112)., and ANR-18-CE12-0007,U4ATAC-BRAIN,Rôle de l'épissage mineur dans le développement cérébral(2018)
Subjects: minor introns, [SDV.GEN]Life Sciences [q-bio]/Genetics, Multidisciplinary, MESH: Humans, MESH: Mutation, MESH: Fetal Growth Retardation, MESH: RNA, Small Nuclear, U4atac, splicing, genetic disease, MESH: Ciliopathies, MESH: Animals, MESH: Zebrafish, MESH: Female, MESH: Spliceosomes, primary cilium
Abstract: In the human genome, about 750 genes contain one intron excised by the minor spliceosome. This spliceosome comprises its own set of snRNAs, among which U4atac. Its noncoding gene, RNU4ATAC , has been found mutated in Taybi-Linder (TALS/microcephalic osteodysplastic primordial dwarfism type 1), Roifman (RFMN), and Lowry-Wood (LWS) syndromes. These rare developmental disorders, whose physiopathological mechanisms remain unsolved, associate ante- and post-natal growth retardation, microcephaly, skeletal dysplasia, intellectual disability, retinal dystrophy, and immunodeficiency. Here, we report bi-allelic RNU4ATAC mutations in five patients presenting with traits suggestive of the Joubert syndrome (JBTS), a well-characterized ciliopathy. These patients also present with traits typical of TALS/RFMN/LWS, thus widening the clinical spectrum of RNU4ATAC -associated disorders and indicating ciliary dysfunction as a mechanism downstream of minor splicing defects. Intriguingly, all five patients carry the n.16G>A mutation, in the Stem II domain, either at the homozygous or compound heterozygous state. A gene ontology term enrichment analysis on minor intron-containing genes reveals that the cilium assembly process is over-represented, with no less than 86 cilium-related genes containing at least one minor intron, among which there are 23 ciliopathy-related genes. The link between RNU4ATAC mutations and ciliopathy traits is supported by alterations of primary cilium function in TALS and JBTS-like patient fibroblasts, as well as by u4atac zebrafish model, which exhibits ciliopathy-related phenotypes and ciliary defects. These phenotypes could be rescued by WT but not by pathogenic variants-carrying human U4atac. Altogether, our data indicate that alteration of cilium biogenesis is part of the physiopathological mechanisms of TALS/RFMN/LWS, secondarily to defects of minor intron splicing.
Published: 2023

36. The Hubble PanCET program: The near-ultraviolet transmission spectrum of WASP-79b

Author: A. Gressier, A. Lecavelier des Etangs, D. K. Sing, M. López-Morales, M. K. Alam, J. K. Barstow, V. Bourrier, L. A. Dos Santos, A. García Muñoz, J. D. Lothringer, N. K. Nikolov, K. S. Sotzen, G. W. Henry, T. Mikal-Evans, PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Pôle Planétologie du LESIA, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Space Telescope Science Institute (STSci), Morton K. Blaustein Department of Earth and Planetary Sciences [Baltimore], Johns Hopkins University (JHU), Department of Physics and Astronomy [Baltimore], Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University-Smithsonian Institution, Carnegie Institution for Science, School of Physical Sciences [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Geneva Observatory, Université de Genève = University of Geneva (UNIGE), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Utah Valley University (UVU), Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), Tennessee State University, Max-Planck-Institut für Astronomie (MPIA), and Max-Planck-Gesellschaft
Subjects: stars, Earth and Planetary Astrophysics (astro-ph.EP), photometry, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Space and Planetary Science, planets and satellites, atmospheres, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: We present Hubble Space Telescope (HST) transit observations of the Hot-Jupiter WASP-79b acquired with the Space Telescope Imaging Spectrograph (STIS) in the near ultraviolet (NUV). Two transit observations, part of the PanCET program, are used to obtain the transmission spectra of the planet between 2280 and 3070{\AA}. We correct for systematic effects in the raw data using the jitter engineering parameters and polynomial modelling to fit the white light curves of the two transits. We observe an increase in the planet-to-star radius ratio at short wavelengths, but no spectrally resolved absorption lines. The difference between the radius ratios at 2400 and 3000{\AA} reaches $0.0191\pm0.0042$ ($\sim$4.5$-\sigma$). Although the NUV transmission spectrum does not show evidence of hydrodynamical escape, the strong atmospheric features are likely due to species at very high altitudes. We performed a 1D simulation of the temperature and composition of WASP-79b using Exo-REM. The temperature pressure profile crosses condensation curves of radiatively active clouds, particularly MnS, Mg$_2$SiO$_4$, Fe, and Al$_2$O$_3$. Still, none of these species produces the level of observed absorption at short wavelengths and can explain the observed increase in the planet's radius. WASP-79b's transit depth reaches 23 scale height, making it one of the largest spectral features observed in an exoplanet at this temperature ($\sim$1700 K). The comparison of WASP-79b's transmission spectrum with three warmer hot Jupiters shows a similar level of absorption to WASP-178b and WASP-121b between 0.2 and 0.3$\mu$m, while HAT-P-41b's spectrum is flat. The features could be explained by SiO absorption., Comment: Accepted for publication January 31, 2023 in the Journal Astronomy & Astrophysics
Published: 2023

