14 results on '"Lawrence Grossman"'
Search Results
2. Refractory inclusions in the pristine carbonaceous chondrites DOM 08004 and DOM 08006
- Author
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Steven B. Simon and Lawrence Grossman
- Published
- 2015
- Full Text
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3. Heating events in the nascent solar system recorded by rare earth element isotopic fractionation in refractory inclusions
- Author
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E. Ercan Alp, Bruce L. A. Charlier, Zhe Zhang, Jing Zhao, Thomas Ireland, Michael Hu, Nicolas Dauphas, François L. H. Tissot, J. Y. Hu, Reika Yokochi, Lawrence Grossman, M. Roskosz, Andrew M. Davis, Fred J. Ciesla, University of Chicago, California Institute of Technology (CALTECH), Boston University [Boston] (BU), Victoria University of Wellington, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Argonne National Laboratory [Lemont] (ANL)
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Condensed Matter::Quantum Gases ,Solar System ,Multidisciplinary ,Materials science ,010504 meteorology & atmospheric sciences ,Rare-earth element ,[SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph] ,Condensation ,Refractory metals ,SciAdv r-articles ,Astrophysics ,010502 geochemistry & geophysics ,01 natural sciences ,Geochemistry ,Meteorite ,Planet ,Physics::Space Physics ,Condensed Matter::Statistical Mechanics ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Formation and evolution of the Solar System ,Refractory (planetary science) ,Research Articles ,0105 earth and related environmental sciences ,Research Article - Abstract
The compositions of the first solar system solids were shaped by nonequilibrium condensation and evaporation., Equilibrium condensation of solar gas is often invoked to explain the abundance of refractory elements in planets and meteorites. This is partly motivated, by the observation that the depletions in both the least and most refractory rare earth elements (REEs) in meteoritic group II calcium-aluminum–rich inclusions (CAIs) can be reproduced by thermodynamic models of solar nebula condensation. We measured the isotopic compositions of Ce, Nd, Sm, Eu, Gd, Dy, Er, and Yb in eight CAIs to test this scenario. Contrary to expectation for equilibrium condensation, we find light isotope enrichment for the most refractory REEs and more subdued isotopic variations for the least refractory REEs. This suggests that group II CAIs formed by a two-stage process involving fast evaporation of preexisting materials, followed by near-equilibrium recondensation. The calculated time scales are consistent with heating in events akin to FU Orionis– or EX Lupi–type outbursts of eruptive pre–main-sequence stars.
- Published
- 2021
4. Mechanisms of DNA Damage and Repair : Implications for Carcinogenesis and Risk Assessment
- Author
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Michael G. Simic, Lawrence Grossman, Arthur C. Upton, David S. Bergtold, Michael G. Simic, Lawrence Grossman, Arthur C. Upton, and David S. Bergtold
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- Carcinogenesis--Congresses, DNA damage--Congresses, DNA repair--Congresses, Health risk assessment--Congresses, Carcinogens--congresses, Mutagens--congresses, Probability--congresses, Radiation Injuries--congresses
- Abstract
This book is based on the papers presented at the conference on'Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment,'held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.
- Published
- 2013
5. Correction for Goodman et al., Phylogenomic analyses reveal convergent patterns of adaptive evolution in elephant and human ancestries
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Leonard Lipovich, Patrick R. Hof, Kirstin N. Sterner, Zhuo Cheng Hou, Munirul Islam, Morris Goodman, Hui Jia, Monica Uddin, Lawrence Grossman, Derek E. Wildman, and Chet C. Sherwood
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Multidisciplinary ,Evolutionary biology ,Biology ,Corrections ,Adaptive evolution - Published
- 2010
6. Mineralogy and Petrology of Comet 81P/Wild 2 Nucleus Samples
