126 results on '"OGUSHI, F."'
Search Results
2. MULTI-TEMPORAL DINSAR TECHNIQUES TO MONITOR THE ACTIVITY OF ASO AND SAKURAJEVIA VOLCANOES, JAPAN
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Tessari, G, Puliero, S, Beccaro, L, Giardino, A, Floris, M, Marzoli, A, Ogushi, F, and Pasquali, P
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Okada ,Aso volcano ,deformation ,Sakurajima volcano ,SAR data ,modeling ,Mogi - Published
- 2019
3. Rheumatoid pleural effusion with detectable level of interleukin-15
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Yanagawa, H., Takeuchi, E., Miyata, J., Maniwa, K., Suzuki, Y., Ogushi, F., and Sone, S.
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- 1998
4. Identification and localization of immunoglobulin binding factor in bronchoalveolar lavage fluid from healthy smokers.
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Ogushi, F, Sone, S, Tani, K, Takehara, H, Endo, T, Haku, T, Nakamura, Y, Ogura, T, Kamada, M, and Aono, T
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- 1995
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5. Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.
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Endo, T, Ogushi, F, Sone, S, Ogura, T, Taketani, Y, Hayashi, Y, Ueda, N, and Yamamoto, S
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- 1995
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6. ANALYSIS OF THE TREND OF THE DEFORMATION AROUND KANTO REGION ESTIMATED BY TIME SERIES OF PALSAR-2 DATA.
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Nonaka, T., Asaka, T., Iwashita, K., and Ogushi, F.
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GAS fields ,STANDARD deviations ,SYNTHETIC aperture radar ,LAND subsidence ,PHASED array antennas ,TREND analysis - Abstract
The South Kanto gas field contains natural gas dissolved in water. In the past, large-scale land subsidence has occurred due to the extraction of this natural gas. Therefore, continuous and accurate monitoring for subsidence using satellite remote sensing is essential to prevent any extreme subsidence events, particularly in urban areas, and ensure the safety of residences. In this study, we adopted the small baseline subset (SBAS) method to understand the subsidence trend. We used Advanced Land Observing Satellite (ALOS)-2 Phased Array type L-band Synthetic Aperture Radar (PALSAR-2) data from 2015 to 2019 for this purpose. The results show that the maximum displacement around the Kujyukuri area is more than 10 mm/year and the mean displacement rate for 2015 to 2019 is -1.4 ± 3.2 mm/year; this value is not as large as some obtained with past PALSAR observations. Comparison of our results with PALSAR observations shows that the number of distributed targets is fewer and the root mean square error of each time-series displacement value is larger. Further quantitative analysis is required to discuss the reliability of the SBAS-derived displacement rates by PALSAR-2. [ABSTRACT FROM AUTHOR]
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- 2019
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7. Simulation Study of Gas-Liquid Interface.
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Landau, David P., Lewis, Steven P., Schüttler, Heinz-Bernd, Ogushi, F., Yukawa, S., and Ito, N.
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Heat conduction of three-dimensional Lennard-Jones particle system are studied using nonequilibrium moleculer dynamics simulation. Geometry of the system is a rectanguler parallelepiped box of the size of Lx ≫ Ly × Lz. Two Nosé-Hoover heat bathes with different temperature TH,L (TH ≥ TL) are attatched on the regions near both ends of x-direction. The density and TH,L are set to be in supercritical fluid, liquid and solid phase. In a single phase system, the heat conductivity shows the system size dependence 1/√Lx where Lx is the system size. Heat flux keeps the system in a gas-liquid coexisting state and an interface exists steadily. Its interface is thicker in gas-side than in liquid-side. Using a characteristic length Xg,l that is desided by the constant density in each phase, we construct a minimul model of an asymmetric interface with tanh form. This model has one parameter L that is the thickness of the interface and this shows good agreement with the simulation results. [ABSTRACT FROM AUTHOR]
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- 2006
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8. A case of bronchogenic cyst with high production of antigen CA 19-9.
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Okubo, Akio, Sone, Saburo, Ogushi, Fumitaka, Ogura, Takeshi, Uyama, Tadashi, Monden, Yasumasa, Ii, Kunio, Okubo, A, Sone, S, Ogushi, F, Ogura, T, Uyama, T, Monden, Y, and Ii, K
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- 1989
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9. Augmentation of lung antineutrophil elastase capacity with recombinant human α-1 -antitrypsin.
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CASOLARO, M. A., FELLS, G., WEWERS, M., PIERCE, J. E., OGUSHI, F., HUBBARD, R., SELLERS, S., FORSTROM, J., LYONS, D., KAWASAKI, G., and CRYSTAL, R. G.
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- 1987
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10. P1.01-32 A Multicenter, Open-Label, Phase II Trial of S-1 Plus Carboplatin in Advanced Non-Small Cell Lung Cancer Patients with Interstitial Lung Disease.
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Hanibuchi, M., Kakiuchi, S., Atagi, S., Ogushi, F., Shimizu, E., Haku, T., Toyoda, Y., Azuma, M., Kondo, M., Kawano, H., Otsuka, K., Sakaguchi, S., Nokihara, H., Goto, H., and Nishioka, Y.
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- 2018
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11. Suppression by interleukin-4 of production of monokines by normal human alveolar macrophages
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Ogura, T., Sone, S., Yanagawa, H., Nishioka, Y., Bhaskaran, G., Nii, A., Mizuno, K., and Ogushi, F.
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- 1991
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12. Complete and durable response of pulmonary large-cell neuroendocrine carcinoma to pembrolizumab.
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Kadota N, Hatakeyama N, Hino H, Kunishige M, Kondo Y, Okano Y, Machida H, Naruse K, Shinohara T, Sakiyama S, Ogushi F, and Takeuchi E
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- Aged, Antibodies, Monoclonal, Humanized therapeutic use, Carboplatin, Humans, Male, Carcinoma, Neuroendocrine diagnosis, Carcinoma, Neuroendocrine drug therapy, Carcinoma, Neuroendocrine pathology, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms pathology
- Abstract
Background: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive tumor with a poor prognosis and standard therapy has not yet been established., Case: A 65-year-old male with a cough for 2 months presented to our hospital. He was clinically diagnosed with non small cell lung cancer cT3N1M0 stage IIIA and underwent right pneumonectomy. The final diagnosis was pulmonary LCNEC pT3N1M0 stage IIIA. Multiple subcutaneous masses were detected 4 months after surgery, and biopsy revealed postoperative recurrence and metastasis. Chemotherapy with carboplatin plus etoposide was initiated. Subcutaneous masses increased and multiple new brain metastases developed after two cycles. Additional tests revealed that epidermal growth factor receptor and anaplastic lymphoma kinase were negative, and the programmed death ligand 1 (PD-L1) expression rate in tumor cells was 40% (22C3 clones). The primary cells infiltrating the tumor were CD3-positive T cells and CD138-positive plasma cells. Second-line treatment with pembrolizumab was started. The shrinkage of subcutaneous masses was observed after one cycle, and the tumor had completely disappeared after six cycles. Treatment was continued for approximately 2 years. This response has been maintained for 4 years and is still ongoing., Conclusion: Pembrolizumab may be used as a treatment option for pulmonary LCNEC., (© 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC.)
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- 2022
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13. A randomized phase II study of docetaxel or pemetrexed with or without the continuation of gefitinib after disease progression in elderly patients with non-small cell lung cancer harboring EGFR mutations (JMTO LC12-01).