37. BRASSINOSTEROID INSENSITIVE1 internalization can occur independent of ligand binding

Author: Lucas Alves Neubus Claus, Derui Liu, Ulrich Hohmann, Nemanja Vukašinović, Roman Pleskot, Jing Liu, Alexei Schiffner, Yvon Jaillais, Guang Wu, Sebastian Wolf, Daniël Van Damme, Michael Hothorn, Eugenia Russinova, Universiteit Gent = Ghent University (UGENT), Shandong Agricultural University (SDAU), VIB [Belgium], Université de Genève = University of Geneva (UNIGE), Austrian Academy of Sciences (OeAW), Institute of Experimental Botany of the Czech Academy of Sciences (IEB / CAS), Czech Academy of Sciences [Prague] (CAS), Shaanxi Normal University (SNNU), Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Reproduction et développement des plantes (RDP), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Center for Plant Systems Biology (PSB Center), Vlaams Instituut voor Biotechnologie [Ghent, Belgique] (VIB), and École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL)
Subjects: PERCEPTION, ligand-binding, RECEPTOR, Physiology, PROTEINS, ENDOCYTOSIS, Biology and Life Sciences, Plant Science, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, DEGRADATION, EXTRACELLULAR DOMAIN, BRI1, brassinosteroids, non-canonical, [SDE]Environmental Sciences, Genetics, KINASE, endocytosis, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, TRAFFICKING
Abstract: The brassinosteroid (BR) hormone and its plasma membrane (PM) receptor BR INSENSITIVE1 (BRI1) are one of the best-studied receptor–ligand pairs for understanding the interplay between receptor endocytosis and signaling in plants. BR signaling is mainly determined by the PM pool of BRI1, whereas BRI1 endocytosis ensures signal attenuation. As BRs are ubiquitously distributed in the plant, the tools available to study the BRI1 function without interference from endogenous BRs are limited. Here, we designed a BR binding-deficient Arabidopsis (Arabidopsis thaliana) mutant based on protein sequence-structure analysis and homology modeling of members of the BRI1 family. This tool allowed us to re-examine the BRI1 endocytosis and signal attenuation model. We showed that despite impaired phosphorylation and ubiquitination, BR binding-deficient BRI1 internalizes similarly to the wild type form. Our data indicate that BRI1 internalization relies on different endocytic machineries. In addition, the BR binding-deficient mutant provides opportunities to study non-canonical ligand-independent BRI1 functions.
Published: 2023

38. New insights into the relationship between mass eruption rate and volcanic column height based on the IVESPA dataset

Author: Thomas Jacques Aubry, Samantha L Engwell, Costanza Bonadonna, Larry Garver Mastin, Guillaume Carazzo, Alexa Van Eaton, David Jessop, Roy Gordon Grainger, Simona Scollo, Isabelle Alice Taylor, Mark Jellinek, Anja Schmidt, Sébastien Biass, Mathieu Gouhier, Université de Genève = University of Geneva (UNIGE), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement et la société-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Catania (INGV), Istituto Nazionale di Geofisica e Vulcanologia, and University of Cambridge [UK] (CAM)
Subjects: [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], [SDU.STU.VO]Sciences of the Universe [physics]/Earth Sciences/Volcanology
Abstract: Relating the mass eruption rate (MER) of explosive eruptions to column height in the atmosphere is key to reconstructing past eruptions and forecasting volcanic hazards. Using 134 eruptive events from the Independent Volcanic Eruption Source Parameter Archive (IVESPA v1.0), we explore the canonical MER-height relationship for four measures of column height: spreading level, sulfur dioxide height, and top height from both directly observed plumes and those reconstructed from deposits. These relationships show significant differences and should be chosen carefully for operational and research applications. The roles of atmospheric stratification, wind, and humidity remain challenging to assess across the large range of eruptive conditions in this database, ultimately resulting in empirical relationships outperforming analytical models that account for atmospheric conditions. This finding reveals the complexity of the height-MER relation that is difficult to constrain based on available heterogeneous observations, which reinforces the need for improved datasets to develop eruptive column models.
Published: 2023

39. Geodynamic controls in the southernmost Northern Andes magmatic arc:Trace elements and Hf-O isotopic systematics in forearc detrital zircon

