18 results on '"Korczak M"'
Search Results
2. Chromosomal localization of 15 large insert BAC clones containing three microsatellites on chicken chromosome 4 (GGA4) which refine its centromere position
- Author
-
Sazanov, A. A., Romanov, M. N., Wardęcka, B., Sazanova, A. L., Korczak, M., Stekolʼnikova, V. A., Kozyreva, A. A., Smirnov, A. F., Jaszczak, K., and Dodgson, J. B.
- Published
- 2005
3. Chromosomal localization of GGA4 BACs containing QTL-linked microsatellites
- Author
-
Sazanov, Alexei A, Romanov, Michael N, Wardecka, B, Sazanova, Anna L, Korczak, M, Stekol'nikova, V A, Kozyreva, Alexandra A, Smirnov, Alexandr F, Dodgson, Jerry B, and Hayes, Hélène
- Subjects
SF ,QH426 ,QR - Abstract
Meeting Abstract: P18. Shell thickness at age 53 weeks (ST53) and egg albumin weight at 33 weeks (AW33) differ by 7.5% and 3.3%, respectively, in Rhode Island Red and Polish Green-legged Partrigenous layers. Analysis of cosegregation in hybrids revealed linkage between ST53 and microsatellite MCW0114 (full linkage) and between AW33 and MCW0170 (1 cM). Chicken genetic map comparisons showed that ADL0241 and LEI0081 were the closest microsatellites to ST53 and AW33 QTLs, respectively. Chicken BAC-libraries 032- JF256-BI and 032-JF256-RI were screened with MCW0114, MCW0170, ADL0241 and LEI0081 and fifteen clones were identified and PCR-controlled. Biotin-labeled BACs were FISH-mapped to chicken mitotic chromosomes. Hybridization signals were detected within two regions: GGA4q11- 12 (BACs containing MCW0114 and ADL0241) and GGA4q21-22 (BACs containing MCW0170). This data will help positional cloning of AW33 and ST53 QTLs. This work was supported by grants PD02-1.4-175 (Russian Ministry of Education), 03-04-48060-, INTAS 04-2163 (Russian Foundation for Basic Research) and projects 99-35205-8566 and 2001-52100-11225 (USDA/ CSREES).
- Published
- 2004
4. The impact of non-pharmacological treatments for diseases of the locomotor system on the prescribed drug use and lifestyles of the patients in the sanatoria in Busko-Zdroj
- Author
-
Korczak Milena and Owczarek Jacek
- Subjects
non-pharmacological treatments ,locomotor system ,anty-inflammatory drugs ,Medicine - Abstract
The article is the result of research on the impact of non-pharmacological therapies for diseases of the locomotor system on the prescribed drug use and lifestyles of the patients of the sanatoria in Busko-Zdroj. The reported research uses primary and secondary measures. The former includes the assessment of the impact of non-pharmacological sanatorium treatments for locomotor system diseases on the use of prescribed drug regimes, while the latter is aimed at assessing the patients’ quality of life. The research was conducted on adult patients of both genders in the sanatoria in Busko-Zdroj. The subjects were patients suffering from disorders of the musculoskeletal system such as rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, osteoporosis and discopathies. The research included two visits, the first at the start of the research and the second at the end of the research. The patients were examined for a period of three consecutive weeks. The study involved 170 patients, 50% of them were women and 50% men.
- Published
- 2015
- Full Text
- View/download PDF
5. Anaerobic treatment of pulp mill effluents
- Author
-
Koziarski, S., Komorowska, B., and Korczak, M. K.
- Subjects
PAPER industry ,WASTEWATER treatment - Published
- 1991
6. Expression of Positional Candidates for Shell Thickness in the Chicken.
- Author
-
Sazanov, A. A., Stekol'Nikova, V. A., Korczak, M., Sazanova, A. L., Jaszczak, K., Ziȩba, G., and Malewski, T.