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Asami K, Ando M, Nishimura T, Yokoi T, Tamura A, Minato K, Mori M, Ogushi F, Yamamoto A, Yoshioka H, Kawahara M, and Atagi S
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- Aged, Disease Progression, Docetaxel therapeutic use, ErbB Receptors genetics, Gefitinib therapeutic use, Humans, Mutation, Pemetrexed therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms drug therapy, Lung Neoplasms genetics, Lung Neoplasms pathology
- Abstract
Background: Gefitinib (G) is a recommended molecular-targeted agent for elderly patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). Docetaxel (Doc) and pemetrexed (Pem) have similar efficacies, and either is often used as the sole agent during treatment. The efficacy of continuing G after progressive disease (PD) develops has been reported. It remains unclear whether the continuation of G in combination with a single cytotoxic agent beyond PD is beneficial for elderly patients. Here, we conducted a randomized phase II study to assess the efficacy and safety of cytotoxic chemotherapy with G for elderly patients with progressive EGFR-mutant NSCLC., Methods: Elderly patients with EGFR-mutant NSCLC with PD previously treated with G were enrolled. Patients received Pem 500 mg/m or Doc 60 mg/m every 21 days and were randomly assigned to receive chemotherapy with 250 mg G (G+ Doc/Pem arm) or without G (Doc/Pem arm) until further disease progression or unacceptable toxicity., Results: This trial was terminated early owing to slow accrual. A group of 22 patients underwent analysis. The primary endpoint, progression-free survival (PFS), was significantly longer in the G + Doc/Pem arm (median: 1.6 months vs. 5.6 months, hazard ratio = 0.40, 95% CI: 0.16-0.99, p = 0.0391). Adverse events ≥ grade 3 were more frequent in the G + Doc/Pem arm (45.5% vs. 90.9%, p = 0.032)., Conclusions: Patients on G and Pem or Doc beyond PD showed a longer PFS than those on single-agent chemotherapy; however, it was associated with increased toxicity., (© 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
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- 2022
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14. Ecology of the digital world of Wikipedia.
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Ogushi F, Kertész J, Kaski K, and Shimada T
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Wikipedia, a paradigmatic example of online knowledge space is organized in a collaborative, bottom-up way with voluntary contributions, yet it maintains a level of reliability comparable to that of traditional encyclopedias. The lack of selected professional writers and editors makes the judgement about quality and trustworthiness of the articles a real challenge. Here we show that a self-consistent metrics for the network defined by the edit records captures well the character of editors' activity and the articles' level of complexity. Using our metrics, one can better identify the human-labeled high-quality articles, e.g., "featured" ones, and differentiate them from the popular and controversial articles. Furthermore, the dynamics of the editor-article system is also well captured by the metrics, revealing the evolutionary pathways of articles and diverse roles of editors. We demonstrate that the collective effort of the editors indeed drives to the direction of article improvement., (© 2021. The Author(s).)
- Published
- 2021
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15. Implementation of Non-Linear Non-Parametric Persistent Scatterer Interferometry and Its Robustness for Displacement Monitoring.
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Ogushi F, Matsuoka M, Defilippi M, and Pasquali P
- Abstract
To derive surface displacement, interferometric stacking with synthetic aperture radar (SAR) data is commonly used, and this technique is now in the implementation phase in the real world. Persistent scatterer interferometry (PSI) is one of the most universal approaches among in- terferometric stacking techniques, and non-linear non-parametric PSI (NN-PSI) was proposed to overcome the drawbacks of PSI approaches. The estimation of the non-linear displacements was successfully conducted using NN-PSI. However, the estimation of NN-PSI is not always stable with certain displacements because wider range of the velocity spectrum is used in NN-PSI than the conventional approaches; therefore, a calculation procedure and parameter optimization are needed to consider. In this paper, optimized parameters and procedures of NN-PSI are proposed, and real data processing with Sentinel-1 in the Kanto region in Japan was conducted. We confirmed that the displacement estimation was comparable to the measurement of the permanent global positioning system (GPS) stations, and the root mean square error between the GPS measurement and NN-PSI estimation was less than 3 mm in two years. The displacement over 2π ambiguity, which the conventional PSI approach wrongly reconstructed, was also quantitatively validated and successfully estimated by NN-PSI. As a result of the real data processing, periodical displacements were also reconstructed through NN-PSI. We concluded that the NN-PSI approach with the proposed parameters and method enabled the estimation of several types of surface displacements that conventional PSI approaches could not reconstruct.
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- 2021
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16. Pulmonary tuberculosis misdiagnosed as extensively drug-resistant tuberculosis due to selection of a nontuberculous mycobacterial colony from a preculture dish used for a drug-susceptibility test.
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Ohji R, Shinohara T, Ohji H, Hatakeyama N, Iwamura S, and Ogushi F
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- Drug Resistance, Bacterial, Humans, Diagnostic Errors, Microbial Sensitivity Tests methods, Nontuberculous Mycobacteria, Tuberculosis, Pulmonary diagnosis, Tuberculosis, Pulmonary microbiology
- Abstract
Drug-susceptibility test (DST) is important for tuberculosis care; however, there are several pitfalls with the procedure. A 70-year-old woman was diagnosed with extensively drug-resistant tuberculosis based on the result of a DST using microdilution method. Because she had no history of medication for tuberculosis and the sputum acid-fast bacillus smear test turned negative during standard treatment, identification of the strain used for DST was performed. Consequently, the strain was found to be M. intracellulare. It was assumed that a colony of M. intracellulare that had existed in the preculture solid medium was selected and used for the DST., Competing Interests: Declaration of Competing Interest The authors have no conflicts of interests to declare., (Copyright © 2020 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
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17. Mycobacterium Shinjukuense Pulmonary Disease Progressed to Pleuritis after Iatrogenic Pneumothorax: A Case Report.
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Taoka T, Shinohara T, Hatakeyama N, Iwamura S, Murase Y, Mitarai S, and Ogushi F
- Abstract
Mycobacterium shinjukuense is a newly identified nontuberculous mycobacteria (NTM) and its gene sequence of 16S rRNA shows high homology to that of Mycobacterium tuberculosis . We present a case of M. shinjukuense pulmonary disease progressed to pleuritis after iatrogenic pneumothorax. The patient was initially diagnosed as tuberculosis based on a positive result for the 16S rRNA of an M. tuberculosis identification kit using scrapings from the cavitary nodule. We need to bear in mind that pneumothorax following bronchoscopy may induce NTM pleuritis and M. shinjukuense infection should be considered in the differential diagnosis of mycobacterial pulmonary disease with effusion., Competing Interests: The authors declare that they have no conflict of interest., (© 2020 The Authors.)
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- 2020
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18. Evaluation of the Trend of Deformation around the Kanto Region Estimated Using the Time Series of PALSAR-2 Data.
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Nonaka T, Asaka T, Iwashita K, and Ogushi F
- Abstract
In the Kanto region of Japan, a large quantity of natural gas is dissolved in brine. The large-scale production of gas and iodine in the region has caused large-scale land subsidence in the past. Therefore, continuous and accurate monitoring for subsidence using satellite remote sensing is essential to prevent extreme subsidence and ensure the safety of residences. This study focused on the small baseline subset (SBAS) method to assess ground deformation trends around the Kanto region. Data for the SBAS method was acquired by the Advanced Land Observing Satellite (ALOS)-2 Phased Array type L-band Synthetic Aperture Radar (PALSAR)-2 from 2015 to 2019. A comparison of our results with reference levelling data shows that the SBAS method underestimates displacement. We corrected our results using linear regression and determined the maximum displacement around the Kujyukuri area to be approximately 20 mm/year; the mean displacement rate for 2015-2019 was -7.9 ± 2.9 mm/year. These values exceed those obtained using past PALSAR observations owing to the horizontal displacement after the Great East Japan Earthquake of 2011. Moreover, fewer points were acquired, and the root mean-squared error of each time-series displacement value was larger in our results. Further analysis is needed to address these bias errors.