Author: César Witt, Marc Poujol, Massimo Chiaradia, Diego Villagomez, Monique Seyler, Olivier Averbuch, Nordine Bouden, Université de Lille, Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), Tectonic Analysis Ltd, Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Institut National des Sciences de l’Univers (INSU)
Subjects: [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Geology
Abstract: U-Pb dating of single detrital zircon grains by laser ablation−inductively coupled plasma−mass spectrometry (LA-ICP-MS) paired with Hf and O isotopic and trace-element analyses provide first-order indicators of the Late Cretaceous−Cenozoic evolution of the southern Ecuadorian magmatic arc. Detrital zircon U-Pb ages define significant clusters that are tentatively interpreted as intense arc magmatism at ca. 72 Ma, ca. 60 Ma, and ca. 43 Ma. A major accretionary event in the Late Cretaceous (75−65 Ma) is marked by a broad range of zircon isotopic values (εHf[t] > 20 and δ18O > 8‰) that suggest melting of both the lower and upper crust (most likely of continental affinity) as well as enriched mantle components. Highly fractionated signatures in trace-element patterns and Eu/Eu* combined with mantle-like δ18O and juvenile εHf values characterize zircons from 60 to 45 Ma, suggesting that the Late Cretaceous−middle Eocene arc originated from an enriched mantle and likely reflects the persistence of overthickened crust previously attributed to the main Late Cretaceous accretionary period. Subsequently, negative shifts in εHf(t) isotopic composition from 45 to 30 Ma are paired with mantle-like δ18O values as well as decreases in U/Yb and Eu/Eu*. These signatures could be attributed to magma emplacement in a thinner crust and the existence of a broad extensional magmatic arc extending from the current forearc toward areas near the craton; however, other scenarios cannot be excluded. This event was characterized by enriched mantle melt sources with residence times pointing to known crustal events (Sunsás) in the Amazonian craton. From 30 to 10 Ma, the isotopic record slightly evolved toward a depleted mantle signature with a substantial increase in fractionation. Our results combined with previously published isotopic records from detrital zircon grains found in modern rivers suggest that, for at least the last 30 m.y., the southernmost Northern Andes magmatic arc has been segmented, with the emplacement of juvenile magmas to the north and more enriched magmas related to the recycling of ancient continental crust and/or subducted sediments to the south—aspects found in other Northern Andes settings in which the continental arc was constructed in both oceanic and continental crust.
Published: 2023

40. Fast and robust single particle reconstruction in 3D fluorescence microscopy

Author: Thibaut Eloy, Étienne Baudrier, Marine Laporte, Virginie Hamel, Paul Guichard, Denis Fortun, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université de Genève = University of Geneva (UNIGE)
Subjects: FOS: Computer and information sciences, Computational Mathematics, Computer Vision and Pattern Recognition (cs.CV), [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Signal Processing, Image and Video Processing (eess.IV), Computer Science - Computer Vision and Pattern Recognition, FOS: Electrical engineering, electronic engineering, information engineering, Electrical Engineering and Systems Science - Image and Video Processing, Computer Science Applications
Abstract: International audience; Single particle reconstruction has recently emerged in 3D fluorescence microscopy as a powerful technique to improve the axial resolution and the degree of fluorescent labeling. It is based on the reconstruction of an average volume of a biological particle from the acquisition multiple views with unknown poses. Current methods are limited either by template bias, restriction to 2D data, high computational cost or a lack of robustness to low fluorescent labeling. In this work, we propose a single particle reconstruction method dedicated to convolutional models in 3D fluorescence microscopy that overcome these issues. We address the joint reconstruction and estimation of the poses of the particles, which translates into a challenging non-convex optimization problem. Our approach is based on a multilevel reformulation of this problem, and the development of efficient optimization techniques at each level. We demonstrate on synthetic data that our method outperforms the standard approaches in terms of resolution and reconstruction error, while achieving a low computational cost. We also perform successful reconstruction on real datasets of centrioles to show the potential of our method in concrete applications.
Published: 2023

