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507 results on '"Pauls, David"'

1. Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Author

Buitelaar, Jan, de Ruiter, Saskia, Naaijen, Jilly, Akkermans, Sophie, Mennes, Maarten, Zwiers, Marcel, Ilbegi, Shahrzad, Hennissen, Leonie, Glennon, Jeffrey, van de Vondervoort, Ilse, Kapusta, Katarzyna, Bielczyk, NaAAtalia, Amiri, Houshang, Havenith, Martha, Franke, Barbara, Poelmans, Geert, Bralten, Janita, Heskes, Tom, Sokolova, Elena, Groot, Perry, Williams, Steven, Murphy, DeAAclan, Lythgoe, David, Bruchhage, Muriel, Dud, Iulia, Voinescu, Bogdan, Dittmann, Ralf, Banaschewski, Tobias, Brandeis, Daniel, Mechler, Konstantin, Berg, Ruth, Wolf, Isabella, Häge, Alexander, Landauer, Michael, Hohmann, Sarah, Schlier, Regina Boecker, Ruff, Matthias, Mandl, René, Dijkhuizen, Rick, Blezer, Erwin, Straathof, Milou, van der Marel, Kajo, Pullens, Pim, Mol, Wouter, van der Toorn, Annette, Otte, Willem, van Heijningen, Caroline, Durston, Sarah, Mensen, VinAAcent, Oranje, Bob, Joel, Daphna, Cryan, John, Petryshen, Tracey, Pauls, David, Saito, Mai, Heckman, Angelique, Bahn, Sabine, Schwalber, Ameli, Florea, Ioana, Blezer, Erwin L.A., Smeele, Christel E., Buitelaar, Jan K., Glennon, Jeffrey C., Otte, Willem M., and Dijkhuizen, Rick M.

Published
2020
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2. Self-reported executive function and hoarding in adults with obsessive-compulsive disorder

Author

Samuels, Jack, Bienvenu, O. Joseph, Krasnow, Janice, Wang, Ying, Grados, Marco A., Cullen, Bernadette, Goes, Fernando S., Maher, Brion, Greenberg, Benjamin D., McLaughlin, Nicole C., Rasmussen, Steven A., Fyer, Abby J., Knowles, James A., McCracken, James T., Piacentini, John, Geller, Dan, Pauls, David L., Stewart, S. Evelyn, Murphy, Dennis L., Shugart, Yin-Yao, Riddle, Mark A., and Nestadt, Gerald

Published
2018
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3. Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome

Author

Abelson, Jesse F., Kwan, Kenneth Y., O'Roak, Brian J., Baek, Danielle Y., Stillman, Althea A., Morgan, Thomas M., Mathews, Carol A., Pauls, David L., Rašin, Mladen-Roko, Gunel, Murat, Davis, Nicole R., Ercan-Sencicek, A. Gulhan, Guez, Danielle H., Spertus, John A., Leckman, James F., Dure, Leon S., Kurlan, Roger, Singer, Harvey S., Gilbert, Donald L., Farhi, Anita, Louvi, Angeliki, Lifton, Richard P., Šestan, Nenad, and State, Matthew W.

Published
2005

6. Autism Spectrum Symptoms in a Tourette’s Disorder Sample

Author

Darrow, Sabrina M., Grados, Marco, Sandor, Paul, Hirschtritt, Matthew E., Illmann, Cornelia, Osiecki, Lisa, Dion, Yves, King, Robert, Pauls, David, Budman, Cathy L., Cath, Danielle C., Greenberg, Erica, Lyon, Gholson J., McMahon, William M., Lee, Paul C., Delucchi, Kevin L., Scharf, Jeremiah M., and Mathews, Carol A.

Published
2017
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7. An investigation of doubt in obsessive–compulsive disorder

Author

Samuels, Jack, Bienvenu, O. Joseph, Krasnow, Janice, Wang, Ying, Grados, Marco A., Cullen, Bernadette, Goes, Fernando S., Maher, Brion, Greenberg, Benjamin D., McLaughlin, Nicole C., Rasmussen, Steven A., Fyer, Abby J., Knowles, James A., Nestadt, Paul, McCracken, James T., Piacentini, John, Geller, Dan, Pauls, David L., Stewart, S. Evelyn, Murphy, Dennis L., Shugart, Yin-Yao, Kamath, Vidya, Bakker, Arnold, Riddle, Mark A., and Nestadt, Gerald