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- 2020
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19. Mycobacterium abscessus ssp. abscessus infection progressing to empyema from vertebral osteomyelitis in an immunocompetent patient without pulmonary disease: a case report.
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Kadota N, Shinohara T, Hino H, Goda Y, Murase Y, Mitarai S, and Ogushi F
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- Anti-Bacterial Agents therapeutic use, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Mycobacterium Infections, Nontuberculous drug therapy, Osteomyelitis drug therapy, Osteomyelitis microbiology, Tomography, X-Ray Computed, Lumbosacral Region pathology, Mycobacterium Infections, Nontuberculous diagnosis, Mycobacterium abscessus isolation & purification, Osteomyelitis diagnosis
- Abstract
Background: Pleural involvement by non-tuberculous mycobacteria (NTM) in patients without distinct pulmonary disease is extremely rare. Vertebral osteomyelitis (VO) with or without pulmonary disease is also a rare clinical presentation of NTM infection, and pleural spread of NTM from VO has not been reported., Case Presentation: A 63-year-old woman was admitted to our hospital with back pain persisting for 4 months and a 2-day history of fever and right chest pain. The patient was initially treated as right-sided empyema due to general bacteria. However, after removal of the chest tube, a previously overlooked paravertebral lesion was observed on CT. MRI confirmed VO at T7/8. Mycobacterium abscessus ssp. abscessus was detected in both the thoracic cavity and the paravertebral lesion. Both VO and the paravertebral abscess were improved by antimycobacterial treatment., Conclusion: VO of the thoracic spine due to non-tuberculous mycobacterial infection should be considered as a cause of pleuritis or empyema without pulmonary disease, especially in patients with back pain.
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- 2019
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20. A lobulated mass in the left lower lobe: not what it seems.
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Kadota N, Shinohara T, Naruse K, Hino H, and Ogushi F
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- Adult, Cysts surgery, Diagnosis, Differential, Female, Humans, Lung surgery, Lung Diseases surgery, Magnetic Resonance Imaging, Pneumonectomy, Positron-Emission Tomography, Tomography, X-Ray Computed, Cysts diagnosis, Lung diagnostic imaging, Lung Diseases diagnosis
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2019
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21. Transition rates for slip-avalanches in soft athermal disks under quasi-static simple shear deformations.
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Saitoh K, Oyama N, Ogushi F, and Luding S
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We study slip-avalanches in two-dimensional soft athermal disks by quasi-static simulations of simple shear deformations. Sharp drops in shear stress, or slip-avalanches, are observed intermittently during steady state. Such stress drops are caused by restructuring of the contact networks, accompanied by drastic changes of the interaction forces, Δf. The changes of the forces happen heterogeneously in space, indicating that collective non-affine motions of the disks are most pronounced when slip-avalanches occur. We analyze and predict the statistics for the force changes, Δf, by transition rates of the contact forces and angles, where slip-avalanches are characterized by wide power-law tails. We find that the transition rates are described by a q-Gaussian distribution regardless of the area fraction of the disks. Because the transition rates quantify structural changes of the force-chains, our findings are an important step towards linking macroscopic observations to a microscopic theory of slip-avalanches in the experimentally accessible quasi-static regime.
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- 2019
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22. Correction: Transition rates for slip-avalanches in soft athermal disks under quasi-static simple shear deformations.
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Saitoh K, Oyama N, Ogushi F, and Luding S
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Correction for 'Transition rates for slip-avalanches in soft athermal disks under quasi-static simple shear deformations' by Kuniyasu Saitoh et al., Soft Matter, 2019, DOI: 10.1039/c8sm01966e.
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- 2019
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23. Temporal inactivation enhances robustness in an evolving system.
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Ogushi F, Kertész J, Kaski K, and Shimada T
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We study the robustness of an evolving system that is driven by successive inclusions of new elements or constituents with m random interactions to older ones. Each constitutive element in the model stays either active or is temporarily inactivated depending upon the influence of the other active elements. If the time spent by an element in the inactivated state reaches T
W , it gets extinct. The phase diagram of this dynamic model as a function of m and TW is investigated by numerical and analytical methods and as a result both growing (robust) as well as non-growing (volatile) phases are identified. It is also found that larger time limit TW enhances the system's robustness against the inclusion of new elements, mainly due to the system's increased ability to reject 'falling-together' type attacks. Our results suggest that the ability of an element to survive in an unfavourable situation for a while, either as a minority or in a dormant state, could improve the robustness of the entire system., Competing Interests: We declare we have no competing interests.- Published
- 2019
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24. Elevated Levels of Intelectin-1, a Pathogen-binding Lectin, in the BAL Fluid of Patients with Chronic Eosinophilic Pneumonia and Hypersensitivity Pneumonitis.
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Shinohara T, Tsuji S, Okano Y, Machida H, Hatakeyama N, and Ogushi F
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- Aged, Alveolitis, Extrinsic Allergic diagnosis, Biomarkers metabolism, Female, GPI-Linked Proteins metabolism, Humans, Male, Middle Aged, Pulmonary Eosinophilia diagnosis, Alveolitis, Extrinsic Allergic metabolism, Bronchoalveolar Lavage Fluid chemistry, Cytokines metabolism, Lectins metabolism, Pulmonary Eosinophilia metabolism
- Abstract
Objective Human intelectin-1 (hITLN-1) binds to galactofuranosyl residues, which are present in the microbial cell wall, but which are absent in mammalian tissues, and has been suggested to play an immunological role against microorganisms. However, the involvement of hITLN-1 in the pathogenesis of diffuse pulmonary diseases remains unknown. The aim of this study was to compare the hITLN-1 concentrations in the bronchoalveolar lavage (BAL) fluid of patients with diffuse pulmonary diseases. Methods The cell components and concentrations of hITLN-1 were analyzed in the BAL fluid of 8 patients with idiopathic chronic eosinophilic pneumonia (ICEP), 3 patients with drug-induced eosinophilic pneumonia, 4 patients with hypersensitivity pneumonitis (HP), 11 patients with sarcoidosis, 9 patients with cryptogenic organizing pneumonia, and 5 patients with idiopathic fibrosing interstitial pneumonia (fibrosing nonspecific interstitial pneumonia or usual interstitial pneumonia). Results The hITLN-1 concentrations in the BAL fluid of patients with ICEP and HP were higher than in those with other diseases. In the ICEP group, no significant difference was observed in the hITLN-1 concentrations of patients with or without a history of bronchial asthma. Conclusion The results of the present study suggest that hITLN-1 may be involved in the pathogenesis of ICEP and HP, and that an increase in the hITLN-1 concentration in the BAL fluid may represent a new biomarker for these diseases.
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- 2018
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25. Pneumocystis jirovecii pneumonia in an HIV-infected patient mimicking acute eosinophilic pneumonia: a case report with a review of the literature.
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Ohji H, Shinohara T, Kadota N, Okano Y, Naruse K, Iwahara Y, and Ogushi F
- Abstract
Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
- Published
- 2018
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26. A multicenter, open-label, phase II trial of S-1 plus carboplatin in advanced non-small cell lung cancer patients with interstitial lung disease.