41. Electroencephalography microstates imbalance across the spectrum of early psychosis, autism, and mood disorders

Author: Iftimovici, Anton, Marchi, Angela, Férat, Victor, Pruvost-Robieux, Estelle, Guinard, Eléonore, Morin, Valentine, Elandaloussi, Yannis, D’halluin, Arnaud, Krebs, Marie-Odile, Chaumette, Boris, Gavaret, Martine, IFR49 - Neurospin - CEA, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Pôle hospitalo-universitaire d’Evaluation Prévention et Innovation Thérapeutique [Paris] (PEPIT), GHU Paris Psychiatrie & Neurosciences, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service d'Epileptologie et de Rythmologie Cérébrale [Hôpital de la Timone, AP-HM], Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE), Functional Brain Mapping Lab, Université de Genève = University of Geneva (UNIGE), Service de neurophysiologie clinique et d'épileptologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Department of Psychiatry [Montréal], McGill University = Université McGill [Montréal, Canada], This work was supported by the GHU Starting Grant'DEMETER' (A.I.), Fondation Bettencourt-Schueller (B.C.), the French government’s 'Investissements d’Avenir' programme, which is managed by theAgence Nationale de la Recherche (ANR) (M-O.K., 'PsyCARE' ANR-18-RHUS-0014)., and ANR-18-RHUS-0014,PSYCARE,Preventing psychosis through personalized care(2018)
Subjects: EEG microstates, Electroencephalography EEG microstates psychosis mood disorders autism spectrul disorder transdiagnostic approaches, autism spectrul disorder, Electroencephalography, psychosis, transdiagnostic approaches, mood disorders, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Background. Electroencephalography (EEG) microstates translate resting-state temporal dynamics of neuronal networks throughout the brain and could constitute possible markers of psychiatric disorders. We tested the hypothesis of an increased imbalance between a predominant self-referential mode (microstate C) and a decreased attentional mode (microstate D) in psychosis, mood, and autism spectrum disorders. Methods. We retrospectively included 135 subjects from an early psychosis outpatient unit, with available eyes-closed resting-state 19 electrodes EEG. Individual-level then group-level modified K-means clustering in controls provided four microstate maps that were then backfitted to all groups. Differences between microstate parameters (occurrence, coverage, and mean duration) were computed between controls and each group, and between disease groups. Results. Microstate class D parameters were systematically decreased in disease groups compared with controls, with an effect size increasing along the psychosis spectrum, but also in autism. There was no difference in class C. C/D ratios of mean duration were increased only in SCZ compared with controls. Conclusions. The decrease in microstate class D may be a marker of stage of psychosis, but it is not specific to it and may rather reflect a shared dimension along the schizophrenia-autism spectrum. C/D microstate imbalance may be more specific to schizophrenia.
Published: 2023

42. Problematic internet use in adults: Cross-cultural study in 15 countries

Author: Olatz Lopez-Fernandez, Lucia Romo, Laurence Kern, Amélie Rousseau, Bernadeta Lelonek-Kuleta, Joanna Chwaszcz, Niko Männikkö, Hans-Jürgen Rumpf, Anja Bischof, Orsolya Király, Ann-Kathrin Gässler, Pierluigi Graziani, Maria Kääriäinen, Nils Inge Landrø, Juan José Zacarés, Mariano Chóliz, Magali Dufour, Lucien Rochat, Daniele Zullino, Sophia Achab, Zsolt Demetrovics, Mark D. Griffiths, Daria J. Kuss, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Université Francisco de Vitoria = Universidad Francisco de Vitoria (UFV), Hospital Universitario Fundación Jiménez Díaz [Madrid, Spain], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Clinique, Psychanalyse, Développement (CliPsyD), Université Paris Nanterre (UPN), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche sur le Sport et le Mouvement (CeRSM), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Centre d’Etudes et de Recherches en Psychopathologie et Psychologie de la Santé (CERPPS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), John Paul II Catholic University of Lublin (KUL), University of Oulu, Oulu University of Applied Sciences, Eötvös Loránd University (ELTE), Université de Nîmes (UNIMES), Laboratoire de Psychologie Sociale (LPS), Aix Marseille Université (AMU), University of Oslo (UiO), Universitat de València (UV), Geneva University Hospital (HUG), Department of Mental Health and Psychiatry, University Hospital of Geneva, Université de Genève = University of Geneva (UNIGE), Neuroscience Center [University of Geneva], Hôpital Universitaire de Genève = University Hospitals of Geneva (HUG), Universität zu Lübeck = University of Lübeck [Lübeck], Oulu University Hospital [Oulu], Université du Québec à Montréal = University of Québec in Montréal (UQAM), University of Gibraltar [Gibraltar] (UG), Nottingham Trent University, European Commission, EC: FP7-PEOPLE-2013-IEF-627999, Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH: KKP126835, This research was funded by the European Commission, grant title: Technological use disorders: European cross-cultural longitudinal and experimental studies for Internet and smartphone problem uses project, code: FP7-PEOPLE-2013-IEF-627999. It was also supported by the Hungarian National Research, Development and Innovation Office (KKP126835)., and European Project: 627999,EC:FP7:PEOPLE,FP7-PEOPLE-2013-IEF,TECH USE DISORDERS(2014)
Subjects: problematic online shopping, problematic social networking, [SDV]Life Sciences [q-bio], problematic online sex, cross-cultural research, impulsivity, [SHS.PSY]Humanities and Social Sciences/Psychology, General Medicine, problematic gaming, problematic gambling, psychopathology, internet addiction, [SCCO]Cognitive science, problematic internet use
Abstract: International audience; Background: The present study compared adult usage patterns of online activities, the frequency rate of problematic internet use (PIU), and risk factors (including the psychopathology associated with PIU, i.e., distress and impulsivity) among adults in 15 countries from Europe, America, and Asia. Methods: A total of 5130 adults from Belgium, Finland, Germany, Italy, Spain, France, Switzerland, Hungary, Poland, UK, Norway, Peru, Canada, US, and Indonesia completed an online survey assessing PIU and a number of psychological variables (i.e., depression, anxiety, stress, and impulsivity). The sample included more females, with a mean age of 24.71 years (SD = 8.70). Results: PIU was slightly lower in European countries (rates ranged from 1.1% in Finland to 10.1% in the UK, compared to 2.9% in Canada and 10.4% in the US). There were differences in specific PIU rates (e.g., problematic gaming ranged from 0.4% in Poland to 4.7% in Indonesia). Regression analyses showed that PIU was predicted by problematic social networking and gaming, lack of perseverance, positive urgency, and depression. Conclusions: The differences in PIU between countries were significant for those between continental regions (Europe versus non-European countries). One of the most interesting findings is that the specific PIU risks were generally low compared to contemporary literature. However, higher levels of PIU were present in countries outside of Europe, although intra-European differences existed.
Published: 2023