- Subjects
- *
EGGSHELLS , *CHICKENS , *GENE expression , *ANIMAL breeding , *POULTRY - Abstract
Expression of 12 positional candidates for QTL affecting shell thickness at 53 wk of lay age (ST53) was investigated by real-time PCR in the distal part of chicken oviducts (uterus) with a forming eggshell. In the local chicken breed Green-legged Partridgenous, the complete cDNA CR523443 (ChEST985k21) was downregulated with ratio of means 0.49 (P ≤ 0.01) in the group with low ST53 (248.6 ± 16.62 µm) relative to the group with the highest ST53 (372.4 ± 2.07 µm). Expression of this gene was highly correlated (0.85, P ≤ 0.01) with shell thickness. No significant difference in expression between the 2 groups with thick (378.4 ± 3.65 µm) and thin (227.8 ± 8.99 µm) shell and no significant correlation of expression level with ST53 were detected in Rhode Island Red, which could be explained by strict selection to egg quality traits, including optimal shell thickness in this commercial layer breed. These data suggested that CR523443 was a candidate gene for QTL ST53 in the chicken. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
7. Evaluating birch leaf tea as a functional herbal beverage: Beneficial impact on the urinary tract, and metabolism in human organism.
- Author
-
Popowski D, Kruk A, Pawłowska KA, Dolzkho D, Korczak M, Piwowarski JP, Roszko M, and Granica S
- Subjects
- Humans, Teas, Herbal, Metabolomics methods, Urinary Tract microbiology, Urinary Tract metabolism, Biological Availability, Animals, Plant Extracts pharmacology, Anti-Inflammatory Agents pharmacology, Male, Functional Food, Plant Leaves chemistry, Betula chemistry, Gastrointestinal Microbiome drug effects, Gastrointestinal Microbiome physiology
- Abstract
Herbal teas are considered as a potential constituent of novel functional beverages consumed daily. One of the commonly used herbal teas is silver birch (Betula pendula Roth) leaf infusion, traditionally used in urinary tract diseases. In this study, the potential of birch leaf infusion as a functional beverage, emphasizing its active ingredients' bioavailability, anti-inflammatory, and antiadhesive properties concerning urinary tract health, was investigated. A complex approach was proposed, which included phytochemical screening, bioavailability, gut microbiota biotransformation, and an in vivo test for urine metabolomics assessment. The bioassays confirmed significant anti-inflammatory (interleukins IL-6 and IL-8 secretion) and anti-adhesive (Uropathogenic Escherichia coli and T24 bladder cells) activities. The high-resolution mass spectrometry metabolomics studies linked gut microbiota metabolites and the metabolites present in the urine. Several metabolites connected with phenolics' consumption were detected in the urine, e.g., glucuronides and sulfates of caffeic acid and dihydroxyphenyl-γ-valerolactones. Based on the presented results, the birch leaf should be considered useful in designing functional beverages, especially targeted to the groups at high risk of urinary diseases., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
8. Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function.
- Author
-
Korczak M, Roszkowski P, Skowrońska W, Żołdak KM, Popowski D, Granica S, and Piwowarski JP
- Subjects
- Humans, Caco-2 Cells, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Anti-Inflammatory Agents, Non-Steroidal metabolism, Tight Junctions, Intestinal Mucosa, Diclofenac pharmacology
- Abstract
Urolithin A (UA) is an ellagitannin-derived postbiotic metabolite which emerged as a promising health-boosting agent, promoting mitophagy, improving skeletal muscle function, and suppressing the inflammatory response. However, phase II intestinal metabolism severely limits its biopotency, leading to the formation of nonactive glucuronides. To address this constraint, a set of new UA derivatives (UADs), conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs), was synthesized. The bioavailability and inhibitory activity of UADs against UA-glucuronidation were evaluated using differentiated Caco-2 cell monolayers. Parallelly, after the administration of tested substances, the transepithelial electrical resistance (TEER) of the cell monolayers was continuously monitored using the CellZscope device. Though investigated UADs did not penetrate Caco-2 monolayers, all of them significantly suppressed the glucuronidation rate of UA, while conjugates with diclofenac increased the concentration of free molecule on the basolateral side. Moreover, esters of UA with diclofenac (DicloUA) and aspirin (AspUA) positively influenced cell membrane integrity. Western blot analysis revealed that some UADs, including DicloUA, increased the expression of pore-sealing tight junction proteins and decreased the level of pore-forming claudin-2, which may contribute to their beneficial activity towards the barrier function. To provide comprehensive insight into the mechanism of action of DicloUA, Caco-2 cells were subjected to transcriptomic analysis. Next-generation sequencing (NGS) uncovered substantial changes in the expression of genes involved, for instance, in multivesicular body organization and zinc ion homeostasis. The results presented in this study offer new perspectives on the beneficial effects of modifying UA's structure on its intestinal metabolism and bioactivity in vitro., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
