1. Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life
- Author
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Kenta Nishi, MD, Chie Yoshimura, MD, Kyohei Morita, MD, Ryoichi Ishikawa, MD, Erika Toyokura, MD, Tadao Nagasaki, Hisako Matsumoto, MD, PhD, and Yasuo Nishizaka, MD
- Subjects
Bronchial thermoplasty ,Severe asthma ,Obesity ,Body mass index ,Phenotype ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan. At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores (P = 0.003), maintenance oral corticosteroid doses (P = 0.027), and exacerbation frequency (P = 0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change (P = 0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight (P = 0.01). This study showed that patients with non-controlled severe asthma exhibiting overweight/obesity and low quality of life had potential benefits from BT.
- Published
- 2023
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