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This article, published in the journal Ultrasound in Obstetrics & Gynecology, evaluates the effectiveness of screening for late-onset pre-eclampsia (PE) between 35 and 38 weeks of gestation using maternal and biophysical factors. The study included 949 pregnancies, with 46 (4.8%) developing PE. The results showed that screening with a combination of maternal factors (age and BMI) and mean arterial pressure (MAP) could identify a high proportion of pregnancies at risk for late-onset PE. The authors suggest that this screening method could be useful in identifying and managing pregnancies at risk for PE. [Extracted from the article]

This article analyzes the perinatal outcomes and complications associated with laser fetoscopy for the treatment of Twin-twin transfusion syndrome (TTTS) in two Chilean hospitals. The study examined 144 laser therapy procedures performed between December 2008 and June 2023. The results showed that the overall survival rate at one month of life for TTTS cases treated with laser therapy was 63.1%, with a survival rate of both twins at 45.4%. The study concludes that the Chilean hospitals have achieved similar results to international centers with high experience in fetal therapy, establishing them as references for such procedures. [Extracted from the article]

This article, titled "OP15.05: First trimester fetal growth: a screening tool for small-for-gestational-age newborns," discusses a study that aimed to develop a predictive model for identifying newborns who are small for gestational age (SGA) in the first trimester. The study involved 3,238 women with a singleton pregnancy and assessed factors such as Crown-rump length (CRL) and uterine artery Doppler (UAD). The results showed that reduced CRL growth in the first trimester is associated with SGA below the third percentile. A combined model including maternal characteristics, CRL growth, and UAD can predict around half of pregnancies with preterm SGA. [Extracted from the article]

This article discusses a study conducted at the Fetal Medicine Unit of the University of Chile Hospital between 2018 and 2020. The study aimed to determine the impact of changes in the uterine artery pulsatility index (UtA-PI) on the outcomes of pregnant women using aspirin to prevent preterm pre-eclampsia (PE). The study found that pregnant women at high risk of preterm PE who were treated with aspirin had greater uterine artery vasodilation between the first and second trimesters compared to control pregnant women. However, further research with a larger sample size is needed to confirm these findings. [Extracted from the article]

This article discusses the perinatal outcomes of twin reverse arterial perfusion (TRAP) sequence in two centers in Chile. The study analyzed a cohort of fetal therapy cases for TRAP sequence between 2010 and 2023. Out of the 14 cases with complete results, 3 were managed using bipolar coagulation (BPC) and 11 underwent intrapelvic laser (IPL) therapy. The average gestational age for therapy was 19+3 weeks. The study found that pregnancies complicated by TRAP sequence have high rates of prenatal morbidity and mortality, but early diagnosis allows for timely intervention to protect the pump twin. [Extracted from the article]

This article presents a study conducted at the Fetal Medicine Unit of Hospital Clínico de la Universidad de Chile, aiming to develop a predictive model for assessing the risk of trisomy 21 (T21) between 20 to 25 weeks of gestation. The study included 3,125 singleton pregnancies and utilized a combination of categorical and quantitative markers such as maternal age, nasal bone length, prenasal thickness, and others. The multivariate model demonstrated a sensitivity of 70.6% and a false positive rate of 2.5%, with an area under the curve (AUC) of 0.975. The integration of second trimester markers with a quantitative approach was found to facilitate personalized T21 risk prediction during this gestational period. [Extracted from the article]

This article, titled "EP09.105: Persistent left superior vena cava: prenatal diagnosis and associations," discusses the prevalence and clinical significance of the prenatal diagnosis of persistent left superior vena cava (LSVC) and its relationship with other cardiac and extracardiac anomalies. The study, conducted between 2005 and 2022 at the Fetal Medicine Unit of the Clinical Hospital of the University of Chile, evaluated 44,728 pregnancies and identified 19 cases of LSVC. The prevalence of LSVC was found to be lower than expected but showed a progressive increase over time. The article emphasizes the importance of systematic screening views for congenital heart disease and recommends thorough morphological examination and echocardiography in cases of suspected LSVC. Routine chromosomal study is not suggested in isolated cases but is strongly recommended in cases with other anomalies. The efficiency of this marker should be further studied in prospective studies. [Extracted from the article]

This article, titled "Use of the cardiovascular resistance index to predict labetalol non-response in the management of hypertensive crisis during pregnancy," explores the role of hemodynamic and biophysical markers in predicting treatment failure with labetalol for hypertensive crisis during pregnancy. The study involved 44 pregnancies, with 57% identified as non-responders to labetalol. Non-responders had a higher cardiovascular resistance index and lower gestational age compared to responders. The findings suggest that recognizing specific hemodynamic profiles is important for personalized management of severe hypertension during pregnancy. [Extracted from the article]

