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Critical pedagogy has the potential to create transformation experiences within early childhood settings, as educators open up children's worlds to explore fairness, equity, and democratic participation across issues of interest and relevance to young children. Using a critical inquiry framework, informed by the work of Paulo Freire, teachers from an Auckland kindergarten provided examples of what the critical pedagogy elements can look like in practice with young children. These illustrative glimpses demonstrate the workability and impact that critical pedagogy can have in an early childhood education setting.

As the COVID-19 virus has spread worldwide, much attention has been paid to its impact on the health and wellbeing of adults, with less attention to how the virus has impacted on young children. This article draws on documentation and video data from a kindergarten in Aotearoa New Zealand. It discusses the working theories of 4 year-old children whose teachers encouraged them to draw, construct images, explain and tell stories about their experiences, ideas and feelings about the virus. A main argument is that children's working theories about the virus, knowledge of the virus and sense of personal control over keeping themselves safe developed over time. Arts-based and storytelling pedagogy were central in enabling children to communicate with others, to be understood themselves and to extend their own understanding.

This article draws from a 2-year TLRI-funded research project looking at how four early childhood centres constructed positive outcomes for children from migrant families. The research questions focused on how the people, places, and practices in early childhood settings support a sense of bicultural belonging to Aotearoa New Zealand, sustain children's connections to homelands and people, and enable them to contribute important cultural aspects from their home country. This article focuses on one of the research settings that participated in this study, Pakuranga Baptist Kindergarten. Observations and staff reflections revealed the ways teachers used the visual arts, storytelling, and play to value children's and their families' cultural funds of knowledge and foster children's sense of belonging in New Zealand.

The COVID‐19 pandemic revealed the pivotal role of digital learning and online lecture videos, leading a shift toward blended and flipped classrooms in the post‐pandemic era. This shift calls for development and (or) refreshment of novel online educational resources, such as Voice‐Over PowerPoint (VOPPT) presentations, specifically designed for asynchronous or synchronous learning methods. However, resource limitations often impede the timely delivery of high‐quality instructional materials. In this descriptive article, the use of AI‐voice cloning technology to automate the creation of VOPPT presentation has been explored. Descripts' Overdub tool, an AI‐voice cloning program, was trained on the 15‐min voice sample of an anatomy professor, and the synthesized voice was used to narrate presentations on inguinal canal and extrahepatic biliary anatomy. The educational use of this novel approach was evaluated based on the second‐year undergraduate medical students' qualitative feedback. Voice similarity analysis using Resemblyzer, an open‐source Python tool, showed a high similarity score of 0.92 between the cloned and original voices. Despite this, students raised concerns about the robotic voice, quick pace, punctuation problems, pronunciation difficulties, and expressed reservations about AI‐generated lecture narration. While the cloned voice closely matched the original, the AI‐generated narration fell short of capturing the nuanced details needed for an effective anatomy instruction. This uncovers AI's current limitations in the educational contexts but establishes a foundation for future progress in AI‐voice cloning technologies aimed at enhancing online educational resources for anatomy and medical education. [ABSTRACT FROM AUTHOR]

Large Language Models (LLMs) have the potential to improve education by personalizing learning. However, ChatGPT‐generated content has been criticized for sometimes producing false, biased, and/or hallucinatory information. To evaluate AI's ability to return clear and accurate anatomy information, this study generated a custom interactive and intelligent chatbot (Anatbuddy) through an Open AI Application Programming Interface (API) that enables seamless AI‐driven interactions within a secured cloud infrastructure. Anatbuddy was programmed through a Retrieval Augmented Generation (RAG) method to provide context‐aware responses to user queries based on a predetermined knowledge base. To compare their outputs, various queries (i.e., prompts) on thoracic anatomy (n = 18) were fed into Anatbuddy and ChatGPT 3.5. A panel comprising three experienced anatomists evaluated both tools' responses for factual accuracy, relevance, completeness, coherence, and fluency on a 5‐point Likert scale. These ratings were reviewed by a third party blinded to the study, who revised and finalized scores as needed. Anatbuddy's factual accuracy (mean ± SD = 4.78/5.00 ± 0.43; median = 5.00) was rated significantly higher (U = 84, p = 0.01) than ChatGPT's accuracy (4.11 ± 0.83; median = 4.00). No statistically significant differences were detected between the chatbots for the other variables. Given ChatGPT's current content knowledge limitations, we strongly recommend the anatomy profession develop a custom AI chatbot for anatomy education utilizing a carefully curated knowledge base to ensure accuracy. Further research is needed to determine students' acceptance of custom chatbots for anatomy education and their influence on learning experiences and outcomes. [ABSTRACT FROM AUTHOR]