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Frank J. Stadermann, Matthew J. Genge, Anders Meibom, David J. Joswiak, D. A. Papanastassiou, Nick Teslich, Lindsay P. Keller, Kyoko Okudaira, Sean Brennan, Thomas H. See, Jean Susini, M. K. Weisberg, Matthieu Gounelle, Frans J. M. Rietmeijer, Keiko Nakamura-Messenger, Zu Rong Dai, J. Warren, Donald E. Brownlee, Loan Le, Kazushige Tomeoka, Pierre Bleuet, Steven B. Simon, Stewart Fallon, Alice Toppani, Damien Jacob, Mitra L. Taheri, John P. Bradley, Denton S. Ebel, Adrian J. Brearley, Laurence Lemelle, Thomas J. Zega, Jeffrey N. Grossman, Philippe Gillet, Falko Langenhorst, Takashi Mikouchi, Akira Tsuchiyama, John Bridges, Michael E. Zolensky, François Robert, Hope A. Ishii, Alexander N. Krot, Anna L. Butterworth, Giles A. Graham, Rhonda M. Stroud, Michael A. Velbel, Christopher J. Snead, Ron K. Bastien, Miaofang Chi, Antonio Lanzirotti, Graciela Matrajt, Benton C. Clark, Murielle C. Perronnet, Thomas Stephan, Kazumasa Ohsumi, Naotaka Tomioka, Patrick Cordier, Iris Weber, Anton T. Kearsley, George J. Flynn, Matthew A. Marcus, Tomoki Nakamura, Smail Mostefaoui, Hugues Leroux, William Rao, Ichiro Ohnishi, Sue Wirick, Ralph P. Harvey, Peter Tsou, T. Ferroir, Hajime Yano, Kenji Hagiya, Phil Bland, Lawrence Grossman, Andrew J. Westphal, Alexandre Simionovici, European Synchrotron Radiation Facility (ESRF), Laboratoire de Sciences de la Terre (LST), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Institut d'Informatique et de Mathématiques Appliquées de Grenoble (IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Environnement et Minéralurgie (LEM), Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Modélisation des Transferts dans l'Environnement (LMTE), Service Mesures et modélisation des Transferts et des Accidents graves (SMTA), Département Technologie Nucléaire (DTN), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Département Technologie Nucléaire (DTN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Advanced Light Source [LBNL Berkeley] (ALS), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Laboratoire de structures et propriétés de l'état solide - UMR 8008 (LSPES), Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
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Multidisciplinary ,Olivine ,x-ray fluorescence ,Chemistry ,Comet ,Sulfur XANES ,Mineralogy ,Pyroxene ,engineering.material ,010502 geochemistry & geophysics ,Protoplanetary disk ,Stardust ,01 natural sciences ,Astrobiology ,Carbonaceous chondrite ,Silicate minerals ,0103 physical sciences ,engineering ,Formation and evolution of the Solar System ,010303 astronomy & astrophysics ,Refractory (planetary science) ,0105 earth and related environmental sciences ,[SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy - Abstract
著者人数: 75名, 資料番号: SA1003700000
- Published
- 2006
7. Association of chromosome 19q13.2-3 haplotypes with basal cell carcinoma: Tentative delineation of an involved region using data for single nucleotide polymorphisms in two cohorts
- Author
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Bjørn A. Nexø, Eszter Rockenbauer, Nicklas Raun Jacobsen, Lars Bolund, Lawrence Grossman, Zuzanna Bukowy, Ulla Vogel, Mohammad Hedayati, Mette H. Bendixen, and Jiaoyang Yin
- Subjects
Adult ,Cancer Research ,Skin Neoplasms ,Genotype ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Cohort Studies ,Exon ,hemic and lymphatic diseases ,Genetic variation ,Humans ,Gene ,Genetics ,Haplotype ,Intron ,Chromosome ,Genetic Variation ,General Medicine ,DNA ,Exons ,Sequence Analysis, DNA ,Middle Aged ,Introns ,Neoplasm Proteins ,Haplotypes ,Carcinoma, Basal Cell ,Case-Control Studies ,Chromosomes, Human, Pair 19 ,Microsatellite Repeats - Abstract
We have previously used single nucleotide polymorphisms to detect an association of basal cell carcinoma (BCC) in Caucasian Americans and Danes with the genome region 19q13.2-3, which contains several genes involved in the nucleotide excision repair of DNA. In this exploratory paper we have extended the data and used them in a chromosomal scan. The results indicate the presence of a gene variation modulating the risk of developing BSS in a submegabase region including and surrounding the gene RAI. Specifically, persons that are homozygous for the haplotype RAI intron 1(A) RAI exon 6(A) appear at increased risk for BCC. In addition, we have looked for possible synergisms between all pairs of markers. We find that a marker in GLTSCR1, presumably separated from RAI by several million bases, supplements the most significant marker in RAI in separating cases from controls, which may suggest the presence of an independent, risk-modulating variation in this second gene region.