This article discusses a study conducted at the Hospital Clínico Universidad de Chile on the impact of Doppler and gestational age (GA) on the prediction of adverse perinatal outcomes (APO) in fetuses with late-onset fetal growth restriction (lateFGR). The study included 495 cases of lateFGR, with an APO rate of 20.4%. The results showed that predictors of APO were a cerebroplacental ratio (CPR) below the 5th percentile and GA below 34 weeks at FGR diagnosis. The study concludes that altered CPR and gestational age at diagnosis are directly related to APO in late-onset FGR fetuses, and the use of CPR appears to have a predictive role in the subgroup between 32 and 34 weeks of gestation. [Extracted from the article]

This article discusses a study that evaluated the performance of new craniofacial markers for predicting Trisomy 21 (T21) during second trimester screening ultrasounds. The study included singleton pregnancies at the Fetal Medicine Unit of Hospital Clínico de la Universidad de Chile between 2004 and 2017. The researchers found that certain craniofacial markers, including prenasal thickness (PNT) and nasal bone length (NBL), were higher in fetuses with T21 compared to euploid fetuses. However, the researchers concluded that further development of reference curves based on the local population is necessary for the utilization of these markers. [Extracted from the article]

Objectives: To determine the quality of Doppler images of the fetal middle cerebral artery (MCA) and umbilical artery (UA) using an objective scale, and to determine the reliability of this scale, within a multicenter randomized controlled trial (Revealed versus concealed criteria for placental insufficiency in unselected obstetric population in late pregnancy (Ratio37)).Methods: The Ratio37 trial is an ongoing randomized, open-label, multicenter controlled study of women with a low-risk pregnancy recruited at 20 weeks. Doppler measurements of the fetal MCA and UA were performed at 37 weeks. Twenty patients from each of the six participating centers were selected randomly, with two images evaluated per patient (one each for the MCA and UA). The quality of a total of 240 images was evaluated by six experts, scored on an objective scale of six items. Inter- and intrarater reliability was assessed using the Fleiss-modified kappa statistic for ordinal scales.Results: On average, 89.2% of MCA images and 85.0% of UA images were rated as being of perfect (score of 6) or almost perfect (score of 5) quality. Kappa values for intrarater reliability of quality assessment were 0.90 (95% CI, 0.88-0.92) and 0.90 (95% CI, 0.88-0.93) for the MCA and UA, respectively. The corresponding inter-rater reliability values were 0.85 (95% CI, 0.81-0.89) and 0.84 (95% CI, 0.80-0.89), respectively.Conclusion: The quality of MCA and UA Doppler ultrasound images can be evaluated reliably using an objective scale. Over 85% of images, which were obtained by operators from a broad range of clinical practices within a multicenter study, were rated as being of perfect or almost perfect quality. Intra- and inter-rater reliability of quality assessment was very good. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]

The customised 95th centile of the UA was higher, and the customised 5th centile of the CPR was lower than only GA-adjusted standards. The 5th centile of the CPR and the 95th centile of the UA PI were modelled by quantile regression. To determine the effect of maternal and fetal physiological characteristics on the 95th/5th centile of the umbilical artery (UA) and cerebroplacental ratio (CPR) Doppler, measured at 37+ weeks; and to evaluate its clinical impact on the classification of term small for gestational age babies. [Extracted from the article]

To describe differences in the diagnosis and management of fetal growth restriction (FGR) in Latin America and the Caribbean (LAC) region. The survey assessed screening strategies, definition, and clinical management of FGR. [Extracted from the article]

To evaluate the impact on perinatal outcomes related with placental insufficiency, by the application of the new 2017 ACC/AHA guidelines to a group of chronic hypertensive pregnancies during their first trimester assessment. The best multivariate predictive model for p-PE included a previous PE background (OR = 15) and mean arterial pressure in mmHg (OR = 1.1). EP01.38: Perinatal outcomes of pregestational hypertension according to blood pressure range at 11-14-week scan: impact of the 2017 ACC/AHA guidelines. [Extracted from the article]

Results A total of 26 patients with diagnosis of Ebstein's anomaly or Tricuspid valve dysplasia were included in our study. Ebstein's anomaly and tricuspid valve dysplasia are rare cardiac malformations associated with high mortality. [Extracted from the article]