Errorless academic compliance training is a graduated, noncoercive approach to treating oppositional behavior in children. In the present study, three teaching staff in a special education classroom were trained to conduct this intervention with three male students diagnosed with autism spectrum disorders. During baseline, staff delivered a range of academic and other classroom requests and recorded student compliance. A hierarchy of compliance probabilities was then calculated, ranging from Level 1 (requests yielding high levels of compliance) to Level 4 (those typically yielding noncompliance). At treatment initiation, teaching staff delivered high densities of Level 1 requests and provided reinforcement for compliance. Subsequent request levels were faded in over time, at a slow enough rate to ensure continued high compliance. By intervention end, all three students demonstrated substantially improved compliance to classroom requests that had commonly yielded noncompliance before intervention. Covariant improvement in on-task skills was also evident. (Contains 1 table and 3 figures.)

The arteriovenous fistula (AVF) is the optimal form of vascular access for end-stage renal failure patients requiring haemodialysis. However, AVFs can fail to mature into a useable conduit or develop recurrent stenoses that result in high surgical re-intervention rates to maintain patency. Here, we performed a narrative review of literature on methods of AVF failure identification such as clinical prediction models, shear stress metrics characterisation with 0D, 1D and 3D computational models and blood flow sound frequency. Clinical risk factors identified by a clinical scoring system fail to predict ongoing AVF status and patency rate. The pulse wave propagation model, although showed positive prospect to support surgical planning, has limited ability in blood flow volume prediction in the anastomotic region. Shear stress metrics were one of the most common indicators to understand flow behaviours in AVF. While transverse wall shear stress seemed promising in characterising multidirectional flow in an AVF, no definitive correlations between shear stress metrics and disease initialisation have been reported. We conclude that further assessment is required to develop a clinical diagnostic marker for AVF failure prediction as no definitive prediction indicator was proposed even though there is an apparent impact of haemodynamic factors in AVF failure. [ABSTRACT FROM AUTHOR]

Computational fluid dynamics (CFD) modelling has been a useful non-invasive measurement tool to analyse the effects of blood flow in diseased arteriovenous fistula (AVF). To translate CFD findings for clinical use, it is essential to model the AVF as closely as possible to the physiological conditions. The AVF geometry consists of three boundary nodes, which require appropriate flow conditions prescribed to each of them. To this end, we modelled three AVF geometries, with three different, commonly used boundary conditions: velocity based on patient-specific waveforms, assumed flow split condition for the retrograde flow and assumed flow split condition for the antegrade flow. Three patient-specific geometries were acquired from an in-house ultrasound scanning system. The patient-specific waveforms were also obtained during these scanning sessions for the CFD models. WSS distribution and recirculating flows were observed at different locations for the three patient datasets, with different sets of boundary conditions. These effects were prominent at the anastomosis and dependent on the geometry of the AVF. There were also discrepancies between resistance values estimated from the patient-specific CFD models and the Hagen–Poiseuille model. These findings highlight the importance of modelling patient-specific AVFs with appropriate boundary conditions for better identification of diseased AVF. [ABSTRACT FROM AUTHOR]

The letter to the editor discusses the impact of artificial intelligence (AI) on assessment in medical education. It highlights the challenges of maintaining assessment validity in the context of AI-generated content and emphasizes the need to shift towards assessment for learning and assessment as learning. The authors suggest programmatic assessment models and AI-facilitated peer-to-peer learning as strategies to enhance student engagement and critical thinking. They also stress the importance of faculty familiarizing themselves with AI tools to design assessments effectively in an AI-enhanced environment. [Extracted from the article]

The article provides information on a transformer-based clustering model named ClusterBot developed to generate a curriculum map. Topics discussed include the potential of generative artificial intelligence (Gen-AI) to revolutionise medical education, how the accuracy of ClusterBot in identifying relevant text was evaluated, and lessons learned from the human-AI hybrid approach.

Aim: To investigate whether a digital sleep intervention improves child and care giver sleep and psychosocial outcomes. Methods: A total of 120 families with children aged 2–13 years, reporting moderate to severe child behavioural sleep problems, were recruited from a hospital sleep clinic waitlist or the community. Children from non‐English speaking families, with known intellectual disability (IQ < 70) or severe medical problems excluded. Tailored behavioural sleep strategies were delivered to primary care givers via a smart phone app and complementary website. Eligible families completed a baseline questionnaire and child 'sleep check' then received the digital sleep intervention for 5 weeks, and then completed a post questionnaire. Outcomes: care giver report of child sleep as no/mild versus moderate/severe problem over past month (primary outcome); problem child sleep patterns (Brief Infant Sleep Questionnaire or Child Sleep Habits Questionnaire), child temperament, care giver mental health (Kessler 6), care giver sleep, health service use for their child's sleep and time off work/activities to access services. Results: At follow up, care givers reported fewer moderate/severe child sleep problems (84.6–40.7%), improved problem child sleep patterns, better temperament and improved care giver mental health. Care giver sleep quality and quantity remained unchanged. Health service use (averaged over a 6‐month period pre‐ and post‐intervention) fell from 18.9% pre‐ to 14.1% post‐intervention. Conclusion: A digital sleep intervention appears promising in improving sleep in children with moderate/severe behavioural sleep problems, and care giver mental health. It may be a useful alternative to face‐to‐face management of behavioural sleep problems. [ABSTRACT FROM AUTHOR]