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Hanibuchi M, Kakiuchi S, Atagi S, Ogushi F, Shimizu E, Haku T, Toyoda Y, Azuma M, Kondo M, Kawano H, Otsuka K, Sakaguchi S, Nokihara H, Goto H, and Nishioka Y
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- Aged, Carboplatin administration & dosage, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell mortality, Disease-Free Survival, Drug Combinations, Female, Humans, Lung Diseases, Interstitial mortality, Lung Neoplasms mortality, Male, Middle Aged, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local mortality, Oxonic Acid administration & dosage, Prospective Studies, Survival Rate, Tegafur administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Diseases, Interstitial drug therapy, Lung Neoplasms drug therapy
- Abstract
Objectives: The clinical benefit of chemotherapy and the appropriate regimen for non-small-cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) remain unclear. To fulfill this unmet medical need, we conducted a phase II study to elucidate the efficacy of S-1 in combination with carboplatin (CBDCA) in NSCLC patients with ILD., Materials and Methods: A total of 33 advanced or recurrent NSCLC patients with ILD were prospectively enrolled in this multicenter, open-label, phase II study. Every 4 weeks, CBDCA at a dose of AUC 5 on day 1 and S-1 at a dose of 80 mg/m
2 daily for 14 days were administered. The primary endpoint was the investigator-assessed objective response rate., Results: The median age at initiating chemotherapy was 70. Sixteen patients (48.5%) had squamous cell carcinoma histology. With respect to the types of ILD, the usual interstitial pneumonia pattern was dominant (66.7%). The median number of cycles administered was 3, and the overall response rate and disease control rate were 33.3% and 78.8%, respectively. The median progression-free survival, the median survival time and the 1-year survival rate were 4.8 months, 12.8 months and 51.4%, respectively. Acute exacerbation of ILD caused by chemotherapy was noted in 2 patients (6.1%)., Conclusion: This is the first prospective study designed to evaluate the efficacy of a specific chemotherapeutic regimen as the primary endpoint in patients with advanced NSCLC with ILD. The combination of S-1 with CBDCA may be a treatment option for advanced NSCLC patients with ILD (The clinical trial registration number: UMIN000011046)., (Copyright © 2018 Elsevier B.V. All rights reserved.)- Published
- 2018
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27. Atypical pulmonary alveolar proteinosis presenting as a mixed nodular ground-glass opacity with focal mucinosis mimicking lung cancer.
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Shinohara T, Hino H, Imanishi S, Naruse K, Ohtsuki Y, and Ogushi F
- Abstract
Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
- Published
- 2018
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28. Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC.
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Arasada RR, Shilo K, Yamada T, Zhang J, Yano S, Ghanem R, Wang W, Takeuchi S, Fukuda K, Katakami N, Tomii K, Ogushi F, Nishioka Y, Talabere T, Misra S, Duan W, Fadda P, Rahman MA, Nana-Sinkam P, Evans J, Amann J, Tchekneva EE, Dikov MM, and Carbone DP
- Subjects
- Animals, Carcinoma, Non-Small-Cell Lung blood, Carcinoma, Non-Small-Cell Lung pathology, Cell Line, Tumor, DNA-Binding Proteins metabolism, Drug Resistance, Neoplasm drug effects, Epithelial-Mesenchymal Transition drug effects, ErbB Receptors genetics, Humans, Lung Neoplasms blood, Lung Neoplasms pathology, Mice, Inbred NOD, Mice, SCID, Neoplastic Stem Cells drug effects, Neoplastic Stem Cells metabolism, Neoplastic Stem Cells pathology, Phenotype, Plasminogen Activator Inhibitor 1 blood, Protein Stability drug effects, Transcription Factors metabolism, beta Catenin antagonists & inhibitors, Carcinoma, Non-Small-Cell Lung genetics, Lung Neoplasms genetics, Mutation genetics, Protein Kinase Inhibitors pharmacology, Receptor, Notch3 metabolism, Signal Transduction, beta Catenin metabolism
- Abstract
EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance is not clear. Here, we show that EGFR inhibition results in the activation of β-catenin signaling in a Notch3-dependent manner, which facilitates the survival of a subset of cells that we call "adaptive persisters". We previously reported that EGFR-TKI treatment rapidly activates Notch3, and here we describe the physical association of Notch3 with β-catenin, leading to increased stability and activation of β-catenin. We demonstrate that the combination of EGFR-TKI and a β-catenin inhibitor inhibits the development of these adaptive persisters, decreases tumor burden, improves recurrence free survival, and overall survival in xenograft models. These results supports combined EGFR-TKI and β-catenin inhibition in patients with EGFR mutant lung cancer.
- Published
- 2018
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29. Spatiotemporal deformation patterns of the Lake Urmia Causeway as characterized by multisensor InSAR analysis.
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Karimzadeh S, Matsuoka M, and Ogushi F
- Abstract
We present deformation patterns in the Lake Urmia Causeway (LUC) in NW Iran based on data collected from four SAR sensors in the form of interferometric synthetic aperture radar (InSAR) time series. Sixty-eight images from Envisat (2004-2008), ALOS-1 (2006-2010), TerraSAR-X (2012-2013) and Sentinel-1 (2015-2017) were acquired, and 227 filtered interferograms were generated using the small baseline subset (SBAS) technique. The rate of line-of-sight (LOS) subsidence of the LUC peaked at 90 mm/year between 2012 and 2013, mainly due to the loss of most of the water in Lake Urmia. Principal component analysis (PCA) was conducted on 200 randomly selected time series of the LUC, and the results are presented in the form of the three major components. The InSAR scores obtained from the PCA were used in a hydro-thermal model to investigate the dynamics of consolidation settlement along the LUC based on detrended water level and temperature data. The results can be used to establish a geodetic network around the LUC to identify more detailed deformation patterns and to help plan future efforts to reduce the possible costs of damage.
- Published
- 2018
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30. Fan-shaped ground-glass opacity (GGO) as a premonitory sign of pulmonary infarction: a case report.
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Shinohara T, Naruse K, Hamada N, Yamasaki T, Hatakeyama N, and Ogushi F
- Abstract
Radiological findings of pulmonary infarction have been well characterized mainly in established infarction. However, the early course CT appearance of patients who develop pulmonary infarction has not yet been fully elucidated. A 50-year-old female with a history of postmenopausal hormone replacement therapy (HRT) presented with dry cough and high-resolution computed tomography (HRCT) findings of fan-shaped segmental ground-glass opacity (GGO) in the right lower lobe. As the parenchymal density in the GGO gradually enlarged over a period of 4 weeks in spite of antibiotic treatment, the patient was referred to our hospital on clinical suspicion of bronchioloalveolar cell carcinoma. However, the pathological findings of a transbronchial biopsy of the lesion were compatible with pulmonary infarction. After an endoscopic examination, the typical CT appearance of established pulmonary infarction was observed. Moreover, enhanced CT detected an intraluminal filling defect in the right lower lobe artery suggesting peripheral pulmonary emboli. Our case was a peripheral pulmonary infarction probably induced by HRT, and suggested that fan-shaped GGO may be a premonitory sign of pulmonary infarction., Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
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- 2018
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31. Phase II study of tailored S-1 monotherapy with a 1-week interval after a 2-week dosing period in elderly patients with advanced non-small cell lung cancer.