- Published
- 2002
8. Transcription coupled nucleotide excision repair by isolated Escherichia coli membrane-associated nucleoids
- Author
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Lawrence Grossman, Oleg I. Kovalsky, and Chien-liang Glenn Lin
- Subjects
DNA, Bacterial ,DNA Repair ,Transcription, Genetic ,DNA damage ,DNA repair ,Ultraviolet Rays ,Pyrimidine dimer ,Biology ,chemistry.chemical_compound ,Bacterial Proteins ,Transcription (biology) ,RNA polymerase ,Genetics ,Escherichia coli ,Nucleoid ,Adenosine Triphosphatases ,Binding Sites ,Membranes ,Escherichia coli Proteins ,DNA-Directed RNA Polymerases ,DNA-Binding Proteins ,Biochemistry ,chemistry ,Genes, Bacterial ,DNA ,Nucleotide excision repair ,Research Article ,DNA Damage - Abstract
One form of nucleotide excision repair (NER) is known to be functionally coupled to transcription, but the nature of this functional link in Escherichia coli is still unclear. Here we have employed the isolated membrane-associated nucleoids from E.coli to examine this issue. We show that the isolated nucleoid fraction is capable of excision of UV-induced pyrimidine dimers when reconstituted with a cytoplasmic fraction resolved by sucrose gradient fractionation. This excision activity by UvrABC is sensitive to rifampicin and is dependent on transcription. By using crosslinking and immunoprecipitation, the damage recognition protein, UvrA, was found to be specifically associated with the RNA polymerase beta subunit on the chromosomal DNA independent of DNA damage. It suggests that at least in one of the NER pathways the search for damage may be directly linked to RNA polymerase. In addition, the role of transcription in the unfolding of the nucleoid structure to allow repair enzymes to gain access to the damaged DNA is described. This study provides insight into the understanding of the transcription-repair coupling in vivo.
- Published
- 1998
9. DNA repair and breast carcinoma susceptibility in women.
- Author
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Juan M. Ramos, Abigail Ruiz, Rivka Colen, Ivette D. Lopez, Lawrence Grossman, and Jaime L. Matta
- Published
- 2004
10. Oxygen isotopic variations in the outer margins and Wark–Lovering rims of refractory inclusions
- Author
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Peter K. Weber, Steven B. Simon, Lawrence Grossman, J. E. P. Matzel, Ian D. Hutcheon, D. Kent Ross, and Justin I. Simon
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CAIs ,Olivine ,010504 meteorology & atmospheric sciences ,Geochemistry ,Melilite ,Pyroxene ,engineering.material ,010502 geochemistry & geophysics ,01 natural sciences ,Parent body ,Isotopes of oxygen ,Protoplanetary disk ,Chondrite ,Geochemistry and Petrology ,Oxygen isotopes ,engineering ,NanoSIMS ,Wark-Lovering rims ,Inclusion (mineral) ,Geology ,Refractory (planetary science) ,0105 earth and related environmental sciences - Abstract
Oxygen isotopic variations across the outer margins and Wark–Lovering (WL) rims of a diverse suite of six coarse-grained Types A and B refractory inclusions from both oxidized and reduced CV3 chondrites suggest that CAIs originated from a 16 O-rich protosolar gas reservoir and were later exposed to both relatively 17,18 O-rich and 16 O-rich reservoirs. The O-isotope profiles of CAIs can be explained by changes in the composition of gas near the protoSun or the migration of CAIs through a heterogeneous nebula. Variability within the inclusion interiors appears to have been set prior to WL rim growth. Modeling the isotopic zoning profiles as diffusion gradients between inclusion interiors and edges establishes a range of permissible time–temperature combinations for their exposure in the nebula. At mean temperatures of 1400 K, models that match the isotope gradients in the inclusions yield timescales ranging from 5 × 10 3 to 3 × 10 5 years. Assuming CAIs originated with a relatively 16 O-rich (protosolar) isotopic composition, differences among the melilite interiors and the isotopic gradients in their margins imply the existence of a number of isotopically distinct reservoirs. Evidence at the edges of some CAIs for subsequent isotopic exchange may relate to the beginning of rim formation. In the WL rim layers surrounding the interiors, spinel is relatively 16 O-rich but subtly distinct among different CAIs. Melilite is often relatively 16 O-poor, but rare relatively 16 O-rich grains also exist. Pyroxene generally exhibits intermediate O-isotope compositions and isotopic zoning. Olivine in both WL and accretionary rims, when present, is isotopically heterogeneous. The extreme isotopic heterogeneity among and within individual WL rim layers and in particular, the observed trends of outward 16 O-enrichments, suggest that rims surrounding CAIs contained in CV3 chondrites, like the inclusions themselves, formed from a number of isotopically distinct gas reservoirs. Collectively, these results support numerical protoplanetary disk models in which CAIs were transported between several distinct nebular reservoirs multiple times prior to accretion onto a parent body.
