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Elevated Levels of Intelectin-1, a Pathogen-binding Lectin, in the BAL Fluid of Patients with Chronic Eosinophilic Pneumonia and Hypersensitivity Pneumonitis.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2018 Dec 15; Vol. 57 (24), pp. 3507-3514. Date of Electronic Publication: 2018 Aug 10. - Publication Year :
- 2018
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Abstract
- Objective Human intelectin-1 (hITLN-1) binds to galactofuranosyl residues, which are present in the microbial cell wall, but which are absent in mammalian tissues, and has been suggested to play an immunological role against microorganisms. However, the involvement of hITLN-1 in the pathogenesis of diffuse pulmonary diseases remains unknown. The aim of this study was to compare the hITLN-1 concentrations in the bronchoalveolar lavage (BAL) fluid of patients with diffuse pulmonary diseases. Methods The cell components and concentrations of hITLN-1 were analyzed in the BAL fluid of 8 patients with idiopathic chronic eosinophilic pneumonia (ICEP), 3 patients with drug-induced eosinophilic pneumonia, 4 patients with hypersensitivity pneumonitis (HP), 11 patients with sarcoidosis, 9 patients with cryptogenic organizing pneumonia, and 5 patients with idiopathic fibrosing interstitial pneumonia (fibrosing nonspecific interstitial pneumonia or usual interstitial pneumonia). Results The hITLN-1 concentrations in the BAL fluid of patients with ICEP and HP were higher than in those with other diseases. In the ICEP group, no significant difference was observed in the hITLN-1 concentrations of patients with or without a history of bronchial asthma. Conclusion The results of the present study suggest that hITLN-1 may be involved in the pathogenesis of ICEP and HP, and that an increase in the hITLN-1 concentration in the BAL fluid may represent a new biomarker for these diseases.
- Subjects :
- Aged
Alveolitis, Extrinsic Allergic diagnosis
Biomarkers metabolism
Female
GPI-Linked Proteins metabolism
Humans
Male
Middle Aged
Pulmonary Eosinophilia diagnosis
Alveolitis, Extrinsic Allergic metabolism
Bronchoalveolar Lavage Fluid chemistry
Cytokines metabolism
Lectins metabolism
Pulmonary Eosinophilia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 57
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 30101907
- Full Text :
- https://doi.org/10.2169/internalmedicine.0841-18