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Evaluating birch leaf tea as a functional herbal beverage: Beneficial impact on the urinary tract, and metabolism in human organism.
- Source :
-
Food research international (Ottawa, Ont.) [Food Res Int] 2024 Aug; Vol. 189, pp. 114481. Date of Electronic Publication: 2024 May 22. - Publication Year :
- 2024
-
Abstract
- Herbal teas are considered as a potential constituent of novel functional beverages consumed daily. One of the commonly used herbal teas is silver birch (Betula pendula Roth) leaf infusion, traditionally used in urinary tract diseases. In this study, the potential of birch leaf infusion as a functional beverage, emphasizing its active ingredients' bioavailability, anti-inflammatory, and antiadhesive properties concerning urinary tract health, was investigated. A complex approach was proposed, which included phytochemical screening, bioavailability, gut microbiota biotransformation, and an in vivo test for urine metabolomics assessment. The bioassays confirmed significant anti-inflammatory (interleukins IL-6 and IL-8 secretion) and anti-adhesive (Uropathogenic Escherichia coli and T24 bladder cells) activities. The high-resolution mass spectrometry metabolomics studies linked gut microbiota metabolites and the metabolites present in the urine. Several metabolites connected with phenolics' consumption were detected in the urine, e.g., glucuronides and sulfates of caffeic acid and dihydroxyphenyl-γ-valerolactones. Based on the presented results, the birch leaf should be considered useful in designing functional beverages, especially targeted to the groups at high risk of urinary diseases.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Teas, Herbal
Metabolomics methods
Urinary Tract microbiology
Urinary Tract metabolism
Biological Availability
Animals
Plant Extracts pharmacology
Anti-Inflammatory Agents pharmacology
Male
Functional Food
Plant Leaves chemistry
Betula chemistry
Gastrointestinal Microbiome drug effects
Gastrointestinal Microbiome physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7145
- Volume :
- 189
- Database :
- MEDLINE
- Journal :
- Food research international (Ottawa, Ont.)
- Publication Type :
- Academic Journal
- Accession number :
- 38876582
- Full Text :
- https://doi.org/10.1016/j.foodres.2024.114481