- Author
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Goto H, Okano Y, Machida H, Hatakeyama N, Ogushi F, Haku T, Kanematsu T, Urata T, Kakiuchi S, Hanibuchi M, Sone S, and Nishioka Y
- Subjects
- Administration, Oral, Aged, Aged, 80 and over, Body Surface Area, Carcinoma, Non-Small-Cell Lung mortality, Creatinine, Drug Administration Schedule, Drug Combinations, Female, Humans, Lung Neoplasms mortality, Male, Metabolic Clearance Rate, Survival Rate, Treatment Outcome, Antimetabolites, Antineoplastic administration & dosage, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, Oxonic Acid administration & dosage, Precision Medicine, Tegafur administration & dosage
- Abstract
Background: S-1 is an oral fluoropyrimidine that is active in the treatment of non-small cell lung cancer (NSCLC); however, an optimal treatment schedule and appropriate dose adjustments of S-1 in elderly patients have not yet been established., Methods: We conducted a phase II trial to evaluate the efficacy and safety of a 2-week S-1 monotherapy treatment followed by a 1-week interval as a first-line treatment of elderly NSCLC patients, by adjusting the dose based on the individual creatinine clearance (Ccr) and body surface area (BSA). The primary endpoint was the disease control rate., Results: Forty patients were enrolled. The disease control and response rates were 89.5% (95% confidence interval [CI] = 79.8-99.2) and 7.9% (95% CI = 0.0-16.4), respectively. The median progression-free survival and overall survival times were 4.4 months (95% CI = 4.2-8.5) and 17.0 months (95% CI = 11.2-18.7), respectively. Neutropenia, anorexia, hyponatremia, hypokalemia, and pneumonia of grade ≥ 3 occurred in 5.0%, 7.5%, 5.0%, 2.5%, and 2.5% of patients, respectively. Among the patient-reported outcomes, most of the individual factors in the patients' quality of life, including upper intestine-related symptoms improved with the treatment, except for dyspnea, which slightly albeit continuously worsened throughout the study., Conclusions: In elderly patients with previously untreated advanced NSCLC, a 2-week S-1 monotherapy treatment, tailored to both the Ccr and BSA, with a 1-week interval was well tolerated and demonstrated promising efficacy. This study was registered at the University Hospital Medical Information Network (UMIN) Center (ID: UMIN000002035), Japan., (Copyright © 2017 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2018
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32. Enhanced robustness of evolving open systems by the bidirectionality of interactions between elements.
- Author
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Ogushi F, Kertész J, Kaski K, and Shimada T
- Abstract
Living organisms, ecosystems, and social systems are examples of complex systems in which robustness against inclusion of new elements is an essential feature. A recently proposed simple model has revealed a general mechanism by which such systems can become robust against inclusion of elements with totally random interactions when the elements have a moderate number of links. The interaction is, however, in many systems often intrinsically bidirectional like for mutual symbiosis and competition in ecology. This study reports the strong reinforcement effect of the bidirectionality of the interactions on the robustness of evolving systems. We show that the system with purely bidirectional interactions can grow with twofold average degree, in comparison with the purely unidirectional system. This drastic shift of the transition point comes from the reinforcement of each node, not from a change in structure of the emergent system. For systems with partially bidirectional interactions we find that the regime of the growing phase gets expanded. In the dense interaction regime, there exists an optimum proportion of bidirectional interactions for the growth rate at around 1/3. In the sparsely connected systems, small but finite fraction of bidirectional links can change the system's behaviour from non-growing to growing.
- Published
- 2017
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33. Cavitary lung cancer with cartilage tissues in the wall mimicking aspergilloma.
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Taoka T, Shinohara T, Naruse K, and Ogushi F
- Subjects
- Aged, Carcinoma surgery, Diagnosis, Differential, Female, Humans, Lung Neoplasms surgery, Carcinoma diagnosis, Lung Neoplasms diagnosis, Pulmonary Aspergillosis diagnosis
- Published
- 2017
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34. Analysis of acute exacerbation of interstitial lung disease associated with chemotherapy in patients with lung cancer: A feasibility of S-1.
- Author
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Kakiuchi S, Hanibuchi M, Tezuka T, Saijo A, Otsuka K, Sakaguchi S, Toyoda Y, Goto H, Kawano H, Azuma M, Ogushi F, and Nishioka Y
- Subjects
- Acute-Phase Reaction, Adult, Aged, Aged, 80 and over, Disease Progression, Drug Combinations, Etoposide administration & dosage, Feasibility Studies, Female, Humans, Incidence, Lung Diseases, Interstitial epidemiology, Lung Diseases, Interstitial prevention & control, Male, Middle Aged, Oxonic Acid administration & dosage, Paclitaxel administration & dosage, Respiratory Insufficiency etiology, Retrospective Studies, Tegafur administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lung Diseases, Interstitial etiology, Lung Neoplasms complications, Lung Neoplasms drug therapy
- Abstract
Background: Interstitial lung disease (ILD) is commonly concomitant with lung cancer, and its acute exacerbation (AE) is the most serious complication in patients receiving treatment for lung cancer., Methods: To investigate the incidence and characteristic features of AE of ILD, we conducted a retrospective study of 665 consecutive patients with lung cancer who were treated at our institute between 2008 and 2014., Results: Among the 665 patients, 74 (11.1%) had preexisting ILD, and 64 of them received chemotherapy. Four of the 64 patients (6.3%) had experienced AE of ILD, and two (3.1%) died of respiratory failure during first-line chemotherapy. The use of a combination of carboplatin with tegafur-gimeracil-oteracil potassium (S-1) or paclitaxel as a first-line chemotherapy for non-small cell lung cancer led to a lower frequency of AE, at 8.3% (1/12) and 9.1% (1/11), respectively. The incidence of AE rose to 12.8% (5/39) during second-line treatment, and 14 (total: 15 times) of the 64 patients (21.9%) experienced AE from the time of diagnosis to the end of treatment. The incidence of AE was 17.7% (6/34), 15.8% (3/19), 5.0% (2/40), and 4.2% (1/24) in the paclitaxel-, vinorelbine-, etoposide-, and S-1-containing regimens, respectively. No difference in clinical features and laboratory data was detected between the AE and non-AE groups., Conclusions: Although this was a small retrospective study, its findings showed that S-1 and etoposide may be relatively safe options for the treatment of patients with lung cancer and concomitant ILD., (Copyright © 2016 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2017
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35. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.
- Author
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Isomura A, Ogushi F, Kori H, and Kageyama R
- Subjects
- Animals, Cell Line, Gene Expression Regulation, Mice, Receptors, Notch metabolism, Cell Communication physiology, Luminescent Measurements, Optogenetics, Signal Transduction, Single-Cell Analysis methods
- Abstract
Cells communicate with each other to coordinate their gene activities at the population level through signaling pathways. It has been shown that many gene activities are oscillatory and that the frequency and phase of oscillatory gene expression encode various types of information. However, whether or how such oscillatory information is transmitted from cell to cell remains unknown. Here, we developed an integrated approach that combines optogenetic perturbations and single-cell bioluminescence imaging to visualize and reconstitute synchronized oscillatory gene expression in signal-sending and signal-receiving processes. We found that intracellular and intercellular periodic inputs of Notch signaling entrain intrinsic oscillations by frequency tuning and phase shifting at the single-cell level. In this way, the oscillation dynamics are transmitted through Notch signaling, thereby synchronizing the population of oscillators. Thus, this approach enabled us to control and monitor dynamic cell-to-cell transfer of oscillatory information to coordinate gene expression patterns at the population level., (© 2017 Isomura et al.; Published by Cold Spring Harbor Laboratory Press.)
- Published
- 2017
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36. Overlapping lung parenchymal and bronchial lesion and hilar lymphadenopathy in pulmonary actinomycosis mimicking lung cancer.