Case 1: 26-year-old (yo) woman referred to our Fetal Medicine Unit (FMU) at 33.4 weeks gestational age (GA) for FGR. Ductus venosus (DV) was not identified, instead an aberrant vessel with abnormal course from umbilical vein (UV) to left hepatic lobe passing to the right reaching the infundibulum at the entrance of inferior vena cava in the right atrium. Umbilical-portal venous circulation has become relevant in the last years for it has a potential role in the pathogenesis of fetal growth restriction (FGR). [Extracted from the article]

In euploid fetuses with NT < 3.5 mm, major birth defects were observed in 0.9%. To determine the perinatal outcomes of fetuses with nuchal translucency above 99th percentile and normal karyotype in a single institution with universal aneuploidy screening program at 11-14 weeks scan. EP15.02: Perinatal outcomes of fetuses with nuchal translucency > 99th percentile at 11-14 weeks' scan and normal karyotype: a single Chilean institutional study. [Extracted from the article]

To compare the reproducibility and concordance of transvaginal and transabdominal uterine artery Doppler (UtAD) assessment at 11 to 14 weeks scan. Despite that both methods were interchangeable (intercept -0.24 [-0.70-0.05]; up-slope 1.14 [0.92-1.43]), intra- and interobserver reproducibility for UtAD-PI was better for transvaginal assessment (intraobserver CCC = 0.89 [0.61-0.92] versus 0.75 [0.64-0.86] and inter-observer CCC = 0.88 [0.80-0.96] versus 0.85 [(0.75-0.94], for v-UtAD and p-UtAD, respectively). First, a transvaginal US was performed for CL and UtAD (v-UtAD) assessment. [Extracted from the article]

EP01.11: Risk of pre-eclampsia according to blood pressure range at 11-14-week scan in a very low-risk population: impact of AHA/ACC 2017 classification Blood pressure (BP) was measured just before the 11 to 14 weeks' ultrasound, and BP range was performed according to the AHA/ACC 2017 classification, as follows: normotensive (< 120/80 mmHg), elevated (120-129 / < 80 mmHg), stage 1 (130-139/80-89 mmHg) and stage 2 (>= 140 and/or 90 mmHg). To estimate the risk of global and preterm pre-eclampsia (PE) according to blood pressure range at first trimester scan in a very low-risk population. [Extracted from the article]

Objective: To determine whether oral glucose tolerance tests (OGTT) play a role as predictors of preeclampsia (PET) in pregnant women. Methods: A retrospective case-control study was conducted in 2,002 singleton pregnancies that had a uterine artery (UtA) Doppler at 22-25 weeks and an OGTT. The UtA Doppler and OGTT were adjusted based on maternal characteristics, and the results were expressed as multiples of the expected normal median and compared between groups. Logistic regression analysis was used to determine whether maternal characteristics, OGTT, and UtA Doppler significantly contribute to the prediction of early- (<34 weeks), intermediate- (34-37 weeks), or late-onset (>37 weeks) PET. The performance of the screening was determined by ROC curves. Results: Women who developed PET were characterized by an older maternal age, an increased body mass index, and an altered UtA Doppler. The group with intermediate-onset PET was the only one associated with higher 2-hour OGTT levels compared to controls. Combined models were developed via logistic regression analysis using maternal characteristics, UtA Doppler, and OGTT to predict PET. These combined models were able to detect around 74, 42, and 21% of women who later developed early-, intermediate-, or late-onset PET, respectively, with only a 5% false-positive rate. Conclusions: This study shows that the combination of maternal characteristics, second-trimester UtA Doppler, and OGTT is a predictor of the development of PET in healthy pregnant women. [ABSTRACT FROM AUTHOR]

Conclusions Sociodemographic characteristics, and not the SARS-COV-2 infection, were the determinants of mental well-being among pregnant and postpartum women during the COVID-19 pandemic. To assess the mental well-being of pregnant and postpartum women during the COVID-19 pandemic. The questions evaluated sociodemographic characteristics, medical and obstetric history, COVID-19 symptoms and infection. [Extracted from the article]

The aim of this pilot study was to determine whether first trimester saliva progesterone (SPr) is altered during the first trimester of pregnancy and its role as a screening test for spontaneous preterm delivery (sPTD). This pilot study concluded that saliva progesterone level is reduced during the first trimester of pregnancy in women who later delivered prematurely, and it might be particularly useful in predicting preterm delivery before 34 weeks of gestation. [Extracted from the article]

EP20.21: Combined predictive model of birthweight at diagnosis of early and late onset pre-eclampsia A multivariate linear regression analysis for birthweight prediction combining maternal characteristics, fetal biometry and UtA Doppler was determined for g-PE, e-PE and l-PE. For g-PE, the best birthweight predictive model included UtA z-score, estimated fetal weight (EFW) z-score, maternal smoking habit and diabetes mellitus background (r = 0.88; p < 0.0001). [Extracted from the article]