Published
2017
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9. Parental bonding and hoarding in obsessive–compulsive disorder

Author

Chen, David, Bienvenu, O. Joseph, Krasnow, Janice, Wang, Ying, Grados, Marco A., Cullen, Bernadette, Goes, Fernando S., Maher, Brion, Greenberg, Benjamin D., McLaughlin, Nicole C., Rasmussen, Steven A., Fyer, Abby J., Knowles, James A., McCracken, James T., Piacentini, John, Geller, Dan, Pauls, David L., Stewart, S. Evelyn, Murphy, Dennis L., Shugart, Yin-Yao, Riddle, Mark A., Nestadt, Gerald, and Samuels, Jack

Published
2017
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10. ADHD and executive functioning deficits in OCD youths who hoard

Author

Park, Jennifer M., Samuels, Jack F., Grados, Marco A., Riddle, Mark A., Bienvenu, O. Joseph, Goes, Fernando S., Cullen, Bernadette, Wang, Ying, Krasnow, Janice, Murphy, Dennis L., Rasmussen, Steven A., McLaughlin, Nicole C., Piacentini, John, Pauls, David L., Stewart, S. Evelyn, Shugart, Yin-Yao, Maher, Brion, Pulver, Ann E., Knowles, James A., Greenberg, Benjamin D., Fyer, Abby J., McCracken, James T., Nestadt, Gerald, and Geller, Daniel A.

Published
2016
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11. Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome

Author

Greenberg, Erica, Tung, Esther S., Gauvin, Caitlin, Osiecki, Lisa, Yang, Kelly G., Curley, Erin, Essa, Angela, Illmann, Cornelia, Sandor, Paul, Dion, Yves, Lyon, Gholson J., King, Robert A., Darrow, Sabrina, Hirschtritt, Matthew E., Budman, Cathy L., Grados, Marco, Pauls, David L., Keuthen, Nancy J., Mathews, Carol A., Scharf, Jeremiah M., and The Tourette Association of America International Consortium for Genetics

Published
2018
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15. Hoarding in children and adolescents with obsessive–compulsive disorder

Author

Samuels, Jack, Grados, Marco A., Riddle, Mark A., Bienvenu, O. Joseph, Goes, Fernando S., Cullen, Bernadette, Wang, Ying, Greenberg, Benjamin D., Fyer, Abby J., McCracken, James T., Geller, Dan, Murphy, Dennis L., Knowles, James A., Rasmussen, Steven A., McLaughlin, Nicole C., Piacentini, John, Pauls, David L., Stewart, S. Evelyn, Shugart, Yin-Yao, Maher, Brion, Pulver, Ann E., and Nestadt, Gerald

Published
2014
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17. Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

Author

McGrath, Lauren M., Yu, Dongmei, Marshall, Christian, Davis, Lea K., Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Gerber, Gloria, Wolf, Aaron, Schroeder, Frederick A., Osiecki, Lisa, O'Dushlaine, Colm, Kirby, Andrew, Illmann, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A., Barr, Cathy L., Bellodi, Laura, Benarroch, Fortu, Bienvenu, O. Joseph, Black, Donald W., Bloch, Michael H., Bruun, Ruth D., Budman, Cathy L., Camarena, Beatriz, Cath, Danielle C., Cavallini, Maria C., Chouinard, Sylvain, Coric, Vladimir, Cullen, Bernadette, Delorme, Richard, Denys, Damiaan, Derks, Eske M., Dion, Yves, Rosário, Maria C., Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernandez, Thomas V., Garrido, Helena, Geller, Daniel, Grabe, Hans J., Grados, Marco A., Greenberg, Benjamin D., Gross-Tsur, Varda, Grünblatt, Edna, Heiman, Gary A., Hemmings, Sian M.J., Herrera, Luis D., Hounie, Ana G., Jankovic, Joseph, Kennedy, James L., King, Robert A., Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F., Lennertz, Leonhard, Lochner, Christine, Lowe, Thomas L., Lyon, Gholson J., Macciardi, Fabio, Maier, Wolfgang, McCracken, James T., McMahon, William, Murphy, Dennis L., Naarden, Allan L., Neale, Benjamin M., Nurmi, Erika, Pakstis, Andrew J., Pato, Michele T., Pato, Carlos N., Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I., Richter, Margaret A., Riddle, Mark, Robertson, Mary M., Rosenberg, David, Rouleau, Guy A., Ruhrmann, Stephan, Sampaio, Aline S., Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S., Smit, Jan H., Stein, Dan J., Tischfield, Jay A., Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendland, Jens R., Shugart, Yin Yao, Miguel, Euripedes C., Nicolini, Humberto, Oostra, Ben A., Moessner, Rainald, Wagner, Michael, Ruiz-Linares, Andres, Heutink, Peter, Nestadt, Gerald, Freimer, Nelson, Petryshen, Tracey, Posthuma, Danielle, Jenike, Michael A., Cox, Nancy J., Hanna, Gregory L., Brentani, Helena, Scherer, Stephen W., Arnold, Paul D., Stewart, S. Evelyn, Mathews, Carol A., Knowles, James A., Cook, Edwin H., Pauls, David L., Wang, Kai, and Scharf, Jeremiah M.