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Imanishi S, Shinohara T, Naruse K, and Ogushi F
- Subjects
- Actinomycosis complications, Adult, Airway Obstruction complications, Airway Obstruction diagnostic imaging, Bronchial Diseases complications, Bronchial Diseases diagnostic imaging, Diagnosis, Differential, Humans, Lung Diseases complications, Lung Neoplasms diagnostic imaging, Lymphatic Diseases complications, Male, Tomography, X-Ray Computed, Actinomycosis diagnostic imaging, Lung Diseases diagnostic imaging, Lymphatic Diseases diagnostic imaging
- Published
- 2016
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37. Disseminated tuberculosis after pregnancy progressed to paradoxical response to the treatment: report of two cases.
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Shinohara T, Kagawa K, Okano Y, Sawada T, Kobayashi T, Takikawa M, Iwahara Y, and Ogushi F
- Subjects
- Acute Disease, Adult, Disease Progression, Female, Humans, Peritonitis, Tuberculous diagnostic imaging, Peritonitis, Tuberculous immunology, Postpartum Period immunology, Pregnancy, Psoas Abscess diagnostic imaging, Psoas Abscess etiology, Psoas Abscess immunology, Puerperal Infection diagnostic imaging, Puerperal Infection immunology, Radiography, Thoracic, Tomography, X-Ray Computed, Treatment Outcome, Tuberculosis, Pulmonary diagnostic imaging, Tuberculosis, Pulmonary immunology, Tuberculosis, Spinal complications, Tuberculosis, Spinal diagnostic imaging, Tuberculosis, Spinal immunology, Antitubercular Agents therapeutic use, Peritonitis, Tuberculous drug therapy, Psoas Abscess drug therapy, Puerperal Infection drug therapy, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Spinal drug therapy
- Abstract
Background: Early postpartum women are more likely to develop tuberculosis than nonpregnant women mainly due to immune reconstitution after delivery. Paradoxical response (PR) during antituberculosis treatment also arises via recovery from immunosuppression. However, no study focused on PR during antituberculosis treatment in a postpartum patient has been reported., Case Presentation: We present two sequential cases (Patient 1: 26-year-old; Patient 2: 29-year-old) of postpartum tuberculosis with pulmonary and extrapulmonary lesions (Patient 1: peritonitis; Patient 2: psoas abscess secondary to spondylitis). Both cases progressed to PR (worsening of pre-existing lung infiltrations (Patients 1, 2) and new contralateral effusion (Patient 2)) in a relatively short time after initiation of treatment (Patient 1: 1 week; Patient 2: 3 weeks), suggesting that immune modulations during pregnancy and delivery may contribute to the pathogenesis of both disseminated tuberculosis and its PR. The pulmonary lesions and effusion of both cases gradually improved without change of chemotherapy regimen., Conclusion: Physicians should recognize PR in tuberculosis patients with postpartum and then evaluate treatment efficacy.
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- 2016
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38. Miliary pulmonary nodules due to Mycobacterium xenopi in a steroid-induced immunocompromised patient successfully treated with chemotherapy: a case report.
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Okano Y, Shinohara T, Imanishi S, Takahashi N, Naito N, Taoka T, Kadota N, and Ogushi F
- Subjects
- Adult, Clarithromycin therapeutic use, Ethambutol therapeutic use, Humans, Immunocompromised Host, Male, Rifampin therapeutic use, Tomography, X-Ray Computed, Bronchoalveolar Lavage Fluid microbiology, Mycobacterium Infections, Nontuberculous diagnostic imaging, Mycobacterium Infections, Nontuberculous drug therapy, Mycobacterium xenopi isolation & purification, Sputum microbiology
- Abstract
Background: Mycobacterium xenopi-infected patients have a high prevalence of pulmonary cavities and nodules. However, the clinical course for patients with miliary nodules due to M. xenopi has not yet been reported., Case Presentation: We encountered a case of miliary nodules with gradually worsening coughing and sputum production in a 44-year-old male who had renal dysfunction due to glomerulosclerosis with a decade-long history of steroid therapy. Although we started anti-tuberculosis treatment on clinical suspicion of miliary tuberculosis, cultures of sputum and bronchial lavage were both positive for M. xenopi. The patient was successfully treated with rifampin, ethambutol and clarithromycin, without fibrosis. It was unclear whether the miliary pattern was induced by hematogenous or endobronchial spread of the M. xenopi infection., Conclusion: Even when clinical and radiological disease manifestations are similar to those of miliary tuberculosis, M. xenopi infection should be considered in the differential diagnosis of miliary nodules.
- Published
- 2016
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39. Acute respiratory distress syndrome caused by Mycoplasma pneumoniae without elevated pulmonary vascular permeability: a case report.
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Takahashi N, Shinohara T, Oi R, Ota M, Toriumi S, and Ogushi F
- Abstract
Sporadic patients with acute respiratory distress syndrome (ARDS) caused by Mycoplasma pneumoniae have been reported. However, knowledge about the pathophysiology and pharmacological treatment of this condition is insufficient. Moreover, the pulmonary vascular permeability in ARDS related to M. pneumoniae infection has not been reported. We report a case of ARDS caused by Mycoplasma pneumoniae without elevated pulmonary vascular permeability, which was successfully treated using low-dose short-term hydrocortisone, suggesting that pulmonary infiltration in ARDS caused by Mycoplasma pneumoniae does not match the criteria of permeability edema observed in typical ARDS.
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- 2016
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40. Carboplatin plus Weekly Paclitaxel with Bevacizumab for First-line Treatment of Non-small Cell Lung Cancer.
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Kubota T, Okano Y, Sakai M, Takaoka M, Tsukuda T, Anabuki K, Kawase S, Miyamoto S, Ohnishi H, Hatakeyama N, Machida H, Urata T, Yamamoto A, Ogushi F, and Yokoyama A
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Bevacizumab administration & dosage, Carboplatin administration & dosage, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Female, Humans, Lung Neoplasms mortality, Lung Neoplasms pathology, Male, Middle Aged, Paclitaxel administration & dosage, Prospective Studies, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bevacizumab therapeutic use, Carboplatin therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, Paclitaxel therapeutic use
- Abstract
Aim: The present study aimed to evaluate the effectiveness and safety of weekly paclitaxel (PTX) combined with carboplatin (CBDCA) plus bevacizumab (BEV), followed by maintenance BEV in patients with advanced NSCLC., Patients and Methods: Patients with unresectable stage IIIB and IV NSCLC (n=43) were treated with CBDCA (AUC 6, day 1), BEV (15 mg/kg, day 1), and PTX (70 mg/m(2), days 1, 8, 15) intravenously every 4 weeks, for 3 to 6 cycles, followed by maintenance BEV (15 mg/kg) every 3 weeks., Results: The objective response rate and disease control rate were 67.4% and 90.7%, respectively. The median progression-free survival was 7.6 months. The median overall survival was 17.7 months. Common adverse events were tolerable bone marrow suppression, fatigue, hypertension, and nasal bleeding., Conclusion: Weekly administration of PTX combined with CBDCA plus BEV therapy was effective, and well-tolerated by advanced NSCLC patients., (Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Published
- 2016
41. Kikuchi-Fujimoto disease associated with community acquired pneumonia showing intrathoratic lymphadenopathy without cervical lesions.
- Author
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Naito N, Shinohara T, Machida H, Hino H, Naruse K, and Ogushi F
- Abstract
Introduction: Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare entity of unknown etiology in young adults that is typically characterized by cervical lymphadenopathy and persistent fever. The pathogenesis of KFD has been suggested to be an abnormal immune response, and infections or autoimmune diseases are considered to be involved in KFD. However, KFD associated with community acquired pneumonia (CAP) has not been reported., Case Description: A 35-year-old male was admitted due to high fever, diffuse air-space consolidation in the right lung with ipsilateral pleural effusion and massive mediastinal and hilar lymphadenopathy without cervical lesions. On clinical suspicion of malignant lymphoma complicated with pneumonia, we performed a video-assisted thoracoscopic lymph node biopsy, and the diagnosis of KFD was established. Complete cure of the intrathoratic lesions was observed by administration of β-lactam antibiotics alone without steroid therapy., Discussion and Evaluation: Previous large case series have identified no pathogenic relationship between KFD and pneumonia. The hilar adenopathy could have caused airway compression leading to pneumonia., Conclusions: KFD should be considered in the differential diagnosis of massive mediastinal and hilar lymphadenopathy, even when there are no superficial lesions. In addition, we need to bear in mind that unexpected disorders occasionally coexist with common diseases.
