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Four new norceanothane-type triterpenes, cyclopalin A-D (1-4), and sixteen known compounds (5-20) were obtained from the fruits of Cyclocarya paliurus. Their structures were determined by spectroscopic data, experimental electronic circular dichroism (ECD) and X-ray single crystal analyses. All isolated compounds were assayed for their anti-HIV-1IIIB activity. Compound 18 exhibited potent anti-HIV-1IIIB activity with an EC50 value of 1.32 μM (SI = 151.52). [ABSTRACT FROM AUTHOR]

Abstract A phytochemical study on the stem bark of Metasequoia glyptostroboides led to the isolation of sixty-one diterpenoids and sesquiterpenoids, including seventeen previously undescribed compounds, metaglyptins A-Q. Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, and 1H, 13C and 2D NMR). The absolute configurations of metaglyptins I, J, and O were determined by the ECD data and single-crystal X-ray diffraction analysis. The undescribed compounds were evaluated for their cytotoxicity against HeLa, AGS, and MDA-MB-231 cancer cell lines. The results revealed that metaglyptin A exhibited moderate cytotoxicity against MDA-MB-231 cell line with IC 50 value of 20.02 μ M. Graphical abstract Seventeen previously undescribed diterpenoids and sesquiterpenoids, as well as forty-four known compounds, were isolated and structurally characterized from the stem bark of Metasequoia glyptostroboides. The isolated undescribed compounds were evaluated for their cytotoxic activity. Image 1 Highlights • Seventeen undescribed terpenoids were isolated from Metasequoia glyptostroboides. • Forty-four known diterpenoids and sesquiterpenoids were isolated. • Metaglyptin A exhibited moderate cytotoxicity against MDA-MB-231 cell line. [ABSTRACT FROM AUTHOR]

A rare carotane-type sesquiterpenoid, forkienin A (1), a new eudesmane-type sesquiterpenoid, forkienin B (2), and a new natural eudesmane-type sesquiterpenoid, forkienin C (3), were isolated from the twigs and leaves ofFokienia hodginsii, along with eight known sesquiterpenoids. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, including 1D and 2D NMR methods. All compounds were evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines. [ABSTRACT FROM PUBLISHER]

Four new norceanothane-type triterpenes, cyclopalin A-D ( 1-4 ), and sixteen known compounds ( 5-20 ) were obtained from the fruits of Cyclocarya paliurus . Their structures were determined by spectroscopic data, experimental electronic circular dichroism (ECD) and X-ray single crystal analyses. All isolated compounds were assayed for their anti-HIV-1 IIIB activity. Compound 18 exhibited potent anti-HIV-1 IIIB activity with an EC 50 value of 1.32 μM (SI = 151.52).

Three rearranged labdane-type diterpenoids, hypophyllins A-C (1-3), and a caged labdane diterpenoid possessing a 8,9-dioxatricyclic[4.2.1.1 3,7 ]decane moiety, hypophyllin D (4), as well as two new biogenetically related diterpernoids, hypophyllins E (5) and F (6), were isolated from the aerial parts of Hypoestes phyllostachya "Rosea". The absolute configurations of 1-4 were determined by X-ray diffraction analysis. The plausible biogenetic pathway for 1-4 was also proposed. Compounds 4 and 5 showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.