Published
2014
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18. Social Anxiety in Parents of High-Functioning Children with Autism and Asperger Syndrome

Author

Kuusikko-Gauffin, Sanna, Pollock-Wurman, Rachel, Mattila, Marja-Leena, Jussila, Katja, Ebeling, Hanna, Pauls, David, and Moilanen, Irma

Abstract

We evaluated social anxiety (SA) symptoms in parents of children with autism spectrum disorders (ASDs; N = 131) and community parents (N = 597) using the Social Phobia and Anxiety Inventory (SPAI). SA was significantly more common in ASD than control mothers (15.6 vs. 6.7 %) and more equal between the ASD and control fathers (3.3 vs. 4.8 %). The ASD mothers scored significantly higher than control mothers on all SPAI scales. ASD fathers scored significantly higher than control fathers on the somatic, cognitive, avoidance and agoraphobic symptoms of SA. It is of clinical import to support ASD parents' well-being as their psychiatric features may contribute greatly to their children's emotional development and the well-being of the whole family.

Published
2013
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19. An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder

Author

van de Vondervoort, Ilse, Poelmans, Geert, Aschrafi, Armaz, Pauls, David L., Buitelaar, Jan K., Glennon, Jeffrey C., and Franke, Barbara

Subjects
Obsessive-compulsive disorder -- Physiological aspects, Insulin -- Health aspects, Dendritic cells -- Health aspects, Cellular signal transduction -- Observations, Health, Psychology and mental health
Abstract

Background: Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with onset in childhood and is characterized by obsessions (recurrent, intrusive, persistent thoughts, impulses and/or ideas that often cause anxiety or distress) and compulsions (ritualized and stereotypic behaviours or mental acts that are often performed to relieve anxiety or distress associated with obsessions). Although OCD is a heritable disorder, its complex molecular etiology is poorly understood. Methods: We combined enrichment analyses and an elaborate literature review of the top-ranked genes emerging from the 2 published genome-wide association studies of OCD and candidate genes implicated through other evidence in order to identify biological processes that, when dysregulated, increase the risk for OCD. Results: The resulting molecular protein landscape was enriched for proteins involved in regulating postsynaptic dendritic spine formation-- and hence synaptic plasticity--through insulin-dependent molecular signalling cascades. Limitations: This study is a first attempt to integrate molecuar information from different sources in order to identify biological mechanisms underlying OCD etiology. Our findings are constrained by the limited information from hypothesis-free studies and the incompleteness and existing limitations of the OCD literature and the gene function annotations of gene enrichment tools. As this study was solely based on in silico analyses, experimental validation of the provided hypotheses is warranted. Conclusion: Our work suggests a key role for insulin and insulin-related signalling in OCD etiology and--if confirmed by independent studies--could eventually pave the way for the development of novel OCD treatments., Introduction Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder that affects an estimated 2.5% of the world's population (1,2) and is characterized by obsessive and/or compulsive behaviours. (3) Obsessive behaviours include [...]

Published
2016
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22. Maternal Early Life Factors Associated with Hormone Levels and the Risk of Having a Child with an Autism Spectrum Disorder in the Nurses Health Study II

Author

Lyall, Kristen, Pauls, David L., and Santangelo, Susan

Abstract

It is not known whether reproductive factors early in the mother's life influence risk of autism spectrum disorders (ASD). We assessed maternal age at menarche, menstrual cycle characteristics during adolescence, oral contraceptive use prior to first birth, body shape, and body mass index (BMI) in association with ASD using binomial regression in a cohort study of 61,596 women, including 743 cases. Overall, early life factors were not associated with ASD, though early age at menarche (RR for age 10 or less = 1.54, 95% CI 1.18, 2.02, p = 0.0002) and BMI at age 18 of greater than or equal to 30 (RR 2.03, 95% CI 1.34, 3.08, p = 0.0008) were significantly associated with increased risk of ASD. Further work should investigate the potential influence of these factors.