- Published
- 2015
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42. Asymptomatic tracheal MALT lymphoma discovered on spirometric findings presenting with elevated respiratory resistance.
- Author
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Kadota N, Shinohara T, Machida H, Nakanishi H, Suehiro F, Toda H, Yoshino T, and Ogushi F
- Subjects
- Airway Obstruction etiology, Airway Obstruction physiopathology, Asymptomatic Diseases, Biopsy, Bronchoscopy, Female, Humans, Lymphoma, B-Cell, Marginal Zone complications, Lymphoma, B-Cell, Marginal Zone physiopathology, Lymphoma, B-Cell, Marginal Zone radiotherapy, Middle Aged, Predictive Value of Tests, Tomography, X-Ray Computed, Tracheal Neoplasms complications, Tracheal Neoplasms physiopathology, Tracheal Neoplasms radiotherapy, Treatment Outcome, Airway Obstruction diagnosis, Airway Resistance, Lymphoma, B-Cell, Marginal Zone diagnosis, Spirometry, Tracheal Neoplasms diagnosis
- Abstract
Background: Central airway obstruction (CAO) may be caused by various etiologies. However, conventional chest X-rays are rarely diagnostic for patients with CAO., Case Presentation: We here described a 64-year-old asymptomatic female with tracheal mucosa-associated lymphoid tissue lymphoma discovered on spirometric findings during a complete physical examination. The plateau of forced expiratory flow was consistent with CAO. A decreased peak expiratory flow rate was noted at least 3 years before the diagnosis, and was attributed to an insufficient effort by the patient. Impulse oscillometric measurements, which were taken during quiet breathing and were effort-independent, suggested elevated respiratory resistance. These abnormalities completely disappeared after radiation therapy., Conclusion: The addition of impulse oscillometry to spirometry may be useful for screening CAO in routine health examinations.
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- 2015
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43. Primary Gingival Tuberculosis Diagnosed Based on Genetic Identification.
- Author
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Okano Y, Yoshida S, Shinohara T, Takahashi N, Naito N, Kagawa K, Machida H, Hatakeyama N, Ohno A, Wada T, and Ogushi F
- Subjects
- Aged, Biopsy, Diagnosis, Differential, Ethambutol administration & dosage, Female, Humans, Isoniazid administration & dosage, Mycobacterium tuberculosis genetics, Pyrazinamide administration & dosage, Rifampin administration & dosage, Treatment Outcome, Tuberculosis, Oral drug therapy, Antitubercular Agents administration & dosage, DNA, Bacterial isolation & purification, Gingival Diseases diagnosis, Gingival Diseases microbiology, Mycobacterium tuberculosis isolation & purification, Tuberculosis, Oral diagnosis
- Abstract
A case of primary gingival tuberculosis in a 71-year-old Japanese woman is herein presented. A serous saliva culture was positive for tuberculosis, and we recognized that the origin of the tuberculosis infection was the gingiva based on the genetic identification in gingival biopsy tissue. The definitive diagnosis was facilitated by the genetic identification, a useful modern tool for diagnosing infectious diseases. The location and clinical presentation of this lesion were unusual, which underlines the importance of considering tuberculosis in the differential diagnosis of oral lesions that affect the gingiva.
- Published
- 2015
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44. Improvement in idiopathic nonspecific interstitial pneumonia after smoking cessation.
- Author
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Shinohara T, Kadota N, Hino H, Naruse K, Ohtsuki Y, and Ogushi F
- Abstract
Although cigarette smoking has been recognized as a risk factor for the development of several interstitial lung diseases, the relationship between smoking and nonspecific interstitial pneumonia (NSIP) has not yet been fully elucidated. We here present a case of fibrotic NSIP with mild emphysema in an elderly male with normal pulmonary function, whose symptoms, serum KL-6 level, and high-resolution computed tomography findings of interstitial changes markedly improved without medication following the cessation of smoking. Our case suggests that smoking may be an etiological factor in some patients with NSIP and that early smoking cessation before a clinically detectable decline in pulmonary function may be critical for smokers with idiopathic NSIP.
- Published
- 2014
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45. Predictors of mortality in patients with interstitial lung disease treated with corticosteroids: results from a cohort study.
- Author
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Migita K, Arai T, Jiuchi Y, Izumi Y, Iwanaga N, Kawahara C, Suematsu E, Miyamura T, Tsutani H, Kawabe Y, Matsumura R, Mori S, Ohshima S, Yoshizawa S, Suenaga Y, Ogushi F, Kawabata M, Furukawa H, Matsui T, Bito S, and Tohma S
- Subjects
- Aged, Cohort Studies, Connective Tissue Diseases complications, Connective Tissue Diseases diagnosis, Drug Administration Schedule, Female, Humans, Lung Diseases, Interstitial etiology, Male, Middle Aged, Outcome Assessment, Health Care, Prognosis, Risk Factors, Survival Analysis, Connective Tissue Diseases mortality, Glucocorticoids therapeutic use, Lung Diseases, Interstitial drug therapy, Lung Diseases, Interstitial mortality
- Abstract
Interstitial lung disease (ILD) has a heterogeneous clinical presentation and establishing prognosis for these patients is challenging. We investigated the clinical characteristics and outcome of patients with idiopathic interstitial pneumonias (IIPs) and patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). We conducted a multicenter prospective study on 104 patients diagnosed with IIPs and 29 patients diagnosed with CTD-ILD, which were newly diagnosed and treated with corticosteroids initially. We compared the clinical characteristics, high-resolution computed tomography (HRCT) imaging date, and outcomes. Cox proportional hazard regression analysis was used to identify variables with increased risk of death. Survival was analyzed according to the Kaplan-Meier method and was assessed with the log-rank test. Of 133 patients with IIPs (n = 104) or CTD-ILD (n = 29), 44 patients died during the follow-up period (mean: 1.6 ± 0.78 years). Patients with IIPs seemed to be associated with worse survival compared with those with CTD-ILD; however, this difference was not significant (log-rank test, P = 0.084). Significant predictors for mortality in patients with IIPs at baseline were lower for performance status and definite usual interstitial pattern (UIP) on HRCT. Patients with UIP experienced worse survival than those with non-UIP. A definite UIP on HRCT and lower baseline performance status have important prognostic implications in patients with IIPs.
- Published
- 2014
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46. BCG-induced pneumonitis with lymphocytic pleurisy in the absence of elevated KL-6.