Copyright of Journal on Developmental Disabilities is the property of Ontario Association on Developmental Disabilities and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article discusses the use by hospitals of electronic health records (EHRs) to optimize patient care and the development of clinical decision support (CDS) systems to further such goal. Topics covered include examples of CDS, such as pop-up alerts and drug-dose calculators, the meaningful-use stage 1 EHR guidelines established by the Centers for Medicare and Medicaid Services for U.S. hospitals, and the CDS alerts developed by Sharp Healthcare system in San Diego, California.

Several studies suggest a relationship between anesthesia-induced tau hyperphosphorylation and the development of postoperative cognitive dysfunction. This study further characterized the effects of continuous propofol infusion on tau protein phosphorylation in rats, with or without temperature control. Propofol was administered intravenously to 8-10-week-old male Sprague-Dawley rats and infused to the loss of the righting reflex for 2 h continuously. Proteins from cortex and hippocampus were examined by western blot and immunohistochemistry. Rectal temperature was significantly decreased during propofol infusion. Propofol with hypothermia significantly increased phosphorylation of tau at AT8, AT180, Thr205, and Ser199 in cortex and hippocampus except Ser396. With temperature maintenance, propofol still induced significant elevation of AT8, Thr205, and Ser199 in cortex and hippocampus; however, increase of AT180 and Ser396 was only found in hippocampus and cortex, respectively. Differential effects of propofol with or without hypothermia on multiple tau related kinases, such as Akt/GSK3β, MAPK pathways, or phosphatase (PP2A), were demonstrated in region-specific manner. These findings indicated that propofol increased tau phosphorylation under both normothermic and hypothermic conditions, and temperature control could partially attenuate the hyperphosphorylation of tau. Further studies are warranted to determine the long-term impact of propofol on the tau pathology and cognitive functions. [ABSTRACT FROM AUTHOR]

Exposure to anesthetic agents has been linked to abnormal tau protein phosphorylation, an antecedent to the development of neurofibrillary tangles. This study evaluates the direct and indirect effects of dexmedetomidine. Primary culture of cortical neurons established from Sprague-Dawley (SD) rat embryos were exposed to dexmedetomidine for 1 or 6 hours, and the degree of tau phosphorylation at the AT8, AT180, and S396 sites was assessed by western blot analysis. To assess and compare their relative in vivo effects, the same agent was administered intravenously to 8 to 10 week old male SD rats and titrated to the loss of the righting reflex for 2 hours. After 1 hour of recovery, the rats were sacrificed and samples taken from the cortex and hippocampus were subjected to western blot and immunohistochemical analysis. The in vitro studies reviewed significant hyperphosphorylation only at the S396 site, and these changes have largely disappeared at 6 hours. With temperature maintenance, dexmedetomidine induced significant changes in hyperphosphorylation at the AT8 site in the cortex and hippocampus and at the AT180 in the hippocampus. The direct effect of anesthetic agents on fully differentiated cortical neurons is epitope-specific and short-lived. The in vivo effects are comparatively more complicated and depend not only on the phosphorylation site but the regions of the brain examined. These findings suggest that dexmedetomidine increases tau phosphorylation both in vitro and in vivo under normothermic conditions, and further studies are warranted to determine the long-term impact of this anesthetic on the tau pathology and even cognitive function. [ABSTRACT FROM AUTHOR]

Mesembryanthemum crystallinum L. is a nutritious edible facultative halophyte. This study aimed to investigate the physiology and quality of M. crystallinum L. grown under different salinities and salt-priming conditions. All plants were first grown in 10% artificial seawater (ASW) for 10 days. After that, some plants remained in 10% ASW while the others were transferred to 20%, 30%, 40%, or 50% ASW for another 10 days. Some plants also underwent a salt priming by transferring them gradually from 10% to 100% ASW over a span of 10 days (defined as salt primed). All plants were green and healthy. However, there were reductions in shoot and root productivity, leaf growth, and water content, but also an increase in leaf succulence after transferring plants to higher salinities. The salt-primed plants showed higher photosynthetic light use efficiency with higher chlorophyll concentration compared to other plants. The concentrations of proline, ascorbic acid (ASC), and total phenolic compounds (TPC) increased as percentages of ASW increased. The salt-primed plants switched from C3 to crassulacean acid metabolism photosynthesis and accumulated the greatest amounts of proline, ASC, and TPC. In conclusion, higher salinities and salt priming enhance the nutritional quality of M. crystallinum L. but compromises productivity. [ABSTRACT FROM AUTHOR]