43. Exploring Fundamental Particle Acceleration and Loss Processes in Heliophysics through an Orbiting X-ray Instrument in the Jovian System (A White Paper for the 2024-2033 Solar and Space Physics (Heliophysics) Decadal Survey)

Author: Dunn, W, Berland, G, Roussos, E, Clark, G, Kollmann, P, Turner, D, Feldman, C, Stallard, T, Branduardi-Raymont, G, Woodfield, E, Rae, I, Ray, L, Carter, J, Lindsay, S, Yao, Z, Marshall, R, Jaynes, A, Ezoe, Y, Numazawa, M, Hospodarsky, G, Wu, X, Weigt, D, Jackman, C, Mori, K, Nénon, Quentin, Desai, R, Blum, L, Nordheim, T, Ness, J, Bodewits, D, Kimura, T, Li, W, Smith, H, Millas, D, Wibisono, A, Achilleos, N, Koutroumpa, Dimitra, Mcentee, S, Collier, H, Bhardwaj, A, Martindale, A, Wolk, S, Badman, S, Kraft, R, University College of London [London] (UCL), Centre for Planetary Sciences [UCL/Birkbeck] (CPS), University of Colorado [Boulder], Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), University of Leicester, Mullard Space Science Laboratory (MSSL), British Antarctic Survey (BAS), Natural Environment Research Council (NERC), University of Northumbria at Newcastle [United Kingdom], Lancaster University, Chinese Academy of Sciences [Beijing] (CAS), University of Iowa [Iowa City], Tokyo Metropolitan University [Tokyo] (TMU), Université de Genève = University of Geneva (UNIGE), Dublin Institute for Advanced Studies (DIAS), Columbia University [New York], Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Imperial College London, University of Warwick [Coventry], Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA), Auburn University (AU), Tokyo University of Science [Tokyo], Boston University [Boston] (BU), HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), University of Applied Sciences and Arts Northwestern Switzerland (FHNW), Physical Research Laboratory [Ahmedabad] (PRL), Indian Space Research Organisation (ISRO), Smithsonian Astrophysical Observatory, and Smithsonian Institution
Subjects: [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR]
Published: 2023

44. Glycosaminoglycans: What Remains To Be Deciphered?

Author: Serge Perez, Olga Makshakova, Jesus Angulo, Emiliano Bedini, Antonella Bisio, Jose Luis de Paz, Elisa Fadda, Marco Guerrini, Michal Hricovini, Milos Hricovini, Frederique Lisacek, Pedro M. Nieto, Kevin Pagel, Giulia Paiardi, Ralf Richter, Sergey A. Samsonov, Romain R. Vivès, Dragana Nikitovic, Sylvie Ricard Blum, Perez, Serge, Makshakova, Olga, Angulo, Jesu, Bedini, Emiliano, Bisio, Antonella, Luis de Paz, Jose, Fadda, Elisa, Guerrini, Marco, Hricovini, Michal, Hricovini, Milo, Lisacek, Frederique, Nieto, Pedro M., Pagel, Kevin, Paiardi, Giulia, Richter, Ralf, Samsonov, Sergey A., Vivès, Romain R., Nikitovic, Dragana, Ricard Blum, Sylvie, Centre de Recherches sur les Macromolécules Végétales (CERMAV), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Kazan Scientific Centre of the Russian Academy of Sciences, Consejo Superior de Investigaciones Científicas [Spain] (CSIC), University of Naples Federico II = Università degli studi di Napoli Federico II, Istituto di Chimica e Biochimica G. Ronzoni, National University of Ireland Maynooth (Maynooth University), Slovak Academy of Science [Bratislava] (SAS), Université de Genève = University of Geneva (UNIGE), Swiss Institute of Bioinformatics [Genève] (SIB), Institut für Chemie und Biochemie [Berlin], Freie Universität Berlin, Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS ), Universität Heidelberg [Heidelberg] = Heidelberg University, University of Leeds, University of Gdańsk (UG), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), University of Crete [Heraklion] (UOC), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: hyaluronan, glycosaminoglycans, keratan sulfate heparosan, [CHIM]Chemical Sciences, heparan sulfate, heparin, 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften, dermatan sulfate, chondroitin sulfate
Abstract: International audience; Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural diversity and fulfilling various functions mediated by thousands of interactions in the extracellular matrix, at the cell surface, and within the cells where they have been detected in the nucleus. It is known that the chemical groups attached to GAGs and GAG conformations comprise "glycocodes" that are not yet fully deciphered. The molecular context also matters for GAG structures and functions, and the influence of the structure and functions of the proteoglycan core proteins on sulfated GAGs and vice versa warrants further investigation. The lack of dedicated bioinformatic tools for mining GAG data sets contributes to a partial characterization of the structural and functional landscape and interactions of GAGs. These pending issues will benefit from the development of new approaches reviewed here, namely (i) the synthesis of GAG oligosaccharides to build large and diverse GAG libraries, (ii) GAG analysis and sequencing by mass spectrometry (e.g., ion mobility-mass spectrometry), gas-phase infrared spectroscopy, recognition tunnelling nanopores, and molecular modeling to identify bioactive GAG sequences, biophysical methods to investigate binding interfaces, and to expand our knowledge and understanding of glycocodes governing GAG molecular recognition, and (iii) artificial intelligence for in-depth investigation of GAGomic data sets and their integration with proteomics.
Published: 2023