The aim of this study is to describe the prenatal diagnosis and perinatal outcomes in fetuses with agenesis of the ductus venosus (ADV) and to perform a systematic review of literature. As for perinatal results, of 36 patients 9 died; 30 had some anomaly (aneuploidy or major abnormality associated), and 6 were healthy. [Extracted from the article]

To evaluate the role of third trimester cerebroplacental ratio (CPR) in predicting abnormal perinatal outcomes in fetuses growing over the 10 SP th sp centile. This was a retrospective study of 1,190 non-small fetuses attending the fetal medicine unit for a routine third trimester ultrasound at 35-41 weeks' gestation. The CPR <5 SP th sp centile detection rate was 21.5% for a false positive rate of 10%, however a combined model including maternal age, parity, estimated fetal weight and CPR had a sensitivity of 46.4%. [Extracted from the article]

EP04.02: Ultrasound reference ranges for fetal prenasal thickness and its role as screening test for chromosomal abnormalities at 16-25 weeks of gestation To determine PNT reference ranges for our population, the fetal profile was examined in 3,904 consecutive euploid singleton pregnancy between 16 to 41 weeks gestation since April 2010 to October 2016. To determine the role of PNT as second trimester screening test for fetal aneuploidy, 3,249 pregnant women who underwent a routine ultrasound scan at 16-25 weeks gestation were included. [Extracted from the article]

Azygos vein is formed at 7 to 10 weeks from last menstrual period, derived from the supracardinal system, with a cranial drainage into the superior vena cava. In a follow-up ultrasound with advanced echocardiography at 32+2 weeks, azygos vein dilatation was observed, with a 2 mm diameter, at expense of a left renal vein shunt identified with 4Dflow® (figure 1). [Extracted from the article]

The aim of this study is to describe the clinical behaviour of pregnancies with corrected transposition of the great arteries (CTGA) and perform systematic review of literature. In our series, maternal age was 31,6 years (23 to 40), gestational age to diagnosis was 26,6 (21 to 34), and there were no isolated cases. Our series and systematic review, shows similar findings, diagnosis during second trimester, most associated to others cardiac malformations. [Extracted from the article]

To determine reference ranges of first trimester nasal bone length (NBL) and to assess its role on aneuploidy screening in a Chilean population. To determine the role of NBL in aneuploidy screening, another cohort of 6,004 patients were assessed at 11+0 to 13+6 weeks of gestation. An absent nasal bone has a better performance than hypoplastic NB for first trimester aneuploidy screening. [Extracted from the article]

We reported the prenatal diagnosis and perinatal outcome of seven cases of neuroblastoma. According to our results, the poor prognosis groups were: diagnosis before 28 weeks, solid tumours and the presence of metastasis. This information is relevant to manage and counseling patients with prenatal diagnosis of neuroblastoma. [Extracted from the article]

An abstract of the article "Screening of spontaneous preterm delivery by obstetric history and second trimester ultrasound in an unselected Chilean population," by M. Parra-Cordero, G. Rencoret, A. Sepulveda-Martinez, H. Muñoz, D. Pedraza is presented.

An abstract of the article "A randomised trial of arginine supplementation to prevent pre-eclampsia," by M. Parra-Cordero and colleagues is presented.

An abstract of the article "Lymphocytes and cytokines pattern as potential markers for screening of pre-eclampsia and fetal growth restriction during the first trimester of pregnancy," by M. Parra-Cordero and colleagues is presented.

An abstract of the article "Prediction of pre-eclampsia by maternal characteristic and biophysical markers during the first trimester of pregnancy" by M. Parra-Cordero and colleagues is presented.

An abstract of the article "Twin pregnancy: screening test for spontaneous preterm delivery and pre-eclampsia during the first trimester of pregnancy," by A. Sepúlveda-Martínez and colleagues is presented.

An abstract of the article "Maternal plasma nerve growth factor at 11 to 13 weeks as a novel angiogenic marker of pre-clampsia," by C. Romero and colleagues is presented.

An abstract of the article "Role of mean blood pressure as screening test for small-for-gestational age without pre-eclampsia during the first trimester of pregnancy," by J. Figueroa and colleagues is presented.

An abstract of the article "Characterisation of immune patterns in pregnancies defined as high- or low-risk according to first trimester uterine artery Doppler," by M. Lopez and colleagues is presented.

An abstract of the article "Fetal cardiac tumours, diagnosis and prognosis," by H. Muñoz and colleagues is presented.