9. Detailed metabolite profiling and in vitro studies of Urospermum picroides as a potential functional food.
- Author
-
Saber FR, Elosaily AH, Mahrous EA, Pecio Ł, Pecio S, El-Amier YA, Korczak M, Piwowarski JP, Świątek Ł, and Skalicka-Woźniak K
- Subjects
- Functional Food, Plants, Edible chemistry, Plant Extracts chemistry, Anti-Inflammatory Agents, Asteraceae chemistry, Sesquiterpenes
- Abstract
Wild edible plants (WEP) are part of the Mediterranean culinary culture and can be used as famine foods in times of severe food shortages. Urospermum picroides is a WEP that grows under harsh conditions and represents an opportunity to expand and diversify the global food supply. However, little is known about its chemical profile. In this study, liquid chromatography coupled to HRESIMS allowed the identification of 77 metabolites in U. picroides extract, among which 12 sesquiterpene-amino acid conjugates are reported here for the first time. Due to the novelty of these conjugates, GNPS molecular networking was used to provide information on their fragmentation pathway. Further, the sesquiterpene enriched U. picroides extract showed a moderate anti-inflammatory effect in LPS-stimulated THP1-macrophages by increasing IL-10 secretion while decreasing pro-inflammatory IL-6 secretion at 50 µg/mL. Our study provides evidence for the potential use of U. picroides as an anti-inflammatory functional food and nutraceutical agent., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
10. Phytotherapy of mood disorders in the light of microbiota-gut-brain axis.
- Author
-
Korczak M, Pilecki M, Granica S, Gorczynska A, Pawłowska KA, and Piwowarski JP
- Subjects
- Animals, Brain-Gut Axis, Phytotherapy methods, Herbal Medicine methods, Plants, Medicinal, Biological Products
- Abstract
Background: Clinical research in natural product-based psychopharmacology has revealed a variety of promising herbal medicines that may provide benefit in the treatment of mild mood disorders, however failed to unambiguously indicate pharmacologically active constituents. The emerging role of the microbiota-gut-brain axis opens new possibilities in the search for effective methods of treatment and prevention of mood disorders., Purpose: Considering the clinically proven effectiveness juxtaposed with inconsistencies regarding the indication of active principles for many medicinal plants applied in the treatment of anxiety and depression, the aim of the review is to look at their therapeutic properties from the perspective of the microbiota-gut-brain axis., Method: A literature-based survey was performed using Scopus, Pubmed, and Google Scholar databases. The current state of knowledge regarding Hypericum perforatum, Valeriana officinalis, Piper methysticum, Passiflora incarnata, Humulus lupulus, Melissa officinalis, Lavandula officinalis, and Rhodiola rosea in terms of their antimicrobial activity, bioavailability, clinical effectiveness in depression/anxiety and gut microbiota - natural products interaction was summarized and analyzed., Results: Recent studies have provided direct and indirect evidence that herbal extracts and isolated compounds are potent modulators of gut microbiota structure. Additionally, some of the formed postbiotic metabolites exert positive effects and ameliorate depression-related behaviors in animal models of mood disorders. The review underlines the gap in research on natural products - gut microbiota interaction in the context of mood disorders., Conclusion: Modification of microbiota-gut-brain axis by natural products is a plausible explanation of their therapeutic properties. Future studies evaluating the effectiveness of herbal medicine and isolated compounds in treating mild mood disorders should consider the bidirectional interplay between phytoconstituents and the gut microbiota community., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier GmbH. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
11. Author Correction: Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential.
- Author
-
Korczak M, Roszkowski P, Granica S, and Piwowarski JP
- Published
- 2022
- Full Text
- View/download PDF
12. Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential.