- Full Text
- View/download PDF
11. An Endonuclease from Escherichia coli That Acts Preferentially on UV-Irradiated DNA and Is Absent from the uvrA and uvrB Mutants*
- Author
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Andrew G. Braun and Lawrence Grossman
- Subjects
Ultraviolet Rays ,Mutant ,Pyrimidine dimer ,medicine.disease_cause ,Coliphages ,Catalysis ,Chromatography, DEAE-Cellulose ,Endonuclease ,chemistry.chemical_compound ,medicine ,Escherichia coli ,Methods ,Cellulose ,chemistry.chemical_classification ,Mutation ,Chromatography ,Multidisciplinary ,biology ,Metabolism ,Endonucleases ,Molecular biology ,Enzyme ,Biochemistry ,chemistry ,DNA, Viral ,biology.protein ,Biological Sciences: Biochemistry ,DNA - Abstract
At least two endonucleolytic activities that preferentially incise ultraviolet (UV)-irradiated DNA exist in extracts of E. coli . These two activities can be separated by phosphocellulose chromatographic fractionation. The subject of this paper is one of these activities, which elutes from phosphocellulose with 0.25 M potassium phosphate, pH 7.5. This endonucleolytic activity specific for UV-irradiated DNA is absent from partially purified extracts of uvrA and uvrB mutants, which are defective in excision of pyrimidine dimers, but is present in normal amounts in the uvrC excision-defective mutant. The enzyme binds very tightly and specifically to UV-irradiated DNA. Binding can be prevented by prior treatment of the irradiated DNA with photoreactivating enzyme. This binding activity is absent in uvrA and uvrB mutants, but present in uvrC and uvrD mutants.
- Published
- 1974
12. THE EFFECTS OF ULTRAVIOLET-IRRADIATED POLYURIDYLIC ACID IN CELL-FREE PROTEIN SYNTHESIS IN E. COLI*†
- Author
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Lawrence Grossman
- Subjects
Poly U ,Biochemical Phenomena ,Ultraviolet Rays ,Phenylalanine ,medicine.disease_cause ,Biochemistry ,Serine ,Nucleic Acids ,Ultraviolet light ,medicine ,Escherichia coli ,Irradiation ,chemistry.chemical_classification ,Multidisciplinary ,Chemistry ,Radiochemistry ,Proteins ,Diploidy ,Amino acid ,Protein Biosynthesis ,Nucleic acid ,lipids (amino acids, peptides, and proteins) ,Carbon-14 - Abstract
The incorporation of U-C14-L-phenylalanine prepared from poiy-L- phenylaianine from Escherichia coli into acidinsoluble material and poly-L- phenylaianine following ultraviolet irradiation of poiyuridylic acid was examined. Irradiation of the polyuridylic acid with doses of ultraviolet light from 24 to 72 x 104 ergs/mm2 resulted in a marked depression in C14- phenyiaianine incorporation and was accompanied by an increase in C14- serine uptake into both acid-soluble material as well as polyphenylaianine.
- Published
- 1962
13. Refractory inclusions in the Murchison meteorite
- Author
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MacPherson, Glenn J., Bar-Matthews, Miryam, Tanaka, Tsuyoshi, Olsen, Edward, and Lawrence, Grossman
- Published
- 1983
- Full Text
- View/download PDF
14. Recombinant DNA Methodology
- Author
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Ray Wu, Lawrence Grossman, Kivie Moldave, Ray Wu, Lawrence Grossman, and Kivie Moldave
- Subjects
- Recombinant DNA, Recombinant DNA--Research--Methodology, Genetic engineering--Technique
- Abstract
Recombinant DNA methods are powerful, revolutionary techniques that allow the isolation of single genes in large amounts from a pool of thousands or millions of genes and the modification of these isolated genes or their regulatory regions for reintroduction into cells for expression at the RNA or protein levels. These attributes lead to the solution of complex biological problems and the production of new and better products in the areas of medicine, agriculture, and industry. Recombinant DNA Methodology, a volume in the Selected Methods in Enzymology series produced in benchtop format, contains a selection of key articles from Volumes 68, 100, 101, 153, 154, and 155 of Methods in Enzymology. The essential and widely used procedures provided at an affordable price will be an invaluable aid to the graduate student and the researcher. - Enzymes in DNA research - DNA isolation, hybridization, and cloning - DNA sequence analysis - cDNA cloning - Gene products - Identification of cloned genes and mapping of genes - Monitoring cloned gene expression - Cloning and transferring of genes into yeast cells - Cloning and transferring of genes into plant cells - Cloning and transferring of genes into animal cells - Site-directed mutagenesis - Protein engineering - Expression vectors
- Published
- 1989
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