- Author
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Tobiume M, Shinohara T, Kuno T, Mukai S, Naruse K, Hatakeyama N, and Ogushi F
- Subjects
- Adjuvants, Immunologic therapeutic use, Aged, 80 and over, BCG Vaccine therapeutic use, Carcinoma, Renal Cell drug therapy, Female, Humans, Kidney Neoplasms drug therapy, Adjuvants, Immunologic adverse effects, BCG Vaccine adverse effects, Lymphocytes, Pleurisy chemically induced, Pleurisy complications, Pneumonia chemically induced, Pneumonia complications
- Abstract
Background: Pneumonitis is a rare complication of bacillus Calmette-Guerin (BCG) immunotherapy seen in patients with urothelial cancer following the repeated administration of BCG. However, no case of BCG-induced pleurisy has been reported., Case Presentation: We here report the first case of pneumonitis with lymphocytic pleurisy following bacillus Calmette-Guerin (BCG) immunotherapy. Although marked T helper cell alveolitis was found by bronchoalveolar lavage and transbronchial biopsies, no acid-fast bacillus could be identified in recovered BALF or pleural effusion. The lymphocyte stimulation test of BCG was strongly positive. However, levels of serum and bronchoalveolar lavage fluid KL-6, a useful marker for hypersensitivity pneumonitis (HP), were within normal ranges., Conclusion: We speculate that the pathogenesis of our case may be a hypersensitive reaction to the proteic component of BCG entering the lung and pleural space, which is different from the etiology of the common type of HP.
- Published
- 2014
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47. Thallium-201-scintigraphy-positive recurrent pulmonary hyalinising granuloma with elevated IgG4.
- Author
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Takashima M, Shinohara T, Morishita A, Naruse K, Hino H, and Ogushi F
- Subjects
- Biomarkers analysis, Biomarkers blood, Biopsy, Granuloma, Respiratory Tract diagnostic imaging, Granuloma, Respiratory Tract immunology, Granuloma, Respiratory Tract surgery, Humans, Immunoglobulin G blood, Lung Diseases diagnostic imaging, Lung Diseases immunology, Lung Diseases surgery, Male, Middle Aged, Predictive Value of Tests, Recurrence, Tomography, X-Ray Computed, Up-Regulation, Granuloma, Respiratory Tract diagnosis, Hyalin, Immunoglobulin G analysis, Lung chemistry, Lung diagnostic imaging, Lung immunology, Lung surgery, Lung Diseases diagnosis, Radiopharmaceuticals, Thallium Radioisotopes, Tomography, Emission-Computed, Single-Photon
- Published
- 2014
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48. Rates of serious intracellular infections in autoimmune disease patients receiving initial glucocorticoid therapy.
- Author
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Migita K, Arai T, Ishizuka N, Jiuchi Y, Sasaki Y, Izumi Y, Kiyokawa T, Suematsu E, Miyamura T, Tsutani H, Kawabe Y, Matsumura R, Mori S, Ohshima S, Yoshizawa S, Kawakami K, Suenaga Y, Nishimura H, Sugimoto T, Iwase H, Sawada H, Yamashita H, Kuratsu S, Ogushi F, Kawabata M, Matsui T, Furukawa H, Bito S, and Tohma S
- Subjects
- Adult, Aged, Asian People, Female, Follow-Up Studies, Glucocorticoids administration & dosage, Humans, Japan epidemiology, Male, Middle Aged, Risk Factors, Autoimmune Diseases drug therapy, Autoimmune Diseases microbiology, Autoimmune Diseases mortality, Glucocorticoids adverse effects, Infections chemically induced, Infections microbiology, Infections mortality, Registries
- Abstract
Background/aims: The Japanese National Hospital Organization evidence-based medicine (EBM) Study group for Adverse effects of Corticosteroid therapy (J-NHOSAC) is a Japanese hospital-based cohort study investigating the safety of the initial use of glucocorticoids (GCs) in patients with newly diagnosed autoimmune diseases. Using the J-NHOSAC registry, the purpose of this observational study is to analyse the rates, characteristics and associated risk factors of intracellular infections in patients with newly diagnosed autoimmune diseases who were initially treated with GCs., Methodology/principal Findings: A total 604 patients with newly diagnosed autoimmune diseases treated with GCs were enrolled in this registry between April 2007 and March 2009. Cox proportional-hazards regression was used to determine independent risk factors for serious intracellular infections with covariates including sex, age, co-morbidity, laboratory data, use of immunosuppressants and dose of GCs. Survival was analysed according to the Kaplan-Meier method and was assessed by the log-rank test. There were 127 serious infections, including 43 intracellular infections, during 1105.8 patient-years of follow-up. The 43 serious intracellular infections resulted in 8 deaths. After adjustment for covariates, diabetes (Odds ratio [OR]: 2.5, 95% confidence interval [95% CI] 1.1-5.9), lymphocytopenia (≦1000/μl, OR: 2.5, 95% CI 1.2-5.2) and use of high-dose (≧30 mg/day) GCs (OR: 2.4, 95% CI 1.1-5.3) increased the risk of intracellular infections. Survival curves showed lower intracellular infection-free survival rate in patients with diabetes, lymphocytopaenia and high-dose GCs treatments., Conclusions/significance: Patients with newly diagnosed autoimmune diseases were at high risk of developing intracellular infection during initial treatment with GCs. Our findings provide background data on the risk of intracellular infections of patients with autoimmune diseases. Clinicians showed remain vigilant for intracellular infections in patients with autoimmune diseases who are treated with GCs.
- Published
- 2013
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49. Bronchopleural fistula following M. abscessus infection 11 years after lobectomy for lung cancer.
- Author
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Inayama M, Shinohara T, Yoshida M, Hino H, Hatakeyama N, and Ogushi F
- Abstract
Bronchopleural fistula (BPF) is a potentially fatal complication of lung cancer resection surgery that occurs during the healing process of the bronchial stump. However, the vulnerability of the healed surgical wound to overlapping acquired airway destruction has not yet been determined in detail. We herein present a case of fatal BPF following Mycobacterium abscessus (M. abscessus) infection, which occurred 11 years after right upper lobectomy for lung cancer. The findings of the present study suggest that patients with M. abscessus pulmonary disease in which airway destruction is progressing towards the bronchial stump of previous lobectomy should be considered for early completion pneumonectomy to prevent fatal BPF.
- Published
- 2013
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50. Carboplatin plus either docetaxel or paclitaxel for Japanese patients with advanced non-small cell lung cancer.
- Author
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Kawahara M, Atagi S, Komuta K, Yoshioka H, Kawasaki M, Fujita Y, Yonei T, Ogushi F, Kubota K, Nogami N, Tsuchiya M, Shibata K, Tomizawa Y, Minato K, Fukuoka K, Asami K, and Yamanaka T
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Area Under Curve, Carboplatin administration & dosage, Carcinoma, Non-Small-Cell Lung mortality, Disease-Free Survival, Docetaxel, Female, Humans, Japan, Kaplan-Meier Estimate, Lung Neoplasms mortality, Male, Paclitaxel administration & dosage, Taxoids administration & dosage, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy
- Abstract
Aim: Assessment of the efficacy of docetaxel plus carboplatin vs. paclitaxel plus carboplatin in Japanese patients with advanced non-small cell lung cancer (NSCLC)., Patients and Methods: Chemotherapy-naïve patients were randomly assigned at a ratio of 2 to 1 to receive six cycles of either docetaxel (60 mg/m(2)) plus carboplatin [area under the curve (AUC)=6 mg/ml min] or paclitaxel (200 mg/m(2)) plus carboplatin (same dose), on day 1 every 21 days. The primary end-point was progression-free survival (PFS)., Results: A total of 90 patients were enrolled. Overall response rate, median PFS and median survival time in the docetaxel-plus-carboplatin group and the paclitaxel-plus-carboplatin group were 23% vs. 33%, 4.8 months vs. 5.1 months, and 17.6 months vs. 15.6 months, respectively. The docetaxel-plus-carboplatin group had a higher incidence of grade 3 or 4 neutropenia (88% vs. 60%)., Conclusion: Both regimens were similarly effective in Japanese patients with advanced NSCLC.
- Published
- 2013
Catalog
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