- Author
-
Korczak M, Roszkowski P, Granica S, and Piwowarski JP
- Subjects
- Anti-Inflammatory Agents metabolism, Anti-Inflammatory Agents pharmacology, Coumarins, Humans, Ibuprofen pharmacology, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Antineoplastic Agents pharmacology
- Abstract
Urolithin A (UA, 1), a gut microbiota postbiotic metabolite is attributed to express interesting biological activities indicated by in vitro, in vivo and clinical studies. Due to its strong anti-inflammatory properties it is considered as a promising lead molecule for further drug development, however, its strong phase II metabolism, severely limits its oral application. Therefore, monoesterified UA derivatives with selected NSAIDs: ibuprofen (Mix 3a/3b), mefenamic acid (Mix 4a/4b), diclofenac (Mix 5a/5b) and aspirin (Mix 6a/6b) were designed. Performed array of stability assays indicated Mix 4a/4b as a most suitable candidate for further studies due to its exceptional stability in human plasma. Thus, we evaluated effects of Mix 4a/4b on cell viability as well as the impact on cytokines secretion in THP-1 derived macrophages and compared it to UA. At high concentration (50 µM) Mix 4a/4b expressed a cytotoxic effect, however at concentration of 5 µM it significantly suppressed TNF-α secretion, and significantly increased ani-inflammatory IL-10 secretion at 10 µM without affecting cell viability. This work has led to selection of a novel UA derivatives, which are stable in solutions and in human plasma as well as posess anti-inflammatory activity towards THP-1 macrophages at non-cytotoxic concentrations., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
13. GABA B receptor intracellular signaling: novel pathways for depressive disorder treatment?
- Author
-
Korczak M, Kurowski P, Leśniak A, Grönbladh A, Filipowska A, and Bujalska-Zadrożny M
- Subjects
- Animals, Humans, Intracellular Signaling Peptides and Proteins drug effects, gamma-Aminobutyric Acid physiology, Antidepressive Agents pharmacology, Depressive Disorder drug therapy, Intracellular Signaling Peptides and Proteins physiology, Receptors, GABA-B drug effects, Receptors, GABA-B physiology, Signal Transduction drug effects
- Abstract
Affecting over 320 million people around the world, depression has become a formidable challenge for modern medicine. In addition, an increasing number of studies cast doubt on the monoamine theory of depressive disorder and, worryingly, antidepressant medications only significantly benefit patients with severe depression. Thus, it is not surprising that researchers have shown an increased interest in new theories attempting to explain the pathogenesis of this disease. One example is the excitatory/inhibitory transmission imbalance theory. These abnormalities involve glutamate and γ-aminobutyric acid (GABA) signaling. Studies on GABA
B receptors and their antagonists are particularly promising for the treatment of depressive disorders. In this paper, intracellular pathways controlled by GABAB receptors and their links to depression are described, including the impact of ketamine on GABAergic synaptic transmission., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF
14. Personal Sound Amplification Products vs a Conventional Hearing Aid for Speech Understanding in Noise.
- Author
-
Reed NS, Betz J, Kendig N, Korczak M, and Lin FR
- Subjects
- Aged, Aged, 80 and over, Equipment Design, Female, Humans, Male, Middle Aged, Hearing Aids, Hearing Loss rehabilitation, Speech Perception
- Published
- 2017
- Full Text
- View/download PDF
15. Cytotoxic effect of some medicinal plants from Asteraceae family on J-45.01 leukemic cell line--pilot study.
- Author
-
Wegiera M, Smolarz HD, Jedruch M, Korczak M, and Koproń K
- Subjects
- Apoptosis drug effects, Humans, Jurkat Cells, Pilot Projects, Antineoplastic Agents, Phytogenic pharmacology, Asteraceae chemistry, Plant Extracts pharmacology, Plants, Medicinal chemistry
- Abstract
In this study the in vitro cytotoxic properties of ethanol extracts from the herbs, inflorescents and roots of selected Asteraceae species: Arctium lappa, Artemisia absinthium, Calendula officinalis, Centaurea cyanus, Tanacetum vulgare and Tragopogon pratensis on J-45.01 human acute T leukemia cell line was examined. All tested samples possess antileukemic properties and induce cells death via apoptosis. The correlation between antileukemic activity and total polyphenol content was determined.