Confocal fluorescence demonstrates that single molecules of dye-labelled Cytochrome C or B5 containing paramagnetic Fe(iii) can be magnetically placed into the interstices of super-crystal which is composed of three dimensional regular arrays of Fe3O4nanoparticles. [ABSTRACT FROM AUTHOR]

Introduction: The developmentally variable nature of autism poses challenges in providing timely services tailored to a child's needs. Despite a recent focus on longitudinal research, priority-setting initiatives with stakeholders highlighted the importance of studying a child's day-to-day functioning and social determinants of health to inform clinical care. To address this, we are conducting a pragmatic multi-site, patient-oriented longitudinal investigation: the Pediatric Autism Research Cohort ( PARC) Study . In young children (<7 years of age) newly diagnosed with autism, we will: (1) examine variability in trajectories of adaptive functioning from the point of diagnosis into transition to school; and (2) identify factors associated with trajectories of adaptive functioning., Methods and Analysis: We aim to recruit 1300 children under 7 years of age with a recent (within 12 months) diagnosis of autism from seven sites: six in Canada; one in Israel. Participants will be followed prospectively from diagnosis to age 8 years, with assessments at 6-month intervals. Parents/caregivers will complete questionnaires administered via a customized online research portal. Following each assessment timepoint, families will receive a research summary report describing their child's progress on adaptive functioning and related domains. Analysis of the longitudinal data will map trajectories and examine child, family and service characteristics associated with chronogeneity (interindividual and intraindividual heterogeneity over time) and possible trajectory turning points around sensitive periods like the transition to school., Ethics and Dissemination: Ethics approvals have been received by all sites. All parents/respondents will provide informed consent when enrolling in the study. Using an integrated knowledge translation approach, where stakeholders are directly engaged in the research process, the PARC Study will identify factors associated with trajectories of functioning in children with autism. Resulting evidence will be shared with government policy makers to inform provincial and national programs. Findings will be disseminated at conferences and published in peer-reviewed journals., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Objective: The day-to-day experience of families with an Autistic child may be shaped by both, child characteristics and available resources, which often are influenced by the socioeconomic context of the family. Using a socioecological approach, this study explored the quantitative associations between child autistic symptoms, family socioeconomic status, and family life. Methods: Data came from the Pediatric Autism Research Cohort-PARC Study (pilot). Parents of children with a recent diagnosis of autism completed a set of assessments, including the Autism Family Experience Questionnaire, Autism Impact Measure, and a Sociodemographic Questionnaire. A series of multiple, iterative linear regression models were constructed to ascertain quantitative associations between child autistic symptoms, socioeconomic context, and family life. Results: A total of 50 children (mean age: 76 months; SD: 9.5 months; and 84% male) with data on the variables of interest were included in the analysis. The frequency of child autistic symptoms was associated with family life outcomes ( p = 0.02 and R 2 = 24%). Once autistic symptom frequency, symptom impact, and sociodemographic variables were considered, parents of higher educational attainment reported worse family life outcomes compared to their lesser-educated counterparts. This cumulative regression model had considerable explanatory capability ( p = 0.01, R 2 = 40%). Conclusion: This study demonstrates the utility of using a socioecological approach to examine the dynamic interplay between child characteristics and family circumstances. Our findings suggest that family life for parents (of an autistic child) who have obtained higher education is reported (by the parents themselves) as less satisfactory compared to that of parents without higher education, once adjusted for the autistic symptom frequency of child, symptom impact, and income. These findings can inform the design and delivery of more family-centered care pathways during the years following a diagnosis of autism., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Koziarz, Roncadin, Kata, Duku, Cauwenbergs, Mahoney, Di Rezze, Anderson, Drmic, Eerkes, Dekker, Georgiades, Hoult, Kraus de Camargo, Ng, Rosenbaum, Mesterman, Gentles, Robertson, Bennett and Georgiades.)

This is the first work that revealed the neuro-protective effect of functionalized quantum dots against the cytotoxicity induced by beta-amyloid peptides. This study gives insight into the future treatment of Alzheimer's disease. It opens many avenues for the development of the next generation nanotechnology for biomedical and therapeutic applications.