45. Exceptionally Stable Dimers and Trimers of Au 25 Clusters Linked with a Bidentate Dithiol: Synthesis, Structure and Chirality Study

Author: Michal Swierczewski, Fabrice Cousin, Ewa Banach, Arnulf Rosspeintner, Latevi Max Lawson Daku, Abolfazl Ziarati, Rania Kazan, Gunnar Jeschke, Raymond Azoulay, Lay‐Theng Lee, Thomas Bürgi, Université de Genève = University of Geneva (UNIGE), Groupe Diffusion petits angles (GDPA), Laboratoire Léon Brillouin (LLB - UMR 12), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université de Neuchâtel (UNINE), Départment de Chimie Physique, Department of Chemistry and Applied Biosciences [ETH Zürich] (D-CHAB), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), LLB - Matière molle et biophysique (MMB), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: [CHIM.COOR]Chemical Sciences/Coordination chemistry, General Medicine, General Chemistry, Catalysis
Abstract: International audience; A bidentate chiral dithiol (diBINAS) is utilised to bridge Au 25 nanoclusters to form oligomers. Separation by size allows the isolation of fractions that are stable thanks to the bidentate nature of the linker. The structure of the products is elucidated by smallangle X-ray scattering and calculated using density functional theory. Additional structural details are studied by diffusion-ordered nuclear magnetic resonance spectroscopy, transmission electron microscopy and matrix-assisted laser desorption/ionization time of flight mass spectrometry. Significant changes in the optical properties are analysed by UV/Vis and fluorescence spectroscopies, with the latter demonstrating a strong emission enhancement. Furthermore, the emergent chiral characteristics are studied by circular dichroism. Due to the geometry constraints of the nanocluster assemblies, diBINAS can be regarded as a templating molecule, taking a step towards the directed selfassembly of metal clusters.
Published: 2023

46. New Generation Stellar Spectral Libraries in the Optical and Near-infrared. I. The Recalibrated UVES-POP Library for Stellar Population Synthesis

Author: Sviatoslav B. Borisov, Igor V. Chilingarian, Evgenii V. Rubtsov, Cédric Ledoux, Claudio Melo, Kirill A. Grishin, Ivan Yu. Katkov, Vladimir S. Goradzhanov, Anton V. Afanasiev, Anastasia V. Kasparova, Anna S. Saburova, Université de Genève = University of Geneva (UNIGE), Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University-Smithsonian Institution, Sternberg Astronomical Institute [Moscow], Lomonosov Moscow State University (MSU), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), Portuguese Space Agency, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Abu Dhabi University (ADU), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics - Astrophysics of Galaxies, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract: We present re-processed flux calibrated spectra of 406 stars from the UVES-POP stellar library in the wavelength range 320-1025 nm, which can be used for stellar population synthesis. The spectra are provided in the two versions having spectral resolving power R=20,000 and R=80,000. Raw spectra from the ESO data archive were re-reduced using the latest version of the UVES data reduction pipeline with some additional algorithms that we developed. The most significant improvements in comparison with the original UVES-POP release are: (i) an updated Echelle order merging, which eliminates "ripples" present in the published spectra, (ii) a full telluric correction, (iii) merging of non-overlapping UVES spectral setups taking into account the global continuum shape, (iv) a spectrophotometric correction and absolute flux calibration, and (v) estimates of the interstellar extinction. For 364 stars from our sample, we computed atmospheric parameters $T_\mathrm{eff}$, surface gravity log $g$, metallicity [Fe/H], and $\alpha$-element enhancement [$\alpha$/Fe] by using a full spectrum fitting technique based on a grid of synthetic stellar atmospheres and a novel minimization algorithm. We also provide projected rotational velocity $v\sin i$ and radial velocity $v_{rad}$ estimates. The overall absolute flux uncertainty in the re-processed dataset is better than 2% with sub-% accuracy for about half of the stars. A comparison of the recalibrated UVES-POP spectra with other spectral libraries shows a very good agreement in flux; at the same time, $Gaia$ DR3 BP/RP spectra are often discrepant with our data, which we attribute to spectrophotometric calibration issues in $Gaia$ DR3., Comment: 26 pages, 19 figures, accepted for publication in ApJS
Published: 2023