Published
2011
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23. Managing Complexity: Impact of Organization and Processing Style on Nonverbal Memory in Autism Spectrum Disorders

Author

Tsatsanis, Katherine D., Noens, Ilse L. J., Illmann, Cornelia L., Pauls, David L., Volkmar, Fred R., Schultz, Robert T., and Klin, Ami

Abstract

The contributions of cognitive style and organization to processing and recalling a complex novel stimulus were examined by comparing the Rey Osterrieth Complex Figure (ROCF) test performance of children, adolescents, and adults with ASD to clinical controls (CC) and non-impaired controls (NC) using the "Developmental Scoring System." The ROCF task involves a complex structure with strong organizational or integrative processing demands. The individuals with ASD relied on a predominantly part-oriented strategy to cope with the complexity of the task and did not make the typical developmental shift to a configurational approach. Both processing style and organization (whether pieces of information were perceived as connected to one another in a meaningful way) contributed to structural recall in the ASD group.

Published
2011
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24. Multi-Informant Reports of Psychiatric Symptoms among High-Functioning Adolescents with Asperger Syndrome or Autism

Author

Hurtig, Tuula, Kuusikko, Sanna, Mattila, Marja-Leena, Haapsamo, Helena, Ebeling, Hanna, Jussila, Katja, Joskitt, Leena, Pauls, David, and Moilanen, Irma

Abstract

The aim of the study was to examine psychiatric symptoms in high-functioning adolescents with autism spectrum disorders reported by multiple informants. Forty-three 11- to 17-year-old adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) and 217 typically developed adolescents completed the Youth Self-Report (YSR), while their parents completed the Child Behavior Checklist (CBCL). Teachers of adolescents with AS/HFA completed the Teacher Report Form (TRF). The informants reported significantly more psychiatric symptoms, especially withdrawn, anxious/depressed, social and attention problems, in adolescents with AS/HFA than in controls. In contrast to findings in the general population, the psychiatric problems of adolescents with AS/HFA are well acknowledged by multiple informants, including self-reports. However, anxiety and depressive symptoms were more commonly reported by adolescents with AS/HFA and their teachers than their parents, indicating that some emotional distress may be hidden from their parents. (Contains 4 tables.)

Published
2009
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25. Social Anxiety in High-Functioning Children and Adolescents with Autism and Asperger Syndrome

Author

Kuusikko, Sanna, Pollock-Wurman, Rachel, Jussila, Katja, Carter, Alice S., Mattila, Marja-Leena, Ebeling, Hanna, Pauls, David L., and Moilanen, Irma

Abstract

We examined social anxiety and internalizing symptoms using the Social Phobia and Anxiety Inventory for Children (SPAI-C), the Social Anxiety Scale for Children -Revised (SASC-R), and the Child Behavior Checklist (CBCL) in a sample of fifty-four high-functioning subjects with autism or Asperger syndrome (HFA/AS) (M = 11.2 plus or minus 1.7 years) and 305 community subjects (M = 12.2 plus or minus 2.2 years). Children and adolescents completed the SPAI-C and SASC-R, and their parents completed the CBCL Internalizing scale. Adolescents with HFA/AS scored higher than the community sample on all measures. Behavioural avoidance and evaluative social anxiety increased by age within the HFA/AS group, whereas behavioural avoidance decreased by age in control participants. Data support that HFA/AS in adolescents may be associated with clinically relevant social anxiety symptoms.

Published
2008
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26. High Sibling Correlation on Methylphenidate Response but No Association with DAT1-10R Homozygosity in Dutch Sibpairs with ADHD

Author

van der Meulen, Emma M., Bakker, Steven C., Pauls, David L., Oteman, Nicole, Kruitwagen, Cas L. J. J., Pearson, Peter L., Sinke, Richard J., and Buitelaar, Jan K.

Abstract

Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles. Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques. Results: The Intraclass Correlation Coefficient was significant (r = 0.563, p = 0.001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles. Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population.

