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2 results on '"Mark D. Greenberger"'

1. Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences

Author

Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G. Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Schaeffer, Felix Y. Feng, Brandon Mahal, Paul L. Nguyen, Robert B. Den, Mark D. Greenberger, Randy Bradley, Justin M. Watson, Matthew Beamer, Lambros Stamatakis, Darrell J. Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A. Deane, Dimple Chakravarty, Kamlesh K. Yadav, Kosj Yamoah, Sujit S. Nair, and Ashutosh K. Tewari

Subjects
Biology (General), QH301-705.5
Abstract

Walter Rayford, Alp Tuna Beksac et al. investigated gene expression alterations in African-American and European-American men who underwent radical prostatectomy for prostate cancer. The observed differences include higher expression of inflammation genes and lower expression of mismatch repair genes in African-American men.

Published
2021
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2. Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences

Author

Dimple Chakravarty, Randy V. Bradley, Ashutosh K. Tewari, Irtaza Khan, Paul L. Nguyen, Elai Davicioni, Yang Liu, Justin Watson, Walter Rayford, Daniel E. Spratt, Shivanshu Awasthi, Mark D. Greenberger, Sujit S. Nair, Felix Y. Feng, Leslie A. Deane, Rachel Weil, Mohammed Alshalalfa, Edward M. Schaeffer, Kamlesh K Yadav, Ugo Falagario, Nihal Mohamed, Alp Tuna Beksac, Lambros Stamatakis, Mohsen Ahmed, Robert B. Den, Brandon A. Mahal, Harri Merisaari, Jordan Alger, Darrell J. Carmen, Kosj Yamoah, Matthew Beamer, and Jonathan Hwang

Subjects
Male, 0301 basic medicine, Oncology, medicine.medical_specialty, DNA repair, QH301-705.5, Medicine (miscellaneous), White People, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, Internal medicine, parasitic diseases, Gene expression, Cancer genomics, medicine, Humans, Biology (General), Aged, Neoplasm Staging, Retrospective Studies, Regulation of gene expression, business.industry, Gene Expression Profiling, Prostatic Neoplasms, Genomics, Health Status Disparities, Middle Aged, Prognosis, medicine.disease, United States, Black or African American, Gene Expression Regulation, Neoplastic, MSH6, 030104 developmental biology, medicine.anatomical_structure, MSH2, Immune System, 030220 oncology & carcinogenesis, Tumour immunology, DNA mismatch repair, General Agricultural and Biological Sciences, business
Abstract

Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P, Walter Rayford, Alp Tuna Beksac et al. investigated gene expression alterations in African-American and European-American men who underwent radical prostatectomy for prostate cancer. The observed differences include higher expression of inflammation genes and lower expression of mismatch repair genes in African-American men.

Published
2021

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