47. Automatic Ferroelectric Domain Pattern Recognition Based on the Analysis of Localized Nonlinear Optical Responses Assisted by Machine Learning

Author: Boris Croes, Iaroslav Gaponenko, Cédric Voulot, Olivier Grégut, Kokou D. Dorkenoo, Fabien Cheynis, Stefano Curiotto, Pierre Müller, Frédéric Leroy, Kumara Cordero‐Edwards, Patrycja Paruch, Salia Cherifi‐Hertel, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Department of Quantum Matter Physics [Geneva] (DQMP), Université de Genève = University of Geneva (UNIGE), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE92-0052,TOPELEC,Topologie de Parois Ferroélectriques Conductrices(2018), ANR-22-CE08-0023,FETh,Contrôle ferroélectrique de la conduction électrique et thermique à l'échelle nanométrique dans GeTe(2022), ANR-17-EURE-0024,QMAT,Quantum Science and Nanomaterials(2017), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), CHERIFI-HERTEL, Salia, APPEL À PROJETS GÉNÉRIQUE 2018 - Topologie de Parois Ferroélectriques Conductrices - - TOPELEC2018 - ANR-18-CE92-0052 - AAPG2018 - VALID, Contrôle ferroélectrique de la conduction électrique et thermique à l'échelle nanométrique dans GeTe - - FETh2022 - ANR-22-CE08-0023 - AAPG2022 - VALID, Quantum Science and Nanomaterials - - QMAT2017 - ANR-17-EURE-0024 - EURE - VALID, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, and Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID
Subjects: MESH: Non-Negative Matrix Factorization, MESH: Ferroelectrics, MESH: Machine Learning, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], MESH: Second-Hermonic Generation, MESH: Clustering Methods, [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], MESH: Domains
Abstract: International audience; Second-harmonic generation (SHG) is a nonlinear optical method allowing the study of the local structure, symmetry, and ferroic order in noncentrosymmetric materials such as ferroelectrics. The combination of SHG microscopy with local polarization analysis is particularly efficient for deriving the local polarization orientation. This, however, entails the use of tedious and time-consuming modeling methods of nonlinear optical emission. Moreover, extracting the complex domain structures often observed in thin films requires a pixel-by-pixel analysis and the fitting of numerous polar plots to ascribe a polarization angle to each pixel. Here, the domain structure of GeTe films is studied using SHG polarimetry assisted by machine learning. The method is applied to two film thicknesses: A thick film containing large domains visible in SHG images, and a thin film in which the domains' size is below the SHG resolution limit. Machine learning-assisted methods show that both samples exhibit four domain variants of the same type. This result is confirmed in the case of the thick film, both by the manual pixel-by-pixel analysis and by using piezoresponse force microscopy. The proposed approach foreshows new prospects for optical studies by enabling enhanced sensitivity and high throughput analysis.
Published: 2022

48. Climate Controlled Fluvial Stratigraphic Architecture in the Middle Eocene Escanilla Formation, South-Central Pyrenees, Spain

Author: Sharma, Nikhil, Whittaker, Alexander, Watkins, Stephen, Valero, Luis, Vérité, Jean, Puigdefàbregas, Cai, Adatte, Thierry, Garces, Miguel, Guillocheau, François, Castelltort, Sébastien, Université de Genève = University of Geneva (UNIGE), Imperial College London, Laboratoire de Planétologie et Géosciences - Le Mans (LPG - Le Mans), Laboratoire de Planétologie et Géosciences [UMR_C 6112] (LPG), Université d'Angers (UA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université d'Angers (UA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), University of Barcelona, Université de Lausanne = University of Lausanne (UNIL), Universitat de Barcelona (UB), Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), and American Geophysical Union
Subjects: [SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/Stratigraphy
Abstract: International audience; Ancient fluvial deposits typically display repetitive patterns in their depositional architecture such as alternating intervals of laterally-stacked, high-amalgamation (HA) channels, and floodplain-dominated intervals with vertically-stacked, low-amalgamation (LA) channels. Such patterns are usually ascribed to base-level driven changes in accommodation space. However, “upstream” factors such as water discharge and sediment flux have also been recognized for their potential role in controlling stratigraphic architecture but have not been tested in ancient fluvial systems. Here, we use paleohydraulic reconstructions to document riverbed gradient evolution within three middle Eocene (~40 Ma) fluvial HA-LA sequences in the Escanilla formation in the south-Pyrenean foreland basin. We show, in an ancient fluvial system, that river slope was primarily driven by climate-controlled water discharge variations rather than base-level changes as commonly assumed. These results have fundamental implications for the interpretation of the fluvial stratigraphic record and for our ability to reconstruct ancient hydroclimates.
Published: 2022