Published
2005
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27. Three Diagnostic Approaches to Asperger Syndrome: Implications for Research

Author

Klin, Ami, Pauls, David, and Schultz, Robert

Abstract

Objective: To examine the implications for research of the use of three alternative definitions for Asperger syndrome (AS). Differences across the three nosologic systems were examined in terms of diagnostic assignment, IQ profiles, comorbid symptoms, and familial aggregation of social and other psychiatric symptoms. Method: Standard data on diagnosis, intellectual functioning, comorbidity patterns, and family history were obtained on 65 individuals screened for a very high probability of having autism without mental retardation (or higher functioning autism, FHA) or AS. Diagnoses of AS were established based on three different approaches: DAM-IV, presence/absence of communicative phrase speech by 3 years, and a system designed to highlight prototypical features of AS. Results: Agreement between the three diagnostic systems was poor. AS could be differentiated from FHA (but not from PD-NOS) on the basis of IQ profiles in two of the three systems. Differences in patterns of comorbid symptomatology were obtained in two of the three systems, although differences were primarily driven by the PD-NOS category. Only one of the approaches yielded differences relative to aggregation of the broader phenotype in family members. Conclusions: Diagnostic assignments of AS based on three commonly used approaches have low agreement and lead to different results in comparisons of IQ profiles, patterns of comorbidity, and familial aggregation of psychiatric symptoms across the approach specific resultant groups of FHA, AS, and PD-NOS.

Published
2005
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29. A Descriptive Study of Hyperlexia in a Clinically Referred Sample of Children with Developmental Delays.

Author

Grigorenok, Elena L., Klin, Ami, Pauls, David L., Senft, Riley, Hooper, Catalina, and Volkmar, Fr

Abstract

This study of hyperlexia in 80 children with developmental delays found no significant differences in the frequency of hyperlexia in girls compared with boys; a significantly elevated frequency of hyperlexia in children diagnosed with pervasive developmental disorders (PDD) compared with children with non-PDD diagnoses; and a similar range of IQ and developmental outcomes for children with and without hyperlexia. (Contains references.) (Author/DB)

Published
2002

31. Nosological and Genetic Aspects of Asperger Syndrome.

Author

Volkmar, Fred R., Klin, Ami, and Pauls, David

Abstract

This paper examines the validity of Asperger syndrome as a condition apart from high-functioning autism. Potential differences between Asperger syndrome and autism is possible if both are strictly defined. The importance of genetic factors in Asperger syndrome is stressed. Research on the nosological validity of this condition and its relationship to the pervasive developmental disorder spectrum is urged. (DB)

Published
1998

32. OBSESSIVE–COMPULSIVE PERSONALITY DISORDER: EVIDENCE FOR TWO DIMENSIONS

Author

Riddle, Mark A., Maher, Brion S., Wang, Ying, Grados, Marco, Bienvenu, Joseph O., Goes, Fernando S., Cullen, Bernadette, Murphy, Dennis L., Rauch, Scott L., Greenberg, Benjamin D., Knowles, James A., McCracken, James T., Pinto, Anthony, Piacentini, John, Pauls, David L., Rasmussen, Steven A., Shugart, Yin Yao, Nestadt, Gerald, and Samuels, Jack

Published
2016
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35. The orphan drug and research tax credits: the 'substantially all' rule

Author

Korniakov, Alexander, Pauls, David W., and Hopkins, Tom

Subjects
Orphan drugs -- Research, Research and development tax credit -- Laws, regulations and rules, Pharmaceutical research -- Taxation, Banking, finance and accounting industries, Business, Internal Revenue Code (I.R.C. 41)
Abstract

The research credit under Sec. 41 (when in effect) and the orphan drug credit under Sec. 45C are sometimes available for the same expenses incurred during the development of pharmaceuticals. [...]

Published
2014

38. Social anxiety in parents of high-functioning children with autism and Asperger syndrome

Author

Kuusikko-Gauffin, Sanna, Pollock-Wurman, Rachel, Mattila, Marja-Leena, Jussila, Katja, Ebeling, Hanna, Pauls, David, and Moilanen, Irma

Subjects
Parents -- Health aspects -- Social aspects, Asperger syndrome -- Risk factors -- Research, Social phobia -- Causes of, Health
Abstract

We evaluated social anxiety (SA) symptoms in parents of children with autism spectrum disorders (ASDs; N = 131) and community parents (N = 597) using the Social Phobia and Anxiety [...]