- Published
- 2012
16. Digestive system fistula: a problem still relevant today.
- Author
-
Głuszek S, Korczak M, Kot M, Matykiewicz J, and Kozieł D
- Subjects
- Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Causality, Comorbidity, Digestive System Fistula drug therapy, Digestive System Fistula mortality, Digestive System Fistula surgery, Digestive System Surgical Procedures statistics & numerical data, Drainage methods, Female, Gastroenteritis epidemiology, Gastrointestinal Neoplasms epidemiology, Humans, Male, Middle Aged, Poland, Postoperative Complications epidemiology, Postoperative Complications prevention & control, Retrospective Studies, Treatment Outcome, Young Adult, Digestive System Fistula diagnosis, Digestive System Fistula therapy, Digestive System Surgical Procedures adverse effects
- Abstract
Digestive system fistula originates most frequently as a complication after surgical procedures, less often occurs in the course of inflammatory diseases, but it can also result from neoplasm and injuries. THE AIM OF THE STUDY was to analyze the causes and retrospectively assess the perioperative procedures as well as the results of digestive system fistula treatment. MATERIAL AND METHODS. Own experience in digestive system fistula treatment was presented. The subject group consisted of 32 patients treated at the General Surgery, Oncology and Endocrinology Clinical Department between 01.05.2005 and 30.04.2010 due to different digestive tract diseases. The causes of the occurrence of digestive system fistula, methods and results of treatment were analyzed. RESULTS. The analysis covered 32 patients with digestive system fistula, among them 15 men and 17 women. Average age for men was 57 years (20-78), and for women 61 years (24-88). In 11 patients idiopathic fistula causally connected with primary inflammatory disease (7 cases) and with neoplasm (4 cases) was diagnosed, in 19 patients fistula was the result of complications after surgery, in 2 - after abdominal cavity injury. Recovery from fistula was achieved in 23 patients (72%) with the use of individually planned conservative therapy (TPN, EN, antibiotics, drainage, and others) and surgery, depending on the needs of individual patient. 5 patients (16%) died, whereas in 4 left (12%) recovery wasn't achieved (fistula in palliative patients, with advanced stages of neoplasm - bronchoesophageal fistula, the recurrence of uterine carcinoma). CONCLUSIONS. Recently the results of digestive system fistula treatment showed an improvement which manifests itself in mortality decrease and shortening of fistula healing time. Yet, digestive system fistula as a serious complication still poses a very difficult surgical problem.
- Published
- 2011
- Full Text
- View/download PDF
17. Divergent selection for skeletal malformations in chickens alters polymorphism at microsatellite loci.
- Author
-
Wardecka B, Jaszczak K, Pierzchała M, Parada R, and Korczak M
- Subjects
- Alleles, Animals, Chickens anatomy & histology, Microsatellite Repeats, Polymorphism, Genetic, Poultry Diseases, Scoliosis genetics, Scoliosis veterinary, Selection, Genetic, Species Specificity, Bone and Bones abnormalities, Chickens genetics
- Abstract
The objective of this study was to determine microsatellite polymorphism in Rhode Island Red (RIR) and Sussex (SX) chickens, divergently selected over six generations for high (H) or low (L) incidence of skeletal defects in embryos (30.7% for H lines, 3.7% for L lines). The polymorphism analysis covered 15 microsatellite markers within four lines (a total of 60 individuals). Eight alleles were identified as specific to H lines and six alleles as specific to L lines. The selection for skeletal malformation appears to have affected the frequency of microsatellite alleles. The experimental material examined constitutes a valuable source for identification of real genes causing skeletal defects.
- Published
- 2004
18. A profile of undergraduate/graduate entrants from non-nursing discipline to the pre-registration nursing programme at Royal Adelaide Hospital from 1987-1990.
- Author
-
Korczak MM
- Subjects
- Australia, Career Choice, Education, Nursing, Diploma Programs, Hospitals, Teaching, Humans, School Admission Criteria, Surveys and Questionnaires, Education, Nursing, Baccalaureate, Education, Nursing, Graduate, Students, Nursing
- Published
- 1991
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.