49. Dietary Recommendations in the Prevention and Treatment of Osteoporosis

Author: Emmanuel Biver, Julia Herrou, Guillaume Larid, Mélanie A. Legrand, Sara Gonnelli, Cédric Annweiler, Roland Chapurlat, Véronique Coxam, Patrice Fardellone, Thierry Thomas, Jean-Michel Lecerf, Bernard Cortet, Julien Paccou, Geneva University Hospital (HUG), Université de Genève = University of Geneva (UNIGE), Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Naval Group, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), University of Lille, Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 (MABLab (ex-pmoi)), Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Subjects: Rheumatology, fractures, bone mineral density, diet, osteoporosis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Nutrition
Abstract: International audience; Introduction: This article presents the initial recommendations of the French Rheumatology Society (Société Française de Rhumatologie - SFR) and the Osteoporosis Research and Information Group (Groupe de Recherche et d'Informations sur les Ostéoporoses - GRIO) on the role of diet in the prevention and treatment of osteoporosis.Methods: The recommendations were produced by a working group composed of rheumatologists, physician nutrition specialists and a geriatrician. Fifteen (15) questions pertaining to "daily practices" were preselected by the working group. For the literature review, the working group focussed mainly on the effects of diet on bone mineral density (BMD) and fractures, and primarily on meta-analyses of longitudinal studies and dietary intervention studies.Results: A Mediterranean-type diet and the daily consumption of 2 to 3 dairy products are recommended. Together, these provide the calcium and "high quality" protein required to maintain a normal calcium-phosphorus balance and bone metabolism, and are associated with lower fracture risk. Conversely, unbalanced Western diets, vegan diets, weight-loss diets in non-overweight individuals, alcohol consumption and daily consumption of sodas are advised against. In terms of the beneficial effects on bone mineral density and fracture risk, current scientific data are either insufficient or too divergent to recommend increasing or restricting the consumption of tea or coffee, vitamins other than vitamin D, vitamin D-enriched or phytoestrogen-rich foods, calcium-enriched plant-based beverages, oral nutritional supplements, or dietary sources of prebiotics and probiotics.Conclusions: These are the first set of recommendations addressing the role of diet in the prevention and treatment of osteoporosis. More research is necessary to direct and support guidelines.
Published: 2022

50. Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B

Author: Caroline Cazin, Yasmine Neirijnck, Corinne Loeuillet, Lydia Wehrli, Françoise Kühne, Isabelle Lordey, Selima Fourati Ben Mustapha, Amin Bouker, Raoudha Zouari, Nicolas Thierry-Mieg, Serge Nef, Christophe Arnoult, Pierre F. Ray, Zine-Eddine Kherraf, Thierry-Mieg, Nicolas, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), CHU Grenoble, Université de Genève = University of Geneva (UNIGE), Polyclinique les Jasmins [Tunis], Modèles et Algorithmes pour la Génomique (TIMC-MAGe), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)
Subjects: QH301-705.5, [SDV]Life Sciences [q-bio], CCT6B, General Medicine, C1orf185, spermatogenesis, whole exome sequencing, [SDV] Life Sciences [q-bio], non-obstructive azoospermia, genetics of male infertility, CRISPR/Cas9, Biology (General)
Abstract: The genetic landscape of male infertility is highly complex. It is estimated that at least 4000 genes are involved in human spermatogenesis, but only few have so far been extensively studied. In this study, we investigated by whole exome sequencing two cases of idiopathic non-obstructive azoospermia (NOA) due to severe hypospermatogenesis. After variant filtering and prioritizing, we retained for each patient a homozygous loss-of-function (LoF) variant in a testis-specific gene, C1orf185 (c.250C>T; p.Gln84Ter) and CCT6B (c.615-2A>G), respectively. Both variants are rare according to the gnomAD database and absent from our local control cohort (n = 445). To verify the implication of these candidate genes in NOA, we used the CRISPR/Cas9 system to invalidate the mouse orthologs 4930522H14Rik and Cct6b and produced two knockout (KO) mouse lines. Sperm and testis parameters of homozygous KO adult male mice were analyzed and compared with those of wild-type animals. We showed that homozygous KO males were fertile and displayed normal sperm parameters and a functional spermatogenesis. Overall, these results demonstrate that not all genes highly and specifically expressed in the testes are essential for spermatogenesis, and in particular, we conclude that bi-allelic variants of C1orf185 and CCT6B are most likely not to be involved in NOA and male fertility.
Published: 2022

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