Published
2013
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40. Valence Scaling of Dynamic Facial Expressions is Altered in High-Functioning Subjects with Autism Spectrum Disorders: an fMRI Study

Author

Rahko, Jukka S., Paakki, Jyri-Johan, Starck, Tuomo H., Nikkinen, Juha, Pauls, David L., Kätsyri, Jari V., Jansson-Verkasalo, Eira M., Carter, Alice S., Hurtig, Tuula M., Mattila, Marja-Leena, Jussila, Katja K., Remes, Jukka J., Kuusikko-Gauffin, Sanna A., Sams, Mikko E., Bölte, Sven, Ebeling, Hanna E., Moilanen, Irma K., Tervonen, Osmo, and Kiviniemi, Vesa

Published
2012
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41. Sex-specific clinical correlates of hoarding in obsessive-compulsive disorder

Author

Samuels, Jack F., Bienvenu, O. Joseph, Pinto, Anthony, Murphy, Dennis L., Piacentini, John, Rauch, Scott L., Fyer, Abby J., Grados, Marco A., Greenberg, Benjamin D., Knowles, James A., McCracken, James T., Cullen, Bernadette, Riddle, Mark A., Rasmussen, Steven A., Pauls, David L., Liang, Kung-Yee, Hoehn-Saric, Rudolf, Pulver, Ann E., and Nestadt, Gerald

Published
2008
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45. Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Author

Pinto, Anthony, Greenberg, Benjamin D., Grados, Marco A., Bienvenu, O. Joseph, III, Samuels, Jack F., Murphy, Dennis L., Hasler, Gregor, Stout, Robert L., Rauch, Scott L., Shugart, Yin Y., Pauls, David L., Knowles, James A., Fyer, Abby J., McCracken, James T., Piacentini, John, Wang, Ying, Willour, Virginia L., Cullen, Bernadette, Liang, Kung-Yee, Hoehn-Saric, Rudolf, Riddle, Mark A., Rasmussen, Steven A., and Nestadt, Gerald

Published
2008
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48. L-histidine decarboxylase and Tourette's syndrome

Author

Ercan-Sencicek, A. Gulhan, Stillman, Althea A., Ghosh, Ananda K., Bilguvar, Kaya, O'Roak, Brian J., Mason, Christopher E., Abbott, Thomas, Gupta, Abha, King, Robert A., Pauls, David L., Tischfield, Jay A., Heiman, Gary A., Singer, Harvey S., Gilbert, Donald L., Hoekstra, Pieter J., Morgan, Thomas M., Loring, Erin, Yasuno, Katsuhito, Fernandez, Thomas, Sanders, Stephan, Louvi, Angeliki, Cho, Judy H., Mane, Shrikant, Colangelo, Christopher M., Biederer, Thomas, Lifton, Richard P., Gunel, Murat, and State, Matthew W.

Subjects
Decarboxylases -- Genetic aspects, Gene mutations -- Analysis, Histidine -- Research, Tourette's syndrome -- Genetic aspects, Tourette's syndrome -- Diagnosis, Tourette's syndrome -- Care and treatment
Abstract

An analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase and Tourette's syndrome, the rate-limiting enzyme in histamine biosynthesis is described. The study findings along with the published data from model system provide insight into the role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics.

Published
2010

49. Genetic association signal near NTN4 in Tourette syndrome

Author

Paschou, Peristera, Yu, Dongmei, Gerber, Gloria, Evans, Patrick, Tsetsos, Fotis, Davis, Lea K., Karagiannidis, Iordanis, Chaponis, Jonathan, Gamazon, Eric, Mueller-Vahl, Kirsten, Stuhrmann, Manfred, Schloegelhofer, Monika, Stamenkovic, Mara, Hebebrand, Johannes, Noethen, Markus, Nagy, Peter, Barta, Csaba, Tarnok, Zsanett, Rizzo, Renata, Depienne, Christel, Worbe, Yulia, Hartmann, Andreas, Cath, Danielle C., Budman, Cathy L., Sandor, Paul, Barr, Cathy, Wolanczyk, Thomas, Singer, Harvey, Chou, I-Ching, Grados, Marco, Posthuma, Danielle, Rouleau, Guy A., Aschauer, Harald, Freimer, Nelson B., Pauls, David L., Cox, Nancy J., Mathews, Carol A., and Scharf, Jeremiah M.

Published
2014
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